Jin X.-H.,Harison International Peace Hospital |
Zhang Q.-S.,Harison International Peace Hospital |
Yang J.-B.,Harison International Peace Hospital |
Liu G.-H.,Harison International Peace Hospital |
And 3 more authors.
Chinese Journal of Tissue Engineering Research | Year: 2013
BACKGROUND: Allogeneic tendon graft is an ideal method to repair tendon defects. But post-transplantation rejections limit the use of allogeneic tendons. OBJECTIVE: To investigate the effect of acellular tendon of Banna mini-pig inbred-lines on repair of rabbit Achiles tendon, and then to evaluate the feasibility and validity of porcine-derived xenogeneic graft. METHODS: Forty Japanese white rabbits were enrolled to prepare Achilles tendon defect models of the both hind legs, and then were randomly divided into two groups: acellular porcine tendon group treated with acellular tendon from Banna mini-pig inbred-lines and autologous tendon group treated with rabbit autologous tendon. End-to-end anastomosis was performed with a 3-0 tendon thread using improved HEMI-KESSLER method. RESULTS AND CONCLUSION: Within 2 weeks post transplantation, there were no significant differences in white blood cell count and C-reactive protein level between the two groups (P > 0.05). Local reactions in the two groups after transplantation were few, the wound healed at stage I, and flexor ankle function returned to normal. Histological results exhibited no lymphocytic infiltration, but interconnected collagen fibers at tendon suture site. These findings indicate that acellular tendons from Banna mini-pig inbred-lines can successfully reconstruct defected rabbit Achilles tendon with good histocompatibility and little rejection. Source