Zadegan F.G.,Lund University |
Krenz-Baath R.,Hamm-Lippstadt University of Applied Sciences |
Larsson E.,Lund University
Proceedings - International Test Conference | Year: 2017
IEEE 1687 enables flexible access to on-chip instruments via dynamically reconfigurable networks. Reconfiguration allows reducing instrument access time by keeping only those instruments on the scan-path which are required for each access. To perform reconfiguration and execute commands described in instrument access procedures, scan vectors are generated in a process called retargeting. These vectors are then applied through a number of capture-shift-update (CSU) operations. Generating the optimal set of vectors w.r.t. application time is modeled as an Integer Linear Optimization Problem, which is an NP-hard problem. In the modeling, an IEEE 1687 network is represented as a sequential problem unrolled over a number of time frames, each frame corresponding to a CSU operation. A key challenge is to find the number of required CSU operations, which should be sufficiently high so that the optimal solution is included in the search space but kept as low as possible to keep the model less complex and thus suitable for large IEEE 1687 networks. In this work, we propose a method to compute an upper-bound on the number of required CSU operations. Through experiments, we show that our method results in a tight upper-bound, is applicable to a large variety of IEEE 1687 network designs, and is able to handle large designs. © 2016 IEEE.
Krakowski-Roosen H.,Hamm-Lippstadt University of Applied Sciences
Onkologe | Year: 2017
Background: In the press there are statements, such as “sport more important than a cancer medicine” and tumor patients regularly participate in a growing number of sports. What is the therapeutic value of sport for patients, what is the impact of such a sport offer and how often and intensively should sport be practiced? Questions that are asked by doctors, therapists and patients. Objectives: The potential of sport in the prevention of cancer should be considered in the sense of the three classical prevention levels (primary, secondary and tertiary): can practicing sport change the risk of developing cancer? Can sport contribute to the early detection of cancer? Does sport help tumor patients with their disease? Material and methods: This article is based on a selective literature search of the PubMed database for the topics “sports, exercise and physical activity” and “cancer”. In addition, data from the own patient population were evaluated. Results and conclusion: Epidemiological studies show an effective reduction of molecular factors, such as high insulin and insulin-like growth factor (IGF) levels as well as high insulin resistance through sport, which are high risk factors for numerous tumor diseases. Other factors, such as interleukin 6 (IL-6) are also mediators of the disease but are part of physiological adaptation responses to training in sport so that their role in the sense of a preventive causal chain can be critically questioned. The practice of sport and also negative side effects, such as increased intake of performance enhancing substances may also increase the risk of cancer. In the sense of secondary prevention, sports and sports scientific methods can contribute to uncovering threatening side effects of the disease, such as cachexia in the early stages of cancer. Concrete recommendations are given for the design of training programs for tumor patients. © 2017 Springer Medizin Verlag GmbH
Weber A.,Hamm-Lippstadt University of Applied Sciences |
Health Policy | Year: 2016
Amenable mortality has been recently included in the joint monitoring tool by the European Commission and Member States to assess a country's health system performance. Amenable deaths are premature deaths, which should not have occurred at this stage in the light of timely and effective health care.This paper recalculated annual amenable mortality rates for 28. EU countries and the EU for the period 1994-2013 based on the recently published list of deaths amenable to health care by Eurostat. Thereby, it offers a consistent calculation of amenable mortality across European Member States and provides time series data on amenable mortality. In addition, a sensitivity analysis of the amenable mortality indicator for varying age limits and attributional weights of circulatory system diseases is carried out.While large improvements were made in reducing amenable deaths in all European countries, great variations persist among Member States. Most of the decreases in amenable mortality are explained by a substantial reduction of deaths due to circulatory system diseases. In addition, even in countries with good national performance on amenable mortality, sub-national analysis shows that great regional disparities exist. The sensitivity analysis revealed that for the large majority of countries results are stable across different attributional weights used for ischaemic heart diseases and cerebrovascular diseases. © 2017 Elsevier B.V.
Zhang J.,Helmholtz Center Munich |
Gotz S.,Helmholtz Center Munich |
Vogt Weisenhorn D.M.,Helmholtz Center Munich |
Simeone A.,CNR Institute of Genetics and Biophysics Adriano Buzzati Traverso |
And 4 more authors.
Neurobiology of Disease | Year: 2015
The protracted and age-dependent degeneration of dopamine (DA)-producing neurons of the Substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) in the mammalian midbrain is a hallmark of human Parkinson's Disease (PD) and of certain genetic mouse models of PD, such as mice heterozygous for the homeodomain transcription factor Engrailed 1 (. En1+/- mice). Neurotoxin-based animal models of PD, in contrast, are characterized by the fast and partly reversible degeneration of the SNc and VTA DA neurons. The secreted protein WNT1 was previously shown to be strongly induced in the neurotoxin-injured adult ventral midbrain (VM), and to protect the SNc and VTA DA neurons from cell death in this context. We demonstrate here that the sustained and ectopic expression of Wnt1 in the SNc and VTA DA neurons of En1+/Wnt1 mice also protected these genetically affected En1 heterozygote (. En1+/-) neurons from their premature degeneration in the adult mouse VM. We identified a developmental gene cascade that is up-regulated in the adult En1+/Wnt1 VM, including the direct WNT1/β-catenin signaling targets Lef1, Lmx1a, Fgf20 and Dkk3, as well as the indirect targets Pitx3 (activated by LMX1A) and Bdnf (activated by PITX3). We also show that the secreted neurotrophin BDNF and the secreted WNT modulator DKK3, but not the secreted growth factor FGF20, increased the survival of En1 mutant dopaminergic neurons in vitro. The WNT1-mediated signaling pathway and its downstream targets BDNF and DKK3 might thus provide a useful means to treat certain genetic and environmental (neurotoxic) forms of human PD. © 2015 Elsevier Inc.
