Hamamatsu, Japan
Hamamatsu, Japan

Hamamatsu University is a private university in Hamamatsu City, Shizuoka Prefecture, Japan.Hamamatsu University was established as Tokoha Gakuen Hamamatsu University in 1988. It added a Department of International Economics in 1994, and a graduate studies program in 1996. In 1998, it changed its name to "Hamamatsu University". Wikipedia.

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Sullivan J.C.,Georgia Regents University | Bhatia K.,Georgia Regents University | Yamamoto T.,Hamamatsu University | Elmarakby A.A.,Georgia Regents University
Hypertension | Year: 2010

Females are less sensitive to the hypertensive effects of angiotensin II compared with males, although the molecular mechanisms responsible are unknown. We hypothesize that differential activation of angiotensin II, angiotensin (1-7), angiotensin II type 1, angiotensin II type 2, and mas levels in the renal cortex of male and female spontaneously hypertensive rats contribute to sex differences in the blood pressure response to angiotensin II infusion. Males had a greater increase in blood pressure after angiotensin II infusion than females (males: 150±2 to 186±3 mm Hg; females: 137±3 to 160±4 mm Hg; P<0.05). Angiotensin II infusion resulted in comparable increases in plasma and renal cortical angiotensin II levels in both sexes. Renal cortical angiotensin (1-7) levels were higher in female rats under basal conditions (195±10 versus 67±11 ng/g of cortex; P<0.05) and after angiotensin II infusion (281±25 versus 205±47 ng/g of cortex; P<0.05) compared with male rats. In the renal cortex of male rats, angiotensin II infusion decreased angiotensin II type 1 protein expression and increased angiotensin II type 2 expression with no change in mas expression. In female rats there was an increase in mas receptor protein expression with angiotensin II infusion, although angiotensin II type 1 and angiotensin II type 2 expressions were unchanged. Male and female rats were then treated with the angiotensin (1-7) mas receptor antagonist A-779 in the absence and presence of angiotensin II. A-779 equalized the blood pressure response to angiotensin II in males and females (blood pressure at the end of treatment: males, 166±4 mm Hg; females, 164±5 mm Hg). In conclusion, angiotensin (1-7) contributes to the sex difference in angiotensin II-induced increases in blood pressure in spontaneously hypertensive rats. © 2010 American Heart Association, Inc.

Tanaka K.,Gifu University | Katayama K.,Hamamatsu University | Tanaka M.,Gifu University
Optics Express | Year: 2011

Nanofocusing of surface plasmon polariton by a conical metalcoated dielectric probe was investigated numerically using the three dimensional volume integral equation. The basic characteristics of the nanofocused optical fields generated by this probe were investigated in detail. The intensity distribution near the probe tip was found to be very sensitive to the shape of the probe tip. Enhanced local fields interfere near the tip for certain probe tip shapes. © 2011 Optical Society of America.

Tanaka K.,Gifu University | Katayama K.,Hamamatsu University | Tanaka M.,Gifu University
Optics Express | Year: 2010

A numerical study of the nanofocusing of surface plasmon polaritons (SPPs) by a pyramidal structure on a rectangular aperture is performed by the volume integral equation method. It is possible to perform nanofocusing using this structure by using a linearly polarized wave as the incident wave. The focusing process of SPPs by the tip of the pyramidal structure has been demonstrated numerically. The characteristics of the focused optical field near the tip have been investigated in detail. It was found to be similar to that of monopole rather than that of a tiny dipole. The optical field at the tip is sensitive to the local shape of the tip. The enhanced intensity on the tip increases with an increase in the aperture width. © 2009 Optical Society of America.

STUDY DESIGN:: Retrospective clinical study.PURPOSE:: To investigate the outcomes after indirect posterior decompression and dekyphosis using multilevel Ponte osteotomies for ossification of posterior longitudinal ligament (OPLL) of the thoracic spine.SUMMARY OF BACKGROUND DATA:: There are no previous reports on the use of Ponte osteotomy to treat thoracic OPLL.METHODS:: The subjects were 10 patients with an average age at surgery of 47 years who underwent indirect posterior decompression and dekyphosis using multilevel Ponte osteotomies at our institute. Minimum follow-up period was 2 year, and averaged 2 year 6 months. Using radiographs and CT images, we investigated fusion range, pre- and postoperative Cobb angles of thoracic fusion levels, intraoperative ultrasonography and clinical results.RESULTS:: The mean fusion area was 9.8 vertebraes, with average laminectomy of 7.3 laminas. The mean preoperative thoracic kyphosis of fusion levels on standing radiograph measured 35° and was changed to 21° after surgery. The mean number of Ponte osteotomies was 3 levels. The mean pre- and postoperative (at the 1 y follow-up) JOA scores were 3.5 and 7.5 points, respectively, and the recovery rate was 56%. On intraoperative ultrasonography, 7 of the cases were included in the floating (+) and 3 in the floating (−) groups, and the recovery rates were 66.0% and 33.4%, respectively.CONCLUSIONS:: “The Ponte procedure for indirect spinal cord decompression” is a novel concept used for the first time with thoracic OPLL in our study, and we consider it a useful method to achieve more effectively dekyphosis and indirect spinal cord decompression if there is not the spinal cord free from OPLL on intraoperative ultrasonography after only laminectomies. © 2014 by Lippincott Williams & Wilkins, Inc.

