Hartwick College is a non-denominational, private, four-year liberal arts and science college located in Oneonta, New York, in the United States. The institution's origin is rooted in the founding of Hartwick Seminary in 1797 through the will of John Christopher Hartwick. In 1927, Hartwick Seminary moved to expand into a four-year college and was offered land by the city of Oneonta to move to Hartwick College's current location. The school has 1,500 undergraduate students from 30 states and 22 countries, 187 faculty members and the student-faculty ratio is 11-1. Wikipedia.
Ceresola R.,Hartwick College
Voluntas | Year: 2017
How do volunteers interpret what their service means to them? Is it based on the values the program instills, or on their experiences before volunteering? To answer these questions, I investigate service interpretation in the AmeriCorps program, a US-based social service agency. I conduct 22 in-depth interviews with AmeriCorps members to highlight how they use their cultural capital—rooted in their raised-class background—to interact differently with those they serve and to interpret different benefits of AmeriCorps. I find members from lower-income backgrounds use their past as a form of cultural capital to connect with their service population. On the other hand, members from more privileged backgrounds see the program as beneficial in the context of future work, yet have more difficulty connecting with those they serve. I conclude that the cultural capital learned from different social classes fosters different service interpretations for AmeriCorps members. © 2017 International Society for Third-Sector Research and The Johns Hopkins University
News Article | May 8, 2017
LearnHowToBecome.org, a leading resource provider for higher education and career information, has evaluated the top colleges in New York state for 2017. Of the 50 four-year schools who made the site’s “Best” list, Columbia University in the City of New York, Cornell University, Yeshiva University, University of Rochester and New York University were in the top five. Of the 39 two-year schools that were included, Monroe Community College, Hudson Valley Community College, Niagara County Community College, SUNY Westchester Community College and Genesee Community college took the top five spots. A full list of schools is included below. “New York state offers a wide variety of educational options, but the schools on our list are those going the extra mile for students,” said Wes Ricketts, senior vice president of LearnHowToBecome.org. “Not only do they offer outstanding certificate and degree programs, they also provide students with resources that help them make successful career choices after college.” To be included on the “Best Colleges in New York” list, institutions must be regionally accredited, not-for-profit schools. Each college is ranked on additional statistics including the number of degree programs offered, the availability of career and academic resources, the opportunity for financial aid, graduation rates and annual alumni earnings 10 years after entering college. Complete details on each college, their individual scores and the data and methodology used to determine the LearnHowToBecome.org “Best Colleges in New York” list, visit: The Best Four-Year Colleges in New York for 2017 include: Adelphi University Alfred University Barnard College Canisius College Clarkson University Colgate University College of Mount Saint Vincent Columbia University in the City of New York Cooper Union for the Advancement of Science and Art Cornell University CUNY Bernard M Baruch College CUNY City College CUNY Hunter College CUNY Queens College Daemen College D'Youville College Fordham University Hamilton College Hartwick College Hobart William Smith Colleges Hofstra University Houghton College Iona College Ithaca College Le Moyne College LIU Post Manhattan College Manhattanville College Marist College Molloy College Nazareth College New York University Niagara University Pace University-New York Rensselaer Polytechnic Institute Rochester Institute of Technology Saint John Fisher College Saint Joseph's College-New York Siena College St Bonaventure University St John's University-New York St Lawrence University Stony Brook University SUNY at Binghamton Syracuse University Union College University at Buffalo University of Rochester Vassar College Yeshiva University The Best Two-Year Colleges in New York for 2017 include: Adirondack Community College Bramson ORT College Bronx Community College Cayuga County Community College Clinton Community College Columbia-Greene Community College Corning Community College CUNY Borough of Manhattan Community College CUNY LaGuardia Community College Dutchess Community College Erie Community College Finger Lakes Community College Fulton-Montgomery Community College Genesee Community College Herkimer County Community College Hostos Community College Hudson Valley Community College Jamestown Community College Jefferson Community College Kingsborough Community College Mohawk Valley Community College Monroe Community College Nassau Community College New York Methodist Hospital Center for Allied Health Education Niagara County Community College North Country Community College Onondaga Community College Professional Business College Queensborough Community College Rockland Community College Schenectady County Community College Stella and Charles Guttman Community College Suffolk County Community College SUNY Broome Community College SUNY Orange SUNY Sullivan SUNY Ulster SUNY Westchester Community College Tompkins Cortland Community College ### About Us: LearnHowtoBecome.org was founded in 2013 to provide data and expert driven information about employment opportunities and the education needed to land the perfect career. Our materials cover a wide range of professions, industries and degree programs, and are designed for people who want to choose, change or advance their careers. We also provide helpful resources and guides that address social issues, financial aid and other special interest in higher education. Information from LearnHowtoBecome.org has proudly been featured by more than 700 educational institutions.
