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Nagasaki-shi, Japan

Kawano Y.,Nagasaki Harbor Medical Center
Japanese Journal of Clinical Radiology | Year: 2014

We reported MDCT findings of 5 cases of PTP ingestion without complication, and made reference to relationship between PTP material and phantom. PTP forms very small shadow on body CT, and the contents show various attenuation, therefor it is necessary to observe MDCT findings carefully to detect PTP lesion. Geometrical structure of the contents and surrounding air space on MDCT are important for diagnosis rather than difference of PTP material, mainly PVC (polyvinyl chloride) and PP (polypropylene). Prerequisite for endoscopic withdrawal, MDCT is very useful to find out the region of PTP in long alimentary tract. Source


Takeshita S.,Nagasaki Harbor Medical Center | Asano H.,Tosei General Hospital | Hata T.,Kyoto Kujo Hospital | Hibi K.,Yokohama City University | And 16 more authors.
American Journal of Cardiology | Year: 2014

The frequency of radial artery occlusion was compared between patients receiving 4Fr versus 6Fr transradial coronary interventions (TRIs) in an open-label randomized trial (ClinicalTrials.gov identifier: NCT00815997). The primary outcome measure was radial artery occlusion on the day after TRI. The secondary outcome measures were the procedural success, major advanced cardiac events, access site-related complications, procedural times, fluoroscopy times, and contrast dye usage. A total of 160 patients were included. The procedure was successful in 79 of 80 patients (99%) in both groups. Whereas the 4Fr group showed no access site-related complications, the 6Fr developed 5 (6%), including 3 radial artery occlusions and 2 bleedings (1 radial artery perforation and 1 massive hematoma; p = 0.02). Although the radial artery occlusion rate was lower in the 4Fr versus the 6Fr groups, the difference was not significant (0% vs 4%, p = 0.08). The mean hemostasis time was significantly shorter in the 4Fr than in the 6Fr groups (237 ± 105 vs 320 ± 238 minutes, p = 0.007). In conclusion, these findings suggest that 4Fr TRI may become a less invasive alternative to 6Fr TRI in treating coronary artery diseases. © 2014 Elsevier Inc. All rights reserved. Source


Haramura T.,Nagasaki Harbor Medical Center | Haraguchi M.,Nagasaki Harbor Medical Center | Irie J.,Nagasaki Harbor Medical Center | Ito S.,Nagasaki Harbor Medical Center | And 8 more authors.
World Journal of Gastroenterology | Year: 2015

Plasmablastic lymphoma (PBL) is a rare form of non-Hodgkin's lymphoma that is associated with human immunodeficiency virus (HIV) infection. Although PBL is most commonly observed in the oral cavity of HIV-positive patients, it can also be observed at extra-oral sites in HIV-negative patients. This report represents an unusual case of HIV-negative PBL that occurred in the sigmoid colon. This patient had a history of systemic lupus erythematosus and an underlying immunosuppressive state from long term steroid therapy. The lymphoma cells were positive for CD138, kappa light chain restriction and Epstein-Barr virus and negative for CD20/L26, CD3, CD79a, UCHL1 (CD45RO) and cytokeratin (AE1/AE3). The patient died approximately 2 mo after the operation. In the present paper, we review cases of PBL of the colon in HIVnegative patients. © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. Source


Kuramitsu M.,Japan National Institute of Infectious Diseases | Okuma K.,Japan National Institute of Infectious Diseases | Yamochi T.,Tokyo Medical University | Sato T.,St. Marianna University School of Medicine | And 34 more authors.
Journal of Clinical Microbiology | Year: 2015

Quantitative PCR (qPCR) analysis of human T-cell leukemia virus type 1 (HTLV-1) was used to assess the amount of HTLV-1 provirus DNA integrated into the genomic DNA of host blood cells. Accumulating evidence indicates that a high proviral load is one of the risk factors for the development of adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis. However, interlaboratory variability in qPCR results makes it difficult to assess the differences in reported proviral loads between laboratories. To remedy this situation, we attempted to minimize discrepancies between laboratories through standardization of HTLV-1 qPCR in a collaborative study. TL-Om1 cells that harbor the HTLV-1 provirus were serially diluted with peripheral blood mononuclear cells to prepare a candidate standard. By statistically evaluating the proviral loads of the standard and those determined using in-house qPCR methods at each laboratory, we determined the relative ratios of the measured values in the laboratories to the theoretical values of the TL-Om1 standard. The relative ratios of the laboratories ranged from 0.84 to 4.45. Next, we corrected the proviral loads of the clinical samples from HTLV-1 carriers using the relative ratio. As expected, the overall differences between the laboratories were reduced by half, from 7.4-fold to 3.8-fold on average, after applying the correction. HTLV-1 qPCR can be standardized using TL-Om1 cells as a standard and by determining the relative ratio of the measured to the theoretical standard values in each laboratory. Copyright © 2015, American Society for Microbiology. All Rights Reserved. Source

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