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Hangzhou, China

Wang B.,Key Laboratory for Biomedical Engineering of Education Ministry of China | Wang B.,Zhejiang Provincial Key Laboratory Of Cardio Cerebral Vascular Detection Technology And Medicinal Eff Appraisal | Zheng H.,Hangzhou Dental Hospital | Chang M.-W.,Key Laboratory for Biomedical Engineering of Education Ministry of China | And 3 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2016

Hollow magnetic fibers for trigger based drug release were synthesized using one-step co-axial electrospinning (COX-ES). This was achieved by encapsulating the antifungal active 'ketoconazole' (KCZ) and iron oxide (Fe3O4) nanoparticles (NPs) in composite form within the core shell polymeric matrix material (polycaprolactone, PCL) during the COX-ES process. Dimethyl silicone oil was used as the inner core (liquid) of co-flowing solutions, which subsequently perfused out of the two-phase electrospun microstructures to form hollow fibers. Resulting drug-loaded magnetic hollow fibers were characterized using optical microscopy, scanning electron microscopy and Fourier Transform Infra-Red. The tensile strength and magnetization properties of composite fibers were also assessed. KCZ drug concentration in electrospinning solutions strongly influenced resulting fiber morphology, drug loading efficiency and release. Expedited drug release during a slow-sustained phase was demonstrated through the application of an auxiliary magnetic field. Variations in tensile strength (~1.3-6.3 MPa) were due to composite fiber components compromising polymer chain integrity. In-vitro cell studies (using human cervical carcinoma cell lines) demonstrated fiber biocompatibility. The present study demonstrates the potential application of magnetic hollow fibers for controlled treatment of fungal infections and antimicrobial indications. © 2016 Elsevier B.V.

Gai C.-A.,Hangzhou Dental Hospital | Zhu Z.-R.,Zhejiang University | Hu Z.-Y.,Zhejiang University | Jiang Y.-L.,Zhejiang University
National Medical Journal of China | Year: 2013

Objective: To compare the clinical efficacies and safety of sevoflurane and propofol versus remifentanil and propofol anesthesia for children with cleft lip and palate repair surgery. Methods: Upon the approval of hospital ethical committee, a total of 60 pediatric patients undergoing cleft lip and palate repair surgery were recruited from two hospitals between April 2011 and December 2012. All patients were randomly divided into 2 groups (n=30 each). Group S: sevoflurane and propofol anesthesia; and group R: propofol and remifentanil anesthesia. Heart rate (HR), mean arterial pressure (MAP) and pulse oxygen saturation (SpO2) were recorded at the time before the induction (T0), after 2 min of induction (T1), the beginning of surgery (T2) and the end of surgery (T3). Intubating satisfaction, time to extubation, incidence of emergence agitation, postoperative nausea and vomiting, and the complications of the airway were recorded. Results: Satisfactory intubation rate was 90% in group S, versus 83% in group R. And there was no significantly difference between the two group. There were no significantly difference between the two group with MAP and HR. Compared with T0, There were significantly difference with MAP and HR at Tl, T2 in group R (P < 0.05). The incidence of emergence agitation was significantly higher in group S (7 cases) than that in group R (2 cases). there were no records of nausea, vomiting and laryngospasm. Conclusion: Under an adequate depth anesthesia, these two anesthesia techniques are safe for cleft lip and palate repair surgery, emergence agitation was high in sevoflurane anesthesia, propofol and remifentanil anesthesia provides lower heart rate. Copyright © 2013 by the Chinese Medical Association.

Bao T.,Zhejiang University | Wang H.,Zhejiang University | Wei D.,Zhejiang University | Yu D.,Hangzhou Dental Hospital
Journal of Laryngology and Otology | Year: 2012

Objective: We report a modified surgical technique for transplanting an ectopic, lingual thyroid to the submandibular space, in order to maintain thyroid function while relieving obstructive symptoms. Case report: A 52-year-old woman complained of progressive dysphagia and dyspnoea. Ectopic lingual thyroid tissue was diagnosed. The ectopic thyroid gland was transplanted into the submandibular region via a lateral pharyngeal approach. A random muscle pedicle was prepared to provide a vascular supply to the transposed gland. Results: Twelve-month follow up confirmed the survival of the transplanted thyroid gland, with preserved thyroid function. Conclusion: Surgical transplantation of a lingual thyroid to the submandibular region offers an alternative treatment method for this anomaly, which avoids the need for resection and lifelong thyroxine replacement. © JLO (1984) Limited 2012.

Lin M.,Wenzhou University | Zhang L.,Wenzhou University | Wang J.,Wenzhou University | Chen X.,Zhejiang University | And 8 more authors.
Journal of Materials Chemistry B | Year: 2014

Gypsum is a promising material for bone defect repair due to its osteoconductivity, whereas it is still limited in orthopedic and dental surgeries due to its low bioactivity and too rapid resorption so that one major concern is the significant loss in microstructural stability in vivo. In the present strategy some key features were significantly improved by introducing rapidly biodegradable but highly bioactive calcium silicate (CS) for regulating the physicochemical properties and biological performances of the gypsum-based cements at the same liquid/solid ratio. We demonstrated that introduction of 23% CS into β-calcium sulfate hemihydrate (CSH) could improve the physicochemical properties but would not compromise the mechanical strength of the composite. The surface bioactivity was significantly enhanced by introducing 23% CS, and these biphasic composites were favorable for decelerating the biodegradation rate by nearly 18.5% in 28 days in vitro. A mild bioresorption rate, with 39.6% of composite residual 4 weeks after operation, was determined when implanted in subcutaneous tissue of rats. 8 weeks after implantation, the composite cement containing 23% CS significantly enhanced new bone tissue regeneration with a much higher relative bone content (∼68.6%) than pure gypsum in critical size femoral defects in rabbits. The novel CSH-CS biocements represent promising candidates for rapid bone resconstruction and repair in trauma and pathological conditions. This journal is © the Partner Organisations 2014.

Yang X.,Zhejiang University | Liu M.,Hangzhou Dental Hospital | Zhao Y.,Hangzhou Dental Hospital | Jia H.,Hangzhou Dental Hospital | And 6 more authors.
Journal of Materials Chemistry B | Year: 2014

The integration of physicochemical and biological performances in root canal treatment represents a challenge for long-time antileakage, antibacterial, and even inducing periradicular cementum/bone tissue regeneration. The objective of this work is to develop a β-Ca2SiO3 (β-C2Si)-based cement as a new root canal filler with good antibacterial ability, sealability and bioactivity. β-C2Si powders with controllable free CaO content were prepared by regulating the calcium/silicate molar ratio in reaction medium. It was demonstrated that a composite paste with 10-30 wt% α-gypsum at a liquid-to-powder ratio of 0.6 ml g-1 remained injectable for 12 min and provided a significant pH rise during setting. Notably, the hydraulic cements with high free CaO contents exhibited bactericidal or bacteriostatic properties against three bacterial strains, Streptococci mutans, Actinomyces naeslundii, and Actinomyces viscosus, which were demonstrated by the agar diffusion method. Also, the injected paste in root canal ex vivo showed extremely low microleakage of Rhodamine B but a good apatite-mineralization response. Therefore, these intrinsic antibacterial activity, bioactivity, injectability and tight adaption to root canal sealability make β-C2Si/α-gypsum composites preferential candidates for application in endodontics, such as root-end filling, pulp capping therapy, microleakage prevention, as well as for inducing hard tissue regeneration. This journal is © the Partner Organisations 2014.

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