Neuenhaus M.,Hamm-Lippstadt University of Applied Sciences |
Aly M.,Hamm-Lippstadt University of Applied Sciences
Conference on Human Factors in Computing Systems - Proceedings | Year: 2017
Nowadays, Syrian refugees are facing major challenges to mingle with the social life of German society. The purpose of this on-going study is to create support and increase empathy of German youths towards Syrian refugees with the developed concept called "Empathy-Up" (EMP-UP). The concept aims at levelling the playing field for them through a mobile game. The research done has shown two main critical problems faced by refugees (Syrian): (1) they do not get in contact with locals (Germans), and (2) they feel that Germans do not want to interact with them or accept them in their society. The study shows that when combining a geo-location based mobile game that addresses cultural differences within the game scenario, it's more likely to connect players emotionally with these different cultures. This resulted in minimizing prejudices by locals, increasing their willingness to get to know refugees, and making the first contact with a refugee simpler and more positive. The empathy is created during the game while players are going through the story scenario and when the game ends, both players (locals and refugees) surprisingly meet face-to-face in reality. Copyright © 2017 by the Association for Computing Machinery, Inc. (ACM).
Spura C.,Hamm-Lippstadt University of Applied Sciences
Forschung im Ingenieurwesen/Engineering Research | Year: 2015
Gear couplings are essential machine elements and where used in many areas of the gear and transmission technology. The significant advantages of gear couplings are the transmission of high drive power and torque in a small space, and the compensation of an existing radial and/or angular displacement. For this compensation a geometrically complicated special gearing and the knowledge of the load distribution within the teeth is essential. To calculate the load distribution, the focal factor is the tooth stiffness and its dependence on various influencing variables. The following article shows the basic principles and the present knowledge of the tooth stiffness calculation for gear couplings and shows the application of the methods for calculating the contemporary practical use in the design phase of this machine element. © 2015, Springer-Verlag Berlin Heidelberg.
Meyer J.,Hamm-Lippstadt University of Applied Sciences |
Tappe F.,Hamm-Lippstadt University of Applied Sciences
Advanced Optical Materials | Year: 2015
The efficient generation of white light by phosphor-converted LEDs (pcLEDs) suffers from a trade-off between high color rendition, low correlated color temperatures, and luminous efficacy. While this is partially an inherent problem, it is also caused by the spectral efficiency of the materials used. The particular challenges for materials research lie, amongst the demanding general requirements, in finding very narrow-band or line-emitting materials: excitable with blue light, emitting in the near red. A way to design Mn(IV) activated line emitters is proposed, and methods for high-throughput combinatorial syntheses are specified. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Thomae D.,Jena University of Applied Sciences |
Maass J.,Carl Zeiss GmbH |
Sandfuchs O.,Hamm-Lippstadt University of Applied Sciences |
Gatto A.,Carl Zeiss GmbH |
Brunner R.,Jena University of Applied Sciences
Applied Optics | Year: 2014
A flexible illumination system for Talbot lithography is presented, in which the Talbot mask is illuminated by discrete but variable incidence angles. Changing the illumination angle stepwise in combination with different exposure doses for different angles offers the possibility to generate periodic continuous surface relief structures. To demonstrate the capability of this approach, two exemplary micro-optical structures were manufactured. The first example isa blazed grating with a stepsize of 1.5 μm. The second element is a specific beam splitter with parabolic-shaped grating grooves. The quality of the manufacturing process is evaluated on the basis of the optical performance of the resulting micro-optical elements. © 2014 Optical Society of America.
Bittmann B.,Schrodinger |
Haupert F.,Hamm-Lippstadt University of Applied Sciences |
Schlarb A.K.,University of Kaiserslautern
Journal of Applied Polymer Science | Year: 2012
Nanocomposites gained more and more importance in the last few years because of their improved performance over the neat polymer matrix, that is, toughness and stiffness can be enhanced simultaneously by the addition of nanoparticles. However, the dispersion of these particles in the matrix remains a big challenge. In this study, two types of TiO 2 nanoparticles were dispersed in two different epoxy resins by means of ultrasound. The particle size development in dependence on the dispersion time was investigated by dynamic light scattering for the different material systems. Furthermore, the influence of the viscosity on the sonication process' efficiency was analyzed. The resulting nanocomposites were tested for fracture and Charpy toughness. SEM images revealed that the improved fracture toughness properties are correlated to a rougher fracture surface, whose formation dissipates more energy. © 2011 Wiley Periodicals, Inc.
Agency: European Commission | Branch: FP7 | Program: CP | Phase: ICT-2013.3.1 | Award Amount: 4.65M | Year: 2014
Today, an average family spends annually over 50 Euros on No-Failure-Found (NFF) investigations - a known problem of an unknown origin. Tomorrow, the electronic engine control system in a car will be dying after two-three years of operation due to CMOS ageing. Actions are urgently needed!A group of European experts will unite their forces in BASTION to fight against ageing and NFF issues. The project will investigate currently unknown defects, uncertain fault coverage and unclassified field returns. A new defect universe will be assembled and faults will be classified into comprehensive classes. BASTION will study the mechanisms of ageing and improve the longevity of electronic products. Embedded instrumentation and the IEEE P1687 standard will be applied to develop an ultra-low-latency, scalable error detection and localization infrastructure as well as to integrate all heterogeneous technologies into a homogeneous system.The project will complete in three years, at only a negligible fraction of costs wasted by society on NFF annually.