Harbin Medical University

www.hrbmu.edu.cn
Harbin, China

Harbin Medical University is a public university located in Harbin, Heilongjiang, China. Wikipedia.


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Scientific experiments, especially those that are meant to be used in the medical field, usually raise ethical concerns. However, one experiment published in the CNS Neuroscience and Therapeutics took the adage "two heads are better than one" quite literally. Tech Times reported in August 2016 that a Russian man volunteered to become the donor for a head transplant. Now it seems that it is possible after scientists successfully grafted a small rat head onto a bigger one. It is already a bizarre but remarkable event when the rare polycephaly condition appears, but it is rather unsettling when scientists force the condition by experimenting on animals, regardless of success rate, with the intention of expanding the procedure to humans. Researchers from China, along with Harbin Medical University researcher Xiaoping Ren, and Italian neurosurgeon Sergio Canavero, however, claim to have successfully transplanted a small rat's head onto a recipient rat without it suffering from blood loss or hypothermia. The key, apparently, is to use a third rat as a blood source during the procedure. By connecting the donor rat to the third rat using a silicone tube that is connected to a pump, blood flow to the brain tissue was guaranteed. The silicone tube also regulated the temperature to ensure that the donor rat's brain tissue is protected from hypothermia. Using the new bicephalic model the scientists developed, they concluded that there were no brain-damaging blood loss that occurred throughout the entire operation. They also found that the temperature-regulated silicone tube effectively protected brain tissue from hypothermia, allowing for a successful head transplant. The scientists noted, however, that the donor rat — the small rat whose head was cut off to be attached to another rat — showed signs that it was in pain. "Postoperative donor has pain reflex and corneal reflex," the study notes. The rats only survived for a short period after the experiment. Of course, the scientists are aiming to achieve long-term survival for both host and donor but it must be noted that the experiment was done to test the effectiveness of the transplant model they developed. While that seems cruel and unethical, the scientists were satisfied with the positive result of the model they developed. Satisfied enough, in fact, that Canavero already plans to test the procedures on humans in December 2017 — which could be either an exciting or extremely painful time for its volunteer, Valery Spiridonov. © 2017 Tech Times, All rights reserved. Do not reproduce without permission.


Zhao Y.,Harbin Medical University
American Journal of Epidemiology | Year: 2013

Adenomatous polyposis coli gene (APC) polymorphisms may influence the risk for colorectal neoplasia. However, results thus far have been inconclusive. We performed a systematic literature search of the Medline, Embase, Cochrane Collaboration, and HuGE databases and reviewed the references of pertinent articles through May 2012. Odds ratios with 95% confidence intervals were used to estimate the association between 3 APC polymorphisms (D1822V, E1317Q, and I1307K) and colorectal neoplasia. In total, 40 studies from 1997 to 2010 were included in this meta-analysis, and individuals with the D1822V variant homozygote VV genotype had a slight decrease in the risk for colorectal neoplasia compared with the wild-type homozygote DD genotype (pooled odds ratio = 0.87, 95% confidence interval: 0.77, 0.99). There was a small association between the APC E1317Q polymorphism and a risk for colorectal neoplasia (variant vs. wild-type: pooled odds ratio = 1.41, 95% confidence interval: 1.14, 1.76), particularly for colorectal adenomas (variant vs. wild-type: odds ratio = 2.89, 95% confidence interval: 1.83, 4.56). Compared with those who carried the wild-type I1307K, Ashkenazi Jews who carried the I1307K variant were at a significantly increased risk for colorectal neoplasia, with a pooled odds ratio of 2.17 (95% confidence interval: 1.64, 2.86). Our study suggests that APC is a candidate gene for colorectal neoplasia susceptibility. © 2013 © The Author 2013. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.


Yin J.J.,Harbin Medical University
Autophagy | Year: 2012

In pancreatic β-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesis, as this is where the protein-folding machinery for secretory proteins is localized. Perturbations to ER function of the β-cell, such as those caused by high levels of free fatty acid and insulin resistance, can lead to an imbalance in protein homeostasis and ER stress, which has been recognized as an important mechanism for type 2 diabetes. Macroautophagy (hereafter referred to as autophagy) is activated as a novel signaling pathway in response to ER stress. In this review, we outline the mechanism of ER stress-mediated β-cell death and focus on the role of autophagy in ameliorating ER stress. The development of drugs to take advantage of the potential protective effect of autophagy in ER stress, such as glucagon like peptide-1, will be a promising avenue of investigation.


