Haidian District Institute of Products Quality Supervision and Inspection

Beijing, China

Haidian District Institute of Products Quality Supervision and Inspection

Beijing, China

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Xian Y.-P.,Guangzhou Quality Supervision and Testing Institute | Guo X.-D.,Guangzhou Quality Supervision and Testing Institute | Mu T.-N.,Haidian District Institute of Products Quality Supervision and Inspection | Dong H.,Guangzhou Quality Supervision and Testing Institute | And 4 more authors.
Journal of Chinese Mass Spectrometry Society | Year: 2014

A method of liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed for the detection of migration levels of fluorescent whitening agent (FWA) 184 and 393 in food contact plastic container. Through the experiment investigation and analysis, the fat simulant (95% alcohol) was confirmed as soaking solution. The migration rule of analytes in two different migration temperatures (low storage condition of 5℃ and room storage condition of 40℃) and varied migration time were studied by LC-MS/MS, and the corresponding migration equation was established. The results show that the linearity ranges from 0.03 μg/L to 20 μg/L with the correlation coefficients of 0.9992 and 0.9996 for FWA 184 and FWA 393, respectively, and the detection limits are all 0.01 μg/L. The recoveries range from 91.1% to 105.3% and RSD (n=6) range from 2.7% to 6.4% at the spiked levels of 0.03, 0.3 and 3 μg/L. The migration levels of FWA 184 and FWA 393 are increased with the increase of storage temperature and storage time. The method is sensitive, accurate, and suits for determining the migration of FWA184 and FWA393 in food contact plastic container. ©, 2014, Journal of Chinese Mass Spectrometry Society. All right reserved.


Wang H.,Haidian District Institute of Products Quality Supervision and Inspection | Zhou X.-J.,Haidian District Institute of Products Quality Supervision and Inspection | Liu Y.-Q.,Haidian District Institute of Products Quality Supervision and Inspection | Yang H.-M.,Haidian District Institute of Products Quality Supervision and Inspection | Guo Q.-L.,Haidian District Institute of Products Quality Supervision and Inspection
Journal of Agricultural and Food Chemistry | Year: 2011

A reliable, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of chloramphenicol and aflatoxin M1 in milk has been developed. This method includes simple extraction of sample with acetonitrile, separation on a MGIII-C 18 column using 5 mM ammonium acetate aqueous solution/methanol (60:40, v/v) as mobile phase, and MS/MS detection using multiple reaction monitoring mode. The method was validated according to Commission Decision 2002/657/EC. The limits of detection (LODs) were 0.05 μg/kg for chloramphenicol and 0.005 μg/kg for aflatoxin M1. The limits of quantification (LOQs) were 0.2 μg/kg for chloramphenicol and 0.02 μg/kg for aflatoxin M1. The recovery values ranged from 88.8% to 100.6%, with relative standard deviation lower than 15% in all cases, when samples were fortified at three different concentrations. The decision limits (CCα) and detection capability (CCβ) of the method were also reported. This method has been successfully applied for simultaneous analysis of chloramphenicol and aflatoxin M1 residues in milk from local supermarkets in China. © 2011 American Chemical Society.


Wang H.,Haidian District Institute of Products Quality Supervision and Inspection | Zhao L.,Haidian District Institute of Products Quality Supervision and Inspection | Yang H.,Haidian District Institute of Products Quality Supervision and Inspection | Guo Q.,Haidian District Institute of Products Quality Supervision and Inspection | And 3 more authors.
Analytical Methods | Year: 2014

