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Zhong H.,Chongqing Medical University | Song Z.,Chongqing Medical University | Chen W.,TU Munich | Li H.,Chongqing Medical University | And 18 more authors.
Allergy: European Journal of Allergy and Clinical Immunology | Year: 2014

Background: The epidemiologic profiles of chronic urticaria (CU) vary considerably among regions, and few such data are available from China. Methods: We performed a multicenter open questionnaire investigation about the clinical and laboratory features of CU, defined as recurrent wheals with/without angioedema lasting for ≥6 weeks, among 3027 patients. Results: Female preponderance was observed (female/male ratio, 1.46: 1). The mean age at diagnosis was 34.7 ± 13.8 years, and the mean disease duration was 18.5 ± 46.1 months (range, 1.5-127 months). Patients were classified as having chronic spontaneous urticaria (CSU, 61.0% of patients), physical urticaria (PU, 26.2%), or other urticaria types (OU, 2.3%). Nocturnal attacks were reported by 60% of cases. The Urticaria Activity Score (UAS) in patients with CSU was 3.8 ± 1.4. The mean Dermatology Life Quality Index was 7.3 ± 3.4 (range 0-30). Induction or exacerbation of wheals with alcohol drinking was reported by 55.7% of patients. Chronic hepatitis B was less prevalent in our CU patients compared with the general Chinese population (2.7% vs 7%). Positive autologous serum skin tests (ASSTs) were observed in 66.9% of patients. Patients with positive ASST had higher UAS, greater angioedema frequencies, longer disease durations, and poorer QoL compared with patients with negative ASST (P < 0.05). Conclusion: In this Chinese population, CU usually affected youth, and CSU was the most common subtype. Autoreactivity and alcohol consumption were the top two triggers for CU, whereas latent infectious and chronic inflammatory diseases were not as common as in previous reports. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Wang Y.-Q.,Hangzhou Third Peoples Hospital | Liu Y.-X.,Hangzhou Third Peoples Hospital | Yang J.-W.,Hangzhou Third Peoples Hospital
Journal of Practical Oncology | Year: 2015

Objective: To evaluate the efficacy and safety of high-dose methotrexate (HD-MTX) combined with multi-drug chemotherapy for patients with ostetmarcoma. Methods: Clinical data of 63 ostetmarcoma patients treated by HD-MTX combined with multi-drug chemotherapy were retrospectively reviewed. Factors related to the survival and prognosis of patients were analyzed. Results: Three-year overall survival rate was 67.7% among 63 patients, while that for patients who completed 4 cycles of postoperative chemotherapy was 81.4% (P<0.05). Three-year overall survival rate was significantly related to tumor size, serum AKP level, surgery, complete chemotherapy course, chemotherapy efficacy, and distant metastasis (all P<0.05). Cox-model showed that surgery and complete chemotherapy course were independent prognostic factors (P<0.05). Conclusion: HD-MTX combined with multi-drug chemotherapy in treatment of osteosareoma is effective, which should be given based on surgery and complete therapeutic courses. ©, 2015, Journal of Practical Oncology, Editorial Board. All right reserved.

Ping S.,Hangzhou Third Peoples Hospital | Ming W.H.,Hangzhou Third Peoples Hospital | Bin S.H.,Hangzhou Third Peoples Hospital | Wen W.D.,Central South University | And 4 more authors.
Journal of B.U.ON. | Year: 2014

Purpose: To compare the clinicopathological characteristics of patients with occult (OBC) and non-occult breast cancer (non OBC).Methods: A total of 93 female patients with OBC registered at the First and Second Affiliated Hospitals of Zhe-jiang Chinese Medical University from January 1980 to December 2005 were included in this retrospective study. Their clinicopathological data were analyzed and compared with those from 1,576 female patients with non OBC, registered during the same time period.Results: The rates of estrogen receptors (ER) and progesterone receptors (PR) in OBC cases were 46.2 and 56.6%, respectively, and 44.1 and 55.6%, respectively (p<0.05). The overall 5- and 10-year overall survival rates for OBC were 51 and 43%, respectively; the overall 5-year survival rates for stage 0-1, stage II and stage III OBC patients were 90, 83 and 52%, respectively, while the overall 10-year survival rates of the three stage groups were 83, 76 and 42%, respectively.Conclusions: Compared to non OBC, the ER positive rate of OBC was lower. Furthermore, no significant difference was noticed in 5- and 10-year survival rate between OBC and stage III non OBC patients.

