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Rai B.K.,har University | Kumar A.,K C T C College | Baluni A.,Government Higher Secondary School
Oriental Journal of Chemistry | Year: 2012

Schiff base complexes of general formula [M(MDES)2X2] where M = Co(II), Ni(II) and Cu(II), MDES = 1-methyl- 2, 6 diethyl piperidone semicarbazone and X = Cl-, Br-, I- and NO3 -, have been synthesized. The ligand as well as metal complexes were characterized by elemental analyses, IR spectra, electronic spectra, molar conductivity and magnetic susceptibility measurements. On the basis of above observations it has been observed that ligand acts as neutral bidentate manner and coordination proposed through azomethine nitrogen and carbonyl oxygen of semicarbazone moiety. The remaining coordination centres are satisfied by anions such as Cl-, Br-, I- and NO 3 -. On the basis of electronic spectral data and magnetic susceptibility data the gometry of the complexes tentatively proposed octahedral. Antibacterial activity of ligand and complexes were also determined.

El-Kalyoubi S.,har University | Agili F.,Jazan University | Youssif S.,Jazan University | Youssif S.,Zagazig University
Molecules | Year: 2015

Several fused imidazolopyrimidines were synthesized starting from 6-amino-1- methyl-2-thiouracil (1) followed by nitrosation, reduction and condensation with different aromatic aldehydes to give Schiff's base. The dehydrocyclization of Schiff's bases using iodine/DMF gave Compounds 5a-g. The methylation of 5a-g using a simple alkylating agent as dimethyl sulfate ((CH3)2SO4) gave either monoalkylated imidazolopyrimidine 6a-g at room temperature or dialkylated derivatives 7a-g on heating 6a-g with ((CH3)2SO4). On the other hand, treatment of 1 with different aromatic aldehydes in absolute ethanol in the presence of conc. hydrochloric acid at room temperature and/or reflux with acetic acid afforded bis-5,5′-diuracylmethylene 8a-e, which cyclized on heating with a mixture of acetic acid/HCl (1:1) to give 9a-e. Compounds 9a-e can be obtained directly by refluxing of Compound 1 with a mixture of acetic acid/HCl. The synthesized new compounds were screened for antimicrobial activity, and the MIC was measured. © 2015 by the authors; licensee MDPI, Basel, Switzerland.

Tolba A.M.,har University | Salama A.A.A.,National Research Center of Egypt
Der Pharma Chemica | Year: 2016

Melamine became an adulterant and associated with the pets deaths in some country. The aim of the present study is to evaluate the adverse effects of administration of melamine formaldehyde on the liver, kidney and brain of Wister rats. Rats were randomly designed in to 14 groups (6 rats each) as follows: Groups 1 & 2 were given distilled water (10 ml/kg) for 7 & 14 days and served as normal controls, Groups 3-5 were treated orally with melamine formaldehyde (0.88, 1.16, 3.2 mg/kg) for seven days. Groups 6-8 were fed on food mixed with the same three doses of melamine formaldehyde for 7 days. Groups 9-11 treated orally with melamine formaldehyde (0.88, 1.16, 3.2 mg/kg) for 14 days. Groups 12-14 were fed on food mixed with the same three doses of melamine formaldehyde for 14 days. Liver enzymes and kidney functions were affected and malondialdehyde (MDA) content, glutathione peroxidase (GPx) and acetyl cholinesterase activities in brain was altered by the melamine. The histological examination of liver of melamine showed many degenerative changes including cytoplasmic vacuolization of the hepatocytes, fatty infiltrations, leucocytic infiltrations, congestion of blood vessels and fibrosis and kidney necrosis, atrophy some glomerular and tubular epithelium. Chromosomal aberration showed fragmentation, polyploidy, breaking gaps, deletion, and multiple aberrations. In conclusions, melamine should be absent from diet at milligram concentrations to safe our health.

Rai B.K.,har University | Kumar S.,Jagdam College | Pandey A.,M H Degree College
Oriental Journal of Chemistry | Year: 2013

A series of coordination compounds have been prepared with tridentate Schiff base ligands, 2 ethyl-[(hydroxy propyl)]-3, 1 (4H) quinazoline-4- semicarbazone [EHPQS) and 2-ethyl-[(hydroxy propyl)]- 3, 1 (4H) quinazoline- 4-thiosemicarbozone [EHPQT]. The obtained complexes were characterized by molar mass, elemental analysis, infrared spectra, electronic spectra, magnetic susceptibility molar conductance analysis and spectral studies show that the Schiff base EHPQS/EHPQT behaves as tridentate chelating agent and coordinated to metal ions via, azomethine nitrogen alcoholic oxygen atom and with either carbonyl or thione sulphur atom of ligand. The electronic spectra and molar susceptibility of the complexes show a distorted octahedral geometry for Cu(II) complexes where as octahedral geometry for Co(II) and NI(II) metal ions. The Schiff base ligand and their metal complexes have been tested for antimicrobial activities against Gram positive bacteria; Staphylococci aureus and Gram negative bacteria Escherichia coli.

Rai B.K.,har University
Oriental Journal of Chemistry | Year: 2013

The present work is concerned with synthesis and study on metal complexes of Co(II), Ni(II) amd Cu(II) with bidentate Schiff base ligand, 2-methyl-[3(hydroxyl butyl)]-3, 1(4H) quinazoline-4-Hydrazone (MHBQH). The complexes have the general formulae [(ML)2 X2], Where M=Co(II), Ni(II) and Cu(II); L=MHBQH and X=NH3, pyridine, α, β and γ picolines. The structure of the ligand, mode of bonding and overall geometry of the complexes were determined through, Infrared, electronic spectral studies of elemental analyses, molar mass, magnetic susceptibility and molar conductance. These studies revealed octahedral complexes for Co(II) and Ni(II) and distorted octahedral geometry for Cu(II) complexes. Biocidal activity of the ligands and its metal complexes against several organisms, Escherichia coli and Staphylococcus aureus are reported. Compounds exhibited the high effect of activity.

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