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Chen S.,Hainan Provincial Peoples Hospital
Hong Kong Journal of Emergency Medicine | Year: 2011

Introduction: The Utstein template has been used to guide the assessment and study of cardiopulmonary resuscitation (CPR) in many countries. This article used the Utstein templates for cardiac arrest and resuscitation registries to evaluate outcomes of CPR at Hainan Provincial People's Hospital (HPPH), China. Methods: A prospective observational study using Utstein CPR registry form to evaluate the epidemiological characteristics and outcomes of 511 resuscitation cases in the emergency department, HPPH. Results: A total of 511 CPR patients registered were studied. Higher cardiac arrest rates were observed for the group of patients who were 40-70 years old. In preexisting chronic diseases, cardiovascular diseases (190, 37.2%) cerebrovascular diseases (48, 9.4%) and respiratory diseases (39, 7.6%) were common in the recruited patients. (173, 33.9%) of the cardiac arrest patients had underlying cardiac causes, of which 109 (21.3%) had acute myocardial infarct (AMI). Eighty (15.7%) patients had ventricular fibrillation as the first witnessed arrest rhythm. The return of spontaneous circulation (ROSC) and survival to discharge rates were 47.0% and 13.5% in the in-hospital cardiac arrest (IHCA) group but 16.7% and 4.7% in out-of-hospital cardiac arrest (OHCA) group (p<0.01) respectively. Conclusions: This study indicated that the cardiovascular diseases, cerebrovascular diseases, and respiratory diseases were the most common preexisting chronic diseases. Myocardial infarct, stroke and trauma were the most common precipitation cause of cardiac arrest in the recruited patients. The rate of ROSC and survival to discharge for the patients with IHCA were higher than the ones with OHCA, but figures were still low.

Chang S.-W.,Hainan Provincial Peoples Hospital
Journal of Practical Oncology | Year: 2013

Objective: To investigate the clinical effect and side effects of paclitaxel combined with eapecitabine in the treatment for patients with advanced gastric cancer.Methods: Twenty patients with advanced gastric cancer recurrence after chemotherapy were treated with the combination of paclitaxel and capecitabine. The patients were administrated with oral capecitabine (1000 mg/m2, bid, d 1-14) and intravenous paclitaxel (135 mg/m2, d 1, d 8) in a 21-day cycle regimen.Results: A total of 5 cases showed PR (25.0%), 12 SD (60.0%) and 3 PD (15.0%). Meanwhile, the response rate (RR) was 25.0% and the disease control rate (DCR) was 85.0%. The median remission time and the median survival time were 5 months and 12 months, respectively. The main side effects were myelosuppression and hand-foot syndrome. The degree of these side reactions were only I or II level.Conclusion: The combination of paclitaxel and capecitabine is effective and well-tolerated in the treatment of advanced gastric cancer recurrence after chemotherapy.

Liu F.J.,Hainan Provincial Peoples Hospital
Zhonghua nan ke xue = National journal of andrology | Year: 2013

To investigate the clinicopathological characteristics, differential diagnosis and prognosis of testicular cellular fibroma. We comprehensively analyzed the clinical presentation, histomorphology and immunohistochemistry of a case of testicular cellular fibroma, reviewed the relevant literature, and discussed its pathological features and differential diagnosis. A 30-year-old man presented with complaint of discomfort and painless enlargement in the right testis. The tumor was found to be a testicular fibroma characterized by a solid, thickly or thinly encapsulated, circumscribed and gray-white mass. Microscopically, fusiform cells were arranged into a storiform and herringbone pattern or fascicles. The tumor exhibited a great deal of cellularity and no nuclear polymorphisms, with a mitotic rate of 0-1/10 HP. Immunohistochemistry showed that the tumor cells were positive for Vimentin, patchily positive for S-100 and SMA, but negative for Desmin, alpha-inhibin, CD34 and CD99. The positive rate of Ki-67 was less than 1%. Testicular cellular fibroma is a rare testicular sex cord stromal tumor, pathologically resembling its ovarian counterpart. It can be distinguished from other testicular spindle cell tumors by morphology and immunohistochemical staining. For the treatment of testicular cellular fibroma, surgical resection often has a good prognosis.

