Haifa, Israel
Haifa, Israel

The University of Haifa is a public research university in Haifa, Israel.The University of Haifa was founded in 1963 by Haifa mayor Abba Hushi, to operate under the academic auspices of the Hebrew University of Jerusalem, Haifa university is located on Mount Carmel. In 1972 University of Haifa declared its independence and became the sixth academic institution in Israel and the fourth university.About 18,100 undergraduate and graduate students study in the university a wide variety of topics, specializing in social science, humanities, law and education. The University is broadly divided into six Faculties: Humanities, Social science, Law, Science and Science Education, Social Welfare and Health Studies, and Education. There is also the Graduate School of Management, The Leon H. Charney School of Marine science and the Continuing Education and Extension Studies.Beyond the objective of a first-rate higher education, the University of Haifa aims to provide equal educational opportunities to all sectors of the society, and in particular to encourage mutual understanding and cooperation between the Jewish and Arab populations on and off campus.The university is a home for students from all the edges of the Israeli society - Jews, Muslims, Christians, Druze, religious and secular students and also many students from all over the world who study in the international school.The University of Haifa is home to the Hecht Museum of archeology and art, several research centers and institutes, including the Evolution Institute, Center for the Study of the Information Society, Center for the Study of National Security, Tourism Research Center, and more. The University also hosts a large IBM research center on its campus. Wikipedia.

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Patent
Haifa University | Date: 2016-12-08

The present invention provides an antagonist of a Bcl-2 prosurvival protein containing a BH3-like domain. The antagonist of the invention comprises ARTS and any fragment or peptide that comprises a BH3-like domain. The invention further provides compositions, combined compositions and kits as well as methods for treating Bcl-2 over-expressing disorders.


An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.


An active agent capable of reducing quinone reductase 2 activity, for use in improvement of cognition in a subject is provided. Such an active agent may be a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 or an inhibitor of quinone reductase 2 activity. A vector comprising a nucleic acid molecule that reduces the gene expression level of quinone reductase 2 and a pharmaceutical composition comprising an active agent capable of reducing quinone reductase 2 activity or said vector are provided as well.


Patent
Samsung, Haifa University and Bar - Ilan University | Date: 2016-02-23

Disclosed are an apparatus and a method for encryption. The apparatus includes, a key table generation unit configured to generate random values derived from a seed value and generate a key table including the generated random values, and an encryption unit configured to encrypt a plain text data block by generating an encryption algorithm by repeatedly combining the generated key table with a permutation function in a crossing manner, and using the generated encryption algorithm.


Patent
Samsung, Haifa University and Bar - Ilan University | Date: 2015-12-28

Disclosed are an apparatus and a method for encryption. The apparatus includes a key table generator configured to generate random values based on a seed value and generate a key table including the generated random values; and an encryptor configured to apply the generated key table to a round function, generate a block encryption algorithm having a Feistel structure based on the round function, and encrypt a plaintext data block based on the generated block encryption algorithm.


Shamay-Tsoory S.G.,Haifa University | Abu-Akel A.,University of Birmingham
Biological Psychiatry | Year: 2016

Oxytocin is a nonapeptide that also serves as a neuromodulator in the human central nervous system. Over the last decade, a sizeable body of literature has examined its effects on social behavior in humans. These studies show that oxytocin modulates various aspects of social behaviors such as empathy, trust, in-group preference, and memory of socially relevant cues. Several theoretical formulations have attempted to explain the effects of oxytocin. The prosocial account argues that oxytocin mainly enhances affiliative prosocial behaviors; the fear/stress theory suggests that oxytocin affects social performance by attenuating stress; and the in-/out-group approach proposes that oxytocin regulates cooperation and conflict among humans in the context of intergroup relations. Nonetheless, accumulating evidence reveals that the effects of oxytocin are dependent on a variety of contextual aspects and the individual's characteristics and can induce antisocial effects including aggression and envy. In an attempt to reconcile these accounts, we suggest a theoretical framework that focuses on the overarching role of oxytocin in regulating the salience of social cues through its interaction with the dopaminergic system. Crucially, the salience effect modulates attention orienting responses to external contextual social cues (e.g., competitive vs. cooperative environment) but is dependent on baseline individual differences such as gender, personality traits, and degree of psychopathology. This view could have important implications for the therapeutic applications of oxytocin in conditions characterized with aberrant social behavior. © 2016 Society of Biological Psychiatry.


