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Wilson D.W.,Durham University | de Meester F.,The Tsim Tsoum Institute | Singh R.B.,Halberg Hospital and Research Institute | Gerasimova E.,Voronezh State Medical Academy
World Heart Journal | Year: 2013

Background. Following the emergence of cosmic spacetime, fundamental particles, mass, gravity and radiation that led to the formation of Earth, the origin of life occurred probably with the emergence of the protocell. The functions of this protocell were under influence of geophysical forces and solar periodicities resulting in circadian and other frequency rhythms in biological systems integrated with the external environment i.a. comprising nutrients. Methods. Internet search and discussion with colleagues. Results. The discourse in space-time, fundamental particles, gravity, mass and radiation allows progression towards periodic events in parts of the observable universe and of relevance to this paper, in life itself. Conclusions. Diet and lifestyle factors and geophysical cycles may trigger the circadian system and adversely affect cardiovascular events. © 2013 Nova Science Publishers, Inc.

Pella D.,steur University Hospital | Otsuka K.,Tokyo Women's Medical University | Singh R.B.,Halberg Hospital and Research Institute
Open Nutraceuticals Journal | Year: 2011

Background: There is evidence on the relation between brain dysfunction and pathogenesis of metabolic syndrome leading to cardiovascular diseases, type 2 diabetes and insulin resistance. Methods: Medline search till Dec, 2009 and articles published in various national and international journals were reviewed. Experts working in the field were also consulted. Results: Increased intake of refined carbohydrates, linoleic acid, saturated and total fat and low dietary n-3 fatty acids and other long chain polyunsarurated fatty acids (PUFA) in conjunction with sedentary behaviour and mental stress and various personality traits can predispose inflammation and central obesity. There may be increased sympathetic activity with increased secretion of catecholamine, cortisol and serotonin and proinflammatory cytokines that appear to be underlying mechanisms of metabolic syndrome. Excess secretion of these neurotransmitters in conjunction of underlying long chain PUFA deficiency, may damage the neurons via proinflammatory cytokines, in the ventromedial hypothalamus and insulin receptors in the brain, especially during fetal life, infancy and childhood, resulting into their dysfunction. Since 30-50% of the fatty acids in the brain are long chain PUFA, especially omega-3 fatty acids, which are incorporated in the cell membrane phospholipids, it is possible that their supplementation may be protective. Omega-3 fatty acids are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines IL-4 and IL-10, as well as acetylecholine in the hippocampus. It is possible that marginal deficiency of long chain PUFA, especially n-3 fatty acids, due to poor dietary intake during the critical period of brain growth and development in the fetus and infant, and also possibly in the child, adolescents and adults, may enhance the release of tumor necrosis factor-alpha, interleukin-1, 2 and 6 and cause neuronal dysfunction. Experimental studies indicate that ventromedial hypothalamic lesion in rats induces hyperphagia, resulting into glucose intolerance and insulin resistance. Treatment with neuropeptide Y abolished the hyperphagia and ob mRNA (leptin mRNA) in these rats. Long term infusion of norepinephrine and serotonin into the ventromedial hypothalamus, impaired pancreatic islet function in as much as, ventromedial hypothalamic norepinephrine and serotonin levels are elevated in hyperinsulinemic and insulin resistant animals. Treatment with insulin was associated with restoration of these hypothalamic neurotransmitter abnormalities indicating that a dysfunction of ventromedial hypothalamus can impair pancreatic beta cells resulting into metabolic abnormalities consistent with metabolic syndrome. Treatment with omega-3 fatty acids, coenzyme Q10, meditation, active prayer, beta blockers, ACE inhibitors, and oestrogen may have a beneficial influence on insulin receptors and ventromedial hypothalamic dysfunction. However, no definite and precise insight into the patho-physiological link between metabolic syndrome and brain and nutrition is available. Despite this weakness, epidemiological studies and intervention trials indicate that treatment with n-3 fatty acids may be applied to clinical practice and used to direct therapy for prevention of metabolic syndrome, type 2 diabetes, hypertension, coronary artery disease, and atherosclerosis. © Pella et al.

Singh R.B.,Halberg Hospital and Research Institute | Cornelissen G.,University of Minnesota | Otsuka K.,Tokyo Women's Medical University | Juneja L.,Taiyo Kagaku | Halberg F.,University of Minnesota
Open Nutraceuticals Journal | Year: 2012

Wang and co-workers reported on ethnic differences in ambulatory blood pressure (ABP) in African Americans compared to people of European origin [1]. Data on ABP and heart rate (HR) on American Indians and Asian Indians could have made this study even more interesting [2]. Details on diet and lifestyle factors also appear to be important for mapping circadian changes in blood pressure (BP) in populations studied by the BIOCOS group [3]. Circadian changes in BP are synchronized by the daily routine via plasma concentrations of neurotransmitters, released by the pineal, pituitary and adrenal cortices, coordinated by clock genes situated in the brain's suprachiasmatic nucleus [2], and at the cellular level [4, 5]. © Singh et al.

