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Kim S.Y.,Chungnam National University | Jeon S.H.,Hans Biomedical Daeduk Institute
Journal of Industrial and Engineering Chemistry

Calcium phosphate cement (CPC) is a promising material for use in minimally invasive surgery for bone defect repair due to its similarity to the mineral phase of bone, biocompatibility, bioactivity, self-setting characteristics, low setting temperature, adequate stiffness and ease of shaping in complicated geometrics. In this study, we systematically investigate the influence of preparation variables on the final properties of CPCs. We determined the effects of CPC composition, accelerators, seed hydroxyapatite and reaction temperatures on the setting times and compressive strength of CPCs based on tetracalcium phosphate (TTCP), dicalcium phosphate dehydrate (DCPD), dicalcium phosphate anhydrous (DCPA), and α-tricalcium phosphate (α-TCP). The three types of CPCs (TTCP/DCPD, TTCP/DCPA, and TTCP/α-TCP-based bone cements) were prepared by varying the amounts of seed hydroxyapatite and citric acid used as a hardening accelerator. After 24. h of incubation, all three types of bone cements exhibited the characteristic peaks attributable to hydroxyapatite (HA) without characteristic peaks of unreacted raw materials. These results indicated that the bone cements were completely converted to HA. TTCP/DCPD-based bone cements showed faster setting times than TTCP/DCPA and TTCP/α-TCP-based bone cements. As citric acid concentrations in the liquid phase increased, the setting times of all three types of bone cements gradually decreased. However, the concentrations of seed HA in the cements were not related to significant changes in setting time. The compressive strengths of CPCs were significantly influenced by composition and reaction temperature. We also studied the effects of immersion time in physiological solution on the properties of the various CPCs. In the results of in vivo tests, subjects with bone defects implanted with CPCs exhibited more bone formation than control subjects that did not receive implantations of CPCs. © 2011 The Korean Society of Industrial and Engineering Chemistry. Source

Kim J.,Catholic University of Daejeon | Lee S.M.,Catholic University of Korea | Her S.-H.,Catholic University of Korea | Lee K.E.,Catholic University of Daejeon | And 4 more authors.
Tissue Engineering and Regenerative Medicine

Various prosthetic materials have been employed to reconstruct abdominal wall defects. Prosthetic materials have been used widely to repair the abdominal defects; however, complications with mesh infection and adhesion have led to the recent use of more biocompatible implants derived from animal or human sources for the surgical repair of abdominal wall defects. The purpose of the present study was to evaluate the effectiveness of the newly developed acellular porcine dermis (XenoDerm) to prevent adhesion in the reconstruction of abdominal wall defects compared with human acellular dermal matrix (SureDerm™) in a rat model. Forty adult Sprague-Dawley rats underwent repair of surgically created ventral hernias using porcine, acellular dermal-matrix or human acellular dermal-matrix. The grade of adhesion (peritoneal adhesions by Hooker score and intra-abdominal adhesions by Knightly score), histologic analysis (using hematoxylin-eosin stain, Masson-trichrome stain and immunohistochemical stain) and tensile strength (by MultiTest 1-i tensiometer) were assessed, after the animals were euthanized at 1 week and at 4 week postoperatively. At 4 week after the repair of abdominal wall defect, the porcine acellular dermal matrix incorporated into the host tissue and revealed no significant difference in adhesion, histologic analysis, or tensile strength compared with the human acellular dermal matrix. Based on these results, we conclude that acellular porcine dermal matrix (XenoDerm) is useful for abdominal wall reconstruction. However, subsequent studies with longer time periods and clinical studies will be needed to reveal the consequences of its use in abdominal wall defect reconstruction. © Springer, Part of Springer Science+Business Media. Source

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