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Hainan Weikang Pharmaceutical Qianshan Co. | Date: 2011-09-06

A puncture free bottle cork has a body and a cap for covering a bottle opening. The body has at least one channel defined therein for receiving a syringe or an infusion bottle connector. The body is composed of an exterior body and a flange integrally formed with and extending downward from the exterior body for direct insertion of the bottle opening. The number of the at least one channel corresponds to number of the syringe or the infusion bottle connector such that when the number of the at least one channel is one, injection and drawing of medication to/from the bottle is using the single one channel and when the number of the at least one channel is plural, injection and drawing of medication to/from the bottle is using different channels.

Hainan Weikang Pharmaceutical Qianshan Co. | Date: 2012-09-28

A compound ambroxol hydrochloride composition and a preparation method therefor, which relate to the field of medicine. 0.1%-99.9% by mass of ambroxol hydrochloride and 99.9%-0.1% by mass of scopolamine serving as main ingredients and mannitol are added into water for injection; stir to dissolve, then adjusting to pH 5.0 by adding an NaOH solution; add 0.1% of activated carbon with stirring for 30 minutes; filter out the activated carbon, and then filtering the liquid with 0.45 m and 0.22 m microporous filter membranes; fill the filtered liquid into a large plate or a vial; send into a lyophilizer, cool to 40 C., and hold the temperature for 2 hours; warm to 5 C. to 0 C. slowly to lyophilize the liquid, heat to 35 C., and hold the temperature for 3 hours; take out of the lyophilizer after lyophilizing to obtain a lyophilized powder injection containing ambroxol hydrochloride and scopolamine; crush the lyophilized powder injection under a sterile conditions, and sieve with a 180-mesh sieve to obtain sterile lyophilized powder containing ambroxol hydrochloride and scopolamine; and prepare various dosage forms by using the lyophilized powder as a raw material.

Ahmed A.,Institute of Materials Engineering | Ahmed A.,Nanjing University | Yu H.,Institute of Materials Engineering | Han D.,Hainan Weikang Pharmaceutical Qianshan Co. | And 3 more authors.
Macromolecular Bioscience

Surface engineered nanoparticles (NPs) are fabricated from polycaprolactone-polyethylenimine-folic acid (PCL-PEI-FA) and polycaprolactone-S-S-polyethylene glycol (PCL-S-S-PEG) copolymers. FESEM reveals the core-shell structure of these NPs of about 230 nm size. It is assumed that the inner cores of these NPs are composed of PCL, while the outer shells are adorned with PEG and folic acid, introducing a stealthy nature and specific targeting capability. Moreover, the disulfide bonds in the PCL-S-S-PEG copolymers provide a reduction-induced degradation characteristic in these NPs. Cell line experiments demonstrate the enhanced endocytosis and cytotoxicity of these NPs. Thus PCL-PEI-FA/PCL-S-S-PEG NPs could be a better candidate for the tumor specific delivery of hydrophobic drugs. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Source

Chen L.,Jiangxi University of Traditional Chinese Medicine | Chen L.,CAS Shanghai Institute of Materia Medica | Wang L.-Y.,Hainan Weikang Pharmaceutical Qianshan Co. | Yin X.-Z.,CAS Shanghai Institute of Materia Medica | And 9 more authors.
Yaoxue Xuebao

The crystal form of solid substance had intrinsic correlation with its three dimensional crystal morphology. Based on the characterization of the three dimensional crystal morphology of clopidogrel bisulfate, this research is to establish a model based on the three dimensional morphological parameters. The granular samples composed of polymorphs of clopidogrel bisulfate and microcrystalline cellulose (MCC) were scanned by synchrotron radiation X-ray microscopic CT technology (SR-uCT) and the three dimensional structural models for which were constructed. Seven groups of three dimensional morphological parameters were calculated. Finally, the mathematical model was established with the multi-layer perception (MLP) artificial neutral network methods to identify and predict the polymorphs of clopidogrel bisulfate. The success rate of the model prediction for the polymorphs of clopidogrel bisulfate was 92.7% and the area under the ROC curve was 96.2%. The polymorphs of drugs could be identified and predicted through the numerical description of the three dimensional morphology. The volume, number of the vertices and the surface area were the major determinants for the identification of the polymorphs of clopidogrel bisulfate. Source

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