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Zhang S.-J.,Zhejiang Chinese Medical University | Ding Z.-S.,Zhejiang Chinese Medical University | Jiang F.-S.,Zhejiang Chinese Medical University | Ge Q.-F.,Hangzhou Minsheng Pharmaceutical Group Co. | And 3 more authors.
MedChemComm | Year: 2014

A series of xanthone analogues modified from vadimezan 6 with carboxyl substitution were synthesized as esters, amides, arylidene hydrazides, diacylhydrazides and acyl thiosemicarbazides, and their structures were confirmed by IR, 1H NMR, MS, HRMS or elemental analysis. The in vitro anticancer activities were evaluated by the MTT method. It was found that compounds 8f, 8g and 10e were effective against A549 with an IC50 at 10.8 μM, 9.4 μM and 11.5 μM respectively, and that 8e was effective against HL-60 with an IC50 at 4.6 μM. Compounds 8f-h showed a significant inhibitory effect on HUVEC growth and migration in vitro, among which 8h inhibited HUVEC growth with an IC50 at 6.4 μM and HUVEC migration by 67.6% and 89.7% at 2.5 μg mL-1 and 10 μg mL -1 respectively. More spectacularly, docking study indicated that compound 8h might target the ATP binding site of VEGFR2. In addition, compounds 8a, 8f-h exhibited moderate in vivo antitumor efficacy against the S180 xenograft in ICR mice by 22.4-29.6% tumor weight inhibition. © 2014 the Partner Organisations. Source


Li Z.-B.,Hangzhou Minsheng Pharmaceutical Group Co. | Shen L.-L.,Zhejiang University of Technology | Li J.-J.,Hangzhou Radio and University
Acta Crystallographica Section E: Structure Reports Online | Year: 2011

The title compound, C7H7NO2S, adopts an E conformation about the C=C bond. The torsion angle C=C - C - C is -177.7 (3)°. The crystal structure features weak intermolecular by C - H⋯O interactions. Source


Wang Y.-F.,Zhejiang University of Technology | Chen R.-X.,Zhejiang University of Technology | Wang K.,Zhejiang University of Technology | Zhang B.-B.,Zhejiang University of Technology | And 2 more authors.
Green Chemistry | Year: 2012

The chiral squaramide derivatives as hydrogen bonding catalyst for the Michael addition reactions of 1,3-dicarbonyl compounds to nitroolefins under solvent-free conditions was developed using a planetary ball mill. High yields, high enantioselectivities and shorter reaction times were achieved with low catalyst loading. © 2012 The Royal Society of Chemistry. Source


Wang Y.,Zhejiang University of Technology | Chen R.,Zhejiang University of Technology | Li Z.,Hangzhou Minsheng Pharmaceutical Group Co. | Xu D.,Zhejiang University of Technology
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

The title compound, C 14H 14BrNO 5, has two chiral C atoms. The quaternary C atom in the oxolanone ring has an S configuration, while the adjacent tertiary C atom has an R configuration. The oxolanone ring adopts an envelope conformation, with the flap C atom lying 0.298(3) Å from the mean plane of the remaining four atoms. In the crystal, molecules are connected into chains along [010] via weak C-H···O hydrogen bonds. Source


Wang Y.,Zhejiang University of Technology | Wang K.,Zhejiang University of Technology | Li Z.,Hangzhou Minsheng Pharmaceutical Group Co. | Xu D.,Zhejiang University of Technology
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

The title compoud, C 19H 18BrNO 5, was synthesized by an organocatalytic reaction. The aymmetric unit contains two independent mol-ecules, in each of which the carbon between the two carbonyl groups adopts an R configuration, while the adjacent C atom has an S configuration. The dihedral angle between the two benzene rings is different in the two mol-ecules [11.64 (3) and 58.96 (4)°]. Source

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