Hamdard Institute of Medical science and Research

Raipur, India

Hamdard Institute of Medical science and Research

Raipur, India
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Pujani M.,Hamdard Institute of Medical science and Research
Asian Pacific journal of cancer prevention : APJCP | Year: 2016

PURPOSE: To evaluate the expression of Her2/neu and Ki-67 in benign and malignant gallbladder lesions, and to establish correlations with clinico-pathologic parameters.MATERIALS AND METHODS: A retrospective analysis was conducted on formalin fixed paraffin embedded (FFPE) benign (n=25) and malignant gallbladder (n=25) tissue samples. Hematoxylin and eosin stained slides of each case were reviewed for: type of malignancy (whether adenocarcinoma, squamous cell carcinoma, or any other type); grade (well, moderate, and poor); depth of invasion; and pre-neoplastic changes in adjacent mucosal epithelium like metaplasia and dysplasia. Immunohistochemistry for Her 2 neu and Ki-67 was performed and data analysis was conducted using SPSS 17 software. Chi-square test was used to compare categorical/dichotomous variables. A P value of ≤0.05 was considered significant.RESULTS: The difference of Her 2 neu expression and Ki67 index between benign and malignant groups was found to be statistically significant. Her2/neu positivity did not have any significant correlation with various clinicopathological parameters other than liver involvement. Five cases of gallbladder cancer showed both Her2/neu and Ki67 positivity. Ten cases were Ki67 positive but Her2/neu negative while one case was Her2/neu positive but Ki67 negative.CONCLUSIONS: The present study demonstrated overexpression of Her2/neu and Ki67 in gallbladder cancer. A trend of decreasing Her2/neu expression with increasing grade of tumor was observed. Furthermore, greater Ki67 positivity was found in cases with lymph node metastasis and distant metastasis. Future studies with a larger number of patients will be required to precisely define the correlation of Her2/neu expression and Ki67 positivity with clinicopathological parameters. The results however are encouraging and suggest evaluation of Her2/neu as a candidate for targeted therapy.


Padhy B.M.,Hamdard Institute of Medical science and Research | Gupta Y.K.,All India Institute of Medical Sciences
Journal of Postgraduate Medicine | Year: 2011

Drug discovery and development is an expensive, time-consuming, and risky enterprise. In order to accelerate the drug development process with reduced risk of failure and relatively lower costs, pharmaceutical companies have adopted drug repositioning as an alternative. This strategy involves exploration of drugs that have already been approved for treatment of other diseases and/or whose targets have already been discovered. Various techniques including data mining, bioinformatics, and usage of novel screening platforms have been used for identification and screening of potential repositioning candidates. However, challenges in clinical trials and intellectual property issues may be encountered during the repositioning process. Nevertheless, such initiatives not only add value to the portfolio of pharmaceutical companies but also provide an opportunity for academia and government laboratories to develop new and innovative uses of existing drugs for infectious and neglected diseases, especially in emerging countries like India.


Nigam A.,Hamdard Institute of Medical science and Research
BMJ Case Reports | Year: 2014

Endometriosis is a growth of endometrial tissue outside the uterine cavity which is responsive to hormonal stimulation. Extrapelvic endometriosis is less common of which skin is the most common site. The patient presents with mass, pain and cyclic symptoms. Subcutaneous endometriosis is very rare and has been reported only thrice in the literature. We report a case where the patient with lower abdominal pain and dyspareunia. Dyspareunia due to subcutaneous endometriosis has not been reported before when there is no evidence of intrapelvic endometriosis on laparoscopy. Copyright 2014 BMJ Publishing Group. All rights reserved.


Kumar C.M.,Hamdard Institute of Medical science and Research | Singh S.,Rama Medical College and Hospital
Pakistan Paediatric Journal | Year: 2013

Introduction: Protein Energy Malnutrition (PEM) is a global problem among children. Worldwide 27% under five children are malnourished. PEM is more prevalent in India where almost half (47%) the children are underweight. Assessment of PEM has traditionally been clinical which is time consuming and skill dependent, with considerable inter-observer variability. Hence, biochemical markers like serum protein and albumin measurements may be used for the assessment of nutritional status. At the same time, there is a controversy, whether edema can be considered as a reliable clinical marker of hypoalbuminemia. Readily available and reliable tests and can often detect nutritional deficiencies before they have an adverse effect on biological functions and certainly before deficiencies can be detected by physical examination. Aims and Objectives: The study was designed to assess PEM in children using biochemical markers like serum protein, albumin and protein electrophoresis and establishing a correlation between edema and hypoalbuminemia. Materials and Methods: This analytical case control study was done in the Narayana Medical College and Hospital from September 2007 to September 2009. The material for the study consisted of 50 cases of PEM and 20 normal healthy children. Result: In PEM cases, total protein and serum albumin were found to be significantly lower in comparison to normal healthy controls. Thus total protein and serum albumin may become useful indicators of the nutritional status of the malnourished children and good markers of PEM. Albumin and beta fractions of Serum Protein Electrophoresis were significantly lower while alpha1, alpha 2 and gamma globulin fractions were significantly higher in malnourished children in comparison to controls.


