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Zheng Z.,Weifang Medical University | Zhang W.,Weifang Medical University | Sun W.,Hangzhou Singclean Medical Products Co. | Li X.,University of Kentucky | And 4 more authors.
Journal of Materials Science: Materials in Medicine | Year: 2013

The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-β1 and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion. © 2013 Springer Science+Business Media New York.

Ding J.-J.,Hangzhou Singclean Medical Products Co. | Sun W.-Q.,Hangzhou Singclean Medical Products Co.
Chinese Journal of Tissue Engineering Research | Year: 2015

BACKGROUND: Hyaluronan with special linear macromolecular structure and rheologic property has good biocompatibility and becomes a signal matter of the cell surface, which possesses a promising application potential in tissue-engineering field. OBJECTIVE: To review the research progress in medical hyaluronan composites. METHODS: Related literatures concerning preparation, safety evaluation and clinical trials of hyaluronan composites were extensively reviewed and comprehensively analyzed in the three following aspects: cartilage scaffold, cornea scaffold and submucous bulking agent. RESULTS AND CONCLUSION: The hyaluronan composite has a potential use in cartilage scaffold and cornea scaffold as its suitable porosity and pore size, biomimetic three-dimensional microstructure, excellent physical and chemical property and biological property. The hyaluronan composite as a bulking agent has been applied clinically, and results from some clinical trials have shown that the composite used as bulking agent has the problems about low efficacy and complications, which need to do further improvement. More researches are needed in product design, evaluation of performance and safety for expending and optimizing the clinical applications of the hyaluronan composite. © 2015, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.

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