Akirav I.,Haifa University
Neuroscience and Biobehavioral Reviews | Year: 2013

Bidirectional and functional relationships between glucocorticoids and the endocannabinoid system have been demonstrated. Here, I review the interaction between the endocannabinoid and glucocorticoid/stress systems. Specifically, stress is known to produce rapid changes in endocannabinoid signaling in stress-responsive brain regions. In turn, the endocannabinoid system plays an important role in the downregulation and habituation of hypothalamic-pituitary-adrenocortical (HPA) axis activity in response to stress. Glucocorticoids also recruit the endocannabinoid system to exert rapid negative feedback control of the HPA axis during stress.It became increasingly clear, however, that cannabinoid CB1 receptors are also abundantly expressed in the basolateral amygdala (BLA) and other limbic regions where they modulate emotional arousal effects on memory. Enhancing cannabinoids signaling using exogenous CB1 receptor agonists prevent the effects of acute stress on emotional memory. I propose a model suggesting that the ameliorating effects of exogenously administered cannabinoids on emotional learning after acute stress are mediated by the decrease in the activity of the HPA axis via GABAergic mechanisms in the amygdala. © 2013 Elsevier Ltd.


Shamay-Tsoory S.,Haifa University
Neuropsychologia | Year: 2011

This paper presents a novel neurobiological model of theory of mind (ToM) that incorporates both neuroanatomical and neurochemical levels of specificity. Within this model, cortical and subcortical regions are functionally organized into networks that subserve the ability to represent cognitive and affective mental states to both self and other. The model maintains that (1) cognitive and affective aspects of ToM are subserved by dissociable, yet interacting, prefrontal networks. The cognitive ToM network primarily engages the dorsomedial prefrontal cortex, the dorsal anterior cingulate cortex and the dorsal striatum; and the affective ToM network primarily engages the ventromedial and orbitofrontal cortices, the ventral anterior cingulate cortex, the amygdala and the ventral striatum; (2) self and other mental-state representation is processed by distinct brain regions within the mentalizing network, and that the ability to distinguish between self and other mental states is modulated by a functionally interactive dorsal and ventral attention/selection systems at the temporoparietal junction and the anterior cingulate cortex; and (3) ToM functioning is dependent on the integrity of the dopaminergic and serotonergic systems which are primarily engaged in the maintenance and application processes of represented mental states. In addition to discussing the mechanisms involved in mentalizing in terms of its component processes, we discuss the model's implications to pathologies that variably impact one's ability to represent, attribute and apply mental states. © 2011 Elsevier Ltd.


Grant
Agency: European Commission | Branch: H2020 | Program: CSA | Phase: INFRADEV-03-2016-2017 | Award Amount: 2.72M | Year: 2017

Europe has a long and rich tradition as a centre for the arts and humanities. However, the digital transformation poses challenges to the arts and humanities research landscape all over the world. Responding to these challenges the Digital Research Infrastructure for Arts and Humanities (DARIAH) was launched as a pan-European network and research infrastructure. After expansion and consolidation, which involved DARIAHs inscription on the ESFRI roadmap, DARIAH became a European Research Infrastructure Consortium (ERIC) in August 2014. The DESIR project sets out to strengthen the sustainability of DARIAH and firmly establish it as a long-term leader and partner within arts and humanities communities. By DESIRs definition, sustainability is an evolving 6-dimensional process, divided into the following challenges: Dissemination: DESIR will organise a series dissemination events, including workshops in the US and Australia, to promote DARIAH tools and services and initiative collaborations. Growth: DESIR sets out to prepare the ground for establishing DARIAH membership in six new countries: the UK, Finland, Spain, Switzerland, Czech Republic and Israel. Technology: DESIR will widen the DARIAH research infrastructure in three areas, vital for DARIAHs long-term sustainability: entity-based search, scholarly content management, visualization and text analytic services. Robustness: DESIR will make DARIAHs organizational structure and governance fit for the future and develop a detailed business plan and marketing strategy. Trust: DESIR will measure the acceptance of DARIAH, especially in new communities, and define mechanisms to support trust and confidence in DARIAH. Education: Through training and teaching DESIR will promote the use of DARIAH tools and services. The DESIR consortium is composed of core DARIAH members, representatives from potential new DARIAH members and external technical experts. It is balanced between the different European regions.


Lamprecht R.,Haifa University
Progress in Neurobiology | Year: 2014

The ability to efficiently store memories in the brain is a fundamental process and its impairment is associated with multiple human mental disorders. Evidence indicates that long-term memory (LTM) formation involves alterations of synaptic efficacy produced by modifications in neural transmission and morphology. The actin cytoskeleton has been shown to be involved in these key neuronal processes by subserving events such as presynaptic vesicle movement, postsynaptic glutamate receptors trafficking and dendritic spines morphogenesis. Actin cytoskeleton dynamics and structure underlying such cellular events can be regulated by extracellular signals through its regulatory proteins. Recent findings show that the actin cytoskeleton and its regulatory proteins are needed for memory formation and extinction in different organisms throughout the phyla from invertebrates such as Caenorhabditis elegans and Drosophila to mammalians. The actin cytoskeleton and its regulatory proteins participate in the formation of various types of memories that are subserved by different neurons and brain regions. The actin cytoskeleton may therefore mediate between synaptic transmission during learning and long-term cellular alterations mandatory for memory formation. © 2014 Elsevier Ltd.

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