The HAN University of Applied science , often abbreviated as HAN, is a vocational university of applied science with campuses in Arnhem and Nijmegen in the Netherlands. It offers Bachelor and Master degrees in a wide range of subjects. Arnhem Business School is the international department of HAN University. Wikipedia.
Tarenskeen D.,HAN University of Applied Sciences
ACM International Conference Proceeding Series | Year: 2016
Conceptual independence is a novel approach for adaptable information systems. It extends the ideas of Model Driven Development. Conceptual independence eases adaptability by a separation of the Business domain terms from the functions that use the terms in the application. Although in practice many examples can be found in which parts of this approach are applied, a consistent application of this idea is not often encountered. The principle of Conceptual independence is sketched in this paper in a pattern. Since developing information systems often depends on the content of the Business domain, and the conceptual model of the domain needs frequent adaptation, systems need to be adaptable. In this paper we describe a complete decoupling of the software system from its conceptual model of the domain. We illustrate the relevance of this approach for the professional practice of software development and architecture. Furthermore, we describe related approaches for adaptable systems. © 2016 ACM.
Furlan A.J.,HAN University of Applied Sciences |
Reisman M.,Swedish Medical Center |
Massaro J.,Harvard University |
Mauri L.,Harvard University |
And 8 more authors.
New England Journal of Medicine | Year: 2012
BACKGROUND: The prevalence of patent foramen ovale among patients with cryptogenic stroke is higher than that in the general population. Closure with a percutaneous device is often recommended in such patients, but it is not known whether this intervention reduces the risk of recurrent stroke. METHODS: We conducted a multicenter, randomized, open-label trial of closure with a percutaneous device, as compared with medical therapy alone, in patients between 18 and 60 years of age who presented with a cryptogenic stroke or transient ischemic attack (TIA) and had a patent foramen ovale. The primary end point was a composite of stroke or transient ischemic attack during 2 years of follow-up, death from any cause during the first 30 days, or death from neurologic causes between 31 days and 2 years. RESULTS: A total of 909 patients were enrolled in the trial. The cumulative incidence (Kaplan-Meier estimate) of the primary end point was 5.5% in the closure group (447 patients) as compared with 6.8% in the medical-therapy group (462 patients) (adjusted hazard ratio, 0.78; 95% confidence interval, 0.45 to 1.35; P = 0.37). The respective rates were 2.9% and 3.1% for stroke (P = 0.79) and 3.1% and 4.1% for TIA (P = 0.44). No deaths occurred by 30 days in either group, and there were no deaths from neurologic causes during the 2-year follow-up period. A cause other than paradoxical embolism was usually apparent in patients with recurrent neurologic events. CONCLUSIONS: In patients with cryptogenic stroke or TIA who had a patent foramen ovale, closure with a device did not offer a greater benefit than medical therapy alone for the prevention of recurrent stroke or TIA. (Funded by NMT Medical; ClinicalTrials.gov number, NCT00201461.) Copyright © 2012 Massachusetts Medical Society.
Schaafsma G.,HAN University of Applied Sciences
British Journal of Nutrition | Year: 2012
PDCAAS is a widely used assay for evaluating protein quality. It is a chemical score, which is derived from the ratio between the first limiting amino acid in a test protein and the corresponding amino acid in a reference amino acid pattern and corrected for true faecal N digestibility. Chemical scores exceeding 100% are truncated to 100%. The advantages of the PDCAAS are its simplicity and direct relationship to human protein requirements. The limitations are as follows: the reference pattern is based on the minimum amino acid requirements for tissue growth and maintenance and does not necessarily reflect the optimum intake. Truncated PDCAAS of high-quality proteins do not give any information about the power of these proteins to compensate, as a supplement, for low levels of dietary essential amino acids in low-quality proteins. It is likely that faecal N digestibility does not take into account the loss from the colon of indispensable amino acids that were not absorbed in the ileum. Anti-nutritional factors, such as lectins and trypsin inhibitors, in several plant protein sources can cause heightened endogenous losses of amino acids, an issue which is particularly relevant in animal feedstuffs. The assumption that amino acid supplementation can completely restore biological efficiency of the protein source is incorrect since the kinetics of digestion and absorption between supplemented free amino acids and amino acids present in dietary proteins, are different. © 2012 The Author.
