Hamilton Bonaduz AG

Bonaduz, Switzerland

Hamilton Bonaduz AG

Bonaduz, Switzerland
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The present invention relates to a reference electrode arrangement (10) for an electrochemical sensor (100; 200), in particular for a potentiometric sensor, comprising a reference half-cell chamber with a reference electrode (22) provided therein, wherein the reference half-cell chamber has a storage chamber (12), in which there is a reference electrolyte (24), at least when the reference electrode arrangement (10) is in a storing state, wherein the reference half-cell chamber also has a lock chamber (12), which is permeable at least with respect to allowing reference electrolyte (24) through into the vicinity of the reference half-cell chamber, wherein the storage chamber (12) is separated from the lock chamber (14) with respect to allowing reference electrolyte (24) through when the reference electrode arrangement (10) is in the storing state, wherein the reference electrode arrangement (10) is formed in such a way that a connection (32) that is permeable in terms of allowing reference electrode (24) through from the storage chamber (12) into the lock chamber (14) can be created between the storage chamber (12) and the lock chamber (14) in order to change the reference electrode arrangement (10) over from the storing state into an operating state.


A fluid line element for building a fluid line section comprising a plurality of identical fluid line elements, wherein the fluid line element comprises: an element body, a first throughflow opening provided on the element body and a second throughflow opening, different from the first, and a flow channel provided in the element body, which fluidically connects the first and the second throughflow openings for throughflow along a channel path. In a first region of the fluid line element, located closer to the first than to the second throughflow opening, a throughflow body formed separately from the element body is provided, which forms a part of the flow channel, is formed from a material having a lower elasticity modulus than the material of the element body, and on the longitudinal end thereof facing into the interior of the element body, comprises a valve seat formation surrounding the channel path.


A reference electrode assembly for an electrochemical sensor, in particular for a potentiometric sensor, comprising a reference half-cell space having a reference electrode provided therein, the reference half-space comprising a storage space in which a reference electrolyte is provided at any rate in a storage state of the reference electrode assembly, the reference half-cell space further comprising a lock space that is permeable at any rate with respect to the passage of reference electrolyte into an environment of the reference half-cell space, the storage space, in the storage state of the reference electrode assembly, being separated from the lock space with respect to the passage of reference electrolyte, the reference electrode assembly being designed such that a connection permeable for the passage of reference electrolyte from the storage space to the lock space can be created between the storage space and the lock space in order to transfer the reference electrode assembly from the storage state to an operative state.


Patent
Hamilton Bonaduz Ag | Date: 2017-04-28

The invention relates to a sample processing system and method for processing biological samples, comprising a sample processing device having: a receiving plate, which is arranged substantially horizontally in a plane; a first and second working arm, which can move relative to the receiving plate and extend substantially parallel to each other in a second direction (Y) over the receiving plate; at least one pipetting device mounted on the first working arm, which is movable in the second direction (Y) and in a third direction (Z) orthogonal in relation to the first and second direction (X, Y); at least one gripping device, mounted on the second working arm, with grippers that can be rotated around a gripper axis of rotation (GA) parallel to the third direction (Z); and a control device for controlling the pipetting device and the gripping device.


The present invention relates, inter alia, to a fluid line element (16, 16c) for building a fluid line section comprising a plurality of identical fluid line elements (16, 16c), wherein the fluid line element (16, 16c) comprises: an element body (60); a first throughflow opening (64) provided on the element body (60) and a second throughflow opening (66) different from the first; and a flow channel (62) provided in the element body (60), which connects the first (64) and the second throughflow opening (66) in a mechanically fluid manner for throughflow along a channel path (K). According to the invention, a throughflow body (70) formed separately from the element body (60) is provided in a first region of the fluid line element (16), wherein said region is nearer to the first (64) than the second throughflow opening (66), wherein said throughflow body forms a part of the flow channel (62), is formed from a material comprising a lower elasticity modulus than the material of the element body (60), and comprises a valve seat formation (72) surrounding the channel path (K) on the longitudinal end (70a) thereof facing into the interior of the element body (60).


The invention relates to a laboratory container (10), in particular a cell culture container, comprising a container volume (20) which is surrounded by a container body (12) and which can be accessed from the outside through a container opening (64) of the container body (12). The container has a fluid line (42) which communicates with the container volume (20) and which comprises a valve arrangement (40). The fluid line (42) is designed to conduct fluid in order to discharge and/or introduce fluid out of and/or into the container volume (20). The fluid line (42) can be selectively released in order to conduct a fluid or blocked by the valve arrangement (40), and the container additionally has a gas balancing opening (52), through which gas can be introduced into or discharged out of the container volume (20) in counterflow to a possible fluid flow in the fluid line (42). The gas compensating opening (52) is provided on a gas compensating line (50) which extends along a virtual channel course axis (K) and which has a line channel that is surrounded by a channel wall (56), said line channel running from the gas balancing opening (52) into the container volume (20) and opening into said container volume.