This study develops a gel permeation chromatography-high performance liquid chromatography-fluorescence detection (GPC-HPLC-FLD) method for determination of benzo(a)pyrene and aflatoxins (B1, B2, G1, G2) in vegetable oil. In the method, sample is extracted with ethyl acetate/cyclohexane (1 : 1, v/v), and cleaned up with the GPC. The separation of target compounds is performed on a Extend C18 column (4.6 × 250 mm, 5 μm) at 25 °C with methanol and 10 mmol L-1 ammonium acetate solution as mobile phase with gradient elution at a flow rate of 1.0 mL min-1. The injection volume was 10 μL, detection wavelengths were set at 360 nm (λex) and 440 nm (λem) at 0-23 min, and 380 nm (λex) and 408 nm (λem) at 23-35 min using FLD. The detection limits of benzo(a)pyrene and aflatoxins (B1, B2, G1, G2) were 0.5, 1.0, 1.0, 1.0 and 1.0 μg kg-1, respectively. The linear detection ranges of benzo(a)pyrene and aflatoxins (B1, B2, G1, G2) are 0.5-25.0 μg kg-1, 1.0-30.0 μg kg-1, 1.0-10.0 μg kg -1, 1.0-30.0 μg kg-1, 1.0-10.0 μg kg-1 with correlation coefficients (R2) of 0.9998, 0.9999, 0.9997, 0.9998, 0.9996, respectively. Recovery rates in vegetable oil spiked with target compounds are in the range of 82.6-101.6%, with the relative standard deviation of 4.85-9.84%. The real sample tests show that this simple and accurate method can be used for determination of benzo(a)pyrene and aflatoxins (B1, B2, G1, G2) in vegetable oil. © 2014 The Royal Society of Chemistry.


Liu Y.,Haidian District Institute of Products Quality Supervision and Inspection | Wang H.,Haidian District Institute of Products Quality Supervision and Inspection | Yang H.,Haidian District Institute of Products Quality Supervision and Inspection | Shi H.,Haidian District Institute of Products Quality Supervision and Inspection | Guo Q.,Haidian District Institute of Products Quality Supervision and Inspection
Chinese Journal of Chromatography (Se Pu) | Year: 2011

An analytical method based on high performance liquid chromatography with a diode array detector (HPLC-DAD) has been established for the simultaneous determination of 3 benzalkonium chloride homologs (n-C 12H 25-C 9H 13NCl, n-C 14H 29-C 9H 13NCl, TC-C 16H 33-C 9H 13NCl) in cosmetics. The sample was extracted with methanol (including 0.5% formic acid) under ultrasonic operation; the HPLC separation was carried out on a CAPCELL PAK SCX column (250 mm x4. 6 mm, 5 μxm), the mobile phases were 40 mmol/L ammonium acetate solution (including 0. 1% triethylamine) and acetonitrile with gradient elution, the Kflow rate was 1.0 mL/min, the detection wavelength was 260 nm, the column temperature was 25 t, and the injection volume was 20 μxL. The limit of detection was 50. 0 mg/kg and the quantitation limit was 200. 0 mg/kg for 3 benzalkonium chloride honaologs \m cosmetics. The linear plots were obtained between 5. 0 mg/L and 3 000. 0 mg/L. Overall recoveries were between 92. 5% and 102. 1% with the relative standard deviations (RSDs) between 3. 81% and 6. 66%. The methodis simpl, rapid, accurate and suitable for the determination of 3 benzalkonium chloride homo-logs in cosmetics.


Guo X.,Guangzhou Quality Supervision and Testing Institute | Mu T.,Haidian District Institute of Products Quality Supervision and Inspection | Xian Y.,Guangzhou Quality Supervision and Testing Institute | Luo D.,Guangzhou Quality Supervision and Testing Institute | Wang C.,Jinan University
Food Chemistry | Year: 2016