News Article | April 20, 2016
Normal is the new strange for the world’s largest cave salamanders. Biologists are thinking deep thoughts about why some of Europe’s olm salamanders living in darkness have (gasp!) skin coloring and eyes with lenses. Most salamanders, of course, have skin pigments and grow adult eyes like other vertebrates. But after eons of cave life, olms (Proteus anguinus) have become mostly pinkish-white beasts, about 30 centimeters head to tail, that spend long lifetimes (maybe 70 years) slinking in cold, subterranean water. Living at 11 to 12° Celsius, olms don’t mature sexually until about age 11 for males and 14 for females. Even then, they never really grow up, staying in water like giant larvae and keeping such youthful features as neck fluff gills into old age. “They look a little creepy, especially if you look at the skull,” says Stanley Sessions of Hartwick College in Oneonta, N.Y. Their blunt heads have no real upper jaw, and their adult eyes start to form but then regress to nubbins buried under skin. These salamanders live frugally. They can go more than a year without eating. (Lilijana Bizjak Mali of the University of Ljubljana in Slovenia says a lab-dwelling olm survived even after more than 10 years without food.) Females take six-to-12-year breaks between laying eggs, which “develop extraordinarily slowly,” Sessions says. Recently laid olm eggs in Slovenia’s Postojna Cave took about seven weeks to start forming a nervous system; a common spotted salamander takes about one. Among extreme cave-lifers, the oddballs are the more normal-looking salamanders (for now, called subspecies parkelj), with dark skin and better-developed eyes. For decades, biologists treated these curios as remnants of the most ancient olms that haven’t shed all their daylight ways. But rather than putting the dark salamanders at the base of the genealogical tree of olms, a genetic analysis places them higher among more recent, pale lineages. “This forces you to consider that the black one probably evolved from white ancestors by reversing cave adaptations,” Sessions says. In evolution, “weirder things have happened.”
News Article | February 21, 2017
Call it an ancient thousand man march. Early Bronze Age men from the vast grasslands of the Eurasian steppe swept into Europe on horseback about 5000 years ago—and may have left most women behind. This mostly male migration may have persisted for several generations, sending men into the arms of European women who interbred with them, and leaving a lasting impact on the genomes of living Europeans. “It looks like males migrating in war, with horses and wagons,” says lead author and population geneticist Mattias Jakobsson of Uppsala University in Sweden. Europeans are the descendants of at least three major migrations of prehistoric people. First, a group of hunter-gatherers arrived in Europe about 37,000 years ago. Then, farmers began migrating from Anatolia (a region including present-day Turkey) into Europe 9000 years ago, but they initially didn’t intermingle much with the local hunter-gatherers because they brought their own families with them. Finally, 5000 to 4800 years ago, nomadic herders known as the Yamnaya swept into Europe. They were an early Bronze Age culture that came from the grasslands, or steppes, of modern-day Russia and Ukraine, bringing with them metallurgy and animal herding skills and, possibly, Proto-Indo-European, the mysterious ancestral tongue from which all of today’s 400 Indo-European languages spring. They immediately interbred with local Europeans, who were descendants of both the farmers and hunter-gatherers. Within a few hundred years, the Yamnaya contributed to at least half of central Europeans’ genetic ancestry. To find out why this migration of Yamnaya had such a big impact on European ancestry, researchers turned to genetic data from earlier studies of archaeological samples. They analyzed differences in DNA inherited by 20 ancient Europeans who lived just after the migration of Anatolian farmers (6000 to 4500 years ago) and 16 who lived just after the influx of Yamnaya (3000 to 1000 years ago). The team zeroed in on differences in the ratio of DNA inherited on their X chromosomes compared with the 22 chromosomes that do not determine sex, the so-called autosomes. This ratio can reveal the proportion of men and women in an ancestral population, because women carry two X chromosomes, whereas men have only one. Europeans who were alive from before the Yamnaya migration inherited equal amounts of DNA from Anatolian farmers on their X chromosome and their autosomes, the team reports today in the Proceedings of the National Academy of Sciences . This means roughly equal numbers of men and women took part in the migration of Anatolian farmers into Europe. But when the researchers looked at the DNA later Europeans inherited from the Yamnaya, they found that Bronze Age Europeans had far less Yamnaya DNA on their X than on their other chromosomes. Using a statistical method developed by graduate student Amy Goldberg in the lab of population geneticist Noah Rosenberg at Stanford University in Palo Alto, California, the team calculated that there were perhaps 10 men for every woman in the migration of Yamnaya men to Europe (with a range of five to 14 migrating men for every woman). That ratio is “extreme”—even more lopsided than the mostly male wave of Spanish conquistadores who came by ship to the Americas in the late 1500s, Goldberg says. Such a skewed ratio raises red flags for some researchers, who warn it is notoriously difficult to estimate the ratio of men to women accurately in ancient populations. But if confirmed, one explanation is that the Yamnaya men were warriors who swept into Europe on horses or drove horse-drawn wagons; horses had been recently domesticated in the steppe and the wheel was a recent invention. They may have been “more focused on warfare, with faster dispersal because of technological inventions” says population geneticist Rasmus Nielsen of the University of California, Berkeley, who is not part of the study. But warfare isn’t the only explanation. The Yamnaya men could have been more attractive mates than European farmers because they had horses and new technologies, such as copper hammers that gave them an advantage, Goldberg says. The finding that Yamnaya men migrated for many generations also suggests that all was not right back home in the steppe. “It would imply a continuing strongly negative push factor within the steppes, such as chronic epidemics or diseases,” says archaeologist David Anthony of Hartwick College in Oneonta, New York, who was not an author of the new study. Or, he says it could be the beginning of cultures that sent out bands of men to establish new politically aligned colonies in distant lands, as in later groups of Romans or Vikings.