Patent
Hamilton Bonaduz AG | Date: 2016-12-28

A liquid-container/ventilation-tube kit for a ventilation system that includes (a) a ventilator, (b) a respiratory humidifier having a housing and a liquid container, the housing having a pair of first electrical contact elements, (c) a first inhalation tube extending from the respiratory humidifier to a Y-piece, (d) a second inhalation tube extending from the ventilator to the respiratory humidifier, and (e) an exhalation tube extending from the Y-piece to the ventilator, the kit including the liquid container having a pair of first connection elements for removable connection of the first and second inhalation tubes thereto, and a pair of second connection elements each attached to a respective one of the first and second inhalation tubes and by which each of the inhalation tubes is pneumatically connected to a respective one of the first connection elements along a first connecting direction, each second connection element having a second electrical contact element that is positioned and arranged such that electrical connection with a respective one of the first electrical contact elements is possible in both of two ways, one when the pneumatic connection of the respective ventilation tube to the liquid container is effected after the liquid container has been inserted into the housing and the other when the liquid container is inserted into the housing after the pneumatic connection of the ventilation tubes to the liquid container has been effected.


Patent
Hamilton Bonaduz Ag | Date: 2014-01-08

The invention concerns a sample handling system and a process for the handling of chemical or biological samples, particularly body fluids such as blood, saliva, secretions, etc. or tissue samples, and more specifically for the processing of samples for DNA analysis by means of PCR, comprising a dosing device with a receiving plate (12), with the receiving plate (12) being configured in an essentially horizontal position in a plane defined by a first and a second axis (X, Y); having at least one working arm (14, 16, 18) that is movable in the direction of the first axis (X) relative to the receiving plate (12), preferably along a first edge (13) of the receiving plate (12), and wherein the working arm (14, 16, 18) extends along the second axis (Y) above the receiving plate (12), at least one pipetting mechanism (30) that is movable in the direction of the second axis (Y) is mounted on the working arm (14, 16, 18), the pipetting mechanism (30) comprises at least one pipetting channel (32) that is movable in the direction of a third axis (Z) orthogonal to the direction of the first and second axes (X, Y) and has a pipette tip (33) mounted or mountable thereon, and said pipetting mechanism (30) is configured so as to dispense or aspirate liquid into or out of a sample vessel; and at least one thermal cycler (50, 52) provided in the area of the receiving plate (12). According to the invention, the thermal cycler (50, 52) should be configured on the receiving plate (12) in such a way that the pipetting mechanism (30) is movable in a position above the sample vessels in the thermal cycler (50, 52), making a pipetting step possible. Opening/closing of a closing device (54) of the thermal cycler takes place in accordance with the steps of a PCR process, and pipetting of components into sample vessels in the thermal cycler takes place in accordance with the setting of the closing device (54).


Patent
Hamilton Bonaduz Ag | Date: 2014-06-06

The invention relates to a syringe, comprising: a syringe body (12) having an axial inner cavity (16), which extends in the direction of a longitudinal axis (LA) of the syringe body (12) and in which a plunger (14) can be or is accommodated in such a way that the plunger can be moved in the longitudinal direction, and a needle (18), which can be or is connected to the syringe body (12) at a longitudinal end of the syringe body (12), wherein the syringe body (12) has a coupling segment (20) at the needle-side longitudinal end of the syringe body (12), to which coupling segment (20) the needle (18) can be or is fastened by means of a connecting element (22) that can be slid on in the longitudinal direction. According to the invention, at least one radially inward cavity (34) is provided on the coupling segment (20), which cavity can be brought into engagement or is in engagement with at least one corresponding locking segment (32) provided on the connecting element (22).


The invention relates to a liquid supply interface (62, 62, 62, 62) for a cell culture system for supplying cell cultures found in different cell culture containers (10, 10, 10) with a nutrient medium, wherein the liquid supply interface (62, 62, 62, 62) comprises: a housing (68) defining a flow area (72); a first connection formation (76) for the liquid-transferring connection of a first fluid line (84) to the housing (68); a second connection formation (78) formed separately from the first for the liquid-transferring connection of a second fluid line (88) to the housing (68); a third connection formation (80) formed separately from the first two for the liquid-transferring connection of the housing (68) to a third fluid line; a coupling formation (64, 66) formed separately from the connection formations (76, 78, 80), which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation (38, 40) of a cell culture container (10, 10, 10).

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