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Natural and, Ethiopia

Gashaw T.,Hararnaya University | Reda G.,Hararnaya University | Ayalew H.,Hararnaya University | Babu N.,Hararnaya University | Upadhyay R.,Hararnaya University
Oriental Journal of Chemistry | Year: 2013

A new series of 2-(3-oxo-3-phenyIpropanoy-3-(substituted ary-l -thiazolidin-4-ones has been synthesized by cyclocondensation of ketoanils (the condensation products of 2, 4-dioxo-4- phenyl butanal with primary amines) with mercaptoacetic acid. The chemical structures of the synthesized compounds were elucidated by elemental analysis, molecular weight determination, and UV, IR, 1H, 13C and DEPT-135 NMR spectral measurements. Bactericidal and fungicidal activates of the new products were studied in virto against Staphylococcus aureus and Eseherichia coil bacteria and Asparigillus niger and Rhizoctia bataticola fungi by using ampicillin and bavistin reference drugs, respectively.

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