Organophosphate esters (OPEs) are common flame retardants that are used in a wide variety of products. These compounds might migrate into and pollute food products. An analytical method involving an improved approach called the "quick, easy, cheap, effective, rugged, and safe" (QuEChERS) method and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed to simultaneously measure trace levels of nine OPEs in milk powder. Separation of the nine OPEs was optimized on a reversed-phase column within 7 min. The stable isotope tri-n-butyl phosphate-d27 (TBP-d27) was used as an internal standard. This method was validated in terms of its linearity, sensitivity, precision, accuracy and matrix effects. Matrix-matched calibration curves were constructed with 1/x2 as the weighting factor for all of the target compounds resulting in coefficients of regression lines between 0.9938 and 0.9999. The average accuracy was between 73.5% and 110.2%. Intra- and inter-assay precisions for six replicates ranged from 3.9% to 8.9% or below 11%, respectively. The limits of detection (LODs) were in the range of 0.1-0.25 μg/kg, and the limits of quantification (LOQs) were below 1.5 μg/kg. Significant matrix effects have been observed, but suppression or enhancement of the signal was compensated for by the use of an isotopically labeled internal standard. This validated method was successfully applied to determine the concentrations of the OPEs in milk powder. © 2015 Published by Elsevier Ltd.


Han W.-Q.,Guangzhou Quality Supervision and Testing Institute | Luo H.-Y.,Guangzhou Quality Supervision and Testing Institute | Xian Y.-P.,Guangzhou Quality Supervision and Testing Institute | Luo D.-H.,Guangzhou Quality Supervision and Testing Institute | And 2 more authors.
Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis | Year: 2015

Sixty-four pieces of shark fin dried products (including real, fake and artificial shark fin products) and real products coated with gelatin were rapidly and nondestructively analyzed by attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR). The characteristic of IR spectrograms among the above four kinds of samples were systematically studied and comparied, the results showed that the spectrograms of the same kind of samples were repeatable, and different kinds of shark fin products presented significant differences in the spectrograms, which mainly manifested as the specific absorption peaks of amido bonds in protein (1650, 1544 cm-1) and skeletal vibration in polysaccharide (1050 cm-1). The spectrograms of real shark fins were characterized by the strong absorption peaks of protein characteristic amide I and II absorbent (1650, 1544 cm-1) and relatively weak C-O-C vibration absorbent (1050 cm-1) owing to the high content of protein and relatively low level of polysaccharide. For fake shark fin products that were molded form by mixing together with the offcut of shark, collagen and other substances, the introduction of non-protein materials leaded to the weaker amido bonds absorbent than real products along with a 30 cm-1 blue shift of amide I absorbent. Opposite to the real sample, the relatively strong absorption peak of polysaccharide (~1047 cm-1) and barely existed amide absorbent were the key features of the spectrogram of artificial samples, which was synthersized by polysaccharide like sodium alginate. Real samples coated with gelatin, the peak strength of protein and polysaccharide were decreased simultaneously when the data collection was taken at the surface of sample, while the spectrogram presented no significant difference to real samples when the data was collected in the section. The results above indicated that by analyzing the characteristic of IR spectrograms and the value range of Apro/Apol collected by ATR-FTIR method could perform the undamaged and rapid identification for shark fins. ©, 2014, Science Press. All right reserved.


Wang H.,Haidian District Institute of Products Quality Supervision and Inspection | Zhou X.J.,Haidian District Institute of Products Quality Supervision and Inspection | Liu Y.Q.,Haidian District Institute of Products Quality Supervision and Inspection | Yang H.M.,Haidian District Institute of Products Quality Supervision and Inspection | Guo Q.L.,Haidian District Institute of Products Quality Supervision and Inspection
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment | Year: 2010

A sensitive and reliable method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with an electrospray-positive ionization method was developed for the determination of aflatoxin M1 in milk. This method includes simple extraction of the sample with acetonitrile by ultrasonic, separation on an MGIII-C18 column using 0.01% formic acid buffer/acetonitrile (60:40, v/v) as mobile phase, and MS/MS detection using multiple reaction-monitoring mode. Average recoveries of aflatoxin M1 from spiked samples at concentrations of 0.02 and 1 ng ml-1 ranged from 77% to 94%, with a 6% relative standard deviation. The limit of detection and limit of quantification were 0.006 and 0.02 ng ml-1, respectively. The standard curve was linear between 0.02 and 20.0 ng ml-1. The recommended method is simple, rapid, specific and reliable for the routine monitoring of aflatoxin M1 in milk. © 2010 Taylor & Francis.