Yan Y.,Hangzhou Third Peoples Hospital | Liang L.,Hangzhou Third Peoples Hospital | Chen T.,Hangzhou Third Peoples Hospital | Zhong C.,Hangzhou Third Peoples Hospital | Li P.,Hangzhou Third Peoples Hospital
Revista da Associacao Medica Brasileira | Year: 2012

Objective: To study the efficacy, safety, and feasibility of stent-assistant angioplasty (SAA) in the treatment of symptomatic vertebrobasilar artery stenosis in the elderly. Methods: SAA was performed in 26 elderly patients with symptomatic vertebrobasilar artery stenosis. The success rate, perioperative complications, and long-term effectiveness were evaluated. Results: A total of 29 balloon expandable stents were implanted in these patients. The success ratio was 100%. The degree of stenosis decreased from 81.3 ± 8.8% to 3.7 ± 3.6% (p < 0.01). Complications were absent during the perioperative period. Follow-up was performed for seven to 36 months (median: 21.9 months). Two patients developed the recurrent symptoms of vertebrobasilar artery stenosis, and no cerebral ischemic events were noted in the remaining patients, suggesting a favorable outcome. Conclusion: SAA is a safe and effective strategy for the treatment of symptomatic vertebrobasilar artery stenosis in the elderly. © 2012 Elsevier Editiora Ltda. All right reserved.

Song Y.,Hangzhou Third Peoples Hospital | Yang G.,Hangzhou Third Peoples Hospital | Qiu J.,Hangzhou Third Peoples Hospital | Zhang X.,Hangzhou Third Peoples Hospital | And 2 more authors.
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery | Year: 2014

OBJECTIVE: To evaluate the impact of transanal endoscopic microsurgery (TEM) on postoperative anal function and quality of life in patients with benign rectal tumor and early rectal cancer.METHODS: Clinical data of 50 patients with rectal adenoma and early rectal cancer undergoing transanal endoscopic microsurgery in our hospital from October 2008 to June 2013 were retrospectively analyzed. Anorectal manometry, endorectal ultrasonography (ERUS), the fecal incontinence severity index (FISI), and the physical and mental health status scores (SF-36) were used to evaluate preoperative and postoperative anorectal function and quality of life.RESULTS: Anorectal manometry indicated anal resting pressure (ARP), maximum squeeze pressure (MSP), rectal volume at sensory threshold(RVST), maximum tolerable volume(MTV) decreased significantly at the first month after surgery (P<0.05). MSP returned to preoperative level at the 3rd month (P>0.05). ARP and MTV returned to normal values at the 6th month (P>0.05). RVST returned to normal values at the 9th month (P>0.05). Recto-anal inhibitory reflex(RAIR) was absent in 1 (2%) patient preoperatively and in 30(60%), 18(36%), 7(14%), 2(4%) at the 1st, 3rd, 6th, 9th months after surgery respectively. ERUS showed similar width and thickness of internal sphincter at 1st and 6th month after surgery compared with preoperative measures (P>0.05). Six months after surgery, the mean FISI score decreased(preoperative vs postoperative:8.5 vs 5.8, P<0.05), suggesting an improvement in fecal continence. However, the overall quality of life did not danger significantly after surgery(P>0.05).CONCLUSIONS: TEM has little impact on anorectal anatomic structure. Anal function may be compromised in the short-term, however the vast majority of patients recover completely after 6-9 months. TEM is a safe, effective and minimally invasive surgery.

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