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Wang J.,Chinese PLA General Hospital | Zeng Y.,Hangzhou Innovation TCM Standarization Research Institute Co. | Cheng W.,Zhejiang Institute for Food and Drug Control
Asian Journal of Chemistry | Year: 2012

An approach for screening and identification of multi components in traditional Chinese medicine systems using combination of LC/TOF-MS technique was described in this paper. The chemical profile of Radix A., a well-known traditional Chinese medicine, was studied using the established method as for an application and the possibilities of screening complex traditional Chinese medicine systems and identifying these non-target components with modern data acquisition methods of acceleration time of flight mass spectrometers, such as data-dependent MS to MS/MS switching were investigated. As a result, 33 components were identified. This study is expected to provide a rapid, sensitive, economical and systematical method for the identification and further quality evaluation of traditional Chinese medicine. Source


Cheng W.,Zhejiang Institute for Food and Drug Control | Cheng X.,Zhejiang University | Liu Z.,Zhejiang Institute for Food and Drug Control | Zeng Y.,Hangzhou Innovation TCM Standarization Research Institute Co.
Asian Journal of Chemistry | Year: 2013

Five compounds had been isolated and purified from Alcea rosea, among which two were new compounds. The structure of the two new compounds were elucidated and characterized as 1'-hydroxy-3'-formyl-4-methylol-5-(4''-O-b-D-glucoside-3''- methoxyphenyl)-benzofuran and 1-(2'-methoxy-4'-hydroxy-5'-acetylphenyl)-3- methylbutan-1-one and named as Rosea A and Rosea B, respectively. Source


Cheng W.,Zhejiang Institute for Food and Drug Control | Cheng X.,Zhejiang University | Zeng Y.,Hangzhou Innovation TCM Standarization Research Institute Co. | Zhang W.,Zhejiang Institute for Food and Drug Control
Asian Journal of Chemistry | Year: 2013

The investigation of water-soluble fraction of Chrysanthemum morifolium led to the isolation and purification of two compounds, namely morifonoside A (I) and chlorogenic acid (II), among which morifonoside A was one new flavonoid glycoside. The structure of morifonoside A was characterized as 4',5-dihydroxy-3',5'-dimethoxy flavone 7-O-β-D-glucoside on the spectral analysis of 1D and 2D NMR data. Source


Cheng H.,Beijing Union University | Zeng Y.,Hangzhou Innovation TCM Standarization Research Institute Co. | Fang C.,Zhejiang Institute for Food and Drug Control | Cheng W.,Zhejiang Institute for Food and Drug Control
Asian Journal of Chemistry | Year: 2012

An HPLC method was developed for the simultaneous determination of three diterpenoid alkaloids (mesaconitine, aconitine and hypaconitine) in unprocessed and processed Fuzi. The solid phase was Gemini C18 column with isocratic elution using 0.04 M ammonium acetate-acetonitrile as the mobile phase. The results of methodology all fit the analytical requirements and the recoveries were 95.8- 103.4 %. Quantitative analysis of the three alkaloids showed that the contents of the alkaloids varied significantly. It was the first report that figured out the alkaloids quantitative differences in unprocessed and processed Fuzi and could provide a scientific and technical platform for setting up a quality control standard. Source


Cheng W.,Zhejiang Institute for Food and Drug Control | Tan R.,Shenyang University | Zeng Y.,Hangzhou Innovation TCM Standarization Research Institute Co. | Huang W.,Zhejiang University | Zhang W.,Zhejiang Institute for Food and Drug Control
Asian Journal of Chemistry | Year: 2012

Benzimidazole derivatives exhibit some important pharmacological actions in animals and human beings. The synthesis and pharmacological effects of two novel synthesized compounds, 2-[3-(4-morpholino)propylthio]-5-(difluromethoxy) benzimidazole (BM1) and 2-[3-(4-morpholino)ethylthio]-5-(difluromethoxy) benzimidazole (BM2), were described in this work. The tests showed that BM1 had better antiinflammatory effect than aspirin and better analgesia activity than indomethacin, while these two compounds had lower side effect of gastric ulcer than aspirin. Therefore, BM1 was an ideal antiinflammatory compound for further development. Source

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