PubMed | Haidian District Institute of Products Quality Supervision and Inspection
Type: Journal Article | Journal: Journal of agricultural and food chemistry | Year: 2011

A reliable, rapid, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of chloramphenicol and aflatoxin M(1) in milk has been developed. This method includes simple extraction of sample with acetonitrile, separation on a MGIII-C(18) column using 5 mM ammonium acetate aqueous solution/methanol (60:40, v/v) as mobile phase, and MS/MS detection using multiple reaction monitoring mode. The method was validated according to Commission Decision 2002/657/EC. The limits of detection (LODs) were 0.05 g/kg for chloramphenicol and 0.005 g/kg for aflatoxin M(1.) The limits of quantification (LOQs) were 0.2 g/kg for chloramphenicol and 0.02 g/kg for aflatoxin M(1). The recovery values ranged from 88.8% to 100.6%, with relative standard deviation lower than 15% in all cases, when samples were fortified at three different concentrations. The decision limits (CC) and detection capability (CC) of the method were also reported. This method has been successfully applied for simultaneous analysis of chloramphenicol and aflatoxin M(1) residues in milk from local supermarkets in China.


PubMed | Haidian District Institute of Products Quality Supervision and Inspection
Type: Journal Article | Journal: Se pu = Chinese journal of chromatography | Year: 2011

An analytical method based on high performance liquid chromatography with a diode array detector (HPLC-DAD) has been established for the simultaneous determination of 3 benzalkonium chloride homologs (n-C12H25-C9H13NCl, n-C14H29-C9H13NCl, n-C16,H33-C9H13NCl) in cosmetics. The sample was extracted with methanol (including 0.5% formic acid) under ultrasonic operation, the HPLC separation was carried out on a CAPCELL PAK SCX column (250 mm x 4.6 mm, 5 microm), the mobile phases were 40 mmol/L ammonium acetate solution (including 0.1% triethylamine) and acetonitrile with gradient elution, the flow rate was 1.0 mL/min, the detection wavelength was 260 nm, the column temperature was 25 degrees C, and the injection volume was 20 microL. The limit of detection was 50.0 mg/kg and the quantitation limit was 200.0 mg/kg for 3 benzalkonium chloride homologs in cosmetics. The linear plots were obtained between 5.0 mg/L and 3000.0 mg/L. Overall recoveries were between 92.5% and 102.1% with the relative standard deviations (RSDs) between 3.81% and 6.66%. The method is simple, rapid, accurate and suitable for the determination of 3 benzalkonium chloride homologs in cosmetics.


PubMed | Guangzhou Quality Supervision and Testing Institute, University of Science and Technology of China and Haidian District Institute of Products Quality Supervision and Inspection
Type: | Journal: Food chemistry | Year: 2015

Organophosphate esters (OPEs) are common flame retardants that are used in a wide variety of products. These compounds might migrate into and pollute food products. An analytical method involving an improved approach called the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed to simultaneously measure trace levels of nine OPEs in milk powder. Separation of the nine OPEs was optimized on a reversed-phase column within 7 min. The stable isotope tri-n-butyl phosphate-d27 (TBP-d27) was used as an internal standard. This method was validated in terms of its linearity, sensitivity, precision, accuracy and matrix effects. Matrix-matched calibration curves were constructed with 1/x(2) as the weighting factor for all of the target compounds resulting in coefficients of regression lines between 0.9938 and 0.9999. The average accuracy was between 73.5% and 110.2%. Intra- and inter-assay precisions for six replicates ranged from 3.9% to 8.9% or below 11%, respectively. The limits of detection (LODs) were in the range of 0.1-0.25 g/kg, and the limits of quantification (LOQs) were below 1.5 g/kg. Significant matrix effects have been observed, but suppression or enhancement of the signal was compensated for by the use of an isotopically labeled internal standard. This validated method was successfully applied to determine the concentrations of the OPEs in milk powder.

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