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Esfahani H.,Hamedan University of Medical science
Iranian Journal of Blood and Cancer | Year: 2015

Background: Tumor lysis syndrome caused by widespread tumor cell damage may lead to electrolyte imbalances and express as metabolic disturbance causing clinical abnormalities. Patients and Methods: All patients younger than 16 years with documented malignancy candidate for chemotherapy, in Hamedan province of Iran were enrolled. Results: Out of 69 cancer patients the laboratory form of tumor lysis syndrome was detected in 8 patients (11.6%) and its clinical form was observed in 2 patients (2.9%). Those two patients with clinical tumor lysis syndrome were treated using hydration, allopurinol, rasburicase and dialysis with good metabolic response. Conclusion: Although our sample size was limited we found a comparable prevalence of tumor lysis syndrome among our patients in comparison with previous studies. Further evaluation of the prevalence of this syndrome among Iranian cancer patients is recommended. © 2014, Iranian Pediatric Hematology and Oncology Society. All rights reserved. Source


Behnoud F.,Hamedan University of Medical science
Iranian Journal of Otorhinolaryngology | Year: 2012

Introduction: Chronic rhinosinusitis (CRS), defined as an inflammatory process involving the paranasal sinuses that continues for at least three months, is a major cause of morbidity in the pediatric population and a difficult entity to treat with a poorly defined pathophysiology. The cornerstone of treatment for children with CRS remains aggressive antibiotic therapy, but many patients fail to improve even after extended courses of broad-spectrum oral antibiotics. However, good treatment results with adenoidectomy alone have been reported in pediatric patients with CRS. The purpose of this study was to evaluate the effect of adenotonsillectomy on chronic rhinosinusitis in children. Materials and Methods: In this clinical trial the study population was 40 children under 14 years old who had been selected for adenotonsillectomy. Prior to the procedure, a Waters' view radiograph was performed on individuals that suffered from CRS and displayed symptoms such as rhinorrhea, halitosis, and chronic cough. Only patients with bilateral clouding of the maxillary sinuses were enrolled in study. A further radiograph was performed on the 28th day following the procedure and the outcome of the treatment evaluated. Results: Of the 40 patients under 14 years old who were evaluated, 22 (55%) were female and 18 (45%) were male. The mean age of the patients was 7.22 years while the oldest was 14 and the youngest was 4 years old. Nasal congestion, rhinorrhea, post nasal drip, and chronic cough were present in all of the patients. Following the adenotonsillectomy, these symptoms were significantly reduced and were present in only 15.5%, 0%, 20%, and 20% of the patients, respectively. Multivariate analyses were performed using McNemar's test. Conclusion: According to the results of this study, where 72.5% of patients showed a complete recovery following treatment, an adenotonsillectomy can be considered as a treatment modality for CRS. Source


Chehardoli G.,Hamedan University of Medical science | Zolfigol M.A.,Bu - Ali Sina University
Phosphorus, Sulfur and Silicon and the Related Elements | Year: 2010

Melamine hydrogen peroxide (MHP) as a novel hydrogen peroxide adduct was easily prepared. Both chemo- and homoselective oxidation of thiols and sulfides to their corresponding disulfides and sulfoxides occurred by using MHP in moderate to excellent yields. AlCl3 acts as a suitable activator in the oxidation of sulfides with MHP. Source


Mohammadi Z.,Hamedan University of Medical science
Journal of the Canadian Dental Association | Year: 2010

Paresthesia is a burning or prickling sensation or partial numbness resulting from neural injury. Paresthesia resulting from periapical pathosis or various stages of root canal treatment is of great importance in the feld of endodontics. The purpose of this paper is to review paresthesia caused by periapical lesions, local anesthesia, cleaning, shaping and obturation. Source


Hassanian-Moghaddam H.,Shahid Beheshti University of Medical Sciences | Afzali S.,Hamedan University of Medical science | Pooya A.,Hamedan University of Medical science
Human and Experimental Toxicology | Year: 2014

Study objective: Naltrexone is a competitive opioid receptor antagonist acting at the m- and k-opioid receptors that blocks the euphoric effects of exogenous administered opioids. When used in opioid-dependent patients, naltrexone can cause acute and severe withdrawal symptoms. Methods: This was a cross-sectional study conducted from December 2007 to March 2008 and consisted of patients who had used naltrexone accidentally or deliberately and were referred to Loghman-Hakim Poison Hospital, Tehran, Iran. All symptoms and signs were assessed and the relationship between the dose of naltrexone, opioid dependence, and outcome was evaluated. Results: In 132 patients referred to our hospital, the most frequently reported symptoms and signs occurring in more than 10% of patients were agitation (96.2%), altered level of consciousness (38.6%), nausea (28%), vomiting (27.3%), abdominal pain (24.2%), diarrhea (16.7%), bone and muscle pain (15.9%), tachycardia (12.9%), and dilated pupils (11.4%). Being the most prominent symptom, the agitation was the most difficult aspect of withdrawal to manage. Except for agitation, no relationship was found between the presence of these symptoms and the dose of naltrexone used. Outcome of the patients (classified as complete recovery, partial recovery, death, and no follow-up) was related to the substance of addiction (p < 0.05) but not to the naltrexone dose. Conclusion: Emergency physicians should be aware of the potential for severe agitation from naltrexoneprecipitated hyperacute withdrawal and its appropriate management. Opioid-dependent patients who wish to continue withdrawal and abstinence must be encouraged to visit trained physicians and be warned about misuse of naltrexone. © 2014 The Author(s). Source

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