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Karachi, Pakistan

Hamdard University is a private research university with multiple campuses in Karachi and Islamabad, Pakistan. The university was founded in 1991 by the renowned philanthropist Hakim Said of the Hamdard Foundation. Hamdard is one of the first and the oldest private institutions of higher education in Pakistan. In Karachi alone, Hamdard University is the largest private research university with a campus area of over 350 acres.Hamdard University's central library Bait-ul-Hikmah is one of the largest research libraries in South Asia with a collection of over half a million books, some of them dating back to 17th century. The university includes eight faculties, nine research institutes, three separate university teaching hospitals and three affiliated engineering institutes. There are more than 15,000 alumni of Hamdard University employed in different organisations in Pakistan and worldwide.Major programs of Hamdard University are accredited by and offered in collaboration with bodies such as the Higher Education Commission , Pakistan Engineering Council , Pakistan Medical and Dental Council , Pakistan Bar Council , National Telecommunication Corporation , and the Pakistan Pharmacy Council . Wikipedia.

Ansari J.A.,Hamdard University
Journal of Biological Sciences | Year: 2010

Drugs are an important reason of hepatotoxicity. In general more than 900 drugs, toxins and herbs have been reported to cause hepatotoxicity and drugs account for 20-40% of all instances of fulminant hepatic failure. Specific therapy against drug-induced hepatotoxicity is limited to the use of N-acetylcysteine in the early phases of paracetamol toxicity. L-carnitine is potentially valuable in cases of valproate toxicity. In general, corticosteroids have no definitive role in treatment. They may prevent the systemic features associated with hypersensitivity or allergic reactions. Cholestyramine can be used for alleviation of pruritus. Ursodeoxycholic acid may be used. Lastly, consulting a hepatologist is always useful for other agents, supportive measures and the increasing use of liver-assist devices as well as emergency liver transplantation are available when drug injury evolves into irreversible liver failure. It is expected that a better understanding of hepatotoxicity mechanisms will lead to the development of more specific and effective forms of therapy in the near future. © 2010 Asian Network for Scientific Information. Source

Nasim S.A.,Hamdard University | Dhir B.,University of Delhi
Reviews of Environmental Contamination and Toxicology | Year: 2010

Heavy metals, accumulated naturally in soil, surface water or through industrial and mining processes, pose a potential threat to various terrestrial and aquatic organisms (Greeger 1999; Larison et al. 2000; Dwivedi and Dey 2002; Hsu et al. 2006; Dhir et al. 2008). Exposure to high metal concentrations impinges on the growth and development of plants (Rout and Das 2003; Shanker et al. 2005; Dhir et al. 2009). Such growth effects result from alterations in physiological events such as photosynthesis, respiration, changes in lipid composition, enzyme activity, and distribution of macro and micronutrients at the cellular level (Sheoran et al. 1990; Van Assche and Clijsters 1990; Rout and Das 2003; Shanker et al. 2005). Research also suggests that abiotic factors such as heavy metals may alter the production of bioactive compounds by changing aspects of secondary metabolism (Verpoorte et al. 2002). © 2010 Springer Science+Business Media, LLC. Source

Shakeel F.,University of Benghazi | Faisal M.S.,Hamdard University
Pharmaceutical Development and Technology | Year: 2010

The solubility and dissolution of the poorly soluble drug celecoxib (CXB) was enhanced using many techniques like nanoemulsion, solid lipid nanoparticle and solid dispersion in the present investigation. The solubility of CXB in each formulation was determined using the reported HPLC method at the wavelength of 250nm. Dissolution studies of pure CXB and its formulations were performed using USP dissolution apparatus in distilled water. The highest solubility (228.24mg/mL) as well as % dissolution (99.9) of CXB was obtained with nanoemulsion technique. The results of solubility and dissolution were highly significant using the nanoemulsion technique as compared to other techniques (P<0.01). All three formulations showed a sustained type of drug release. The best sustained type drug release was obtained with nanoemulsion. This indicated that nanoemulsion can be successfully used for sustained and controlled drug delivery of CXB. Overall these findings suggested that nanoemulsion is a promising vehicle for solubility and dissolution enhancement of CXB. Source

Samim M.,Hamdard University
International journal of nanomedicine | Year: 2011

Gold nanorods show a surface plasmon resonance (SPR) band at the near infra-red (NIR) region which enables them to produce heat on irradiation with a NIR laser. As a result of this, gold nanorods have the potential to be used as thermal therapeutic agents for selective damage to cancer cells, bacterial cells, viruses, and DNA. Gold nanorods with an aspect ratio of approximately 5 were prepared by exploiting the normal micellar route of a water/dioctyl sulfosuccinate (Aerosol-T)/hexane system. The shape and size of the gold nanorods were characterized by surface plasmon bands at 520 nm and 980 nm, and by atomic force microscopy and transmission electron microscopy. The length of the gold nanorods was 100 nm and their diameter was 20 nm. X-ray diffraction analysis demonstrated that the gold nanorods formed were metallic in nature. The gold nanorods showed good photothermolysis activity. Gold nanorods injected subcutaneously and irradiated with 980 nm laser caused injury to rat tissue, demonstrating that gold nanorods may be used to kill cancerous cells in tumor tissue. Source

Isah T.,Hamdard University
Acta Physiologiae Plantarum | Year: 2016

Somatic embryogenesis, the in vitro developmental program by which somatic cells are reprogrammed to undergo cellular and molecular changes that make them competent to produce somatic embryos, has been achieved with many woody plants. The program involves the stages of competence acquisition, induction and expression of the morphogenic pathway by the cultured cells and tissues. The ability to express the program in cultured cells/tissues is regulated by many factors, including genotype, explant type and age and culture conditions. In many woody plants, somatic embryogenesis was achieved with mature, immature explants or both. Juvenile tissues as immature and mature zygotic embryos are regarded best explants to establish embryogenic cultures in woody plants and potential to obtain the cultures decline with increasing maturity of the explant. © 2016, Franciszek Górski Institute of Plant Physiology, Polish Academy of Sciences, Kraków. Source

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