Hangzhou Normal University ; traditional Chinese: 杭州師範大學; pinyin: Hángzhōu Shīfàn Dàxué), or Hangzhou Teachers College, is a public university located in Hangzhou, the capital of Zhejiang Province, China. It is a comprehensive university with an excellence in teacher training and professional development.Having merged with Hangzhou Education College and Hangzhou Medical Junior College, HNU comprises nine campuses with a combined area of 513,590 m².HNU has nearly 12,000 full-time students, 9,000 of whom are undergraduates. Of over 1,000 teachers, over 100 have a doctorate degree or are Ph.D. candidates, and 283 have a master's degree. There are nearly 490 professors and associate professors . Wikipedia.
News Article | September 14, 2017
An international team of researchers reports that when children are praised for being smart not only are they quicker to give up in the face of obstacles they are also more likely to be dishonest and cheat. Kids as young as age 3 appear to behave differently when told "You are so smart" vs "You did very well this time." The study, published in Psychological Science, is co-authored by Gail Heyman of the University of California San Diego, Kang Lee of the University of Toronto, and Lulu Chen and Li Zhao of Hangzhou Normal University in China. The research builds on well-known work by Stanford's Carol Dweck, author of "Mindset," who has shown that praising a child's innate ability instead of the child's effort or a specific behavior has the unintended consequence of reducing their motivation to learn and their ability to deal with setbacks. The present study shows there's also a moral dimension to different kinds of praise and that it affects children at younger ages than previously known. Even the kindergarten and preschool set seem to be sensitive to subtle differences in praise. "It's common and natural to tell children how smart they are," said co-author Gail Heyman, a development psychologist at UC San Diego. "Even when parents and educators know that it harms kids' achievement motivation, it's still easy to do. What our study shows is that the harm can go beyond motivation and extend to the moral domain. It makes a child more willing to cheat in order to do well." For their study the researchers asked 300 children in Eastern China to play a guessing game using number cards. In total, there were 150 3-year-olds and 150 5-year-olds. The children were either praised for being smart or for their performance. A control group got no praise at all. After praising the children and getting them to promise not to cheat, the researcher left the room for a minute in the middle of the game. The kids' subsequent behavior was monitored by a hidden camera, which recorded who got out of their seat or leaned over to get a peek at the numbers. Results suggest that both the 3- and 5-year-olds who'd been praised for being smart were more likely to act dishonestly than the ones praised for how well they did or those who got no praise at all. The results were the same for boys and girls. In another study, published recently in Developmental Science, the same co-authors show that the consequences are similar even when children are not directly praised for their smarts but are merely told that they have a reputation for being smart. Why? The researchers believe that praising ability is tied to performance pressure in a way that praising behavior isn't. When children are praised for being smart or are told that they have reputation for it, said co-author Li Zhao of Hangzhou Normal University, "they feel pressure to perform well in order to live up to others' expectations, even if they need to cheat to do so." Co-author Kang Lee, of the University of Toronto's Ontario Institute for Studies in Education, emphasized the take-away for the adults in kids' lives: "We want to encourage children. We want them to feel good about themselves. But these studies show we must learn to give children the right kinds of praise, such as praising specific behavior. Only in this way will praise have the intended positive outcomes."
News Article | September 27, 2017
In 2014, new combination therapies to treat patients with metastatic melanoma hit the market, helping extend the lives of those with this aggressive disease. Yet unfortunately, after several months of treatment, almost all patients on the regimen eventually relapsed. A study out this week in Nature, led by scientists from the University of Pennsylvania and The Wistar Institute, reveals why these relapses occur. While the combination therapies block off the principal pathway that cancer cells use to fuel their growth, the cells come to bypass this blockade and, like vehicles on a detour route, make use of additional pathways to continue growing and spreading. "The tumor cells are smart," said Wei Guo, co-corresponding author on the study and a professor of biology in Penn's School of Arts and Sciences. "Once they block this first pathway, then other pathways can get activated, leading to an even more aggressive disease." These parallel pathways, governed by the PAK family of enzymes, present appealing new targets for melanoma treatment. "Our findings provide a possible flanking strategy to counteract the ability of melanoma cells to re-wire their signaling networks," said co-coresponding author Meenhard Herlyn, Caspar Wistar Professor in Melanoma Research and director of the Melanoma Research Center at The Wistar Institute. "When cancer gets smart, we have to act even smarter." Guo and Herlyn collaborated on the work with co-corresponding authors Xiaowei Xu, a professor of pathology and laboratory medicine and dermatology at Penn's Perelman School of Medicine. The lead authors on the paper are Hezhe Lu and Shujing Liu of Penn and Gao Zhang of Wistar. Around half of all melanomas are attributable to a mutation in a gene caled BRAF. When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK/ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer. Accordingly, drugs have been developed to inhibit BRAF. These therapies have been modestly successful, but some patients fail to respond entirely and those who do respond almost inevitably develop resistance. To bolster the effects of the BRAF inhibitors, recently a new class of drugs was developed to block an enzyme that acts downstream of BRAF/MEK. Pairing the BRAF inhibitor with the MEK inhibitor has given patients with advanced melanoma one of their best treatment options to date. But like the BRAF-inhbitors, the effectiveness has been transient. Several years ago, Guo and his postdoctoral