News Article | December 23, 2015
Christiana Figueres: Climate guardian | Junjiu Huang: Embryo editor | Alan Stern: Pluto hunter | Zhenan Bao: Master of materials | Ali Akbar Salehi: Nuclear diplomat | Joan Schmelz: A voice for women | David Reich: Genome archaeologist | Mikhail Eremets: Super conductor | Christina Smolke: Fermenting revolution | Brian Nosek: Bias blaster | Ones to watch A dynamic leader charted the path to a new global climate agreement. By Jeff Tollefson Hours after the world’s governments adopted a landmark climate accord this month, Christiana Figueres was all smiles on the dance floor of a boisterous night club in Paris. As the leader of the United Nations climate convention, she had spent five long years travelling the world to rally support among environmentalists, businesses and governments for the accord, in which 195 countries pledged to keep global warming to well below 2 °C. But now here she was, leading conga lines and dancing to the Village People’s classic ‘Y.M.C.A.’. Asked whether she ever had any doubts, she flashed a smile, pulled her hands together as if in prayer and pointed skyward. “The stars are guiding us,” she said. Born into a politically powerful family in Costa Rica, Figueres came by her activism naturally. Her father led the republic’s 1948 revolution and served as its first president. Her brother followed suit, with a term as president in the 1990s, and her mother served in the congress. Friends and colleagues credit Figueres for breaking out of her comfort zone in Costa Rica and jumping into the international environmental arena. “In this country, being a Figueres means something,” says Monica Araya, a former climate negotiator who founded Nivela, an environmental think tank based in Heredia, Costa Rica. “She built a whole career outside Costa Rica, and in a very important way she chose climate change as her activity.” Figueres attributes her environmental activism to the demise of a toad that disappeared from Costa Rica’s Monteverde Cloud Forest Reserve. She saw one when she was young, but her daughters missed the chance. “That was a real awakening for me,” she says, because rising temperatures have been linked to the toad’s extinction. “I started reading into the topic, and before I knew it I was devoting my life to climate change.” In 1995, after stints in the Costa Rican government at home and abroad, Figueres created a non-profit organization in Washington DC to encourage Latin American engagement in the newly minted UN climate convention. In parallel, she represented Costa Rica as a non-governmental climate negotiator — a move, Araya says, that helped to pave the way for other members of civil society to join the Costa Rican delegation. Over time, she became increasingly active in the governing secretariat of the UN convention and built up a reputation for getting things done. When Figueres was interviewed for her current post in 2010, she was asked what she would do if she were overruled by her boss. She offered up a quick joke: “Well, to begin with, I would fire him.” “She is brilliant, way above average, and she has a very well-developed sense of humour,” says Marco Gonzalez, a friend and fellow Costa Rican who formerly headed the UN treaty organization that was built to phase out chemicals that damage the stratospheric ozone layer. “She brings success in her backpack.” Figueres took charge of an organization and a process that she describes as “in the garbage can” after the diplomatic meltdown at the Copenhagen climate conference in 2009. The secretariat had previously concerned itself mostly with national governments, but Figueres expanded its sphere by reaching out to local and regional governments as well as the business sector. “Her fingerprint is all over the intense presence of cities and businesses in Paris,” says David Waskow, director of the International Climate Initiative at the World Resources Institute in Washington DC. Figueres used all of her political skills to help herd governments towards the Paris agreement — and her roots in a developing country helped her to bridge the gulf between rich and poor nations, a division that had plagued past negotiations. Although current climate pledges fall short of the accord’s ultimate goal, all nations have now committed to the battle against global warming. Throughout the process, Figueres says she has been driven by the same sense of duty that spurred her father: the desire to protect and expand opportunities for those who are less fortunate. “I happened to choose a different battleground at the global level, but it’s the same thing,” she says. “We have a huge moral responsibility to do everything that we can to improve that situation.” A modest biologist sparked global debate with an experiment to edit the genes of human embryos. By David Cyranoski In April, Junjiu Huang published the world’s first report of human embryos altered by gene editing. The news thrust rapid developments in gene-editing technology into the spotlight and ignited a huge debate about the ethical use of such tools. But Huang, a modest and soft-spoken molecular biologist at Sun Yat-sen University in Guangzhou, chose to stay out of the limelight. Huang and his team used a powerful technique known as CRISPR–Cas9, which can be programmed to precisely alter DNA at specific sequences and has swept through biology labs in the past few years. He told Nature in April that he wanted to edit the genes of embryos because: “It can show genetic problems related to cancer or diabetes, and can be used to study gene function in embryonic development.” In his study, he modified the gene responsible for the blood disorder β-thalassaemia. Huang used spare embryos — from fertility clinics — that could not progress to a live birth. And he expected his paper, which showed that the process created many unexpected mutations, to steer people away from the technology until it had been proved safe. “We wanted to show our data to the world so people know what really happened with this model,” he said at the time. “We wanted to avoid ethical debate.” But the opposite happened: the ensuing discussion polarized the scientific community and nucleated several high-powered forums, including an international summit held in December in Washington DC. The general consensus is that gene editing is not yet ready for altering human embryos for reproductive purposes — and there are concerns that it could be adopted prematurely by rogue fertility clinics. Some scientists argue that the technique is permissible for research, whereas others say that this too should be forbidden for fear of a slippery slope. Huang has been notably absent from the debate, and refused to be interviewed for this article. “Our paper was