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Gowda B.B.K.,Hassan Institute of Medical science HIMS | Yathish T.R.,Hassan Institute of Medical science | Sinhasan Sankappa P.,Hassan Institute of Medical science | Kumar Naik H.,Hassan Institute of Medical science | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2011

Introduction: The oral submucous fibrosis (OSMF) is a precancerous condition of the oral cavity. Untreated and neglected cases of OSMF might end up as invasive squamous cell carcinoma. Some pernicious habits like smoking, pan chewing and tobacco addiction for which human being has succumbed to are causing various dreaded diseases, the important among them being oral submucous fibrosis, leukoplakia and erythroplakia. Free radicals have more recently emerged as mediators of other phenotypic and genotypic changes that lead from mutation to neoplasia. The role of free radicals in the various oxidation processes in the body has lead to the identification of antioxidants in inhibiting and reversing the disease process. Lycopene is a safe antioxidant of utmost importance. Lycopene is a bright red carotene and carotenoid pigment and phytochemical found in tomatoes and other red fruits and vegetables, such as red carrots, watermelons and papayas. Objectives: The main aim and objective of this study is to evaluate the clinical and histopathological response of oral submucous fibrosis to Lycopene-a carotenoid antioxidant. Methods and Materials: The material for this study constitutes 12 adult patients picked from the regular outpatient attending the Department of Dentistry, Hassan institute of Medical Sciences, Hassan, Karnataka, India. Clinically, they are diagnosed as having oral submucous fibrosis. Conclusions: Responses are assessed clinically and histopathologically. We observed clinical and histological improvement in various parameters used in our study. No significant toxicity attributable to Lycopene is encountered in this study.

Shivakumarswamy U.,Hassan Institute of Medical science HIMS | Sankappa S.,Hassan Institute of Medical science HIMS | Purushotham R.,Hassan Institute of Medical science HIMS | Nagesha K.R.,Hassan Institute of Medical science HIMS
Journal of Clinical and Diagnostic Research | Year: 2011

Mesenchymal tumours in the gastrointestinal tract have long been problematic in terms of diagnosis, prognosis and therapy. But recent advances in Immunohistochemistry (IHC) and related therapies have allowed more specific diagnoses. Histopathological examination and the IHC study can correctly identify gastrointestinal stromal tumours (GIST) that are positive for c-KIT. The Imatinib drug which blocks the c-KIT receptor shows remarkable efficacy in the treatment of GIST. We hereby report a case of GIST in a very young male patient who was admitted with a history of pain in the abdomen and recurrent vomiting since 6 months. The clinical examination revealed gastric outlet obstruction. This case report highlights the difficulties which were encountered in the pre-operative diagnosis, where the barium meal and ultrasound (USG) examination findings reported it as a pseudocyst/pancreatic abscess and the CT findings reported it as leiomyoma/lymphoma of the stomach. The histopathological examination of the partial gastrectomy specimen with the tumour tissue showed features which were suggestive of GIST. The IHC study for c-KIT was positive, thus confirming the diagnosis of GIST.

Shivakumarswamy U.,BLDEAs BM Patil Medical College | Shivakumarswamy U.,Hassan Institute of Medical science HIMS | Arakeri S.,Hassan Institute of Medical science HIMS | Karigowdar M.,BLDEAs BM Patil Medical College | Yelikar B.,BLDEAs BM Patil Medical College
Journal of Cytology | Year: 2012

Background: The cytological examinations of serous effusions have been well-accepted, and a positive diagnosis is often considered as a definitive diagnosis. It helps in staging, prognosis and management of the patients in malignancies and also gives information about various inflammatory and non-inflammatory lesions. Diagnostic problems arise in everyday practice to differentiate reactive atypical mesothelial cells and malignant cells by the routine conventional smear (CS) method. Aims: To compare the morphological features of the CS method with those of the cell block (CB) method and also to assess the utility and sensitivity of the CB method in the cytodiagnosis of pleural effusions. Materials and Methods: The study was conducted in the cytology section of the Department of Pathology. Sixty pleural fluid samples were subjected to diagnostic evaluation for over a period of 20 months. Along with the conventional smears, cell blocks were prepared by using 10% alcohol-formalin as a fixative agent. Statistical analysis with the ′z test′ was performed to identify the cellularity, using the CS and CB methods. Mc. Naemer′s 2 test was used to identify the additional yield for malignancy by the CB method. Results: Cellularity and additional yield for malignancy was 15% more by the CB method. Conclusions: The CB method provides high cellularity, better architectural patterns, morphological features and an additional yield of malignant cells, and thereby, increases the sensitivity of the cytodiagnosis when compared with the CS method.

Vijay P.M.,Hassan Institute of Medical science HIMS | Sudha V.M.,Hassan Institute of Medical science HIMS | Doddikoppad M.M.,Hassan Institute of Medical science HIMS
Indian Journal of Public Health Research and Development | Year: 2016

Malignant pigmented villonodular synovitis (MPVNS) is a rare lesion whose existence may be debatable. We studied 10 cases of malignant pigmented Villonodular synovitis among the age group of 20-40yrs. Females dominated males in the incidence & wrist was the commonest joint involved presenting with pain & swelling in most of our cases & only 2 paitents had restricted movements. In 3 cases MPVNS was found to be arising from the previous cases of benign PVNS & 7 cases were primary with histological features similar to that of secondary. Most of the MPVNS showed histological features like nodular, solid infiltrative pattern of the large, plump, round or oval cells with deep eosinophilic cytoplasm and indistinct borders, large nuclei with prominent nucleoli, and necrotic areas. Atypical mitoses were frequent about more than 10 /10hpf. 3 cases showed immunoreactivity for CD68, CD163, and vimentin. 3 cases recurred & died of pulmonary metastasis & inguinal lymph node metastasis in a span of 2 yrs. The malignant nature of this lesion, the histologic architecture similar to that of PVNS, and the fibrohistiocytic appearance of the cells suggest that malignant PVNS is an entity. Thus corroborative evidence of clinical, pathological, radiological & immunohistochemical findings are essential in arriving at a definitive diagnosis & treatment of MPVNS. © 2016, Indian Journal of Public Health Research and Development. All rights reserved.

Shivakumarswamy U.,Hassan Institute of Medical science HIMS | Purushotham R.,Hassan Institute of Medical science HIMS | Kumar Naik H.,Hassan Institute of Medical science HIMS | Nagesha K.,Hassan Institute of Medical science HIMS
Journal of Human Reproductive Sciences | Year: 2012

The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair. Gonads consist usually of seminiferous tubules without spermatogenesis. These patients have a 5-10% risk of developing germ cell tumors, usually after the complete development of secondary female sexual characteristics. We hereby report a case considered as a female with married life of 15 years, who was operated for severe abdominal pain. Phenotype characters were that of female. Microscopic examination of the tumor from the abdomen revealed germinoma and yolk sac tumor with adjacent seminiferous tubules. Karyotyping showed 46XY. Final diagnosis of malignant mixed germ cell tumor in androgen insensitivity syndrome was made. Surveillance may be the most appropriate option when these conditions are initially diagnosed in adulthood to prevent development of germ cell tumors.

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