Muzaffarpur, India
Muzaffarpur, India

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Rai B.K.,har University
Oriental Journal of Chemistry | Year: 2013

The present work is concerned with synthesis and study on metal complexes of Co(II), Ni(II) amd Cu(II) with bidentate Schiff base ligand, 2-methyl-[3(hydroxyl butyl)]-3, 1(4H) quinazoline-4-Hydrazone (MHBQH). The complexes have the general formulae [(ML)2 X2], Where M=Co(II), Ni(II) and Cu(II); L=MHBQH and X=NH3, pyridine, α, β and γ picolines. The structure of the ligand, mode of bonding and overall geometry of the complexes were determined through, Infrared, electronic spectral studies of elemental analyses, molar mass, magnetic susceptibility and molar conductance. These studies revealed octahedral complexes for Co(II) and Ni(II) and distorted octahedral geometry for Cu(II) complexes. Biocidal activity of the ligands and its metal complexes against several organisms, Escherichia coli and Staphylococcus aureus are reported. Compounds exhibited the high effect of activity.


Rai B.K.,har University | Kumar S.,Jagdam College | Pandey A.,M H Degree College
Oriental Journal of Chemistry | Year: 2013

A series of coordination compounds have been prepared with tridentate Schiff base ligands, 2 ethyl-[(hydroxy propyl)]-3, 1 (4H) quinazoline-4- semicarbazone [EHPQS) and 2-ethyl-[(hydroxy propyl)]- 3, 1 (4H) quinazoline- 4-thiosemicarbozone [EHPQT]. The obtained complexes were characterized by molar mass, elemental analysis, infrared spectra, electronic spectra, magnetic susceptibility molar conductance analysis and spectral studies show that the Schiff base EHPQS/EHPQT behaves as tridentate chelating agent and coordinated to metal ions via, azomethine nitrogen alcoholic oxygen atom and with either carbonyl or thione sulphur atom of ligand. The electronic spectra and molar susceptibility of the complexes show a distorted octahedral geometry for Cu(II) complexes where as octahedral geometry for Co(II) and NI(II) metal ions. The Schiff base ligand and their metal complexes have been tested for antimicrobial activities against Gram positive bacteria; Staphylococci aureus and Gram negative bacteria Escherichia coli.


Ibrahim K.A.,Benha University | Ibrahim K.A.,Al Jedaany Hospital | Abdel-Wahab A.A.,har University | Ibrahim A.S.,Ain Shams University | Ibrahim A.S.,Al Jedaany Hospital
Journal of the Pakistan Medical Association | Year: 2011

Objectives: To determine the level of serum procalcitonin, blood leukocyte count (TLC) and C-reactive protein (CRP) in children with bacterial and non bacterial meningitis and document their efficacy in differential diagnosis. Also described are procalcitonin levels variation during treatment. Methods: From March 2005 to February 2008, we evaluated 38 clinically suspected meningitis patients in the paediatric departments, Al-Jedaany Hospital, Jeddah, KSA, for Serum procalcitonin, CRP, TLC and Lumbar punctures and CSF analysis. Patients were classified into bacterial meningitis group I (18) and non bacterial meningitis group II (20). Results: Serum PCT levels were significantly higher in bacterial meningitis (BM) {mean 4.8 ± 3.85 ng/ml (2.9- 11.6)} compared with non bacterial meningitis (NBM) {mean 0.38 ± 0.25ng/ml(0.31-0.61)} {P< 0.001}. Mean of all CSF parameters, TLC {15,000 ± 2,900 cell/ml(BM) & 9,500 ±1,105 cell/ml(NBM)}and CRP {20 ± 6.8 mg/l (BM) & 12.5 ±12.0 mg/l(NBM)}showed a zone of overlapping between the two groups. There is a positive correlation between serum PCT, TLC and CRP in bacterial and non bacterial meningitis cases but this relation becomes highly significant with bacterial meningitis positive group. Day 3 and day 6 treatment serum PCT was less than on admission levels (P<0.001). Conclusion: PCT can be used in the early diagnosis of bacterial meningitis and may be a useful adjunct in differentiating bacterial and non bacterial meningitis than CRP or TLC and diminishing the value of lumbar puncture performed 48-72 hours after admission to assess treatment efficacy.