just basic research, which told people the risk of gene editing,” he wrote in an e-mail. “It’s like he’s hiding,” says Tetsuya Ishii, a bioethicist at Hokkaido University in Sapporo, Japan, who was at the US summit. “That’s strange because there was nothing really ethically problematic about his research. He raised the issue, and that kind of drove discussions on the topic at the summit. That’s a good thing.” But Ishii says that Huang does “have some responsibility to address his critics”, perhaps by discussing cases in which clinical use of gene editing could be worthwhile in the future. Because of the risks, Huang predicted when his paper was published that it could take 50 or 100 years before the world saw a live-born, gene-edited baby. “But who knows, a decade ago, no one knew of CRISPR,” he said. “We don’t know what will happen.” A single-minded planetary scientist brought the dwarf planet into focus. By Alexandra Witze Alan Stern, planetary scientist and workaholic, doesn’t sleep much at the best of times. In the days approaching 14 July — as the spacecraft he had dreamed about, worked for and slaved over for a quarter of a century neared its target — he was down to roughly three hours a night. Stern, of the Southwest Research Institute in Boulder, Colorado, is the principal investigator for NASA’s New Horizons mission, which in July became the first probe to visit Pluto. It whizzed just 12,504 kilometres above the dwarf planet’s surface, in an extraordinarily choreographed fly-by that grabbed images, spectra and other scientific data — as well as headlines around the world. Stern had been preparing for the day since 1989, when he and other young researchers hatched plans to visit the distant world. They submitted their proposal to NASA, and kept their hopes alive even when the agency killed plans for a Pluto mission in 2000 over budget concerns. After Congress revived funding for the concept, and NASA restarted the competition for proposals, Stern’s team won with a lean design that would carry a few key instruments. “That meant a laser focus on getting it there,” he says. Stern is nothing if not laser focused. Under his leadership, New Horizons blasted off in January 2006 at a cost of US$720 million, much less than earlier multibillion-dollar missions to the outer Solar System. His three children went through high school and into university with 14 July 2015 imprinted on their brains. When the day arrived, Stern and the rest of Earth got to see Pluto up close for the first time. Among his favourite discoveries: ice mountains that tower as high as 4 kilometres, dune fields that may ripple across Pluto’s surface, and skies that are tinted blue by atmospheric haze. A heart-shaped feature that showed up on images was a “public-relations bonanza”, he says, inspiring people around the world to connect with the dwarf planet. Stern’s drive to explore new worlds is also reflected in his focus on public relations, says David Grinspoon, a researcher with the Planetary Science Institute in Tucson, Arizona, who is working with Stern on a book about the mission. Stern convened an eclectic group of artists, writers and visionaries in New York City months before the fly-by to pick their brains about ways to connect with the general public. “It wasn’t your normal outreach team,” Grinspoon says. Stern pursues public engagement with a singular passion. He is known for seeking out — and scrutinizing — media coverage. Even during the most intense stages of the mission, Stern was tweeting prolifically and posting to Facebook while overseeing press releases. After the fly-by, Stern found himself swamped with speaking invitations. At an astronomy conference in Vermont, he talked for an hour, took questions for an hour and then met Pluto fans individually. Two university students told him that New Horizons was the best thing that had happened in their lifetime. Months after the Pluto visit, some members of the team experienced a post-fly-by depression. Not Stern. He drives ahead as always, working on the data that will dribble back from the spacecraft until late 2016. He is also resuming work on the European Space Agency cometary mission Rosetta, on which he has an ultraviolet spectrometer instrument, and on plans to fly research payloads on suborbital spacecraft. He has a little more time for sleep these days, but not much. And in October and November, New Horizons ignited its engines to set it on course to visit a second Kuiper belt object, this one on New Year’s Day in 2019. If NASA approves the extended mission, Stern says, “I’m looking forward to finishing what we started”. A chemical engineer is merging electronics with the human body. By Erika Check Hayden Zhenan Bao rummages through a plastic box on her desk, eagerly pulling out samples of materials developed in her lab. She finds a thin, nearly weightless patch made of carbon nanotubes that attaches to the wrist like a sticking plaster and monitors the wearer’s heart rate. Then she picks up an artificial skin that uses tiny carbon-nanotube sensors to detect touch; and a version of it that even features hair-like structures to more closely mimic real skin. Bao, a chemical engineer at Stanford University in California and a founder of the field of thin, flexible organic electronics, shines a laser pointer through a sample of the nanotube material used in many of these devices. She laughs as the beam is diffracted into a spray of green dots on the wall, just as it would be when passing through a crystalline material. “That’s how we know it has regular structure,” she says. Innovations in her field are often inspired by nature, she says: “If we can understand how to design materials with the same degree of complexity, we will be able to address real-world problems.” A prime example is the creation of medical devices that can be worn or implanted to monitor blood sugar, send sensory signals and more. Progress towards that goal has taken off this year, with Bao’s lab among the leaders. In October, her team showed that its artificial skin could mimic the sense of touch (B. C.