Hans Raj Mahila Maha Vidyalaya

Jalandhar, India

Hans Raj Mahila Maha Vidyalaya

Jalandhar, India
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Rupareliya R.H.,Saurashtra University | Joshi H.S.,Saurashtra University | Ram V.R.,Krantiguru Shyamji Krishna Verma Kachchh University | Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University | Khosla E.,Hans Raj Mahila Maha Vidyalaya
International Journal of Pharmaceutical Quality Assurance | Year: 2016

A simple, précised and accurate RP-UPLC method has been developed and validated for the simultaneous assay of Telmisartan and Cilnidipine in tablets. Isocratic RP-UPLC method was developed on LC system of Waters Acquity UPLC with PDA detector onWater Acquity BEH C18, 2.1 x 100mm, 1.7µm column as stationary phase with binary gradient mode by using mobile phase as ACN: 0.01M sodium phosphates monobasic dehydrate buffer pH 3.0 with phosphoric acid (68: 32, v/v), at a flow rate of 0.5 ml/min and the detection was carried out at 245 nm. Forced degradation study was carried out by oxidation, hydrolysis, photolysis and heating the drug. The method was validated for specificity, linearity, precision, accuracy, robustness and solution stability. The method was found to be linear in the concentration range of 40-160 µg/ml with correlation coefficients of 0.9996 for Telmisartan and 10-40 µg/ml with correlation coefficients of 0.9995 for Cilnidipine. Degradation products produced as a result of stress studies did not interfere with the detection of Telmisartan and Cilnidipine: therefore, the assay can be considered to be stability-indicating. © 2016, International Journal of Pharmaceutical Quality Assurance. All rights reserved.


Dubal K.L.,Saurashtra University | Ram V.R.,Krantiguru Shyamji Krishna Verma Kachchh University | Kher G.J.,Saurashtra University | Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University | And 2 more authors.
International Journal of Current Pharmaceutical Review and Research | Year: 2016

A novel UPLC method for determination of chlorhexidine gluconate and lidocaine hydrochloride in throat sprays has been presented as a tool suitable for quality monitoring of these compounds. The developed and validated UPLC method was compared with HPLC method. Experimental parameters like analysis time, sensitivity, mobile phase consumption, validation data, and demands on instrument equipment and operation were compared for two methods. UPLC and HPLC are important methods for routine monitoring of these drugs. In UPLC, Major degradation was found in photolytic condition that product was degraded up to 30 %. The major impurity peaks was found at 3.73 min. The concentration range was varied between 0.040-0.160 mg/mL, 0.016-0.064 mg/mL for chlorhexidine gluconate and lidocaine hydrochloride respectively. The response of the drug was found to be linear in the investigation concentration range and the linear regression equation for both the technique HPLC and UPLC fitted well. The RSD values for intraday precision study and interday precision study was < 2.0 % for chlorhexidine gluconate and lidocaine hydrochloride, which confirms that the method was precise. Recovery of chlorhexidine gluconate and lidocaine hydrochloride was determined at three different concentration levels. The mean recovery for chlorhexidine gluconate was 100.74-102.60 % and 99.07-101.11 % for lidocaine hydrochloride for HPLC and the mean recovery for chlorhexidine gluconate were 98.6-99.80 % and 99.17- 99.52 % for lidocaine hydrochloride for UPLC. The appropriate method should be with less cost, high sensitivity, reproducibility, short analysis time and simplicity. All these necessities are met by both methods. In our work UPLC analysis took only seven minutes to complete a single run therefore UPLC method can be considered ideal for busy laboratories analyzing large numbers of samples.


Bhatia A.,Hans Raj Mahila Maha Vidyalaya | Arora S.,Guru Nanak Dev University | Singh B.,Institute of Himalayan Bioresource Technology | Kaur G.,Guru Nanak Dev University | Nagpal A.,Guru Nanak Dev University
Phytochemistry Reviews | Year: 2011

Plants used in traditional medicine have stood up to the test of time and contributed many novel compounds for preventive and curative medicine to modern science. India is sitting on a gold mine of well recorded and traditionally well practiced knowledge of herbal medicine. Specially, plants growing at high altitude in Himalayan pastures are time-honored sources of health and general well being of local inhabitants. As of today, Himalayan plants are a major contributor to the herbal pharmaceutical industry both of India and other countries. Plants growing at higher altitudes are subjected to an assault of diverse testing situations including higher doses of mutagenic UV-radiation, physiological drought, desiccation and strong winds. Plants interact with stressful environments by physiological adaptation and altering the biochemical profile of plant tissues and producing a spectrum of secondary metabolites. Secondary metabolites are of special interest to scientists because of their unique pharmacophores and medicinal properties. Secondary metabolites like polyphenols, terpenes and alkaloids have been reported to possess antimutagenic and anticancer properties in many studies. The fundamental aspiration of the current review is to divulge the antimutagenic/ anticancer potential of five alpine plants used as food or medicine by the populations living at high altitudes. © Springer Science+Business Media B.V. 2011.


Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University | Kaur S.,Guru Nanak Dev University | Khosla E.,Hans Raj Mahila Maha Vidyalaya
Indian Journal of Chemical Technology | Year: 2011

Sorption experiments are carried out using sewage sludge for the removal of basic dye basic red-12 from aqueous solution. Effects of process parameters such as initial pH, adsorbent dosage, initial dye concentration, contact time and effect of temperature are investigated. The biosorbent is characterized by FTIR, SEM and XRD. The adsorption of dye is pH dependent. The rate of sorption increases with increase in temperature, and the process is found to be endothermic. Equilibrium is established in 120 min. The pseudo first-order equation, pseudo second-order equation and intraparticle diffusion models are tested. The results showed that the process followed pseudo first order equation very well and intraparicle diffusion plays an important role in the sorption process. The Langmuir and Freundlich equations are applied to the data related to adsorption isotherm and the observed maximum adsorption capacity was found to be 295.85 mg/g. Thermodynamic parameters; {increment}H°, {increment}G°and {increment}S° are also evaluated. Column experiments are also carried out to evaluate the bulk removal of color from effluents. The effects of inlet concentration and bed height are evaluated.


Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University | Kaur S.,Guru Nanak Dev University | Khosla E.,Hans Raj Mahila Maha Vidyalaya
Indian Journal of Chemical Technology | Year: 2011

The efficiency of eucalyptus bark as a low cost adsorbent for removing an azo dye from an aqueous solution has been investigated in batch mode. The azo dye, Eriochrome black-T (EBT) is removed by adsorption over field waste eucalyptus bark after minimum chemical treatment. The investigations are carried out to study the effects of pH, adsorbate concentration, adsorbent dosage, contact time and temperature. The thermodynamic parameters were obtained from Langmuir and Freundlich adsorption isotherm models. The kinetic studies showed that the adsorption reaction is of first order. A fixed-bed column has been designed, and necessary parameters have been calculated by applying a mass transfer kinetic approach. Experiments are also performed for the recovery of loaded dye through chemical regeneration of spent columns.


Khosla E.,Hans Raj Mahila Maha Vidyalaya | Kaur S.,Guru Nanak Dev University | Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University
Desalination and Water Treatment | Year: 2013

Toxic dyes can be removed from textile effluents and recovered using dead biomass obtained, as waste from the food industry. In this work, tea waste (TW) was employed to assess its adsorptive capacity for the acidic and basic dyes that usually are present in textile industry waste water. Equilibrium and kinetic experiments were performed in batch and column mode. Adsorption equilibrium and fluid solid mass transfer constant data were analyzed through the concept of ion-exchange sorption isotherm. The equilibrium data were fitted with Langmuir and Freundlich models. Several operation variables, such as TW dosage, contact time, initial pH, and temperature, on the removal of dyes were investigated. The removal efficiency increased with increase in TW dosage. The adsorption process followed pseudo-first-order kinetics. Thermodynamic parameters like ΔH°, ΔS°, and ΔG° were analyzed. The processes were spontaneous for the acidic as well as basic dyes. These results suggest that TW is a potential low-cost food industry waste for textile industry waste water treatment. TW was characterized using Scanning electron micrograph and Fourier transform infrared spectroscopy and techniques. © 2013 © 2013 Balaban Desalination Publications.


Khosla E.,Hans Raj Mahila Maha Vidyalaya | Kaur S.,Guru Nanak Dev University | Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University
Chemistry and Ecology | Year: 2015

