Ōsaka, Japan
Ōsaka, Japan

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Objects of the present invention are to provide an industrially applicable method for producing an optically active -amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ,-disubstituted -amino acid, and to provide an intermediate useful for the above production methods of an optically active -amino acid and an optically active ,-disubstituted -amino acid. The present invention provides a production method of an optically active -amino acid or a salt thereof, the production method comprising introducing a substituent into the carbon in the -amino acid moiety of a metal complex represented by the following Formula (1):


Patent
Hamari Chemicals Ltd. | Date: 2012-10-24

A method is provided for producing optically active alcohols from ketones by reducing a ketone in the presence of an iridium(III) complex having a chiral prolinamide compound as a ligand. The ketone is preferably a compound represented by formula [I]:


Patent
Hamari Chemicals Ltd. | Date: 2011-06-15

Provided is a compound represented by the following formula (1)R^(1) is a hydrogen atom, an optionally substituted alkyl group and the like, R^(2) is a hydrogen atom or an optionally substituted alkyl group,or R^(1) and R^(2) optionally form, together with the adjacent nitrogen atom, an optionally substituted nitrogen-containing heterocyclic group,R^(4) is a hydrogen atom or an optionally substituted alkyl group,R^(3) is an optionally substituted alkyl group, andR^(5) and R^(6) are a hydrogen atom or a methyl group,excluding a compound wherein both R^(2) and R^(4) are hydrogen atoms and a compound wherein both R^(1) and R^(4) are hydrogen atoms, or a tautomer thereof or a salt thereof useful as a bactericidal/disinfectant agent.


Objects of the present invention are to provide an industrially applicable method for producing an optically active -amino acid in high yield and in a highly enantioselective manner, to provide a simple production method of an optically active ,-disubstituted -amino acid, and to provide an intermediate useful for the above production methods of an optically active -amino acid and an optically active ,-disubstituted -amino acid. The present invention provides a production method of an optically active -amino acid or a salt thereof, the production method comprising introducing a substituent into the carbon in the -amino acid moiety of a metal complex represented by the following Formula (1): by an alkylation reaction, an aldol reaction, the Michael reaction, or the Mannich reaction, and releasing an optically pure -amino acid enantiomer or a salt thereof by acid decomposition of the metal complex.


Patent
Hamari Chemicals Ltd. | Date: 2010-04-07

The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.


Patent
Hamari Chemicals Ltd. | Date: 2014-09-03

Provided is an industrially advantageous method for producing optically active alcohols in high yields from ketones of various structures by using an inexpensive chiral catalyst. The method of the present invention for producing optically active alcohols comprises reducing a ketone in the presence of an iridium(III) complex having a chiral prolinamide compound as a ligand. The ketone is preferably a compound represented by formula [I]:^(1) and R^(2) are different from each other, and each represent an optionally substituted straight or branched alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, an optionally substituted heteroaryl group, an optionally substituted aralkyl group, an optionally substituted heteroarylalkyl group, an optionally substituted alkenyl group or an optionally substituted alkynyl group, andR^(1) and R^(2) may be bound to each other at any appropriate position to form a ring, the ring optionally containing one or more atoms which may be the same or different and are selected from an oxygen atom, an optionally substituted nitrogen atom and a sulfur atom, and optionally being condensed with an aromatic or hetero-aromatic ring).


Patent
Hamari Chemicals Ltd. | Date: 2014-05-21

Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process. The disclosed method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines comprises reducing a quinoline compound represented by formula [I]:


An object of the present invention is to provide a method for producing an optically active amino acid in high yield and in a highly enantioselective manner, which method has fewer restrictions on the material that can be used as the substrate, and to provide, among others, a compound useful as a chiral auxiliary for the method. The present invention provides an N-(2-acylaryl)-2-[5,7-dihydro-6H-dibenzo[c,e]azepin-6-yl]ac etamide compound represented by Formula (1):


Patent
Hamari Chemicals Ltd. | Date: 2012-07-13

Provided are a novel chiral iridium(III) complex; and a method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines from 2-substituted-quinolines with the use of the chiral iridium(III) complex through a more economical and easy production process. The disclosed method for producing optically active 2-substituted-1,2,3,4-tetrahydroquinolines comprises reducing a quinoline compound represented by formula [I]: in the presence of a hydrogen donor compound and an iridium (III) complex having a chiral prolinamide compound as a ligand to give an optically active 2-substituted-1,2,3,4-tetrahydroquinoline represented by formula [II]:


The present invention provides a process for producing 2,3-didehydro-3-deoxy-4-ethynylthymidine, which is useful as a medicine, in an efficient and industrially advantageous manner, and more specifically, provides a process for producing 2,3-didehydro-3-deoxy-4-ethynylthymidine as shown below.^(1) and R^(2) independently represent a protective group for a hydroxy group, or R^(1) and R^(2) together form a protective group for two hydroxy groups, R^(3) and R^(4) independently represent a protective group for a hydroxy group, R^(5) represents a protective group for a hydroxy group, R^(6) represents a protective group for a hydroxy group, X represents a leaving group, and Y represents a halogen atom.)

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