Hangzhou Traditional Chinese Medicine Hospital

Hangzhou, China

Hangzhou Traditional Chinese Medicine Hospital

Hangzhou, China

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Tu M.,Hangzhou Traditional Chinese Medicine Hospital | Jiang P.,Hangzhou Traditional Chinese Medicine Hospital | Yao J.,Hangzhou Traditional Chinese Medicine Hospital | Li M.,Hangzhou Traditional Chinese Medicine Hospital | Xia W.,Hangzhou Traditional Chinese Medicine Hospital
Chinese Journal of Interventional Imaging and Therapy | Year: 2016

Objective: To evaluate the application value of real time three-dimensional ultrasound contrast examination system constituted of transvaginal Omni-View three-dimensional ultrasonography (Omni-View 3D-TVS), sonohysterography and real-time three-dimensional hysterosalpingo-contrast sonography (RT-3D-HyCoSy) in the detection of infertility. Methods: Data of 246 patients diagnosed as infertility who underwent the examine of real time three-dimensional ultrasound contrast examination system were retrospectively analyzed. Among them, 56 cases undenwent hysteroscopy with pathological results and 33 cases underwent laparoscopic. Results: Totally 10 cases of uterine cavity adhesion, 15 cases of endometrial polyps, 7 cases of arcuate uterus and 2 cases of uterine septum after operation were detected with Omni-View 3D-TVS. And there were 50 cases of uterine cavity adhesion, 24 cases of endometrial polyps and 2 cases of endometrial deletions diagnosed with sonohysterography. Taking pathology as the gold standard, the sensitivity, specificity and accuracy of Omni-View 3D-TVS in diagnosing endometrial polyps was 33.33% (6/18), 92.11% (35/38) and 73.21% (41/56), respectively; as well as the sensitivity, specificity and accuracy of sonohysterography was 94.44% (17/18), 94.73% (36/38) and 94.64% (53/56), respectively. Moreover, the sensitivity, specificity and accuracy of Omni-View 3D-TVS for the diagnosis of uterine cavity adhesion was 25.00% (8/32), 91.67% (22/24) and 53.57% (30/56), respectively; as well as the sensitivity, specificity and accuracy rate of sonohysterography was 90.63% (29/32), 100% (24/24), 94.64% (53/56), respectively. Compared with laparoscopy, the coincidence rate of RT-3D-HyCoSy was 86.36% (57/66). There was high consistency between the two method (Kappa=0.841, P<0.001). During ultrasound examinations, there were 84 cases with mild adverse reactions, 32 cases with moderate adverse reactions. And no drug adverse reaction was found. All the symptoms of adverse reactions disappeared within 15-20 min after resting. Conclusion: The real time three-dimensional ultrasound contrast examination system can be used to evaluate uterine cavity and fallopian tube comprehensively, and is helpful for the diagnosis of clinical infertility. Copyright © 2016 by the Press of Chinese Journal of Medical Imaging and Technology.


Liu M.,The PLA 117 Hospital | Zhang W.-D.,The PLA 117 Hospital | Zhang M.-O.,Hangzhou Traditional Chinese Medicine Hospital | Chen X.-C.,The PLA 117 Hospital | Zou Q.,The PLA 117 Hospital
Journal of Biomaterials and Tissue Engineering | Year: 2015

The aim of the present study was to develop sustained release (SR) matrix tablet of ketorolac tromethamine using natural polymer xanthan gum with cellulose derivative (sodiumcarboxy methyl cellulose) and Polyvinylpyrrolidone K30 for effective management of pain and inflammation in spinal injuries. The formulated tablets were evaluated for uniformity of weight, drug content, friability, hardness, thickness, swelling index, in vitro drug release and in vivo analgesic and antiinflammatory activity. The physicochemical properties of tablets were found within the limits. The SR matrix tablets of ketorolac showed good swelling (increased with xanthan gum’s concentration), drug content and the dissolution profile. The drug released increased with decrease in swelling properties. The formulation with 20% w/v of xanthan showed the lowest % drug release (49.6%) at the end of 8 hrs. It was concluded that increasing the concentration of gum from 5% w/v to 20% w/v in the formulation decreased the amount of drug release from the tablet. The formulation with 10% xanthan gum found to be the best in % pain reduction (54.6%) and % inhibition of paw edema (51.58%). The xanthan gum based SR matrix tablets of ketorolac tromethamine can be explored for potential therapeutic uses in spinal injuries. © 2015 American Scientific Publishers. All rights reserved.