Kang K.,Harbin Medical University
Journal of the American College of Cardiology | Year: 2012

This study investigated whether cytokine enhancement of a biodegradable patch could restore cardiac function after surgical ventricular restoration (SVR) even when seeded with cells from old donors. SVR can partially restore heart size and improve function late after an extensive anterior myocardial infarction. However, 2 limitations include the stiff synthetic patch used and the limited healing of the infarct scar in aged patients. We covalently immobilized 2 proangiogenic cytokines (vascular endothelial growth factor and basic fibroblast growth factor) onto porous collagen scaffolds. We seeded human mesenchymal stromal cells from young (50.0 ± 8.0 years, N = 4) or old (74.5 ± 7.4 years, N = 4) donors into the scaffolds, with or without growth factors. The patches were characterized and used for SVR in a rat model of myocardial infarction. Cardiac function was assessed. In vitro results showed that cells from old donors grew slower in the scaffolds. However, the presence of cytokines modulated the aging-related p16 gene and enhanced cell proliferation, converting the old cell phenotype to a young phenotype. In vivo studies showed that 28 days after SVR, patches seeded with cells from old donors did not induce functional recovery as well as patches seeded with young cells. However, cytokine-enhanced patches seeded with old cells exhibited preserved patch area, prolonged cell survival, and augmented angiogenesis, and rats implanted with these patches had better cardiac function. The patch became an elastic tissue, and the old cells were rejuvenated. This sustained-release, cytokine-conjugated system provides a promising platform for engineering myocardial tissue for aged patients with heart failure. Copyright © 2012 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.


BACKGROUND: Interleukin 6 (IL-6)-mediated signal transducers and activators of transcription 3 (STAT-3) phosphorylation (activation) is aberrantly sustained in cholangiocarcinoma cells resulting in enhanced myeloid cell leukemia 1 (Mcl-1) expression and resistance to apoptosis. FTY720, a new immunosuppressant, derived from ISP-1, has been studied for its putative anti-cancer properties. This study aimed to elucidate the mechanism by which FTY720 mediates antitumor effects in cholangiocarcinoma (CC) cells.METHODS: Three CC cell lines were examined, QBC939, TFK-1, and HuCCT1. The therapeutic effects of FTY720 were evaluated in vitro and in vivo. Cell proliferation, apoptosis, cell cycle, invasive potential, and epithelial- mesenchy-mal transition (EMT) were examined.RESULTS: FTY720 greatly inhibited CC cells proliferation and EMT in vitro and in vivo, and this effect was associated with dephosphorylation of STAT3tyr705. FTY720 induced apoptosis and G1 phase arrest in CC cells, and inhibited invasion of CC cells. Western blot analysis showed that FTY720 induced cleavage of caspases 3, 8 and 9, and of PARP, in a dose-dependent manner, consistent with a substantial decrease in p-STAT3, Bcl-xL, Bcl-2, survivin, cyclin D1, cyclin E, N-cadherin, vimentin, VEGF and TWIST1. In vivo studies showed that tumor growth and metastasis were significantly suppressed after FTY720 treatment.CONCLUSIONS: These results suggest that FTY720 induces a significant decrease in p-STAT3, which inhibits proliferation and EMT of CC cells, and then induces G1 phase arrest and apoptosis. We have characterized a novel immunosuppressant, which shows potential anti-tumor effects on CC via p-STAT3 inhibition. FTY720 merits further investigation and warrants clinical evaluation.


Patent
Harbin Medical University | Date: 2015-12-14

The invention discloses a short sheath delivery system for a biliary metal stent via an endoscope. The short sheath delivery system comprises a delivery device for a stent and a fixing device, wherein the delivery device is used for delivering a stent part on a stricture lesion via an endoscope along a guidewire; the fixing device is used for fixing the delivery device on an endoscope biopsy port. The delivery device comprises a tip, an inner rod, a secondary rod, a main rod, a sliding rod, a trailing end, a guidewire cavity, an injection tube, a stent, a short sheath, a connection thread and a handle; the stent is preloaded in an empty cavity formed by the inner rod and the short sheath; the length of the short sheath is longer than that of the stent, and is less than that of the secondary rod; the external diameter of the secondary rod is less than the inner diameter of the short sheath, and the external diameter of the main rod is equal to or greater than that of the short sheath; the handle is sleeved around the sliding rod; and the handle is connected with the short sheath by the connection thread. When the short sheath delivery system is operated, the fixing device fixes the main rod part of the delivery device on the endoscope biopsy port, and an operator pulls the handle by a single hand therefore the handle slides along the sliding rod; the connection thread drives the short sheath to move and to sleeve on the secondary rod, therefore the stent is accurately deployed by a single-person without any migration.


