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Hangzhou, China

Zhang G.,Zhejiang Better Pharmaceuticals Co. | Zha L.,Hangzhou Wahaha Group | Zha L.,Zhejiang University
Research on Chemical Intermediates | Year: 2013

Optimized synthesis and purification of erlotinib hydrochloride (N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazoline-4-amine hydrochloride) were studied. Highly polar piperazine was used in a nucleophilic substitution reaction with the chlorinated intermediate byproduct N-(3-ethynylphenyl)-6(2- chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. As a result, N-(3-ethynylphenyl)-6(2-chloroethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride was completely transformed to N-(3-ethynylphenyl)-6(2- piperzinoethoxy)-7-(2-methoxyethoxy)quinazolin-4-amine hydrochloride. The polarity of N-(3-ethynylphenyl)-6(2-piperzinoethoxy)-7-(2-methoxyethoxy) quinazolin-4-amine hydrochloride was changed, and its molecule was enlarged. It was easy to remove this larger, more polar, compound by recrystallization. Highly pure erlotinib hydrochloride was obtained with low impurity content (<1 %). The purity of erlotinib hydrochloride was >99.9 %. © 2012 Springer Science+Business Media B.V. Source


Su L.,Zhejiang Sci-Tech University | Li X.S.,Zhejiang Sci-Tech University | Yin X.,Hangzhou Wahaha Group | Feng X.,Zhejiang Sci-Tech University
Applied Mechanics and Materials | Year: 2012

the reinforcement rib design is one of the key parts in entire bottle design. This paper presents the optimal design of reinforcement rib is based on the orthogonal test and finite element analysis, which is according to the finite element analysis results as its test data, with the target of the minimum stress, analyses the influence of each size of the reinforcement rib on the stress, obtain the optimal design proposal. The results show that the orthogonal experiment method can effectively distinguish different influence of various parameters on the stress, analyze the optimal design proposal, meanwhile, it can guide the bottle design in practical terms. © (2012) Trans Tech Publications, Switzerland. Source


Su L.,Zhejiang Sci-Tech University | Li X.S.,Zhejiang Sci-Tech University | Yin X.,Hangzhou Wahaha Group | Feng X.,Zhejiang Sci-Tech University | Ruan S.W.,Zhejiang Sci-Tech University
Applied Mechanics and Materials | Year: 2012

The reinforcement rib design is one of the key parts in entire bottle design. This paper presents the rib performance prediction system based on the BP algorithm and the finite element analysis, which adopts the finite element analysis results as its learning samples, sets up the rib performance prediction system with BP artificial neural network. The results show that the artificial neural network plays an important role in rib performance prediction; meanwhile it can guide the bottle design in practical terms. © (2012) Trans Tech Publications. Source


Ruan Y.,Hangzhou Wahaha Group | Li Y.,Hangzhou Wahaha Group | Ou K.,Hangzhou Wahaha Group | Lin X.,Hangzhou Wahaha Group | Zha L.,Hangzhou Wahaha Group
Tenside, Surfactants, Detergents | Year: 2014

The foaming capability, which is related to the ratio of surfactants, the dosage and the crystallization rate of ethylene glycol distearate (EGDS), is discussed. By the same progress, with the proportion of ammonium lauryl sulfate (AESA) being increased, the foam height of the body care product is linearly improved. The crystal features of EGDS and pearlescence quality of the body care products are strongly linked to the surface aspect, the size distribution of EGDS crystals and their level of aggregation. Comparing the different crystallization processes, when rapidly being cooled with cold water and stirred at the speed of exceeding to 1000 rpm, the aggregation of the crystals is decreased, and the pearlescence of the body care product is poor. When being ordinary cooled at room temperature and stirred at the speed of no more than 500 rpm, the aggregation of the crystals is increased, and the pearlescence of the body care products is obvious. The microstructures reveal that the oil drops are pierced to smaller by the EGDS needle crystals. Then the smaller oils act as antifoaming agents to cut down the foam height of the body care product. Consequently, the foam height of the body care products with good pearlescent effect is decreased. Furthermore, being added silicone oil emulsion, the foam height falls faster because of demulsifying. The result shows that the silicone oil and the needle-like crystals have a negative synergistic effect on foaming in the body care products. © Carl Hanser Verlag GmbH & Co. KG. Source

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