-L. Tee et al. Science 350, 313–316; 2015). The researchers took inspiration from human skin, in which specialized nerves fire more rapidly as pressure increases, producing a code that the brain interprets as touch. Previous artificial touch sensors required power-hungry external devices to generate that code. But in Bao’s sensors, pressure alters the oscillating frequency of microscopic circuits made from carbon nanotubes to generate the right kind of signals automatically. Although Bao calls the final design “simple”, it was a major accomplishment, says Polina Anikeeva, a neural-interfaces and materials scientist at the Massachusetts Institute of Technology in Cambridge. She notes that Bao has been working on perfecting these materials for years, and that her lab — which comprises around 40 chemists, chemical engineers and materials scientists — is highly interdisciplinary. “It’s not just one idea,” she says, “many ideas came together and made this possible.” “We have many years of work to do,” says Bao, who hopes that the treasures she keeps in the plastic box will one day help to revolutionize health care. “But generally, the path is laid out.” The head of Iran’s nuclear programme helped to forge a pact to keep it peaceful. By Davide Castelvecchi On 14 July 2015, Iran signed an agreement with six world powers to limit the country’s nuclear development in exchange for lifted international-trade sanctions. If the deal is implemented successfully — still far from certain — it could ease years of tension over Iran’s alleged efforts to build nuclear weapons and so allow the country to become a major player in global science. That an accord was reached at all, however, was due in no small measure to nuclear engineer Ali Akbar Salehi, who is head of the Atomic Energy Organization of Iran. He worked closely with his US counterpart, energy secretary Ernest Moniz, to iron out the deal’s technical aspects. Educated at the American University of Beirut and the Massachusetts Institute of Technology in Cambridge, Salehi returned to Iran after the Islamic revolution of 1979 and quickly rose to top posts in both academia and the government. By the 2000s, he had become the international face of Iran’s nuclear programme — a man described as fiercely loyal to his country, but also a voice of reason to whom negotiators could appeal in times of crisis. Salehi is said to be a deeply spiritual person who has the trust — and the ear — of the country’s supreme leader, Ayatollah Ali Khamenei. And he is one of very few people to have held senior posts in both hardline and comparatively liberal governments. This talent for building bridges is what enabled Salehi to work so effectively with Moniz during the negotiations, says Reza Mansouri, an astronomer at the Institute for Research in Fundamental Sciences in Tehran and a former deputy science minister of Iran; they shared the language of science. Mansouri, who has known Salehi for more than three decades, says that he has the modern, rational frame of mind that enables people to “agree on how to talk to each other”. They came forward, one by one. Young female astronomers sought out Joan Schmelz and confided in her about the sexual harassment that they had endured. Schmelz, a solar physicist and chair of the American Astronomical Society’s Committee on the Status of Women in Astronomy from 2009 to 2015, heard too many of these stories — and a lot of them involved the same man. Schmelz told the women that they were not alone, and asked whether they wanted to talk to others who were in the same situation. Thanks in part to those introductions, four women eventually filed complaints. Their actions, which became public this year, led to the resignation of Geoff Marcy, a well-known exoplanet hunter at the University of California, Berkeley. It was one of the most dramatic episodes in a string of gender-equality controversies this year, including Nobel laureate Tim Hunt’s dismissive comments about women working in the laboratory. In astronomy, Schmelz’s behind-the-scenes efforts to expose sexual harassment set the stage for a sea change in community understanding, says Meg Urry, an astronomer at Yale University in New Haven, Connecticut, and president of the astronomical society. After Marcy was outed, astronomy departments at universities and other institutions began frank discussions about unacceptable behaviour. “Without Joan, I don’t think we would have seen this remarkable change,” says Urry. Women were comfortable sharing their stories with Schmelz because she had been through the same thing. Early in her career, Schmelz had found herself the target of harassment by her supervisor. “I was very isolated, and I didn’t have anyone to confide in,” she says. She only began to realize what had happened to her years later, in 1991, when attorney Anita Hill accused Clarence Thomas, a judge nominated for the US Supreme Court, of sexual harassment. In 2011, Schmelz went public, through a blog post on the website of the Committee on the Status of Women in Astronomy. Then the Marcy stories started pouring in. “For a while I kept trying out how we could move forward — I contacted a lot of people, players in the community, to see if there was anything we could do for these women,” she says. Eventually the option emerged of filing complaints under the legislation known as Title IX, which prohibits sexual discrimination on campuses that receive federal funding. In July 2014, the first complaints hit Berkeley. “I wasn’t sure it would ever happen,” says Schmelz. All this intense work took place as Schmelz led a busy career in solar astronomy. In June this year, she took a job as deputy director of Arecibo Observatory in Puerto Rico. Months later, the director resigned, leaving Schmelz in charge of the world’s largest single-dish radio telescope. She now lives just a block from the beach, which offers a much-needed respite when she can spare the time. But Schmelz knows that her work on harassment is not over. She would like to press universities to keep long-term records of complaints. In most institutions, there is no method for tracking whether there have been one, two or ten incidents reported against a given person over time. “Let’s find ways to take the pressure off the young women, so they can work on their science, write a thesis, without all of this extra added burden on them,” says Schmelz. “Let’s change the system.” A big thinker helped to turn ancient genomics from niche pursuit to industrial process. By Ewen Callaway For most of its 30-year history, the field of ancient genetics has revolved around discovering exceedingly rare samples — a bone, a tooth — that harbour enough intact DNA to study. This year, population geneticist David Reich proved that it’s possible to explore human history by powering through ancient genomes en masse. Reich’s genome factory has revealed mass migrations, the spread of farming and the roots of languages. Last month, his group at Harvard Medical School in Boston, Massachusetts, reported genome data from 230 people who lived in Europe and the Middle East over the past 8,000 years, tracking changes in skin colour, immunity and other traits (I. Mathieson et al. Nature http://doi.org/9rb; 2015). At university, “I think I was sort of idealistic”, Reich says. “I was interested in grand unifying theories.” For his first degree, he switched from sociology to