Xiang W.,Hainan Provincial Peoples Hospital
Zhonghua er ke za zhi. Chinese journal of pediatrics | Year: 2011

To study possible influences of 1,25(OH)(2)D(3) on endothelial cell proliferation, apoptosis and endothelial nitric oxide synthase (eNOS) expression of aorta in apolipoprotein E-deficient (apoE(-/-)) mice and to explore the relationship between vitamin D and atherosclerosis. Endothelial cell of aorta in apoE(-/-) mice were isolated and cultured, and the influence of 1,25(OH)(2)D(3) on endothelial cell proliferation were observed by MTT, apoptosis of cells were quantitated by terminal deoxynucleotidyl transferase mediated dUTP nick end labelling, Bcl-2 mRNA, fas mRNA and eNOS mRNA was detected by reverse transcription-polymerase chain reaction. Endothelial cell proliferation rate of aorta did not significantly change in the two control groups (0.162 ± 0.031 vs. 0.158 ± 0.006, P > 0.05). Compared with control groups, 1,25(OH)(2)D(3) stimulated endothelial cell proliferation of aorta (P < 0.05), but endothelial cell proliferation rate did not significantly change in different 1,25(OH)(2)D(3) concentration groups [1,25(OH)(2)D(3) concentration: 10(-4)mol/L, 10(-5) mol/L, 10(-6) mol/L, 10(-7) mol/L, 10(-8) mol/L, endothelial cell proliferation rate: 0.189 ± 0.013 vs. 0.285 ± 0.011 vs. 0.296 ± 0.026 vs. 0.284 ± 0.017 vs. 0.233 ± 0.010, P > 0.05]. 1,25(OH)(2)D(3) research concentration as chosen as 10(-6) mol/L. In 1,25(OH)(2)D(3) 10(-6) mol/L group, the expression of Bcl-2, eNOS mRNA was significantly increased (0.78 ± 0.16 vs. 0.46 ± 0.21 vs. 0.42 ± 0.17, 0.56 ± 0.16 vs. 0.39 ± 0.13 vs. 0.35 ± 0.11, 0.46 ± 0.2 vs. 10.42 ± 0.17 vs. 0.78 ± 0.16, 0.79 ± 0.21 vs. 0.81 ± 0.20 vs. 0.43 ± 0.12), apoptotic index, Fas mRNA was significantly decreased (15.14 ± 3.19 vs. 18.94 ± 4.22 vs. 19.27 ± 4.58, 0.43 ± 0.12 vs.0.79 ± 0.21 vs. 0.81 ± 0.20)(P < 0.05). The quantity of eNOS gene expression was inversely associated with apoptosis index and Fas mRNA, was positively associated with Bcl-2 mRNA (r = -0.676, -0.758, 0.762, P < 0.01). 1,25(OH)(2)D(3) stimulated endothelial cell proliferation, inhibited apoptosis and increased eNOS expression of aorta in apoE(-/-) mice. These results may deepen understanding of the pathogenesis of atherosclerosis.

Liang Z.,Hainan Provincial Peoples Hospital
Nan fang yi ke da xue xue bao = Journal of Southern Medical University | Year: 2010

To assess the value of multi-tumor markers protein biochip in the diagnosis and therapy of pulmonary carcinoma. Twelve tumor markers (CA199, NSE, CEA, CA242, Ferrtin, β-HCG, AFP, f-PSA, PSA, CA125, HGH, and CA153) were detected using protein chip in 308 patients with pulmonary carcinoma, 218 with benign lung lesions and 250 healthy subjects. The positivity rate was 72.4% in pulmonary carcinoma cases, obviously higher than that in the benign cases (22.0%, P<0.01) and healthy subjects (5.6%, P<0.01). The positivity rates differed significantly between the pulmonary carcinoma cases of different pathological types. The positivity rates of CEA, CA125, and CA153 were significantly higher in adenocarcinoma cases than in squamous carcinoma cases (P<0.05), and also higher in cases with lymph node metastasis than in those without (71.9% vs 52.1%, P<0.05). Protein biochip containing multiple tumor markers provides valuable assistance in the diagnosis and therapeutic effect monitoring of pulmonary carcinoma.

