Hanbul Cosmetics Co

South Korea

Hanbul Cosmetics Co

South Korea
SEARCH FILTERS
Time filter
Source Type

Bae J.T.,Hanbul Cosmetics Co. | Ko H.J.,Hanbul Cosmetics Co. | Kim G.B.,Hanbul Cosmetics Co. | Pyo H.B.,Hanbul Cosmetics Co. | Lee G.S.,Hanbul Cosmetics Co.
Phytotherapy Research | Year: 2012

The aqueous extracts of Citrus unshiu peel containing flavonoid glycosides was used as co-substrate with Schizophyllum commune mycelia producing β-glucosidase and its biological activities were studied. β-glucosidase-produced S. commune mycelia converted the glycosides (narirutin and hesperidin) into aglycones (naringenin and hesperetin). The photoprotective potential of fermented C. unshiu peel extract with S. commune (S-CPE) was tested in human dermal fibroblasts (HDFs) exposed to UVA. It was revealed that S-CPE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDFs. The treatment of UVA-irradiated HDFs with S-CPE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. The UVA irradiation raised the proportion of senescence-associated β-galactosidase (SA-β-gal) positive cells in comparison with the normal control group. The treatment of UVA-irradiated HDFs with S-CPE was shown to decrease the level of SA-β-gal (by approximately 45% at an S-CPE concentration 0.1%, w/v) compared with the UVA-irradiated HDFs. It was found that S-CPE containing hesperetin has notable collagen biosynthetic activity for fibroblasts, indicating that S-CPE can be promising cosmetic ingredients. Copyright © 2012 John Wiley & Sons, Ltd. Copyright © 2012 John Wiley & Sons, Ltd.


Zhang X.-Q.,Peking University | Kim J.-H.,Hanbul Cosmetics Co. | Lee G.-S.,Hanbul Cosmetics Co. | Pyo H.-B.,Hanbul Cosmetics Co. | And 3 more authors.
American Journal of Chinese Medicine | Year: 2012

Antioxidant fractions from Ophioglossum thermale were extracted with five different polar solvents using a Soxhlet type extractor. The total phenolic content of the extracts was determined by the Folin-Ciocalteu method. The ethyl acetate fraction of O. thermale was found to contain maximum phenolics. The dried fractions were screened for their antioxidant activity potential using in vitro model systems such as 1,1-diphenyl-2-picryl hydrazyl (DPPH), nitroblue tetrazolium (NBT) and lipid-peroxidation reduction at different concentrations. Results revealed that the EtOAc fraction exhibited the best performance in the DPPH assay, NBT assay and lipid peroxidation. All fractions showed more potent antioxidant capacity than green tea extract, a well-known antioxidant. Furthermore, the EtOAc fraction has the highest total phenolic content (475.65 mg of EGCG/g). In addition, the EtOAc fraction at 0.005% and 0.01% (g/100 ml) also significantly inhibited UVB irradiation-induced ROS generation in human dermal fibroblasts (HDFs). In a carrageenan-induced edema model, the EtOAc fraction showed an inhibitory effect (21.5%, p < 0.05) at 200 mg/kg (p.o.) after 300 min administration. Consequently, 3-O-methylquercetin (3MQ) was also isolated from the antioxidative EtOAc fraction. The data obtained using the above in vitro and in vivo tests suggest that the antioxidant activity of O. thermale and its anti-inflammatory effect on carrageenan-induced acute inflammation can be attributed to its ameliorating effect on oxidative damage, and thus it has great potential as a source for natural health products. To the best of our knowledge, this is the first report on the antioxidant activity of different polar extracts from O. thermale. © 2012 World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine.


Kim J.-H.,Hanbul Cosmetics Co. | Bae J.-T.,Hanbul Cosmetics Co. | Song M.-H.,Hanbul Cosmetics Co. | Lee G.-S.,Hanbul Cosmetics Co. | And 2 more authors.
Archives of Pharmacal Research | Year: 2010

Fructus arctii extract containing phenolic glycosides was cultured with Grifola frondosa mycelia to produce β-glucosidase and its biological activities were studied. This β-glucosidase converted the glycosides (arctiin and caffeic acid derivatives) into aglycones (arctigenin and caffeic acid). Fermented Fructus arctii extract (G-FAE) with G. frondosa had antioxidant and 5-lipoxygenase inhibitory activities. The photoprotective potential of G-FAE was tested in human dermal fibroblasts (HDF) exposed to ultra-violet A (UVA). It was revealed that G-FAE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDF. The treatment of UVA-irradiated HDF with G-FAE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. G-FAE also showed notable stimulation of collagen biosynthetic activity for fibroblasts. These diverse functionalities suggest that G-FAE could be a promising cosmetic ingredient. © 2010 The Pharmaceutical Society of Korea and Springer Netherlands.


