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Nam H.-S.,Hanwha Chemical R and nter | Nam H.-S.,KAIST | Yoon J.-K.,Hanbat National University | Ko J.M.,Hanbat National University | Kim J.-D.,KAIST
Materials Chemistry and Physics | Year: 2010

Nanostructured manganese dioxide, MnO2, was synthesized by a sonochemical method. Nanostructured MnO2 had the shapes of flower-like and nanowires by changing the pH in the aqueous solution, as observed via scanning electron microscopy and transmission electron microscopy. The electrochemical capacitance was studied by cyclic voltammetry. A maximum specific capacitance of 300 Fg-1 was obtained for the nanowires in a potential range from 0.1 to 0.9 V vs. SCE in 1 M sodium sulfate solution at a scan rate of 5 mV s-1. These materials can be useful to increase the specific capacitance by wetting behavior of electrolytes from their structural properties. © 2010 Elsevier B.V. All rights reserved.

Kim J.-G.,Hanwha Chemical R and nter | Jang D.O.,Yonsei University
Tetrahedron Letters | Year: 2010

We developed a mild and convenient trifluoroacetylation process for amines using a combination of trichloroacetonitrile and triphenylphosphine. The reaction that we designed is applicable to the trifluoroacetylation of a wide variety of amines, including amines with stereogenic centers, which underwent trifluoroacetylation without racemization. © 2009 Elsevier Ltd. All rights reserved.

Kim J.-G.,Hanwha Chemical R and nter | Jang D.O.,Yonsei University
Synlett | Year: 2010

We developed a simple, practical, and catalytic method for the N-formylation of a wide variety of amines in the presence of molecular iodine as a catalyst under solvent-free conditions. This reaction is applicable to the chemoselective N-formylation of amino groups and -amino acid esters without epimerization. © 2010 Georg Thieme Verlag Stuttgart · New York.

Cho S.-Y.,Yonsei University | Kim J.-G.,Hanwha Chemical R and nter | Chung C.-M.,Yonsei University
Journal of Nanoscience and Nanotechnology | Year: 2010

Four kinds of cinnamate-type monomers were synthesized as healing agents. Photoirradiation of the monomers gave cyclobutane-containing crosslinked polymers via [2+2] cycloaddition. Cyclobutane cleavage upon cracking of the crosslinked polymers and re-cycloaddition of the cracked polymers were investigated by FT-IR spectroscopy. Photochemical crack healing was demonstrated by measurement of flexural strength of crosslinked, cracked, and healed polymers. It was observed that microcracks with width of 200 nm to 2 μm were healed by photoirradiation. Copyright © 2010 American Scientific Publishers.

Lee J.-H.,Yonsei University | Sohn J.-H.,Yonsei University | Ryu S.Y.,Hanwha Chemical R and nter | Hong C.-S.,Yonsei University | And 2 more authors.
Journal of Cellular and Molecular Medicine | Year: 2013

Asthma is a chronic inflammatory disease induced by Type 2 helper T cells and eosinophils. Vascular cell adhesion molecule-1 (VCAM-1) has been implicated in recruiting eosinophils and lymphocytes to pathological sites in asthma as a regulatory receptor. Accordingly, monoclonal antibody (mAb) against VCAM-1 may attenuate allergic inflammation and pathophysiological features of asthma. We attempted to evaluate whether a recently developed human anti-VCAM-1 mAb can inhibit the pathophysiological features of asthma in a murine asthma model induced by ovalbumin (OVA). Leucocyte adhesion inhibition assay was performed to evaluate the in vitro blocking activity of human anti-VCAM-1 mAb. OVA-sensitized BALB/c mice were treated with human anti-VCAM-1 mAb or isotype control Ab before intranasal OVA challenge. We evaluated airway hyperresponsiveness (AHR) and bronchoalveolar lavage fluid analysis, measured inflammatory cytokines and examined histopathological features. The human anti-VCAM-1 mAb bound to human and mouse VCAM-1 molecules and inhibited adhesion of human leucocytes in vitro. AHR and inflammatory cell counts in bronchoalveolar lavage fluid were reduced in mice treated with human anti-VCAM-1 mAb as compared with a control Ab. The levels of interleukin (IL)-5 and IL-13, as well as transforming growth factor-β, in lung tissue were decreased in treated mice. Human anti-VCAM-1 mAb reduced goblet cell hyperplasia and peribronchial fibrosis. In vivo VCAM-1 expression decreased in the treated group. In conclusion, human anti-VCAM-1 mAb attenuated allergic inflammation and the pathophysiological features of asthma in OVA-induced murine asthma model. The results suggested that human anti-VCAM-1 mAb could potentially be used as an additional anti-asthma therapeutic medicine. © 2013 The Authors.

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