physics. During his second, in biochemistry, he fell for human population genetics, and soon built a reputation for scientific rigour. In the late 2000s, plummeting sequencing costs and other advances made it easier to extract and analyse ancient DNA. Reich realized that by analysing the genomes of large numbers of people, he could see how immigration and interbreeding changed the genetics of entire regions. In 2013, Reich opened his own lab devoted to sequencing ancient remains. Its scale was industrial from day one: the first human samples came from 66 individuals who had lived in what is now Russia, including members of a Bronze Age culture called the Yamnaya. In June, the team described a massive migration of Yamnaya people into Western Europe, some 5,000 years ago (W. Haak et al. Nature 522, 207–211; 2015). It is not the only group powering through ancient genomes: the lab of Eske Willerslev at the Natural History Museum of Denmark in Copenhagen reached a similar conclusion (M. E. Allentoft et al. Nature 522, 167–172; 2015). Reich’s team argued that the Yamnaya migration might also explain the radiation of Indo-European languages across Europe and Asia — advancing a problem that has vexed linguists for decades. By exploring the consequences of genetics for other fields, Reich “is trying to do something that a lot of geneticists might not”, says David Anthony, an archaeologist at Hartwick College in Oneonta, New York. Reich is eager to see genetics inform other debates, such as those about the peopling of the Americas and the prehistory of India. “The invention of ancient DNA as a tool for studying the past is like the invention of a new scientific instrument, like a microscope,” he says. “You can see into things that you couldn’t see before.” Decades of diligence earned one physicist a record for resistance-free electricity. By Edwin Cartlidge As a young researcher during the 1970s and 1980s, Mikhail Eremets proved to have a temperament well suited to life at the Institute for High Pressure Physics outside Moscow. The facilities were often abysmal, but the soft-spoken Belarusian was prepared to work around them — even dialling the same telephone number 100 times just to get a working line. “If I want to do something I am happy to repeat it many, many times,” says Eremets, who is now at the Max Planck Institute for Chemistry in Mainz, Germany. That doggedness has served him well in his quest to understand how materials behave at pressures close to those of Earth’s core — conditions that he recreates by squeezing tiny samples between the tips of two diamond ‘anvils’. These experiments have been painstaking and repetitive, with results that never troubled the Nobel committee. Until late 2014, that is, when Eremets and his colleagues reported hints that pressurized hydrogen sulfide — the compound responsible for the smell of rotting eggs — can become a superconductor, allowing electricity to flow without resistance at a record-breaking 190 kelvin (−83 °C) (A. P. Drozdov et al. Preprint at http://arxiv.org/abs/1412.0460; 2014). He and others published conclusive evidence — and measured an even higher temperature — in August (A. P. Drozdov et al. Nature 525, 73–76; 2015). The advance has been hailed as a giant step towards the long-sought goal of room-temperature superconductivity and the promise of loss-free electrical transmission. It has certainly rocked the physics community, says Igor Mazin of the Naval Research Laboratory in Washington DC. Other materials have produced superconductivity at high temperatures, but the mechanism by which hydrogen sulfide operates has never achieved superconductivity above 40 kelvin. No independent group has confirmed the result entirely, but Eremets is already planning experiments to see whether hydrides doped with chemicals can superconduct at normal, atmospheric pressure — an essential step towards practical use. Having done most of his important work since turning 50, he feels he has plenty of research left in him. “In that sense I am still a young, growing scientist,” he says. A synthetic biologist won a breakneck race to produce opioids in yeast. By Erika Check Hayden Early this year, synthetic biologist Christina Smolke was in a dead-heat race with a handful of other labs to engineer a yeast strain capable of making opioids. These powerful pain-killing drugs are crucial in medicine, but they come solely from opium poppy crops that can have unpredictable yields. Scientists were seeking a more stable production method but faced a daunting hurdle: no one had been able to identify an enzyme that converts reticuline — a chemical building block of morphine and other narcotics — from one form to another. Most other labs hunting for the enzyme were working to isolate it from poppies directly. But Smolke and her team at Stanford University, California, took a different approach: they combed through genetic databases, looking for snippets of sequence that looked as if they might be involved in reticuline metabolism. When they found a hit from several different poppy species, they ordered a synthetic version of the gene that had been built letter-by-letter by a machine. They plugged it into yeast and it worked. “I was super excited, really proud and also relieved,” Smolke says. “It was a bit of a Hail Mary.” The discovery enabled Smolke’s lab to stitch together a pathway of 23 different genes from plants, mammals, bacteria and yeast to produce the world’s first narcotic through synthetic biology (S. Galanie et al. Science 349, 1095–1100; 2015). It was a crowning achievement for a biological wunderkind who started her own lab at the California Institute of Technology in Pasadena at the age of just 28. The opioid-producing yeast cells contain the most complex synthetic-biology pathway developed so far, and mark a turning point for the field by showing how step-by-step engineering can turn microbes into drug factories. “This will significantly impact our future ability to produce many more chemicals through biotechnology,” says Jens Nielsen, a synthetic biologist at the Chalmers University of Technology in Gothenburg, Sweden. Much of the news coverage of the work, however, stirred fears about how it could foster new ways to easily manufacture illegal drugs — and some scientists have argued for tighter regulation of the growing field. Smolke counters that existing regulations already restrict the production and distribution of narcotics; any lab that wishes to work with the yeast strain reported in her paper, for instance, must be licensed by the US Drug Enforcement Administration. So far, no one has requested the strain. In a bid to ground the debate in reality, Smolke, her husband — fellow Stanford synthetic biologist Drew Endy — and another colleague this year attempted to brew opioids using her lab’s strain and standard beer-making equipment (D. Endy et al. Preprint at bioRxiv http://doi.org/9t2; 2015). The set-up produced only a trace amount of reticuline and none of the downstream chemical, thebaine, that is used to synthesize commercial drugs such as oxycodone and oxymorphone — suggesting that it would be difficult for the average home-brewer to start making these pharmaceuticals. (The scientists’ positive fermentation control, an English ale, was “palatable”, the manuscript notes.) Smolke co-founded a company, Antheia, based in Palo Alto, to produce opiate drugs in yeast commercially, and specialists in the field suspect that more will follow. But some onlookers are circumspect. Plant biologist Ian Graham at the University of York, UK, says that it will be hard to beat poppies. “Where plants already do it very well, the arguments for taking a synthetic-biology route are much less convincing,” he says. For Smolke, the goal is not merely to copy plants, but to engineer opioids that are free of side effects such as dependency and addiction. Sitting in the office of a Palo Alto incubator space, wearing jeans and grey Converse sneakers to a meeting with the co-founders of Antheia, Smolke can appear casual — but the intensity that has propelled her to the pinnacle of her field is tangible. For her, the year’s accomplishments are just part of a quest to understand and improve on opioids, which are among the most complex natural chemicals . “It’s a very powerful approach to take inspiration from nature and go beyond it,” she says. A psychologist pledged to improve reproducibility in science. By Brendan Maher When Brian Nosek was a graduate student in experimental psychology, he started working on the implicit-association test, which reveals people’s unconscious prejudices with the push of a button. Tap right every time a male name appears on a screen, for example, and left for a female name. That’s easy — but add some stereotypically male or female roles into the mix and things get interesting. Even the most liberal minds will sometimes stall when asked to press the same button for the word ‘executive’ and for the name ‘Susan’. The tests are challenging, informative and kind of fun. So in 1998 Nosek convinced his mentors, who had developed the test, to put it online. It was a success: about a million people per year now take the test for research, corporate training and other reasons. “It really spread the word about what unconscious bias is,” says Betsy Levy Paluck, a social psychologist at Princeton University, New Jersey. For Nosek, a key demographic still needs to be educated about their biases: scientists. Nosek is convinced that researchers are unconsciously influenced by their hypotheses, that these biases can be seen in common practices that distort the interpretation of data such as p-value hacking, and that they are major drivers of the much-discussed crisis in research reproducibility. In 2013, Nosek took leave from his post at the University of Virginia in Charlottesville to co-found the Center for Open Science (COS), a non-profit company that builds tools to facilitate better research methodology. It hit several milestones this year, accumulating US$18 million in funding and a staff of 68. Nosek also co-authored a set of guidelines for transparency and openness that more than 500 journals have signed up to (B. A. Nosek et al. Science 348, 1422–1425; 2015). But the COS’s most visible output in 2015 was the Reproducibility Project, an ambitious attempt to re-test seminal findings in 100 psychology papers (Open Science Collaboration Science http://doi.org/68c; 2015). The decision to run the project “was quite brave of him”, says Dorothy Bishop, a neuropsychologist at the University of Oxford, UK, because poor results could tarnish the field’s reputation. In the end, 61 of the findings could not be replicated — but the outcome was mostly received well, something for which many psychologists credit Nosek’s careful diplomacy and can-do approach. Nosek is pushing researchers to adopt practices that will improve reproducibility, including preregistering studies, tracking the results in an open way and publishing them whether they are positive or negative. It will be a dramatic culture change, says Bishop, who has begun using systems developed by the COS for her own research. “Yes, it creates a lot more work. You have to document and check it very thoroughly. But it’s not a bad thing to be slowed down a bit.” A second reproducibility project that is focused on findings in cancer biology should begin releasing results next year, and Nosek says that negotiations are in the works for similar projects in ecology and computer science. No one operates completely free of bias, he says, and that includes him. “I try to have some humility and understanding that I am as prone to these behaviours as anyone else.” Gianotti will take charge at the European lab as its Large Hadron Collider clocks up record high-energy particle collisions— and as hopes of the next big discovery soar. If rumours that this observatory has detected gravitational waves prove true, one of the most elusive predictions of the general theory of relativity would be confirmed. By applying for approval to edit the genomes of human embryos, Niakan has placed herself at the front of the fast-moving, controversial CRISPR–Cas9 field. There is intense curiosity about what will emerge next from Hassabis’s efforts to combine neuroscience and machine learning at the Google-owned firm. Yang will be influential at this growing basic-research agency as China overhauls its funding systems and sets its next 5-year plan.
Rinfret S.R.,Hartwick College
Environmental Practice | Year: 2011
In practice, building collaborative relationships between environmental groups and industry is not an easy task during environmental rulemaking. However, this article uses original interview data to document a different perspective from agency officials and stakeholders across two case studies within the Environmental Protection Agency's Office of Transportation and Air Quality (OTAQ): the renewable fuels standard and the locomotive and marine engine rule. This article argues that OTAQ used a new approach, shuttle diplomacy, in these particular cases to negotiate stakeholder differences prior to publication of a Notice of Proposed Rulemaking. The findings from these interviews suggest that the intent of this rule development approach is to provide an atmosphere where stakeholders begin to trust in the process because they are helping to create it. Environmental Practice 13:1-8 (2011) © Copyright National Association of Environmental Professionals 2011.