Liao Z.X.,Hangzhou Traditional Chinese Medicine Hospital
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences | Year: 2012

To isolate exosomes from rabbit aqueous humor and to investigate their immunosuppression function. Aqueous humor was collected from 40 New Zealand rabbits and exosomes were isolated by fractional separation and ultracentrifugation methods; the morphology was studied with electron microscopy. The immunosuppressive-related proteins of exosomes were detected with Western blotting; their inhibitory effect on ConA-induced proliferation of T lymphocyte was estimation with CCK-8 cells proliferation assay. Eight milliliters of aqueous humor were collected from 40 New Zealand rabbits and 200 μg exosomes was yielded. Under electron microscope, the exosomes had typical structure of lipid bi-layer with a diameter of 50-100 nm. The results of Western blotting showed that these exosomes expressed Hsp70, CD9 and Alix but not Grp94, presenting a typical exosomes protein profile. Moreover, exosomes expressed high level of TGF-β and significantly inhibited the proliferation of T lymphocytes. Immunosuppressive exosomes can be isolated from rabbit aqueous humor, which may be involved in immunotolerance of the eye.


Chen Y.,Hangzhou Traditional Chinese Medicine Hospital | Mou L.,Zhejiang University
American Journal of Clinical Oncology: Cancer Clinical Trials | Year: 2011

Background: To improve the estimation of tumor status and facilitate the stage-dependent treatment planning, we developed a reliable and easy-to-use risk score for prediction of tumor-node-metastasis stages in gastric cancer. Methods: Clinicopathological data were collected prospectively from 108 curatively resected patients with gastric cancer. The risk score was established on the basis of independent predictive factors for tumor stages, and its performance was evaluated by receiver operating characteristic (ROC) analysis. Results: The following 4 independent factors were included in our score: serum albumin levels, tumor size, T and N categories determined by helical computed tomography. Using ROC analysis, we chose a score at 7 as the optimal cut point for differentiating the more advanced disease (stage III/IV) from the less advanced one (stage I/II). With the deflned cut point, our score allowed predicting stage III/IV with sensitivity of 79.6%, speciflcity of 85.2%, and accuracy of 82.4%. The discriminative ability of this score was good (the area under the ROC curve, 0.861-0.965). Conclusions: The risk score may be helpful to preoperative gastric cancer staging. It probably assists surgeons in deciding the extent of surgery and in choosing the appropriate perioperative adjuvant therapies. Copyright © 2011 by Lippincott Williams & Wilkins.


Fu X.-Q.,Hangzhou Traditional Chinese Medicine Hospital | Yang Y.,Hangzhou Traditional Chinese Medicine Hospital | Dong L.-W.,Hangzhou Traditional Chinese Medicine Hospital | Cheng G.-M.,Hangzhou Traditional Chinese Medicine Hospital | Wang J.,Hangzhou Traditional Chinese Medicine Hospital
Chinese Journal of Integrative Medicine | Year: 2011

Objective: To study the rule of syndrome differentiation in the patients with thoracic diseases at perioperation stage. Methods: A standard was created referring to the related literature, and it was applied to differentiate the Chinese medicine syndrome in 150 patients before and three days after thoracic operation. Results: Before operation, Chinese medicine syndromes were as differentiated as phlegm type in 45.3%, blood stasis type in 17.3%, and qi-stagnancy type in 16.0%. The patients with asthenia syndrome markedly increased after operation, accounting for 34.0% (51 patients, including qi-, yin-, and blood-deficiency syndromes). The most frequently seen intermixed syndromes were qi-deficiency with phlegm-stasis syndrome and Pi ()-deficiency with phlegm-dampness syndrome. The intermixed syndromes revealed in 37.5% and 42.0% of the patients before and after operation, respectively. Conclusions: The syndrome in the patients with thoracic disease before operation was mostly the excessive syndrome, mainly the phlegm syndrome type; at postoperation stage, Chinese medicine syndrome in patients become asthenia in essence with excessive superficiality, which is mostly revealed as Pi-deficiency with phlegm-dampness. © 2011 Chinese Association of the Integration of Traditional and Western Medicine and Springer-Verlag Berlin Heidelberg.


Chen Z.,Hangzhou Traditional Chinese Medicine Hospital
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery | Year: 2013

To retrospectively analyze the clinical characteristics of the benign paroxysmal positional vertigo (BPPV) secondary to the sudden deafness (SD) and to explore pathogenetic mechanism. One hundred and seventy-eight cases of the SD in our department were retrospectively analyzed. They were all treated under the guidance of clinical guidelines. (1) In all these patient's with SD, there were 31 cases with BPPV secondary to the SD. There were 26 cases of BPPV of posterior semicircular canal and 5 cases of BPPV of lateral BPPV semicircular canal. All patients with BPPV were diagnosed as the same ears as the SD, including 16 cases on left sides and 15 on right sides. (2) The interval between the onset of SD and BPPV was less than one week in 27 cases, between one week and one month in 3 cases, and between one and three months in 1 case. (3) All patients with BPPV secondary to the SD were cured with Epley maneuver or Barbecue roll maneuver. The occurrence of BPPV may follow SD, and the major of BPPV secondary to the SD occurs in the posterior semicircular canal. The canalith repositioning is an effective therapy to the secondary BPPV.


