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Handan, China

Lu S.,Handan No. 1 Hospital | Yang X.,Handan No. 1 Hospital | Gui H.,Handan No. 1 Hospital | Jiang L.,Handan No. 1 Hospital | Sun L.,Handan No. 1 Hospital
Chinese Journal of Clinical Oncology | Year: 2013

Objective: To explore the role of DKK-1 and β-catenin expressions in progression of proximal gastric cancer (PGC). Methods: The expression of DKK-1 and β-catenin in 61 cases with PGC and para-neoplastic tissues and 20 cases with normal gastric mucosa was detected by immunohistochemistry. The related clinical significance in the cases was stuthed. Results: The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in the tissue sections of PGC were 34.4% (21/61) and 68.9% (42/61), respectively. The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in para-carcinoma tissues were 8.2% (5/61) and 6.6% (4/61), respectively. The positive expression rate of DKK-1 and the abnormal expression rate of β-catenin in normal gastric mucosa were 15.0% (3/20) and 10.0% (2/20), respectively. The expression rate was significantly higher in PGC than that in the other tissues (p<0.05). The expression of DKK-1 was positively related to that of β-catenin in PGC (r=0.454, P<0.05), but not in the others. Conclusion: Higher expressions of DKK-1 and the abnormal expression of β-catenin are closely related to the occurrence of PGC. Source

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