The application of egg yolk oil, as well as benzopyrene-eliminated egg yolk oil, is prepared for medicaments for the treatment of allergic rhinitis. By topical application of egg yolk oil in the nasal cavity, symptoms of allergic rhinitis could be improved significantly. After topical treatment with egg yolk oil, levels of inflammatory cytokines IL-4 and IgE antibodies in lymphocytes of model mice with allergic rhinitis may be reduced. The method discloses a new application of egg yolk oil for the treatment of allergic rhinitis. In order to avoid the presence of residual benzopyrene (which is potentially carcinogenic) in egg yolk oil extracted by heating yolk, the method prepares a medicament for treating allergic rhinitis with benzopyrene-eliminated egg yolk oil, thereby avoiding the potential carcinogenic risk of benzopyrene residue.


Patent
Harbin Medical University | Date: 2016-03-17

A double-joint sickle knife for an endoscopy therapy includes a knife head, a knife base, a knife body, an outer sheath, a guide wire, a handle and a sliding rod. The knife head is connected with one end of the knife base by a transverse joint, and the other end of the knife base is connected with a head end of the knife body by a longitudinal joint. The outer sheath is sleeved on the outside of the knife body and capable of sliding along the knife body. The tail end of the knife body is connected with one end of the handle, and a sliding rod for adjusting the transverse joint is arranged on the handle. The guide wire is electric conductive. One end of the guide wire is connected with the knife head, and passes through the knife base, the knife body, the handle and the sliding rod successively. The other end of the guide wire is connected with the power port.


Patent
Harbin Medical University | Date: 2016-09-21

The present invention relates to a double-joint sickle knife for an endoscopy therapy. The knife comprises a knife head (1), a knife base (2), a knife body (5), a guide wire (15), a handle (7) and a sliding rod (8). The knife head (1) is connected with one end of the knife base (2) by a transverse joint (3), and the other end of the knife base (2) is connected with a head end of the knife body (5) by a longitudinal joint (4). The outer sheath (6) is sleeved on the outside of the knife body (5), and capable of sliding along the knife body (5). The tail end of the knife body (5) is connected with one end of the handle (7), and a sliding rod (8) for adjusting the transverse joint (4) is arranged on the handle (7). The guide wire (15) is electric conductive. One end of the guide wire (15) is connected with the knife head (1), and passes through the knife base (2), the knife body (5), the handle (7) and the sliding rod (8) successively. And the other end of the guide wire (15) is connected with the power port (10). By means of the knife, a multi-angle movement of a cutting knife blade of the endoscopy knife can be achieved, wherein the movement includes a circumstance cutting by the knife blade in parallel with mucosal tissues. And the knife blade angle is not limited by the lens of the endoscope, so that the speed and the quality of the endoscopy therapy are greatly improved, and subsidiary injuries potentially occurring to peripheral tissues are minimized to the furthest.


Patent
Harbin Medical University | Date: 2016-06-29

The invention discloses a short sheath delivery system for a biliary metal stent via an endoscope. The short sheath delivery system comprises a delivery device for a stent and a fixing device, wherein the delivery device is used for delivering a stent part on a stricture lesion via an endoscope along a guidewire; the fixing device is used for fixing the delivery device on an endoscope biopsy port. The delivery device comprises a tip, an inner rod, a secondary rod, a main rod, a sliding rod, a trailing end, a guidewire cavity, an injection tube, a stent, a short sheath, a connection thread and a handle; the stent is preloaded in an empty cavity formed by the inner rod and the short sheath; the length of the short sheath is longer than that of the stent, and is less than that of the secondary rod; the external diameter of the secondary rod is less than the inner diameter of the short sheath, and the external diameter of the main rod is equal to or greater than that of the short sheath; the handle is sleeved around the sliding rod; and the handle is connected with the short sheath by the connection thread. When the short sheath delivery system is operated, the fixing device fixes the main rod part of the delivery device on the endoscope biopsy port, and an operator pulls the handle by a single hand therefore the handle slides along the sliding rod; the connection thread drives the short sheath to move and to sleeve on the secondary rod, therefore the stent is accurately deployed by a single-person without any migration.

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