Eppes M.C.,University of North Carolina at Charlotte |
Griffing D.,Hartwick College
Geomorphology | Year: 2010
Here we document for the first time in detail a natural landscape dominated by granular disintegration of marble and the associated production of marble grus sediment and corestones. We provide several lines of evidence for a thermal-mechanical origin for the observed granular disintegration and resulting corestones. In the San Bernardino Mountains of southern California, calcite marble outcrops whose average grain diameter is greater than approximately 0.5 mm are weathering into grus sediment and exhibit a corestone morphology. Minimal soil development in thick grus colluvium combined with results from a simple erosion experiment indicates that grus production and erosion is rapid. Our data indicate that unlike granite, marble granular disintegration and corestone development is a uniquely sub-aerial process. Environmental Scanning Electron Microscope (ESEM) and micro-probe analyses of rock samples collected in recent quarry exposures indicate that detachment of grain boundaries occurs primarily within the upper 2-20 cm of the outcrop surface. There is minimal evidence of secondary calcite dissolution or precipitation at grain boundaries below the upper-most few centimeters of the rock surface, despite widespread intergranular fracturing. At depths greater than 20 cm below the natural ground surface, granular disintegration and corestone weathering are not evident, and dissolution and precipitation of secondary calcite is only observed within a few centimeters of joint planes. Corestone morphology appears to form through the erosion of loosened grus debris at sharp edges of subaerially exposed joints. The resulting form represents a morphologic equifinality to that of granite corestones and results from different processes than those which have been proposed for granite. An 8-month, once-per-three minute temperature record from a thermocouple embedded into a marble corestone indicates that the upper 2.5 cm of the corestone regularly achieves temperatures greater than 40 °C, the temperature which is thought to be sufficient to produce permanent strain in calcite. All of these results are consistent with theoretical and experimental studies that indicate that marble is susceptible to mechanical weathering by thermal processes. Overall, this study provides new documentation that solar heating and cooling can be an important driver of physical weathering in natural systems of the Earth's surface. © 2009 Elsevier B.V. All rights reserved.
Rinfret S.R.,Hartwick College
Review of Policy Research | Year: 2011
The purpose of this article was to question whether interest group actions during the pre-proposal stage of U.S. federal rulemaking influences the language proposed in natural resource agency rules. The influence of interest groups during this stage was examined across three case studies: (1) the United States Fish and Wildlife Service (USFWS) critical habitat designation for Nebraska's Salt Creek tiger beetle, (2) the USFWS critical habitat designation for the Utah/Arizona Shivwits and Holmgren milk vetch, and (3) the USFWS delisting of the Northern Rocky Mountain gray wolf population from the endangered species list. To analyze these three cases, a frame analysis approach is used and offers evidence to support the proposition that the instructive, expertise, and fiscal feasibility frames that stakeholders used during the pre-proposal stage can shape the language of a Notice of Proposed Rulemaking. These cases suggest the rich potential for careful study of the earliest stages in the regulatory and administrative rulemaking process in the United States and beyond. © 2011 by The Policy Studies Organization.
Rrusso A.J.,Hartwick College
Biomarker Insights | Year: 2013
Background: Autism spectrum disorders (ASDs), characterized by impaired social interactions and deficits in verbal and nonverbal communication, are thought to affect 1 in 88 children in the United States. There is much support for the role of growth factors in the etiology of autism. Recent research has shown that epithelial growth factor (EGF) is decreased in young autistic children (2-4 years of age). This study was designed to determine plasma levels of EGF in an older group of autistic children (mean age 10.6 years) and to correlate these EGF levels with putative biomarkers HGF, uPA, uPAR, GAD2, MPO GABA, and HMGB1, as well as symptom severity of 19 different symptoms. Subjects and methods: Plasma from 38 autistic children, 11 children with pervasive developmental disorder (PDD-NOS) and 40 neurotypical, age and gender similar controls was assessed for EGF concentration using ELISAs. Severity of 19 symptoms (awareness, expressive language, receptive language, (conversational) pragmatic language, focus/attention, hyperactivity, impulsivity, perseveration, fine motor skills, gross motor skills, hypotonia (low muscle tone), tiptoeing, rocking/pacing, stimming, obsessions/fixations, eye contact, sound sensitivity, light sensitivity, and tactile sensitivity) was assessed and then compared to EGF concentrations. Results: In this study, we found EGF levels in autistic children and those with PDD-NOS to be significantly lower when compared with neurotypical controls. EGF levels correlated with HMGB1 levels but not the other tested putative biomarkers, and EGF correlated negatively with hyperactivity, gross motor skills, and tiptoeing but not other symptoms. Conclusions: These results suggest an association between decreased plasma EGF levels and selected symptom severity. We also found a strong correlation between plasma EGF and HMGB1, suggesting inflammation is associated with decreased EGF. © the author(s), publisher and licensee Libertas Academica Ltd.
Russo A.J.,Hartwick College
Biomarker Insights | Year: 2013
There is much support for the role of Gamma-Aminobutyric acid (GABA) in the etiology of autism. Recent research has shown that hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. This study was designed to determine and correlate plasma levels of HGF, GABA, as well as symptom severity, in autistic children and neurotypical controls. Plasma from 48 autistic children and 29 neurotypical controls was assessed for HGF and GABA concentration using ELISAs. Symptom severity was assessed in these autistic individuals and compared to HGF and GABA concentrations. We previously reported that autistic children had significantly decreased levels of HGF. In this study, the same autistic children had significantly increased plasma levels of GABA (P = 0.002) and decreased HGF levels correlated with these increased GABA levels (r = 0.3; P = 0.05). High GABA levels correlated with increasing hyperactivity (r = 0.6; P = 0.0007) and impulsivity severity (r = 0.5; P = 0.007), tip toeing severity (r = 0.35; P = 0.03), light sensitivity (r = 0.4; P = 0.02), and tactile sensitivity (r = 0.4; P = 0.01). HGF levels did not correlate significantly with any symptom severity. These results suggest an association between HGF and GABA levels and suggest that plasma GABA levels are related to symptom severity in autistic children. © the author(s), publisher and licensee Libertas Academica Ltd.