researcher, Lu, were fascinated to find that drug-resistant melanoma cells were more aggressive than their parental strains in cell-culture assay. To uncover how this resistance occurs, Guo and Lu teamed with Xu, Herlyn and colleagues examined both cell lines and tumor biopsies from melanoma patients before and after either BRAF inhibitor therapy or BRAF/MEK inhibitor combination therapy. As other groups had previously shown, they found that treatment with BRAF inhibitors alone seemed to reactivate ERK, which is downstream of BRAF in the MAPK pathway. But in many cell lines and patient samples that developed resistance to the combination therapy, the researchers observed something different happening. ERK was not reactivated. Instead, they found that a parallel pathway, governed by the enzyme PAK, was energized. "We found not only was PAK activated in many patients, but also PAK's downstream targets," Guo said. Treating cells resistant to combination therapy with a PAK inhibitor reduced their ability to grow. When the researchers did the opposite, turning on a PAK protein in a metastatic melanoma cell line, they found the cells became even more resistant to inhibitors of the MAPK pathway. PAK proteins allow melanoma to thrive through their action on a few different pathways, both encouraging cell cycle progression and inhibiting apoptosis, a form of cell death, the researchers found. Interestingly, cancer researchers had previously attempted to block PAK as an anti-tumorigenic strategy in the past, only to find it didn't seem to do anything to stop melanoma progression. "It seems it is only when the ERK pathway is inhibited that PAK becomes 'awake,'" Guo said. "Then you can apply the PAK inhibitor and see an effect." "Our discovery may direct new drug development efforts to target PAKs," said Xu. Looking to the future, the Penn-Wistar team sees promise in targeting PAKs as an additional tool to target melanoma tumors. They are following up on some of the parallel pathways downstream of PAK to determine how they operate, and are also pursuing research into immunotherapy approaches in melanoma treatment. In addition to Guo, Xu, Meenhard, Lu, S. Liu and G. Zhang, coauthors included: Penn School of Arts and Sciences' Bin Wu, Yueyao Zhu, Wenqun Zhong, Wei Zhang, Gang Chen, Jingwen Zen and Claire D. Song; Penn Medicine's Xiaoming Liu, Wei Xu, Jephrey Y. Liu, Lynn M. Schuchter, Jeffrey Field, Giorgos C. Karakousis and Ravi K. Amaravadi; Wistar's Sergio Randall, Norah Sadek, Lawrence W. Wu, Clemens Krepler, Katrin Sproesser, Min Xiao and Jianglan Liu; Massachusetts General Hospital's Dennie T. Frederick, Benchun Miao, Ryan J. Sullivan, Keith T. Flaherty and Genevieve M. Boland; Drexel University's Yi Hu; New Jersey Institute of Technology's Chaoran Cheng and Jie Zhang; The University of Texas MD Anderson Cancer Center's Yiling Lu and Gordon Mills; Hangzhou Normal University School of Medicine's Yusheng Cong; Fox Chase Cancer Center's Jonathan Chernoff and Peking University's Jun Guo. The study was supported by the National Institutes of Health (grants GM085146, CA193417, CA174523, CA114046, CA25874, CA025874 and CA114046) and the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation.
Shi Y.,Hangzhou Normal University |
Wan Y.,Shanghai Normal University |
Zhao D.,Fudan University
Chemical Society Reviews | Year: 2011
Ordered mesoporous inorganic non-oxide materials attract increasing interest due to their plenty of unique properties and functionalities and potential applications. Lots of achievements have been made on their synthesis and structural characterization, especially in the last five years. In this critical review, the ordered mesoporous non-oxide materials are categorized by compositions, including non-oxide ceramics, metal chalcogenides, metal nitrides, carbides and fluorides, and systematically summarized on the basis of their synthesis approaches and mechanisms, as well as properties. Two synthesis routes such as hardlating (nanocasting) and softlating (surfactant assembly) routes are demonstrated. The principal issues in the nanocasting synthesis including the template composition and mesostructure, pore surface chemistry, precursor selection, processing and template removal are emphatically described. A great number of successful cases from the softlating method are focused on the surfactant liquid-crystal mesophases to synthesize mesostructured metal chalcogenide composites and the inorganic-block-organic copolymer self-assembly to obtain non-oxide ceramics (296 references). © 2011 The Royal Society of Chemistry.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.5.4 | Award Amount: 2.03M | Year: 2013
In the wake of the financial crisis one of the major challenges faced by policymakers in Europe and around the world is re-kindling economic growth and innovation. Recent research portrays economic growth as a process of evolution of ecosystems of technologies and industrial capabilities. This research has also shown a strong relationship between the development of the complexity of economies in a globalized market and overall output growth. ICT based tools, in particular complex systems analysis, simulation, systems science methods, and big data capabilities offer policymakers new opportunities to empirically map technology and capability ecosystems of countries and industrial sectors, analyse their structure, understand their dynamics, measure economic complexity, and design policy interventions more likely to have positive impacts on growth over time. This project proposes to apply ICT tools in this way to yield insights on the industrial competitiveness and fragility of countries, the evolution of technologies and capabilities, the network of products, the adaptability of companies, and the ecology of E-commerce. In particular, E-commerce provides an important example of the active involvement of citizen in terms of their feedbacks on products and companies. The project will be a European and global collaboration amongst a network of researchers highly experienced in these topics. The teams involved represent an interdisciplinary consortium in which various research lines will be integrated in a network of collaborative effort to address challenging problems for a new vision of a data driven fundamental economics in a strongly connected, globalised world. The results of the project will provide a novel basis for economic forecasting and risk analysis for countries, companies and technological sectors, and they will also provide a new perspective for growth and innovation policymaking.