Handjieva-Darlenska T.,Medical University-Sofia | Hristova K.,National Heart Hospital | Singh R.B.,Halberg Hospital and Research Institute
World Heart Journal | Year: 2014

Antioxidant vitamin deficiency may be important in the pathogenesis of atherosclerosis and cardiovascular diseases (CVD). Epidemiological studies show that vitamin A,E and C and beta-carotine as well as folic acid and selenium were inversely associated with risk of morbidity and mortality due to CVDs and cancer. However, randomized, controlled intervention trials showed no evidence of benefit in CVDs and cancers; but adverse effects were observed in some of the important studies. Hence, there is no evidence to support the use of vitamins in the prevention of CVDs and cancer. Further studies are necessary to find out the role of vitamins and minerals in children, malnutrition and chronically ill people in the elderly population. © 2014 Nova Science Publishers, Inc.

Kawasaki T.,Kyushu Sangyo University | Singh R.B.,Halberg Hospital and Research Institute | Germaine C.,University of Minnesota | Halberg F.,University of Minnesota
Open Nutraceuticals Journal | Year: 2012

Objective: Coenzyme Q10 (CoQ10) appears to be a promising agent in neurodegenerative disorders because they are associated with defects in the inner mitochondrial membrane and in oxidative phosphorylation. This report aims to highlight the role of CoQ10 in amyotrophic lateral sclerosis. Methods: A 75 year old medical scientist (1st author TK) unbiased for treatment with CoQ10, volunteered for CoQ10 ad-ministration. He himself recorded his symptoms, mood, sensations, body weight, using limb Norris score, hand grip power for both hands. He received highly bioavailable CoQ10 in a dose of 500 mg twice daily initially followed by 200mg twice daily for treatment in 2005. (solubilized ubiquinol, Tishcon Corp. NY). His plasma CoQ10 level was ob-tained initially and after treatment with CoQ10. Results: He presented with weakness of left leg along with cramps in the left calf muscle with steppage gate in September 2000. He had wasting of muscles, fasciculations and exaggerated reflexes. He had rapid deterioration in hand grip power in the left hand and weakness in left lower limb followed by right limbs with inability in walking and routine activities. Treatment with ubiquinol in 2005, resulted in better hand grip power, mood and sensation within a month and in 2006, he reported that hand grip power and wasting of muscles are not progressing as rapidly as before administering CoQ10. Interpretations: Treatment with highly solubilized ubiquinol can provide benefit to patients with ALS. Further controlled trials would be necessary to confirm our findings. © Kawasaki et al.; Licensee Bentham Open.

Hristova K.,Sofia University | Cornelissen G.,University of Minnesota | Fedacko J.,Safaric University | Singh R.B.,Halberg Hospital and Research Institute
World Heart Journal | Year: 2014

Background: Synchronization of organisms with their environment along the 24-hour scale is mediated by circadian clocks. This cell-autonomous mechanism has been identified within all cardiovascular-relevant cell types, including cardiomyocytes. Subjects and Methods: The study aims to assess the circadian pattern in the contractility of the left ventricle (LV), using myocardial deformation imaging. The study involved 11 clinically healthy volunteers (mean age 38y ±10), including 4 men (mean age 30.5y ±12.4) and 7 women (mean age 42.7y ±4.8). Automated quantification of LV systolic function by measurement of LV systolic strain from speckle-tracking echocardiography was used. Echocardiography was performed with a commerciallyavailable standard ultrasound scanner, and a 2.5-MHz transducer. All images were obtained at a rate of 50 to 70 frames/s. Strain and twist/untwist measurements were performed offline with dedicated automated software. Results: In health, global longitudinal strain (GLS) varied from −22.35% to −22.87%, global circumferential strain (GCS) from −18.41% to −21.50%, and global radial strain (GRS) from 36.75% to 42.30%. LV twist (LVT) ranged from 8.33° to 10.77° and untwist rate (LVUR) from −87.45°/s to −71.49°/s. Overall, highest values for GLS, GRS, and LVT occurred around 06:00 and overall lowest values of GRS and LVT around 18:00. Considering results from all 6 walls as independent replications, a statistically significant circadian rhythm was found for both regional circumferential strain (P<0.001) and for radial strain (P=0.002). Discussion and Conclusion: This study assessed global physiological consequences of the circadian clock specifically within the myocardial deformation. Apart from influences of the cardiomyocyte circadian clock on heart rate and the responsiveness of the heart to an increased workload, evidence is provided herein for the circadian stage-dependence of regional deformation, an important result pertaining to global ventricular function. © 2014 Nova Science Publishers, Inc.