Rai B.K.,Bra Bihar University | Ranjana,har University | Prakash P.,A.C.C. Cement | Lata P.,Central Hindu School
Oriental Journal of Chemistry | Year: 2012

The present paper is a report on the synthesis of some Co(II), Ni(II) and Cu(II) complexes by the condensation of 2 ethyl indole 3-carboxaldehyde with thiosemicarbazide hydrochloride using ethanol as reaction medium. The bonding pattern and structural studies of ligand and complexes have been carried out on the basis of elemental analyses, molar mass, IR spectra, electronic spectra, molar conductance and magnetic susceptibility measurements. The nonelectrolytic nature of the complexes has been proposed on the basis of their molar mass determination and conductance measurements. The ligand and their complexes have been screened in vitro for their antimicrobial activity. Some of the reported complexes were found to be quite active.


Kumar B.,Rss College | Rail B.K.,har University | Ambastha N.,C o Vishesh Chandra Ambastha
Oriental Journal of Chemistry | Year: 2011

Complexes of general molecular formula [M(AQTC) 2X 2], where M = cobalt(II), nickel(II) and copper(II), AQTC = 2 phenyl quinoxaline thiosemicarbazone, X = Cl, Br, I - and NO 3- have been synthesized. Complexes were characterised by analytical analyses, IR spectra, electronic spectra, molar mass, conductivity measurements.The compound AQTC acts as a neutral, bidentate ligand and bonded to the metal ion through azomethine N and sulphur atom of thiosemicarbazone moiety. The remaining coordinating positions are satisfied by anions such as Cl, Br, I -, and NO 3 -. Electronic spectral and magnetic susceptibility values reveals octahedral geometry for the complexes. The complexes were found to be non electrolytic in nature on the basis of low value of molar conductance. The ligand as well as metal complexes have been screened for their antibacterial and antifungal activity.


PubMed | har University and Jazan University
Type: Journal Article | Journal: Molecules (Basel, Switzerland) | Year: 2015

Several fused imidazolopyrimidines were synthesized starting from 6-amino-1-methyl-2-thiouracil (1) followed by nitrosation, reduction and condensation with different aromatic aldehydes to give Schiffs base. The dehydrocyclization of Schiffs bases using iodine/DMF gave Compounds 5a-g. The methylation of 5a-g using a simple alkylating agent as dimethyl sulfate ((CH)SO) gave either monoalkylated imidazolopyrimidine 6a-g at room temperature or dialkylated derivatives 7a-g on heating 6a-g with ((CH)SO). On the other hand, treatment of 1 with different aromatic aldehydes in absolute ethanol in the presence of conc. hydrochloric acid at room temperature and/or reflux with acetic acid afforded bis-5,5-diuracylmethylene 8a-e, which cyclized on heating with a mixture of acetic acid/HCl (1:1) to give 9a-e. Compounds 9a-e can be obtained directly by refluxing of Compound 1 with a mixture of acetic acid/HCl. The synthesized new compounds were screened for antimicrobial activity, and the MIC was measured.


Rai B.K.,har University | Kumar A.,K C T C College | Baluni A.,Government Higher Secondary School
Oriental Journal of Chemistry | Year: 2012

Schiff base complexes of general formula [M(MDES)2X2] where M = Co(II), Ni(II) and Cu(II), MDES = 1-methyl- 2, 6 diethyl piperidone semicarbazone and X = Cl-, Br-, I- and NO3 -, have been synthesized. The ligand as well as metal complexes were characterized by elemental analyses, IR spectra, electronic spectra, molar conductivity and magnetic susceptibility measurements. On the basis of above observations it has been observed that ligand acts as neutral bidentate manner and coordination proposed through azomethine nitrogen and carbonyl oxygen of semicarbazone moiety. The remaining coordination centres are satisfied by anions such as Cl-, Br-, I- and NO 3 -. On the basis of electronic spectral data and magnetic susceptibility data the gometry of the complexes tentatively proposed octahedral. Antibacterial activity of ligand and complexes were also determined.


