Haikou, China
Haikou, China

Hainan University (simplified Chinese: 海南大学; traditional Chinese: 海南大學; pinyin: Hǎinán Dàxué is a comprehensive provincial university in Haikou, Hainan province established in 2007. Wikipedia.

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Wen W.,Hainan University | Wu J.-M.,Zhejiang University
RSC Advances | Year: 2014

Solution combustion synthesis (SCS) is a worldwide adopted technique to synthesize nanomaterials, especially for oxides, because of its simplicity, energy and time-effectiveness, and low cost. The general difficulty encountered in SCS is the controllability over phases and morphologies of the products, which arises from the inherent rapid and uncontrollable combustion procedure. In this regard, the present work is devoted to review the recent progress on phase- and morphology-controlled SCS in detail. Besides the various metal oxides, SCS is now applicable to fabricate nanomaterials of metal phosphates, metal silicates, metal borates, metal sulfides, metals, and even alloys, through careful selection of solution compositions. Oxides with regular morphologies of flowers, belts, triangles, tubes, wires, and rods can be synthesized by SCS, in the presence of certain templates, or through a self-assembly procedure. The recent progress made on the synthesis of porous materials via SCS is summarized. SCS is also capable of growing metal oxide thin films at low temperatures, enabling the fabrication of low-cost and high-performance electronics on flexible plastic substrates. This journal is © The Royal Society of Chemistry.


Xu J.,Hainan University
RSC Advances | Year: 2015

This review summarizes new findings concerning the sources and characteristics of various natural products that can be extracted from mangrove-associated microbes over the past three years (January 2011-December 2013). The natural products are discussed with a focus on bioactivity, highlighting the unique chemical diversity of these metabolic products. © The Royal Society of Chemistry 2015.


To study the combination effects of glycometabolic regulator NaF and elicitor methyl jasmonate (MJ) on cephalotaxine production in Cephalotaxus mannii suspension cultures, NaF of 10 mg/L, MJ of 100 μmol/L or both of them (NaF + MJ for short below) were added to the shake-flask cultures of C. mannii cell. It was found that NaF increased the activity of glucose 6-phosphate dehydrogenase (G6PDH), but had no significant effects on phenylalanine ammonium-lyase (PAL) activity and phenols formation. In contrast, MJ could activate PAL activity and led to phenols accumulation, but had no significant effects on G6PDH activity. To explore the effects of NaF and MJ on cephalotaxine biosynthesis, harringtonine and homoharringtonine, the two cephalotaxines, were analyzed in this work. The results obtained indicated that NaF + MJ treatment showed the strongest promotion of production in all tests. Harringtonine yield in NaF + MJ treated cells (7.245 mg/L) was 4.8-fold higher than that in control cells (1.506 mg/L), 1.7-fold that in NaF-treated cells (4.12 mg/L) and 1.6-fold that in MJ-treated cells (4.458 mg/L), respectively. No homoharringtonine was found besides in NaF + MJ treated cells (0.491 mg/L). With respect of the product release rates, they were 0%, 78%, 24% and 62% in control, NaF, MJ and NaF + MJ treatment, respectively. These results suggest that the combination of NaF and MJ had contributed to the synthesis and secretion of cephalotaxine in C. mannii cells. © 2014 Elsevier Ltd. All rights reserved.


Bo Ning Z.J.,Hainan University
Journal of Networks | Year: 2013

Existing methods and technologies for Web services discovery mainly consist of two models: service matching based on grammar and based on semantics. With keywords service matching method, we introduce text information retrieval technology with vectors and concept lattice theory. Then a web service discovery algorithm using eigenvectors is put forward. It orders the Web services by correlation among the services in Web service subset. The services which have bigger correlation will get anterior places. According to this algorithm a Web service discovery system based on eigenvectors is designed. We give description to key modules of the system. At last the improved algorithm is compared to methods based on full-text retrieval and pure similarity retrieval. The results show it has better performance in accuracy and response. © 2013 ACADEMY PUBLISHER.


Ma Q.,Hainan University | Lu H.,Chinese Academy of Sciences
Desalination | Year: 2011

Throughout the world, desalination is intensively used as a means to reduce current or future water scarcity, especially for the coastal areas. However, the dramatic increase in desalinated water supply will create a series of problems, the most significant of which are those related to energy consumption and environment impacts. Renewable energy provides an energy security and environmental friendly option simultaneously when decreasing global reserves of fossil fuels threatens the long-term sustainability of global economy. Thus, the integration of renewable resources in desalination and water purification is becoming increasingly attractive. In this paper an attempt has been made to present a review, in brief, work of the highlights that have been achieved during the recent years worldwide and the state-of-the-art for most important efforts in the field of desalination by wind energy, which is one of the most common form of renewable energies. The wind energy transform patterns, modeling and experimental studies of various wind energy powered desalination plant, and the prototypes established worldwide are majorly discussed. Moreover, two important technological problems in wind utilization are discussed, and the present or potential countermeasures for the intermittent characteristic and direct utilization of wind energy are presented. © 2011.


Ma X.,Queen's University of Belfast | Yuan W.,Hainan University | Bell S.E.J.,Queen's University of Belfast | James S.L.,Queen's University of Belfast
Chemical Communications | Year: 2014

Quantitative monitoring of a mechanochemical reaction by Raman spectroscopy leads to a surprisingly straightforward second-order kinetic model in which the rate is determined simply by the frequency of reactive collisions between reactant particles. This journal is © The Royal Society of Chemistry.


The present invention pertains to fields of biochemistry and molecular biology, relates to an O-superfamily conotoxin peptide, pharmaceutical composition thereof, preparation method and use thereof. The present invention further relates to a propeptide of the conotoxin peptide, nucleic acid construct thereof, expression vector and transformed cell thereof, and fusion protein thereof. The present invention further relates to a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The new O-superfamily conotoxin peptide of the present invention is capable of specifically blocking acetylcholine receptor (nAChRs) (e.g., 910 nAChR), and NMDA receptor (e.g., NR2C NMDAR), and has activity for treatment of neuralgia, addiction, and activity for treatment of chemotherapy of cancers, breast cancer, lung cancer, wound healing, epilepsia, ischemia, and thus is promising in the manufacture of analgesic, a medicament for treatment of addiction, and a tool drug for neuroscience.


The present invention pertains to fields of biochemistry and molecular biology, relates to an O-superfamily conotoxin peptide, pharmaceutical composition thereof, preparation method and use thereof. The present invention further relates to a propeptide of the conotoxin peptide, nucleic acid construct thereof, expression vector and transformed cell thereof, and fusion protein thereof. The present invention further relates to a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The new O-superfamily conotoxin peptide of the present invention is capable of specifically blocking acetylcholine receptor (nAChRs) (e.g., 910 nAChR), and NMDA receptor (e.g., NR2C NMDAR), and has activity for treatment of neuralgia, addiction, and activity for treatment of chemotherapy of cancers, breast cancer, lung cancer, wound healing, epilepsia, ischemia, and thus is promising in the manufacture of analgesic, a medicament for treatment of addiction, and a tool drug for neuroscience.


Patent
Hainan University | Date: 2015-07-01

The present invention provides a novel -conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The -conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as 32 nAChRs, 6/323 nAChR or 34 nAChR or 6/34 nAChR), has activity for treatment of neuralgia, addiction, Parkinsons disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.


Patent
Hainan University | Date: 2013-06-18

The present invention provides a novel -conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The -conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as 32 nAChRs, 6/323 nAChR or 34 nAChR or 6/34 nAChR), has activity for treatment of neuralgia, addiction, Parkinsons disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

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