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Hamadān, Iran

Zareii B.,Razi University | Seyfi T.,Hamadan University | Movahedi R.,Ilam University | Cheraghi J.,Ilam University | Ebrahimi S.,Payame Noor University
Journal of Babol University of Medical Sciences | Year: 2014

BACKGROUND AND OBJECTIVE The use of drugs to treat diseases led to the emergence of resistant strains of bacteria. Bacterial resistance to antibiotics is the most common problems in medical science. In this study, the antibacterial effect of ethanolic extract of Alcea digitata L., Satureja bachtiarica L. and Ferulago Angulata L on four pathogenic bacteria, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Streptococcus agalactiae was investigated. METHODS: In this experimental study, the extracts have been prepared from Alcea digitata L., Satureja bachtiarica L. and Ferulago Angulata L. Their antibacterial activity at different concentrations (800, 400, 200, 100 mg/ml) was determined by disk-diffusion agar method and the dilution method. The antibiotics tetracycline and gentamicin as a positive control and DMSO was used as negative control and the MIC and MBC were determined. FINDINGS: Based on the results of this study, three plant extracts dose-dependently increased the bacteria inhibition zone especially in the gram-positive bacteria compared to the gram-negative bacteria (p<0.05). Extract of Ferulago Angulata L has maximum antibacterial activity on the growth of bacteria S. aureus (25±0.57) (p<0.05). CONCLUSION: According to the results of this study, three extracts had growth inhibitory effect on all four bacteria. Extract of Ferulago Angulata L. had greater antibacterial activity than the others and the Staphylococcus aureus was the most sensitive strain to the extracts. © 2014, Babol University of Medical Sciences. All rights reserved.


Amir D.,Hamadan University
JPMA. The Journal of the Pakistan Medical Association | Year: 2012

To evaluate the frequency of complications in Laparoscopic cholecystectomies performed in Hamadan during 1997 to 2005. In this retrospective cross sectional study, 426 patients with cholecystitis who were admitted to Hamadan hospitals including Ekbatan, Tamin Ejtamaiee, Mobasher, Boali and Artesh and were subjected to laparoscopic cholecystectomy from 1997 to 2005 were evaluated. Of the 426 patients studied, 53 (12.44%) were male and 373 (87.56%) were female. The most frequent complication was retained stone (1.64%), followed by biliary duct injury (1.4%), bile leak (1.4%) and bleeding (1.17%). Laparoscopic cholecystectomy has become the gold standard technique in the treatment of gallbladder disease. However, special attention must be paid to high rate of bile duct injuries.


Pashaki A.S.,Hamadan University | Hamed E.A.,Hamadan University | Mohamadian K.,Hamadan University | Abassi M.,Hamadan University | And 2 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: Glioblastoma multiform (GBM) is a highly aggressive tumor with median survival of approximately 14 months. Management consists of maximal surgical resection followed by post-operative chemoradiation with concurrent then adjuvant temozolamide. The standard radiotherapy dose is 60Gy in 2-Gy fractions recommended by the radiation therapy oncology group (RTOG). With the vast majority of tumor recurrences occurring within the previous irradiation field and the poor outcome associated with standard therapy, regimens designed to deliver higher radiation doses to improve local control and enhance survival are needed. In this study, we report a single institutional experience in treatment of 68 consecutive patients with GBM, treated with resection, and given post-operative radiotherapy followed by concurrent and/or adjuvant chemotherapy. Results: Of the 80 patients who entered this study, 68 completed the treatment course; 45 (66.2%) males and 23 (33.8%) females with a mean age at diagnosis of 49.0±12.9 (21-75) years. At a median follow up of 19 months, 39 (57.3%) patients had evidence of tumor progression and 36 (52.9%) had died. The median over all survival for all patients was 16 months and progression free survival for all patients was 6.02 months. All potential prognostic factors were analyzed to evaluate their effects on overall survival. Age ≤50 year, concurrent and adjuvant chemotherapy and extent of surgery had significant p values. We found lower progression rate among patients who received higher doses of radiotherapy (>60Gy). Higher radiation doses improved progression free survival (p=0.03). Despite increasing overall survival, this elevation was not significant. Conclusions: This study emphasize that higher radiation doses of (>60Gy) can improve local control and potentially survival, so we strongly advise prospective multi centric studies to evaluate the role of higher doses of radiotherapy on GBM patient outcome.


Amir D.,Hamadan University | Amin N.,Hamadan University
Journal of the Pakistan Medical Association | Year: 2012

Objective: To evaluate the frequency of complications in Laparoscopic cholecystectomies performed in Hamadan during 1997 to 2005. Methods: In this retrospective cross sectional study, 426 patients with cholecystitis who were admitted to Hamadan hospitals including Ekbatan, Tamin Ejtamaiee, Mobasher, Boali and Artesh and were subjected to laparoscopic cholecystectomy from 1997 to 2005 were evaluated. Results: Of the 426 patients studied, 53 (12.44%) were male and 373 (87.56%) were female. The most frequent complication was retained stone (1.64%), followed by biliary duct injury (1.4%), bile leak (1.4%) and bleeding (1.17%). Conclusion: Laparoscopic cholecystectomy has become the gold standard technique in the treatment of gallbladder disease. However, special attention must be paid to high rate of bile duct injuries.

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