Basten T.G.H.,TNO |
De Bree H.-E.,HAN University of Applied Sciences
Journal of the Acoustical Society of America | Year: 2010
Calibration of acoustic particle velocity sensors is still difficult due to the lack of standardized sensors to compare with. Recently it is shown by Jacobsen and Jaud [J. Acoust. Soc. Am. 120, 830-837 (2006)] that it is possible to calibrate a sound pressure and particle velocity sensor in free field conditions at higher frequencies. This is done by using the known acoustic impedance at a certain distance of a spherical loudspeaker. When the sound pressure is measured with a calibrated reference microphone, the particle velocity can be calculated from the known impedance and the measured pressure. At lower frequencies, this approach gives unreliable results. The method is now extended to lower frequencies by measuring the acoustic pressure inside the spherical source. At lower frequencies, the sound pressure inside the sphere is proportional to the movement of the loudspeaker membrane. If the movement is known, the particle velocity in front of the loudspeaker can be derived. This low frequency approach is combined with the high frequency approach giving a full bandwidth calibration procedure which can be used in free field conditions using a single calibration setup. The calibration results are compared with results obtained with a standing wave tube. © 2010 Acoustical Society of America.
Pauwelussen J.,HAN University of Applied Sciences
Vehicle System Dynamics | Year: 2012
Path tracking driver models assume the observed path deviation ahead of the vehicle to be proportionally transferred to a corrective steering input. The most simple version of such a model includes three parameters, a single preview distance, a steering gain and a delay time, being examined in this paper, in dependency of vehicle properties, driver characteristics, velocity and path. It is shown that, for different and bounded preview lengths, a driver can follow any path with almost the same minimum path error, if the gain is adapted appropriately. The upper boundary is path-dependent but driver and path characteristics have only a minor effect on the resulting relationship between preview length and gain. Consequently, gain and preview length may well vary along some path. This has been examined, experimentally, for different drivers. A too small preview length conflicts with closed-loop stability, explicitly described in terms of vehicle parameters, vehicle speed and driver delay time. The results of this paper provide a basis for enhanced understanding of human driver behaviour. © 2012 Copyright Taylor and Francis Group, LLC.
Guo H.-L.,HAN University of Applied Sciences
Gongcheng Lixue/Engineering Mechanics | Year: 2012
The study of the deep pile cap with a pull pile under an unbalanced bending moment is processed, based on the test and finite element method. The research indicates that this kind of pile cap may induce bending failure due to the beam action, and at the same time, it still acts as a load transfer system of the spatial strut-and-tie due to the arch action. It is definitely universal that both the beam action and the arch action exist in the deep pile cap.
Faust M.,HAN University of Applied Sciences |
Faust M.,Bar - Ilan University |
Kenett Y.N.,HAN University of Applied Sciences
Frontiers in Human Neuroscience | Year: 2014
Neurotypical individuals cope flexibly with the full range of semantic relations expressed in human language, including metaphoric relations. This impressive semantic ability may be associated with distinct and flexible patterns of hemispheric interaction, including higher right hemisphere (RH) involvement for processing novel metaphors. However, this ability may be impaired in specific clinical conditions, such as Asperger syndrome (AS) and schizophrenia. The impaired semantic processing is accompanied by different patterns of hemispheric interaction during semantic processing, showing either reduced (in Asperger syndrome) or excessive (in schizophrenia) RH involvement. This paper interprets these individual differences using the terms Rigidity, Chaos and Integration, which describe patterns of semantic memory network states that either lead to semantic well-being or are disruptive of it. We argue that these semantic network states lie on a rigidity-chaos semantic continuum. We define these terms via network science terminology and provide network, cognitive and neural evidence to support our claim. This continuum includes left hemisphere (LH) hyper-rigid semantic memory state on one end (e.g., in persons with AS), and RH chaotic and over-flexible semantic memory state on the other end (e.g., in persons with schizophrenia). In between these two extremes lie different states of semantic memory structure which are related to individual differences in semantic creativity. We suggest that efficient semantic processing is achieved by semantic integration, a balance between semantic rigidity and semantic chaos. Such integration is achieved via intra-hemispheric communication. However, impairments to this well-balanced and integrated pattern of hemispheric interaction, e.g., when one hemisphere dominates the other, may lead to either semantic rigidity or semantic chaos, moving away from semantic integration and thus impairing the processing of metaphoric language. © 2014 Faustand Kenett.