Lu H.,Nanjing University |
Lu H.,Hangzhou Normal University |
MacK J.,Rhodes University |
Yang Y.,Nanjing University |
Shen Z.,Nanjing University
Chemical Society Reviews | Year: 2014
This review focuses on classifying different types of long wavelength absorbing BODIPY dyes based on the wide range of structural modification methods that have been adopted, and on tabulating their spectral and photophysical properties. The structure-property relationships are analyzed in depth with reference to molecular modeling calculations, so that the effectiveness of the different structural modification strategies for shifting the main BODIPY spectral bands to longer wavelengths can be readily compared, along with their effects on the fluorescence quantum yield (ΦF) values. This should facilitate the future rational design of red/NIR region BODIPY dyes for a wide range of different applications. © 2014 The Royal Society of Chemistry.
Du X.,Hangzhou Normal University
Optics Express | Year: 2013
We investigate the scattering of polychromatic plane light wave incident upon a system formed with two anisotropic particles in different distance. The analytical expression for the spectrum of the scattered field is derived. Numerical examples show the phenomena of spectral shifts and spectral switches of the scattered field. The influences of the scattering direction and the difference of the particles on the spectral switch are illustrated. © 2013 Optical Society of America.
Li F.,Hangzhou Normal University
Biology of reproduction | Year: 2012
FAM110C belongs to a family of proteins that regulates cell proliferation. In the present study, the spatiotemporal expression pattern of FAM110C and its potential role were examined during the periovulatory period. Immature female rats were injected with equine chorionic gonadotropin (eCG) followed by human chorionic gonadotropin (hCG) and ovaries or granulosa cells were collected at various times after hCG administration (n = 3/time point). Expression levels of Fam110c mRNA and protein were highly induced both in intact ovaries and granulosa cells at 8 to 12 h after hCG treatment. In situ hybridization analysis demonstrated Fam110c mRNA expression was induced in theca and granulosa cells at 4 h after hCG, primarily localized to granulosa cells at 8 h and 12 h, and decreased at 24 h after hCG. There was negligible Fam110c mRNA detected in newly forming corpora lutea. In rat granulosa cell cultures, hCG induced expression of Fam110c mRNA was inhibited by RU486, whereas NS398 and AG1478 had no effect, suggesting that Fam110c expression is regulated in part by the progesterone receptor pathway. Promoter activity analysis revealed that an Sp1 site was important for the induction of Fam110c expression by hCG. Overexpression of FAM110C promoted granulosa cells to arrest at the G(1) phase of the cell cycle but did not change progesterone levels. In summary, hCG induces Fam110c mRNA expression in granulosa cells by activation of an Sp1-binding site and the actions of progesterone. Our findings suggest that FAM110C may control granulosa cell differentiation into luteal cells by arresting cell cycle progression.
Yang C.-P.,Hangzhou Normal University
Physical Review A - Atomic, Molecular, and Optical Physics | Year: 2010
We propose a way for implementing quantum information transfer with two superconducting flux qubits by coupling them to a resonator. This proposal does not require adjustment of the level spacings or uniformity in the device parameters. Moreover, neither adiabatic passage nor a second-order detuning is needed by this proposal, thus the operation can be performed much faster when compared with the previous proposals. © 2010 The American Physical Society.
Xu L.-W.,Hangzhou Normal University
Angewandte Chemie - International Edition | Year: 2012
The observation of the stereochemistry of silicon-stereogenic silanes dates back to the pioneering work by Kipping in 1907. However, despite many significant efforts in the past hundred years toward finding new synthetic methodologies to Si-stereogenic silanes, they are still few in number. The enantioselective preparation of these silanes and their functionalized derivatives was not at all a trivial task and remained restricted to optical and kinetic resolution.[1c,d, 2] Undoubtedly, the exploration of new and efficient catalytic methods with high enantioselectivity remains one of the principal challenges in asymmetric catalysis. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Wang J.J.,Hangzhou Normal University
International journal of nanomedicine | Year: 2011
Chitosan nanoparticles are good drug carriers because of their good biocompatibility and biodegradability, and can be readily modified. As a new drug delivery system, they have attracted increasing attention for their wide applications in, for example, loading protein drugs, gene drugs, and anticancer chemical drugs, and via various routes of administration including oral, nasal, intravenous, and ocular. This paper reviews published research on chitosan nanoparticles, including its preparation methods, characteristics, modification, in vivo metabolic processes, and applications.