Xu Z.-Q.,Hainan Provincial Peoples Hospital | Yi Z.-W.,Hainan Provincial Peoples Hospital
Chinese Journal of Contemporary Pediatrics | Year: 2014

Hazardous environmental factors invade the body through multiple routes, including ingestion, inhalation and absorption by contact with the skin and mucous membrane. They are from various sources and soil, water, air, building and decorative materials, foods and daily necessities are the main carriers. According to their physical and chemical properties and morphological characteristics, these hazardous factors are classified as metals, inorganic matter, organic matter, radioactive substances, biological toxins, viruses, bacteria, mycoplasmas, chlamydiae and parasites. They cause diseases through blood and urine and also have kidney susceptibility. This article suggests that pediatricians should fully understand the characteristics and seriousness of hazardous environmental factors that cause renal damage, and pay attention to the prevention and control of these factors so as to minimize renal damage in children.

Sun X.,Hainan Provincial Peoples Hospital | Lan C.,Hainan Provincial Peoples Hospital
Asian Pacific Journal of Tropical Medicine | Year: 2011

Objective: To investigate the expression of Runx3 and TGF-β 1 protein in the colon from rats with irritable bowel syndrome (IBS). Methods: Rat model for IBS was established by intracolonic instillation with acetic acid and restraint stress methods, which was confirmed by determinating the visceral sensitivity of the animals, including abdominal withdrawal reflex (AWR) score and the electronic behavior of the abdomen wall. The rats were randomly assigned into three groups: IBS 1 group (restraint stress, n = 25); IBS 2 group (both instillation with acetic acid and restraint stress, n = 25) and Control group (n=16). The colonic tissue samples were collected for histological study and the expression of Runx3 and TGF-β 1 proteins were detected by immunohistochemistry. Meanwhile, the relationship of these two proteins was calculated. Results: Visceral hypersensitivity (AWR and abdominal electrical activity) was significantly enhanced in IBS 1 and IBS 2 groups than other groups. The colon tissue in all groups did not show any signs of inflammation. Furthermore, the expression of Runx3 and TGF-β 1 protein in the colon from all groups show no significant difference (P>0.05), with no remarkable relevancy between each other (P>0.05). Conclusions: The rat model for IBS was successfully established. We did not find any significant changes in the expression of Runx3 and TGF-β 1 protein in the colon tissue from IBS rats, suggesting that the quantitative changes may be not the way by which Runx3 and TGF-β 1 protein play their roles in IBS. The accurate roles of Runx3 and TGF-β 1 proteins in the pathogenesis of IBS remains to be further studied. © 2011 Hainan Medical College.

Chen P.,Chengdu Seventh Peoples Hospital | Zhu J.,University of Sichuan | Liu D.-Y.,Chengdu Seventh Peoples Hospital | Li H.-Y.,Hainan Provincial Peoples Hospital | And 2 more authors.
Medical Oncology | Year: 2014

The expression of survivin, an inhibitor of apoptosis can be seen in most tumors and is correlated with the angiogenic factor vascular endothelial growth factor (VEGF). But little is known about their contribution in small-cell lung cancer (SCLC). This study was designed to investigate the expression of survivin and VEGF in SCLC, and to explore their correlation with clinical-pathological feature and prognosis. Forty-five patients with pathological histology of SCLC were entered into this study. Forty-five cases of matched adjacent non-tumor samples and 10 samples of operated patients with benign lung tumor were also included as control. The expression of survivin and VEGF was detected by immunohistochemistry (IHC, SP). These two sets of data were processed and tested for correlation with major patients' characteristics, and overall survival. The correlations between survivin and VEGF expressions and the clinical- pathological features were evaluated by chi-square test. The correlation between survivin and VEGF expressions was analyzed by Spearman's rank correlation test; the overall survival was analyzed by the Kaplan-Meier method; and the relationship between clinical and pathological features and overall survival was analyzed by the Cox proportional hazard models. Positive expression rate of survivin and VEGF was significantly higher in SCLC than those of adjacent non-tumor tissues and benign lung tumor tissues (73.3 vs. 15.6 vs. 0 %, P < 0.05) and (75.6 vs. 20 vs. 0 %, P < 0.05), respectively. Survivin and VEGF expressions were significantly associated with lymph node metastasis (P = 0.003, 0.011) and clinical stage (P = 0.006, 0.021). The expression of survivin was significantly coincident with the expression of VEGF (r = 0.644, P = 0.000). The median overall survival in survivin positive group and VEGF positive group was significantly shorter than those in survivin negative and VEGF negative group, respectively (log-rank P = 0.000). Moreover, multivariate analysis showed that survivin expression (HR 0.224; 95 % CI 0.074-0.675; P = 0.008) and VEGF expression (HR 0.172; 95 % CI 0.054-0.559; P = 0.003) were statistically independent predictive factors of poorer prognosis for SCLC patients. Our results indicated that survivin and VEGF were over-expressed in small-cell lung cancer, each of them may be an independent poor prognostic factor. © 2013 Springer Science+Business Media New York.