Suzuki Y.,Hamamatsu University School of Medicine | Yasui H.,Hamamatsu University School of Medicine | Brzoska T.,Hamamatsu University School of Medicine | Mogami H.,Hamamatsu University | Urano T.,Hamamatsu University School of Medicine
Blood | Year: 2011

In a previous study, we demonstrated unique secretory dynamics of tissue plasminogen activator (tPA) in which tPA was retained on the cell surface in a heavy chain-dependent manner after exocytosis from secretory granules in vascular endothelial cells. Here, we examined how retained tPA expresses its enzymatic activity. Retained tPA effectively increased the lysine binding site-dependent binding of plasminogen on the cell surface and pericellular area; this was abolished by inhibition of enzymatic activity of either tPA or plasmin, which suggests that de novo generation of carboxyl-terminal lysine as a consequence of degradation of surface/pericellular proteins by plasmin is essential. Retained tPA initiated zonal clot lysis of a fibrin network that had been formed on vascular endothelial cells, which was preceded by the binding of plasminogen to the lysis front. Our results provide evidence that secreted and retained tPA is essential for maintaining both high fibrinolytic activity and effective clot lysis on the vascular endothelial cell surface. © 2011 by The American Society of Hematology.

Uchiyama H.,Hamamatsu University
Environmental Health and Preventive Medicine | Year: 2015

Methods: Sampling was performed 4 times at 4 points during a 5-month period from July to November at about 1-month intervals from the Sagami River in 1985. River water bacteria were identified, and V. cholera non-O1 isolated. I investigated the relationship between the bacterial flora in river water and the detection of V. cholerae non-O1.Objective: The aim of the present study is Vibrio cholerae non-O1 existing in river. Bacteria are known to inhabit all kinds of environment. Vibrionaceae is widely distributed in environmental water. Vibrio spp. have been identified as a cause of toxicity in fish and shellfish. One condition affecting the survival of pathogenic microorganisms in environmental water is the salt concentration, and they have been reported to inhabit brackish water. However, V. cholerae non-O1 has also been detected in fresh water, and its properties suggest that it can survive in river water.Results: There were significant differences in the composition of bacterial flora with and without the isolation of V. cholerae non-O1 (Chi-square test) (χ2 = 24.70 > 22.0 (p = 0.005), df = 8). A correlation between changes in the composition of the river water bacterial flora and detection of V. cholerae non-O1 was identified.Conclusion: Therefore, V. cholerae non-O1 exists in the river. © 2014, The Japanese Society for Hygiene.

We carried out a nationwide questionnaire survey of pediatric computed tomography (CT) in 339 facilities. Most facilities operated multi detector-row CT (MDCT), and over half operated 64, 128, 256 and 320-slice MDCT. In 32% of facilities, pediatric CT protocols were set taking image quality and dose into consideration. However, in the other facilities, pediatric CT protocols may not be optimized because there is no clear standard for image quality or dosage for pediatric CT examinations in Japan. To promote the optimization of pediatric CT protocols, we regard it as an urgent task to establish diagnostic reference levels for pediatric CT examinations.

Hamamatsu University | Date: 2010-03-01

Provided is a surgery assistance system to perform relatively fast and accurate alignment between three-dimensional surface shape data acquired by measurement using a three-dimensional surface shape scanner and three-dimensional internal shape data acquired in advance, even when the position of the patient and the surface shape of the skin of the patient change during the surgery. A surgery assistance system (1) includes a three-dimensional surface shape scanner (20) for acquiring three-dimensional surface shape data by measuring a three-dimensional surface shape of a patient (60) and a computing device (40) for processing the data from the three-dimensional surface shape scanner. The computing device stores therein three-dimensional internal shape data of the patient that is acquired in advance by measurement using a three-dimensional tomography scanner (30). The computing device has a unit that aligns the three-dimensional internal shape data and the three-dimensional surface shape data with each other by using data of a portion where a distance between a skeleton and a skin surface is small in the three-dimensional internal shape data and three-dimensional surface shape data corresponding to this portion.

Hamamatsu University | Date: 2011-06-03

An object of the present invention is to provide a method for detecting a colorectal tumor, and particularly advanced adenoma and early cancer, by using a component contained in stool as an indicator. Provided is a method for detecting colorectal tumor using a marker gene, comprising: (A) a step for extracting RNA contained in stool collected from a subject, (B) a step for measuring the amount of RNA derived from a marker gene present in the RNA obtained in step (A), and (C) a step for comparing the amount of RNA derived from the marker gene measured in step (B) with preset threshold values for each type of marker gene; wherein, the marker gene is creatine kinase B (CKB) gene.

Fukuta N.,Hamamatsu University
Journal of Information Processing | Year: 2013

A multi-unit combinatorial auction is a combinatorial auction that has some items that can be seen as indistinguishable. Although the mechanism can be applied to dynamic electricity auctions and various purposes, it is difficult to apply to large-scale auction problems due to its computational intractability. In this paper, I present an idea and an analysis about an approximate allocation and pricing algorithm that is capable of handling multi-unit auctions. The analysis shows that the algorithm effectively produces approximation allocations that are necessary in pricing. Furthermore, the algorithm can be seen as an approximation of VCG (Vickrey-Clarke-Groves) mechanism satisfying budget balance condition and bidders' individual rationality without having unrealistic assumptions on bidders' behaviors. I show that the proposed allocation algorithm successfully produced good allocations for those problems that could not be easily solved by ordinary LP solvers due to hard time constraints. © 2013 Information Processing Society of Japan.

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