Patwari A.K.,Hamdard Institute of Medical science and Research
Indian Pediatrics | Year: 2013

Reduction in prevalence of underweight children (under five years of age) has been included as an indicator for one of the targets to eradicate extreme poverty and hunger (Goal 1) of the Millennium Development Goals (MDGs). The most recent MDG report of 2012 indicates that the target of reducing extreme poverty by half has been reached five years ahead of the 2015 deadline but close to one third of children in Southern Asia were underweight. In India, at the historical rate of decline the proportion of underweight children below 3 years, required to be reduced to 26% by 2015, is expected to come down only to about 33%. With barely 3 years left for achieving MDGs, the level of commitment to reduce child undernutrition needs to be gauged and effectiveness of current strategies and programmes ought to be reviewed. Undernutrition in children is not affected by food intake alone; it is also influenced by access to health services, quality of care for the child and pregnant mother as well as good hygiene practices. Would the scenario be different if child undernutrition was a part of Goal 4 of MDGs? What difference it would have made in terms of strategies and programmes if reduction in undernutrition in children underfive was a target instead of an indicator? It is time for nutrition to be placed higher on the development agenda. A number of simple, cost-effective measures to reduce undernutrition in the critical period from conception to two years after birth are available. There is a need for choosing nutrition strategies relevant in Indian context. Experiences from other countries should lead India toward innovative nutritional strategies to reduce underfive undernutrition in the country- that too on a fast track. © 2013 Indian Academy of Pediatrics.


Nigam A.,Hamdard Institute of Medical science and Research
BMJ case reports | Year: 2014

Fetal ascites can occur due to many heterogeneous disorders. Its association with hydrometrocolpos because of persistent urogenital sinus and cloaca is extremely rare. A 29-year-old primigravida presented at 32 weeks of gestation with ultrasonographic evidence of fetal ascites, a cystic pelvic mass, hydronephrosis and oligohydramnios. Fetal ascites in this case was due to fetal urine draining through fallopian tubes into the abdomen as a result of vesicovaginal fistula and distal vaginal atresia. The antenatal ultrasound results along with autopsy findings are discussed. Though rare, a persistent urogenital sinus is to be suspected in isolated fetal ascites cases where the viral tests are negative and there is no evidence of cardiac anomalies as this is a treatable anomaly if diagnosed at early gestational age.


Nigam A.,Hamdard Institute of Medical science and Research
BMJ case reports | Year: 2014

Endometriosis is a growth of endometrial tissue outside the uterine cavity which is responsive to hormonal stimulation. Extrapelvic endometriosis is less common of which skin is the most common site. The patient presents with mass, pain and cyclic symptoms. Subcutaneous endometriosis is very rare and has been reported only thrice in the literature. We report a case where the patient with lower abdominal pain and dyspareunia. Dyspareunia due to subcutaneous endometriosis has not been reported before when there is no evidence of intrapelvic endometriosis on laparoscopy.


Prakash A.,Hamdard Institute of Medical science and Research | Aggarwal R.,Lady Hardinge Medical College And Smt Sucheta Kriplani Hospital
North American Journal of Medical Sciences | Year: 2012

Background: Effective transfusion and chelation have prolonged the quality and longevity of life in thalassemics, who now survive into adulthood. Hence, adult physicians need to be aware of their clinical and laboratory profile and the problems faced by them.Aim: The present study was aimed to evaluate the clinical profile of adult thalassemics. Materials and Methods: Adult (>18 years) thalassemia major patients (n=19) were evaluated clinically and fasting pretransfusion blood samples were analyzed for complete blood counts, kidney and liver function tests, plasma glucose, serum ferritin, and thyroid hormone levels. Results: Average age was 21.65±2.47 years (range 19-28years), 42.1% had Body mass index (BMI) <18.5. Splenectomy had been performed in 47.4% before reaching adulthood, males significantly outnumbered females (72% vs. 12.5%). Hemoglobin levels <8


Kumari A.,Hamdard Institute of Medical science and Research | Nigam A.,Hamdard Institute of Medical science and Research
Journal of Clinical and Diagnostic Research | Year: 2015

Obesity is one of the leading causes of health related disorder and has reached epidemic proportions not only in developed nations but also in developing countries like India. Bariatric surgery has become a popular alternative for obese women planning pregnancy. A multidisciplinary approach involving the obstetrician, the bariatric surgeon and the nutritionist is required to manage pregnancy following bariatric surgery. Early consultation should be done to determine baseline nutritional status and the importance of regular check-ups must be explained. Nutritional supplementation should be tailored to the patient’s status and the type of bariatric surgery performed. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.


Nigam A.,Hamdard Institute of Medical science and Research | Ahmad A.,Hamdard Institute of Medical science and Research
BMJ Case Reports | Year: 2015

Persistent fetal bradycardia in early pregnancy is a rare finding and indicates towards congenital heart block. This is commonly associated with positive maternal anti-Ro/anti-La antibodies. A case of an asymptomatic primigravida with persistent fetal bradycardia on routine antenatal ultrasound is reported with special emphasis on its management options. Copyright 2015 BMJ Publishing Group. All rights reserved.

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