Yun C.-Y.,Chungbuk National University | You S.-T.,Chungbuk National University | Kim J.-H.,Hanbul Cosmetics Co. | Chung J.H.,Seoul National University | And 3 more authors.
Journal of Investigative Dermatology | Year: 2015

p21-activated kinase 4 (PAK4) regulates a wide range of cellular events, including cytoskeletal remodeling, cell growth, and survival. Our previous study identified PAK4 as a key regulator of cAMP-response element-binding protein (CREB) that acts upstream of microphthalmia-associated transcription factor (MITF), a master transcription factor in melanogenesis. We therefore investigated the role of PAK4 in melanogenesis. Melanocytes express both PAK2 and PAK4 isoforms, but only RNA interference knockdown of PAK4 significantly influenced α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis in B16 melanoma cells. Consistent with this result, PAK4 inhibition by PF3758309, a potent ATP-competitive inhibitor of PAKs, suppressed not only α-MSH-induced melanogenesis in B16 melanoma and human epithelial melanocyte cells but also UVB-induced melanogenesis in the skin of melanin-possessing hairless mice (HRM-2) in a dose-dependent manner. Inhibition of PAK4 over several days markedly decreased the levels of CREB, MITF, and tyrosinase in both HRM-2 mice and B16 melanoma cells. Moreover, PAK4 knockdown and inhibition suppressed α-MSH-stimulated β-catenin phosphorylation at serine 675 (S675) but enhanced phosphorylation at S33/37, an indicator for ubiquitination-dependent proteolysis. Together, our results provide evidence that PAK4 promotes α-MSH/UVB-induced melanogenesis via the CREB and Wnt/β-catenin signaling pathways and suggest that PAK4 may be a potential therapeutic target in pigmentation disorders. © 2015 The Society for Investigative Dermatology.


Kang K.-C.,Hanbul Cosmetics Co.
Applied Chemistry for Engineering | Year: 2013

The liquid crystal form with phosphatidylcholine contents containing in the hydrogenated lecithin was confirmed. Composition ingredients of the liquid crystal vesicle were phospholipid, ethanol and water and the rosmarinic acid was encapsulated as index material. The mean particle size of the liquid crystal vesicle appeared to form various particles form 480 nm to 3 μm depending upon the lipid composition and ultrasonic handling time. The liquid crystal vesicle compared with the liposome showed a very high encapsulation efficiency. The quantity of liquid crystal vesicle increased with respect to the increased quantity of lipid contents in the hydrogenated lecithin. The result from release experiments of the liquid crystal vesicle containing rosmarinic acid showed that the liquid crystal vesicle releases much less than that of liposome.


Sun J.-K.,Hanbul Cosmetics Co. | Um E.-H.,Dankook University | Lee C.-T.,Dankook University
Applied Chemistry for Engineering | Year: 2010

Modifying surface of activated carbon for the electrode of EDLC with an organic electrolyte was investigated to improve the electrochemical performance of EDLC by the microwave radiation. Three kinds of activated carbons, prepared activated carbon from petroleum cokes and pitch cokes and commercial activated carbon BP-25, were used for this study. For all investigated activated carbons, hydrophilic functional groups-containing oxygen disappeared from the surface of activated carbon as microwave radiation. And as microwave radiation time was increased, the specific surface area and total pore volume of activated carbons were reduced and average pore diameter were increased. From theses effects, interfacial resistance of EDLC with the modified activated carbon electrode was drastically decreased, and discharge capacitance was increased although the specific surface area of activated carbon was reduced by this microwave radiation.


PubMed | Hanbul Cosmetics Co.
Type: Journal Article | Journal: Phytotherapy research : PTR | Year: 2012

The aqueous extracts of Citrus unshiu peel containing flavonoid glycosides was used as co-substrate with Schizophyllum commune mycelia producing -glucosidase and its biological activities were studied. -glucosidase-produced S. commune mycelia converted the glycosides (narirutin and hesperidin) into aglycones (naringenin and hesperetin). The photoprotective potential of fermented C. unshiu peel extract with S. commune (S-CPE) was tested in human dermal fibroblasts (HDFs) exposed to UVA. It was revealed that S-CPE had an inhibitory effect on human interstitial collagenase (matrix metalloproteinase, MMP-1) expression in UVA-irradiated HDFs. The treatment of UVA-irradiated HDFs with S-CPE resulted in a dose-dependent decrease in the expression level of MMP-1 mRNA. The UVA irradiation raised the proportion of senescence-associated -galactosidase (SA--gal) positive cells in comparison with the normal control group. The treatment of UVA-irradiated HDFs with S-CPE was shown to decrease the level of SA--gal (by approximately 45% at an S-CPE concentration 0.1%, w/v) compared with the UVA-irradiated HDFs. It was found that S-CPE containing hesperetin has notable collagen biosynthetic activity for fibroblasts, indicating that S-CPE can be promising cosmetic ingredients.


Trademark
Hanbul Cosmetics Co. | Date: 2014-11-20

Lipsticks, Mascara, Make-up foundations, Body lotions, Cosmetic preparations for skin care, Cosmetic sunprotecting preparations, Perfumes, Hair conditioners, Make-up removing preparations, Cosmetics, Cosmetic kits, Perfumed oils for the manufacture of cosmetic preparations, False eyelashes, Tissues impregnated with cosmetic lotions, Beauty masks, Cotton sticks for cosmetic purposes, Beauty soap, Shampoos, Liquid bath soaps, Cosmetic soaps.


Trademark
Hanbul Cosmetics Co. | Date: 2016-06-29

functional cosmetics, lipsticks, mascaras, Make-up foundation, body lotion, cosmetic preparations for skin care, perfume, make-up removing preparations, cosmetics, perfume oils for the manufacture of cosmetic preparations, false eyelashes, tissues impregnated with cosmetic lotions, beauty masks, cotton buds for cosmetic purposes, beauty soaps, shampoo, cosmetic soaps, toiletries, essential oil, dentifrices.


PubMed | Jeju National University, Jeju Biodiversity Research Institute, Hanbul Cosmetics Co. and Nakdonggang National Institute of Biological Resources
Type: | Journal: EXCLI journal | Year: 2015

During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 M. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-), interleukin (IL)-1, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.

Loading Hanbul Cosmetics Co collaborators
Loading Hanbul Cosmetics Co collaborators