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Gent, Belgium

Claeys B.,Harelbekestraat 72 | Vervaeck A.,Harelbekestraat 72 | Vervaet C.,Harelbekestraat 72 | Remon J.P.,Harelbekestraat 72 | And 2 more authors.
Macromolecular Rapid Communications | Year: 2012

Here we evaluate poly(2-ethyl-2-oxazoline)s (PEtOx) as a matrix excipient for the production of oral solid dosage forms by hot melt extrusion (HME) followed by injection molding (IM). Using metoprolol tartrate as a good water-soluble model drug we demonstrate that drug release can be delayed by HME/IM, with the release rate controlled by the molecular weight of the PEtOx. Using fenofibrate as a lipophilic model drug we demonstrate that relative to the pure drug the dissolution rate is strongly enhanced by formulation in HME/IM tablets. For both drug molecules we find that solid solutions, i.e. molecularly dissolved drug in a polymeric matrix, are obtained by HME/IM. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

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