Hu Z.-J.,Hangzhou Traditional Chinese Medicine Hospital | Xu H.-B.,Hangzhou Traditional Chinese Medicine Hospital | He J.-L.,Hangzhou Traditional Chinese Medicine Hospital
Journal of Practical Oncology | Year: 2011

Objective: To explore the clinicopathologic features, diagnosis and prognosis of breast apocrine carcinoma. Methods: Breast apocrine carcinoma was diagnosed by morphology and detection of ER, AR, GCDFP-15 with immunohistochemistry, and the literatures were reviewed. Results: Breast apocrine carcinoma had special pathological changes. The tumor was almost completely composed of apocrine cells, there were more high negative rates of ER and PR and positive AR in immunohistochemistry. Conclusions: Breast apocrine carcinoma is a rare kind of breast tumors. It is characterized by pathologic changes and better prognosis, but there is no specific clinic feather. Its diagnosis mainly relies to morphology.


PubMed | Hangzhou Traditional Chinese Medicine Hospital
Type: Journal Article | Journal: American journal of clinical oncology | Year: 2011

To improve the estimation of tumor status and facilitate the stage-dependent treatment planning, we developed a reliable and easy-to-use risk score for prediction of tumor-node-metastasis stages in gastric cancer.Clinicopathological data were collected prospectively from 108 curatively resected patients with gastric cancer. The risk score was established on the basis of independent predictive factors for tumor stages, and its performance was evaluated by receiver operating characteristic (ROC) analysis.The following 4 independent factors were included in our score: serum albumin levels, tumor size, T and N categories determined by helical computed tomography. Using ROC analysis, we chose a score at 7 as the optimal cut point for differentiating the more advanced disease (stage III/IV) from the less advanced one (stage I/II). With the defined cut point, our score allowed predicting stage III/IV with sensitivity of 79.6%, specificity of 85.2%, and accuracy of 82.4%. The discriminative ability of this score was good (the area under the ROC curve, 0.861-0.965).The risk score may be helpful to preoperative gastric cancer staging. It probably assists surgeons in deciding the extent of surgery and in choosing the appropriate perioperative adjuvant therapies.


PubMed | Hangzhou Traditional Chinese Medicine Hospital
Type: Journal Article | Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences | Year: 2012

To isolate exosomes from rabbit aqueous humor and to investigate their immunosuppression function.Aqueous humor was collected from 40 New Zealand rabbits and exosomes were isolated by fractional separation and ultracentrifugation methods; the morphology was studied with electron microscopy. The immunosuppressive-related proteins of exosomes were detected with Western blotting; their inhibitory effect on ConA-induced proliferation of T lymphocyte was estimation with CCK-8 cells proliferation assay.Eight milliliters of aqueous humor were collected from 40 New Zealand rabbits and 200 g exosomes was yielded. Under electron microscope, the exosomes had typical structure of lipid bi-layer with a diameter of 50-100 nm. The results of Western blotting showed that these exosomes expressed Hsp70, CD9 and Alix but not Grp94, presenting a typical exosomes protein profile. Moreover, exosomes expressed high level of TGF- and significantly inhibited the proliferation of T lymphocytes.Immunosuppressive exosomes can be isolated from rabbit aqueous humor, which may be involved in immunotolerance of the eye.


PubMed | Hangzhou Traditional Chinese Medicine Hospital
Type: Journal Article | Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery | Year: 2015

To investigate the onset time and efficacy of sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops in children with house dust mites (HDM)-induced allergic rhinitis (AR).One hundred and forty three children with perennial moderate to severe HDM-induced AR were treated by SLIT with standardized Dermatophagoides farinae extract. One hundred children who finally completed two years treatment were divided into two groups according to the age: younger children group (aged 4-8 years, n = 52) and older children group (aged 9-14 years, n = 48). Respectively, Each children was assessed before and after 1st, 2nd, 3rd, 6th, 12th, 24th months of the treatment. Total nasal symptom score (TNSS), total medication score (TMS) and visual analogue scale (VAS) were evaluated at each visit. All clinical data were analyzed retrospectively with the SPSS 19.0 software.TNSS, TMS and VAS of two groups decreased significantly after three months of the treatment compared with before (younger children group: Z value was -3.843, -3.534, -3.940, older children group: Z value was -3.938, -3.405, -3.953, all P < 0.05). TNSS and VAS of younger children group decreased significantly after two months of the treatment compared with before (6.4 1.6, 5.3 1.4 vs 8.6 1.2, 7.9 1.6, Z value was -3.843, -3.940, both P < 0.05). Five children (5%) experienced local adverse events and 2 children (2%) experienced mild systemic adverse events. No severe adverse events happened during the treatment.SLIT with Dermatophagoides farinae drops is an efficient and safe treatment for children with HDM-induced AR. Its onset of action can be observed as early as 3 months after treatment.

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