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Ankara, Turkey

Ozturk M.,Gulhane Military Medical Academy | Ozler M.,Gulhane Military Medical Academy | Kurt Y.G.,Gulhane Military Medical Academy | Ozturk B.,Gulhane Military Medical Academy | And 14 more authors.
Journal of Pineal Research | Year: 2011

Doxorubicin (DOX) and Trastuzumab (TRAST) are effective agents for the treatment of many neoplastic diseases. Cardiotoxicity is a major side effect of these drugs and limit their use. In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG), or N-(3-(aminomethyl) benzyl) acetamidine (1400W) against the cardiotoxicity of DOX and TRAST were tested. Male Sprague-Dawley rats received an injection of DOX (20 mg/kg) alone or in combination with TRAST (10 mg/kg) to induce cardiotoxicity; daily treatments with MEL (10 mg/kg à - 2), MEG (10 mg/kg à - 2), or 1400W (10 mg/kg à - 2) were begun 36 hr before and continued for 72 hr after DOX and TRAST administration. Oxidant/antioxidant indices of the cardiac tissue, namely, malondialdehyde, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as serum levels of creatine phosphokinase (CK-MB) were measured. Additionally, the injury scores were evaluated histopathologically. Malondialdehyde levels were significantly higher, while SOD and GSH-Px activities were significantly reduced in rats with DOX- or DOX+TRAST-induced cardiotoxicity compared to normal values. All three treatment agents significantly reversed oxidative stress markers. Serum CK-MB levels were significantly increased after treatment with DOX and DOX+TRAST; these changes were also reversed by each of the treatments and resulted in near normal levels. Both the DOX- and DOX+TRAST-treated rats presented similar histopathologic injuries; in the animals treated with the protective agents, histologic protection of the cardiac tissue was apparent. These results suggested that MEL, MEG, as well as 1400W are effective in preventing DOX- or DOX+TRAST-induced cardiotoxicity. © 2010 John Wiley & Sons A/S. Source

Gulcelik N.E.,Hacettepe Medical School | Haul M.,Hacettepe Medical School | Ariogul S.,Hacettepe Medical School | Usman A.,Hacettepe Medical School
Minerva Endocrinologica | Year: 2013

Adipose tissue is an active metabolic organ secreting adipocytokines which are involved in the energy homeostasis and regulation of glucose and lipid metabolism. Aging is associated with fat redistribution, which is characterized by loss of peripheral subcutaneous fat and accumulation of visceral fat. Visceral adipose tissue is more involved in the developement of metabolic diseases than subcutaneous adipose tissue. Aging also alters the function, proliferation, size, and number of adipose cells which leads to alterations in the secretion, synthesis and function of the adipocytokines. Adiponectin is an insulin sensitizing, anti-inflammatory, and antiathoregenic adipokine. Centarians have higher adiponectin levels associated with longevity. However, in older individuals - age 65 or more - adiponectin is associated with higher mortality. Dysregulation of adiponectin in older individuals may be due to loss of function of circulating adiponectin or a response to increased inflammatory process. Longitidunal increase in adiponectin levels 5with aging rather than genetically high adiponectin levels may translate to increased mortality in older patients. The adipocytokine leptin is traditionally viewed as a product of adipocytes that can exert endocrine effects. There have been conflicting reports of not only the effects of aging on leptin, but also the effects of leptin on age-related diseases including sarcopenia, Alzheimer's disease and cardiovascular diseases. Aging is also associated with resistance to leptin and/or to a decrease of receptors for this hormone. In this review, we briefly discuss the role of two major adipocytokines adiponectin and leptin in the aging process and age-related diseases. Source

Yesilkaya Y.,Hacettepe Medical School | Demirbas B.,Hacettepe Medical School | Gokoz O.,Hacettepe Medical School | Akata D.,Hacettepe Medical School
Journal of Diagnostic Medical Sonography | Year: 2012

Eccrine spiradenoma is a well-recognized benign tumor arising from the intradermal straight portion of the eccrine or merocrine sweat glands. It is usually a small, solitary lesion in the cutis and the subcutaneous tissues. As with other lesions in the cutis and the subcutaneous tissue, few cases describing the sonographic findings of eccrine spiradenoma have been reported. This case study demonstrates these sonography findings in a case of eccrine spiradenoma distributed in the right thigh. © The Author(s) 2012. Source

Gulcelik N.E.,Hacettepe Medical School | Bayraktar M.,Hacettepe Medical School | Caglar O.,Hacettepe Medical School | Alpaslan M.,Hacettepe Medical School | Karakaya J.,Hacettepe Medical School
Experimental and Clinical Endocrinology and Diabetes | Year: 2011

Aim: Type 2 diabetic patients have an increased incidence of hip fracture. In this study, we aimed to evaluate the mortality rate after hip fracture and determine the predictors of mortality in diabetic patients. Methods: 356 patients who sustained a hip fracture between January 1997 and June 2008 were retrospectively reviewed for the study. Of the eligible 230 patients, 69 had type 2 diabetes. Each of these patients medical and nursing notes were reviewed to ascertain additional information, including patient demographic factors, prior co-morbidities, fracture type, length of post-fracture stay and post-operative complications, the presence and duration of diabetes, glucose levels, HbA1c levels, albumin and hemoglobin levels. Results: 148 women (64.3%) and 82 men (35.7%) were included in the study. The mean age of the study group was 76.1±10.4 years. The mean age for diabetics was 76.1±12.0 years and was 75.1±9.4 years for non-diabetics (p=0.343). Diabetic patients with hip fracture had a higher risk of mortality than the non-diabetic patients. One year survival probabilities of diabetic and non-diabetic patients were respectively 68.0% and 87.3% (p=0.033). In diabetic patients with a hip fracture, predictors of mortality were advanced age, the presence of postoperative complications and elevated HbA1c levels. Conclusions: Diabetic patients have an increased risk of mortality after hip fracture. The medical care in the post-operative period, including glycemic control and postoperative complications, should be optimized in diabetic patients suffering from hip fracture in order to decrease mortality in these patients. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York. Source

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