Hande science

Suzhou, China

Hande science

Suzhou, China
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Savage S.,Genentech | Babu S.,Genentech | Zak M.,Genentech | Mao Z.,Hande science | And 4 more authors.
Synlett | Year: 2013

We describe the development of a concise route to prepare kilogram quantities of (S)-3-aminopyran, a key intermediate in the synthesis of a Jak1 inhibitor. The chiral amine was introduced via a chiral-pool approach and involves using inexpensive, commercially available l-glutamic acid as the key starting material. Global protection, followed by reduction afforded the N-Boc-amino diol. Intramolecular Mitsunobu cyclization and deprotection afforded the desired compound in 30% overall yield over four steps without the use of chromatography. © Georg Thieme Verlag Stuttgart . New York.

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