The adsorption behaviour of Basic Red 12, Acid Orange 7 and Acid Blue 1 on zinc oxide nanoparticles (ZNP) has been investigated to understand the physicochemical process involved and to explore the possible use of nanoparticles in the treatment and management of textile waste matter. The dye removal capacity of ZNP towards Basic Red 12, Acid Orange 7 and Acid Blue 1 was found to be 15.64, 6.78 and 6.38 mg g−1, respectively. The adsorption process was pH dependent and optimum pH values of 9.0, 2.0 and 4.0 were obtained for Basic Red 12, Acid Orange 7 and Acid Blue 1, respectively. Equilibrium was established after 1.0 h for all dyes. Langmuir, Freundlich and Temkin isotherm models were applied to the system. The adsorbent ZNP was characterised using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET) and Fourier transform infrared (FTIR) techniques. SEM analysis revealed the noticeable nanoporous morphology of the material. The results of FTIR spectroscopy showed that the process is driven by an electrostatic complexation mechanism. XRD studies revealed the nanocrystalline structure of ZNP. BET surface area measurement suggested a high pore volume and large surface area for the adsorbent. The kinetic measurements suggested pseudo-second-order kinetic processes with high regression coefficients and smaller standard error of estimate values and lower residual sum of squares. The thermodynamic measurements suggested that all processes were exothermic and accompanied by negative values for Δ G0, Δ S0 and Δ H0. © 2014, © 2014 Taylor & Francis.


Khosla E.,Hans Raj Mahila Maha Vidyalaya | Kaur S.,Guru Nanak Dev University | Dave P.N.,Krantiguru Shyamji Krishna Verma Kachchh University
Journal of Chemical and Engineering Data | Year: 2012

The adsorption behavior of Basic Red-12 on eucalyptus bark (EB) and its surface derivatives obtained after cationic, anionic, and nonionic surfactant treatment in aqueous solution has been investigated to understand the physicochemical process involved and to explore the potential use of low-cost materials in textile effluent treatment and management. The results revealed that cationic, anionic, and nonionic surfactant modified EB can remove Basic Red-12 dye up to (243.6, 923.0, and 193.28) mg·g -1, respectively, while raw EB can remove dye up to 146.8 mg·g -1 only at 303 K. The adsorption process is found to be pH-dependent, and the optimum pH obtained is 2 to 5. The equilibrium was established in 2 h for EB and in 5 h for surface-modified EB. The process obeys the Langmuir and Freundlich models. Scanning electron microscopic analysis reveals a conspicuous surface morphology change after surfactant modification. The results of Fourier transform infrared (FTIR) spectroscopy reveal that the process is electrostatic complexation mechanism driven. The kinetic measurements suggest Lagergren kinetic processes. The thermodynamical measurements suggest that all processes are exothermic accompanied with negative ΔG o, ΔH o, and ΔS o. © 2012 American Chemical Society.


Kaur H.,Guru Nanak Dev University | Singh B.P.,Guru Nanak Dev University | Singh H.,Hans Raj Mahila Maha Vidyalaya | Nagpal A.K.,Guru Nanak Dev University
Advances in Bioinformatics | Year: 2014

Availability of complete plastid genomes of ten solanaceous species, Atropa belladonna, Capsicum annuum, Datura stramonium, Nicotiana sylvestris, Nicotiana tabacum, Nicotiana tomentosiformis, Nicotiana undulata, Solanum bulbocastanum, Solanum lycopersicum, and Solanum tuberosum provided us with an opportunity to conduct their in silico comparative analysis in depth. The size of complete chloroplast genomes and LSC and SSC regions of three species of Solanum is comparatively smaller than that of any other species studied till date (exception: SSC region of A. belladonna). AT content of coding regions was found to be less than noncoding regions. A duplicate copy of trnH gene in C. annuum and two alternative tRNA genes for proline in D. stramonium were observed for the first time in this analysis. Further, homology search revealed the presence of rps19 pseudogene and infA genes in A. belladonna and D. stramonium, a region identical to rps19 pseudogene in C. annum and orthologues of sprA gene in another six species. Among the eighteen intron-containing genes, 3 genes have two introns and 15 genes have one intron. The longest insertion was found in accD gene in C. annuum. Phylogenetic analysis using concatenated protein coding sequences gave two clades, one for Nicotiana species and another for Solanum, Capsicum, Atropa, and Datura. © 2014 Harpreet Kaur et al.


Khosla E.,Hans Raj Mahila Maha Vidyalaya
International Journal of Current Pharmaceutical Review and Research | Year: 2016

The rapid development of nanotechnology has opened the doors of innovation of many industrial sectors like food technology, food development, food packaging, agricultural sector and pharmaceuticals, sport goods, electronics, paints, varnishes and cosmetics. Some applications of nanoparticles have already been explored and some are under research. The nanotechnology based sectors mainly includes increased efficacy of drugs, agrochemicals and cosmetics. Such a development has poked the human health and environment due to its specific size related propertie and wide spread use and applications. This paper targets the potential risks and harms to the human healths from this technological boon. In absence of any legislative recommendations for production, handling and disposal of nanomaterials, the life of human beings is more prone to damages beyond imagination.

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