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Hamamatsu, Japan

Hamamatsu University is a private university in Hamamatsu City, Shizuoka Prefecture, Japan.Hamamatsu University was established as Tokoha Gakuen Hamamatsu University in 1988. It added a Department of International Economics in 1994, and a graduate studies program in 1996. In 1998, it changed its name to "Hamamatsu University". Wikipedia.

Suzuki Y.,Hamamatsu University School of Medicine | Yasui H.,Hamamatsu University School of Medicine | Brzoska T.,Hamamatsu University School of Medicine | Mogami H.,Hamamatsu University | Urano T.,Hamamatsu University School of Medicine
Blood | Year: 2011

In a previous study, we demonstrated unique secretory dynamics of tissue plasminogen activator (tPA) in which tPA was retained on the cell surface in a heavy chain-dependent manner after exocytosis from secretory granules in vascular endothelial cells. Here, we examined how retained tPA expresses its enzymatic activity. Retained tPA effectively increased the lysine binding site-dependent binding of plasminogen on the cell surface and pericellular area; this was abolished by inhibition of enzymatic activity of either tPA or plasmin, which suggests that de novo generation of carboxyl-terminal lysine as a consequence of degradation of surface/pericellular proteins by plasmin is essential. Retained tPA initiated zonal clot lysis of a fibrin network that had been formed on vascular endothelial cells, which was preceded by the binding of plasminogen to the lysis front. Our results provide evidence that secreted and retained tPA is essential for maintaining both high fibrinolytic activity and effective clot lysis on the vascular endothelial cell surface. © 2011 by The American Society of Hematology. Source

Tanaka K.,Gifu University | Katayama K.,Hamamatsu University | Tanaka M.,Gifu University
Optics Express | Year: 2011

Nanofocusing of surface plasmon polariton by a conical metalcoated dielectric probe was investigated numerically using the three dimensional volume integral equation. The basic characteristics of the nanofocused optical fields generated by this probe were investigated in detail. The intensity distribution near the probe tip was found to be very sensitive to the shape of the probe tip. Enhanced local fields interfere near the tip for certain probe tip shapes. © 2011 Optical Society of America. Source

Tanaka K.,Gifu University | Katayama K.,Hamamatsu University | Tanaka M.,Gifu University
Optics Express | Year: 2010

A numerical study of the nanofocusing of surface plasmon polaritons (SPPs) by a pyramidal structure on a rectangular aperture is performed by the volume integral equation method. It is possible to perform nanofocusing using this structure by using a linearly polarized wave as the incident wave. The focusing process of SPPs by the tip of the pyramidal structure has been demonstrated numerically. The characteristics of the focused optical field near the tip have been investigated in detail. It was found to be similar to that of monopole rather than that of a tiny dipole. The optical field at the tip is sensitive to the local shape of the tip. The enhanced intensity on the tip increases with an increase in the aperture width. © 2009 Optical Society of America. Source

Sullivan J.C.,Georgia Regents University | Bhatia K.,Georgia Regents University | Yamamoto T.,Hamamatsu University | Elmarakby A.A.,Georgia Regents University
Hypertension | Year: 2010

Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although the molecular mechanisms responsible are unknown. We hypothesize that differential activation of angiotensin II, angiotensin (1-7), angiotensin II type 1, angiotensin II type 2, and mas levels in the renal cortex of male and female spontaneously hypertensive rats contribute to sex differences in the blood pressure response to angiotensin II infusion. Males had a greater increase in blood pressure after angiotensin II infusion than females (males: 150±2 to 186±3 mm Hg; females: 137±3 to 160±4 mm Hg; P<0.05). Angiotensin II infusion resulted in comparable increases in plasma and renal cortical angiotensin II levels in both sexes. Renal cortical angiotensin (1-7) levels were higher in female rats under basal conditions (195±10 versus 67±11 ng/g of cortex; P<0.05) and after angiotensin II infusion (281±25 versus 205±47 ng/g of cortex; P<0.05) compared with male rats. In the renal cortex of male rats, angiotensin II infusion decreased angiotensin II type 1 protein expression and increased angiotensin II type 2 expression with no change in mas expression. In female rats there was an increase in mas receptor protein expression with angiotensin II infusion, although angiotensin II type 1 and angiotensin II type 2 expressions were unchanged. Male and female rats were then treated with the angiotensin (1-7) mas receptor antagonist A-779 in the absence and presence of angiotensin II. A-779 equalized the blood pressure response to angiotensin II in males and females (blood pressure at the end of treatment: males, 166±4 mm Hg; females, 164±5 mm Hg). In conclusion, angiotensin (1-7) contributes to the sex difference in angiotensin II-induced increases in blood pressure in spontaneously hypertensive rats. © 2010 American Heart Association, Inc. Source

We carried out a nationwide questionnaire survey of pediatric computed tomography (CT) in 339 facilities. Most facilities operated multi detector-row CT (MDCT), and over half operated 64, 128, 256 and 320-slice MDCT. In 32% of facilities, pediatric CT protocols were set taking image quality and dose into consideration. However, in the other facilities, pediatric CT protocols may not be optimized because there is no clear standard for image quality or dosage for pediatric CT examinations in Japan. To promote the optimization of pediatric CT protocols, we regard it as an urgent task to establish diagnostic reference levels for pediatric CT examinations. Source

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