Hakutsuru Sake Brewing Co.

Kōbe-shi, Japan

Hakutsuru Sake Brewing Co.

Kōbe-shi, Japan
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Mizushina Y.,Kobe Gakuin University | Kuriyama I.,Kobe Gakuin University | Yamazaki A.,Hakutsuru Sake Brewing Co. | Akashi T.,Hakutsuru Sake Brewing Co. | Yoshida H.,Kobe Gakuin University
Food Chemistry | Year: 2013

During the screening of selective DNA polymerase (pol) inhibitors, we isolated cycloartenyl trans-ferulate (CAF), which is a major component of γ-oryzanol, which is a byproduct formed during the production of Japanese rice wine "sake". CAF selectively inhibited the activity of mammalian A, B, and X pol families, but Y family pols were not affected. CAF did not influence the activities of plant or prokaryotic pols, nor the activity of other DNA metabolic enzymes tested. Individual chemical components of CAF, including cycloartenol (CA) and ferulic acid (FA), did not inhibit pol enzyme activities. CAF suppressed TPA (12-O-tetradecanoylphorbol-13-acetate)-induced inflammation in the mouse ear, but CA and FA did not. The ability to inhibit mammalian pol enzymes in vitro was positively correlated with their propensity to suppress inflammation in vivo. These results suggest that this byproduct formed during the sake-brewing process is useful as an anti-inflammatory agent. © 2013 Elsevier Ltd. All rights reserved.


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Hakutsuru Sake Brewing Co. | Date: 2013-04-16

Japanese liquor; western liquor; alcoholic fruit beverages; Chinese liquor; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-11-27

Japanese liquor; western liquor; alcoholic fruit beverages; Chinese liquor; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-11-27

Japanese liquor; western liquor; alcoholic fruit beverages; Chinese liquor; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2013-04-23

Japanese liquor; western liquor; alcoholic fruit beverages; Chinese liquor; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-05-14

Japanese liquor; western liquor; alcoholic fruit beverages; Chinese liquor; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-11-27

Japanese liquor; western liquor; alcoholic fruit beverages; Chinese liquor; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-05-14

Japanese liquors; western liquors; alcoholic fruit beverages; Chinese liquors; spiced or flavored liquor.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-05-14

Japanese liquors; western liquors; alcoholic fruit beverages; Chinese liquors; spiced or flavored liquors.


Trademark
Hakutsuru Sake Brewing Co. | Date: 2012-05-14

Japanese liquors; western liquors; alcoholic fruit beverages; Chinese liquors; spiced or flavored liquors.

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