Singh R.B.,Halberg Hospital and Research Institute
New Research in Cardiovascular Health | Year: 2014

This book presents important research from around the world in the field of cardiovascular science. Particular emphasis is placed on circadian rhythms, chronomics, diet and health, obesity, and coronary artery disease. © 2014 by Nova Science Publishers, Inc. All rights reserved.

Singh R.B.,Halberg Hospital and Research Institute
Cardiovascular Health and Chronomics | Year: 2014

This book presents important research from around the world in the field of cardiovascular science. Particular emphasis is placed on chronomics, immunogenicity, diet and health, diabetes, coronary risk, and cardiovascular disease. © 2014 by Nova Science Publishers, Inc. All rights reserved.

Coronary risk factors; such as hypertension, diabetes mellitus, tobacco consumption, hypercholesterolemia and obesity as well as coronary artery disease (CAD) are a major health problems in developed as well as in developing economies. In developing economies, despite a moderate increase in fat intake and low rates of obesity, the risk of CAD is rapidly increasing. It is a paradox that in some of these countries the increased risk of people to diabetes and CAD, especially at a younger age, is difficult to explain by conventional risk factors. It is possible that the presence of new risk factors especially higher lipoprotein(a)(Lpa), hyperhomocysteinemia, insulin resistance, low high density lipoprotein cholesterol and poor nutrition during fetal life, infancy and childhood may explain at least in part, the cause of this paradox.The prevalence of obesity, central obesity, smoking, physical inactivity and stress are rapidly increasing in low and middle income populations, due to economic development. In high income populations, there is a decrease in tobacco consumption, increase in physical activity and dietary restrictions, due to learning of the message of prevention, resulting into reduction in coronary and sroke mortality. Hypertension,(5-10%) diabetes(3-5%) and CAD(3-4%) are very low in the adult, rural populations of India, China, and in the African sub-continent which has less economic development.However, in urban and immigrant populations of India and China, the prevalence of hypertension (>140/90, 25-30%), diabetes (6-18%) and CAD (7-14%) are significantly higher than they are in some of the high income populations. Mean serum cholesterol (180-200 mg/dl), obesity (5-8%) and dietary fat intake (25-30% en/day) are paradoxically not very high and do not explain the cause of increased susceptibility to CAD and diabetes in some South Asian countries. The force of lipid-related risk factors and refined starches and sugar appears to be greater in these populations due to the presence of the above factors and results into CVD at a younger age in these countries.These findings may require modification of the existing American and European guidelines, proposed for prevention of CAD, in high income populations. Wild foods or designer foods(400-500g/day) substitution (www.columbus-concept.com) for proatherogenic foods; refined carbohydrates, trans fatty acids, saturated fat and w-6 rich oils in conjunction with moderate physical activity and cessation of tobacco, may be protective against deaths and disability due to CVD and diabetes in most of these countries. © 2010 Nova Science Publishers, Inc.

Singh R.B.,Halberg Hospital and Research Institute
World Heart Journal | Year: 2010

The role of diet in acute myocardial infarction is not known. Increased consumption of proinflammatory macronutrients such as w-6 fatty acids, trans fat and saturated fatty acids (SFA) as well as refined carbohydrates may produce oxidative stress, free fatty acids and proinflammatory substances, which results into endothelial dysfunction. Glucose ingestion in normal subjects is associated with increased superoxide generation in leukocytes and mononuclear cells, as well as with raised amount and activity of nuclear factor-κB (NF-κB), a transcriptional factor regulating the activity of at least 125 genes, most of which are pro inflammatory. Increased consumption of refined carbohydrates also causes an increase in two other pro-inflammatory transcription factor, activating protein-1(AP-1) and Egr-1, the first regulating the transcription of matrix metallo-proteinases and the second modulating the transcription of tissue factor and plasminogen activator inhibitor-1. It is possible that simultaneous supplementation with antioxidants such as coenzyme Q10 and w-3 fatty acids can modulate some of these mechanisms, resulting into decrease in these adverse effects. © 2010 Nova Science Publishers, Inc.

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