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Harper Woods, MI, United States

Introduction.: It is a common practice to soak Titan® Coloplast penile implants in antibiotic solution prior to implantation. Aim.: The aim of this study is to identify an ideal solution for soaking the Titan® Coloplast penile implants prior to implantation. Methods.: Titan® strips were soaked in a different combination of antibiotics and the zone of inhibition was studied against Staphylococcus epidermidis and Escherichia coli. This zone of inhibition was compared against zone of inhibition produced by Inhibizone®-coated silicone strips. Zones of inhibitions were also compared for different components of Inhibizone® implant such as cylinder, tubing, connector, rear tip extender, and reservoir, and compared with similar components of Titan® Coloplast penile implants. Main Outcome Measures.: The zone of inhibition against S. epidermidis and E. coli for Titan strips dipped in Rifampin and Gentamicin was compared against other antibiotics. The clinical significance of dipping Titan®-coated Coloplast implant in Rifampin and Gentamicin solution was determined. Results.: Rifampin 10 mg/mL + gentamicin 1 mg/mL (R10/G1) and rifampin 1 mg/mL + gentamicin 1 mg/mL (R1/G1) had excellent coverage against S. epidermidis and E. coli. The zone of inhibition (utilizing the Titan® coating) produced by both these solutions exceeds that produced by Inhibizone® by 40% to 56% for S. epidermidis and 33% for E. coli. Components of the American Medical System implant (tubing connectors and rear tip extenders) are not coated with antibiotics and had no zone of inhibition. Conclusion.: Soaking Titan®-coated Coloplast implants in R10/G1 solution produces a zone of inhibition greater than that produced by Inhibizone®-coated penile implants. The clinical significance of this increased zone of inhibition can only be determined by a separate clinical study. © 2010 International Society for Sexual Medicine. Source

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