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Qing Z.J.,Nanjing University | Qing Z.J.,Hainan Medical University | Qing Z.J.,Hainan Provincial Key Laboratory of RandD on Tropical Medicinal Plants | Qing Z.J.,Haikou Municipal Key Laboratory of Li Nationality Medicines | And 14 more authors.
Archives of Pharmacal Research | Year: 2012

Chemical investigation of the fruits of Alpinia oxyphylla led to an isolation of the two new natural products, 9-hydroxy epinootkatol (1) and (S)-2-pentanol-2-O-β-D-glucopyranoside (2), in addition to the nine known compounds, pinocembrin (3), tectochrysin (4), izalpinin (5), nookatone (6), yakuchinone A (7), protocatechuic acid (8), β-sitosterol (9), daucosterol (10) and β-sitosterol palmitate (11). Their structures were elucidated on the basis of physicochemical constants and NMR spectral data analysis. The effects of the isolated components on nitric oxide production in LPS-induced RAW 264.7 macrophages were examined. The two new natural compounds showed inhibitory activities with IC50 values of 21.8 and 32.8 μg/mL, respectively. © 2012 The Pharmaceutical Society of Korea and Springer Science+Business Media Dordrecht.

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