Hdeib A.,HAN University of Applied Sciences |
Sloan A.E.,HAN University of Applied Sciences
Expert Opinion on Biological Therapy | Year: 2011
Introduction: Despite treatment advances for malignant gliomas in adults, prognosis remains poor, largely due to the infiltrative and heterogeneous biology of these tumors. Response to adjuvant therapy is not always uniform and the blood-brain barrier prevents the majority of chemotherapeutics from adequately reaching primary tumor sites. These obstacles necessitate development of novel delivery methods and agents. Areas covered: 131I-chTNT-1/B mAB (Cotara) is a genetically engineered chimeric monoclonal antibody that binds to the DNA-histone H1 complex. It carries 131I, which delivers sufficient energy to kill adjacent tumor cells. Through convection-enhanced delivery (CED) it provides radioimmunotherapy directly to the resection cavity. We review the pharmacology and clinical experience with 131I-chTNT-1/ B mAB, detailing results of completed Phase I and II trials. Expert opinion: Novel agents and therapeutic modalities, such as 131I-chTNT-1/B mAB, are of interest for treatment of malignant glioma, for which the prognosis continues to be dismal. 131I-chTNT-1/B mAB targets tumor cells and radioisotope labeling allows radiation delivery to the tumor with sharp fall-off. Data from Phase I and II trials of CED delivery of 131I-chTNT-1/B mAB shows it is well tolerated. Phase II trial data suggests it could be promising therapeutically, though conclusions about efficacy require further trials and clinical experience. The compound is currently in a Phase II trial for dose confirmation in patients with malignant gliomas. © Informa UK, Ltd.
Voerman J.S.,HAN University of Applied Sciences
Clinical Journal of Pain | Year: 2016
OBJECTIVES:: The purpose of the present study was to determine whether pain is associated with specific aspects of academic performance, i.e. poorer grades, and with factors critical to an adolescent’s academic performance, i.e. decreased emotional well-being and attention problems. We hypothesized that the association between pain and school grades is mediated by emotional well-being and attention problems. METHODS:: In a large cross-sectional study, we collected data from 2215 pupils, aged 12-13 years old. Pain (no, occasional, and frequent), emotional well-being, and attention problems were measured with self-rating scales. Dutch, English, and math grades were taken as an index of academic performance. RESULTS:: Frequent pain in adolescents was associated with poorer grades (Dutch P=0.02 and math P=0.01). Both occasional and frequent pain were associated with reduced emotional well-being (P=<0.001) and reduced self-reported attention (P=<0.001). However, the association between pain and lower grades disappeared when controlling for emotional well-being and attention. DISCUSSION:: The present study shows that the association between pain and Dutch grades is mediated by reduced emotional well-being and attention problems. The association between pain and math grades is mediated by emotional problems. The results suggest that an intervention targeted at pain in adolescents could have a positive effect on emotional well-being, attention, and school performance. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
Kim R.,HAN University of Applied Sciences
International Food Research Journal | Year: 2013
This paper assesses current conditions of Chinese food safety management system and how policy makers responded to recent incidents of food scares which occurred in China. The paper identifies three aspects of Chinese food safety system which may need to be improved to enhance the system and addresses policy implications for Chinese food safety system. First, administrative structure of Chinese food safety system may need to be consolidated for enhancing efficiency. Second, Chinese consumers' attitude toward food safety system in China was found to be determining factor for future success of sustainable food supply chain in China, and this should be extensively monitored and evaluated to improve risk communication of food in China. Third, international cooperation among major trading partners regarding development of global food supply chain is found to be imminent, as globalization and increased international trade leads to integration of food safety issues of each country. Development of compatible food safety standards and measures is necessary to have coordinated management of food products which are traded across border. © 2008 IFRJ, Faculty of Food Science & Technology, UPM.