Rai B.K.,LNT College | Kumar C.,har University
Oriental Journal of Chemistry | Year: 2010

A series of complexes of the type [M(DDMS)2X2] where M = Co(II), Ni(II) and Cu(II), X = Cl, Br, I" and NO3-; DDMS = 3,4 dihydro- 5,6- dimethoxy isocoumarin semicarbazone. Schiff base ligand DDMS obtained by the condensation of 3,4 dihydro 5,6 dimethoxy isocoumarine and semicarbazide hydrochloride.The ligand as well as complexes have been characterized by elemental analysis, molar conductance, molar mass, magnetic susceptibility, electronic and IR spectral data. Elemental analyses confirm the stoichiometry of the complexes is 1:2 [Metahligand]. Study of IR spectral data proposes DDMS acts as neutral bidentate ligand and coordination takes place through azomethine N and carbonyl oxygen of semicarbazone moiety.The remaining positions of metal ions are satisfied by negative ions, such as Ch, Br, I" and NO3'.The molar conductance measurement in DMF indicates the non electrolytic nature of the complexes.The study of electronic spectral data and magnetic susceptibility measurement proposes the geometry of complexes are octahedral in nature.


Tolba A.M.,har University | Salama A.A.A.,National Research Center of Egypt
Der Pharma Chemica | Year: 2016

Melamine became an adulterant and associated with the pets deaths in some country. The aim of the present study is to evaluate the adverse effects of administration of melamine formaldehyde on the liver, kidney and brain of Wister rats. Rats were randomly designed in to 14 groups (6 rats each) as follows: Groups 1 & 2 were given distilled water (10 ml/kg) for 7 & 14 days and served as normal controls, Groups 3-5 were treated orally with melamine formaldehyde (0.88, 1.16, 3.2 mg/kg) for seven days. Groups 6-8 were fed on food mixed with the same three doses of melamine formaldehyde for 7 days. Groups 9-11 treated orally with melamine formaldehyde (0.88, 1.16, 3.2 mg/kg) for 14 days. Groups 12-14 were fed on food mixed with the same three doses of melamine formaldehyde for 14 days. Liver enzymes and kidney functions were affected and malondialdehyde (MDA) content, glutathione peroxidase (GPx) and acetyl cholinesterase activities in brain was altered by the melamine. The histological examination of liver of melamine showed many degenerative changes including cytoplasmic vacuolization of the hepatocytes, fatty infiltrations, leucocytic infiltrations, congestion of blood vessels and fibrosis and kidney necrosis, atrophy some glomerular and tubular epithelium. Chromosomal aberration showed fragmentation, polyploidy, breaking gaps, deletion, and multiple aberrations. In conclusions, melamine should be absent from diet at milligram concentrations to safe our health.


Biologically important Schiff base ligand 3-phenyl imino 2-indolinone hydrazone (PIIH) have been synthesized by condensation of 3-phenyl imino-2-indolinone with hydrazone hydrate. The metal chelates of PIIH with bivant transition metal ions. Cu(II), Ni(II) and Cu(II) have been synthesized.The structure of Schiff base and their metal chelates have been characterized by elemental analyses, molar mass, IR and electronic spectra, magnetic susceptibility and molar conductivity values.These studies indicate that the compound PIIH acts as neutral bidentate ligand and coordination proposes through indoline N and azomethine N of hydrazone moiety. The rest of coordination position of metal ions are satisfied by neutral ligands such as ammonia, pyridine, α-picoline, β-picoline and γ-picoline. The chelates of Co(II), Ni(II) and Cu(II) proposed to be octahedral in geometry.

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