To discuss the relationship between high sensitive C-reactive protein (hs-CRP), lipoprotein (Lp)(a), blood uric acid (BUA) and severity of coronary artery disease (CHD). A total of 813 cases of suspected or established coronary atherosclerotic heart disease patients were recruited. The patients received selective coronary arteriography and they were divided into normal and CHD groups according to the result of selective coronary arteriography. The dividing mark was coronary artery stenosis more than 50% by selective coronary arteriography. Patients in CHD group were further divided into 1-4 vessel disease. Blood glucose, cholesterol, triglyceride, LDL-ch, hs-CRP and BUA were detected by automatic biochemical analyzer. Among them, 754 cases (CHD group, 92.7%) were confirmed as coronary heart disease while 59 cases (control group, 7.3%) confirmed as non-coronary heart disease. There were significantly difference between two groups (P < 0.05): hs-CRP (7.12 ± 4.48 vs 1.71 ± 1.42) mg/L, Lp(a) (0.45 ± 0.42 vs 0.18 ± 0.03) mmol/L and BUA (402 ± 103 vs 327 ± 88) μmol/L. The levels of hs-CRP, Lp(a) and BUA in different number of diseased coronary vessels significantly differed from each other (P < 0.05). A comparison of 1-vessel disease group versus 4 vessel disease group was as follows: hs-CRP (3.59 ± 2.93 vs 13.11 ± 3.00) mg/L, Lp(a) (0.37 ± 0.25 vs 0.58 ± 0.17) mmol/L and BUA (384 ± 126 vs 444 ± 91) μmol/L. Logistic regression analysis showed that hs-CRP, Lp(a) and BUA were independent risk factors of coronary artery disease. The elevations of hs-CRP, LP(a) and BUA promote the establishment and development of coronary artery disease. A joint detection of hs-CRP, Lp(a) and BUA shows a comparatively great value in evaluating high-risk groups and the patient's condition. And it provides references for an active intervention of clinical coronary heart disease.

Yang B.,Chongqing Medical University | Zhou X.,Chongqing Medical University | Lan C.,Hainan Provincial Peoples Hospital
BMC Gastroenterology | Year: 2015

Background: Irritable bowel syndrome (IBS) is a highly prevalent functional gastrointestinal disorder. Post-infectious IBS (PI-IBS) is caused by an acute gastrointestinal infection preceding the onset of symptoms. However, the pathophysiology of PI-IBS is not clear, and the purpose of this study was to investigate the probable immune mechanisms of PI-IBS. Methods: C57BL/6 mice were randomly assigned to either an infection group or a control group. Mice in the infection group were infected with Trichinella spiralis to establish a model of PI-IBS (500 Trichinella), while control mice received only salt solution. Visceral sensitivity of colorectal distention in mice was evaluated by abdominal withdrawal reflex scores and intestinal inflammation was assessed using hematoxylin-eosin staining; at day 56 post-infection, the mRNA and protein levels of specific cytokines in the gut segments were detected using reverse-transcription polymerase chain reaction and enzyme-linked immunoabsorbent assay. Results: Levels of interferon γ and interleukin (IL)-17 in the PI-IBS group were significantly increased in the duodenum and ileum, and IL-10 was decreased in the jejunum, ileum, and colon compared with control mice. However, the expression level of IL-1β was not significantly different between the two groups. Conclusions: The present study suggests that the local low-grade inflammation and immune activation that are an important component of the pathophysiology of PI-IBS are primarily induced and maintained by specific cytokines. © Yang et al.; licensee BioMed Central.

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