Miguel Servet

Martín Miguel, Spain

Miguel Servet

Martín Miguel, Spain
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Ciga Lozano M.T.,Complejo Hospitalario Of Navarra | Codina Cazador A.,Hospital Josep Trueta | Ortiz Hurtado H.,Public University of Navarra | Lujan J.,Virgen de la Arrixaca | And 42 more authors.
Cirugia Espanola | Year: 2015

Objective: This multicentre observational study aimed to compare outcomes of anterior resection (AR) and abdominal perineal resection (APR) in patients treated for rectal cancer. Methods: Between March 2006 and March 2009 a cohort of 1,598 patients diagnosed with low and mid rectal cancer were operated on in the first 38 hospitals included in the Spanish Rectal Cancer Project. In 1,343 patients the procedure was considered curative. Clinical and outcome results were analysed in relation to the type of surgery performed. All patients were included in the analysis of clinical results. The analysis of outcomes was performed only on patients treated by a curative procedure. Results: Of the 1,598 patients, 1,139 (71.3%) underwent an AR and 459 (28.7%) an APR. In 1,343 patients the procedure was performed with curative intent; from these 973 (72.4%) had an AR and 370 (27.6%) an APR. There were no differences between AR and APR in mortality (29 vs. 18 patients; P=.141). After a median follow up of 60.0 [49.0-60.0] months there were no differences in local recurrence (HR 1.68 [0.87-3.23]; P=.12), metastases (HR 1.31 [0.98-1.76]; P=.064). However, overall survival was worse after APR (HR 1.37 [1.00-1.86]; P=.048). Conclusion: This study did not identify abdominoperineal excision as a determinant of local recurrence or metastases. However, patients treated by this operation have a decreased overall survival. © 2014 AEC.


Effect of melatonin implants and flock mates on mating performance of rams To evaluate the effect of melatonin implants on mounting capacity of the rams in spring, both in group and individually, 6 males received three implants on February (M), while another 6 males remained as control (C). In late March, 60 ewes were synchronized in estrus and divided into 3 groups (n = 20), introducing 4 males in each group (2M+2C). During six hours a sexual test was performed, recording the number of services and mounts, and the interval between services. Four days later, 60 ewes were divided into 12 groups (n = 5), introducing one male in each group to run single tests. Treated males showed a greater sexual activity than control ones (C: 24.5 ± 3.0; M: 25.9 ± 2.3 mounts+services; P < 0.05) anda shorter interval between services (C: 36.6 ± 6.6; M: 27.6 ± 2.1 min; P < 0.05). In group rams were able to mount and serve a greater number of times than individually (Group: 27.8 ± 3.1; Individual: 22.6 ± 1.8; P < 0.05). In conclusion, treatment of rams with melatonin implants in spring resulted in an increased number and frequency of mounting activity. Moreover, a higher sexual activity was observed when rams were in group. © 2015, Asociacion Interprofesional para el Desarrollo Agrario. All rights reserved.


Ortiz H.,Public University of Navarra | Wibe A.,Norwegian University of Science and Technology | Ciga M.A.,Complejo Hospitalario Of Navarra | Kreisler E.,University of Barcelona | And 97 more authors.
Diseases of the Colon and Rectum | Year: 2014

BACKGROUND: A surgical teaching and auditing program has been implemented to improve the results of treatment for patients with rectal cancer. OBJECTIVE: The aim of this study was to assess the treatment and outcome in patients resected for rectal cancer, focusing on differences relating to the type of resection. DESIGN: This was an observational study. SETTINGS: The study took place throughout the network of hospitals that compose the National Health Service in Spain. PATIENTS: This study included a consecutive cohort of 3355 patients from the Spanish Rectal Cancer Project. The data of patients who were operated on electively, with curative intent, by anterior resection (n = 2333 [69.5%]), abdominoperineal excision (n = 774 [23.1%]), and Hartmann procedure (n = 248 [7.4%]) between March 2006 and May 2010 were analyzed. MAIN OUTCOME MEASURES: Clinical, pathologic, and outcome results were analyzed in relation to the type of surgery performed. RESULTS: After a median follow-up time of 37 months (interquartile range, 30-48 months), bowel perforations were found to be more common in the Hartmann procedure (12.6%) and abdominoperineal groups (10.1%) than in the anterior resection group (2.3%; p < 0.001). Involvement of the circumferential resection margin was also more common in the Hartmann (16.6%) and abdominoperineal groups (14.3%) than in the anterior resection group (6.6%; p < 0.001). Multivariate analysis showed a negative influence on local recurrence, metastasis, survival for advanced stage, intraoperative perforation, invaded circumferential margin, and Hartmann procedure. However, abdominoperineal excision did not significantly influence local recurrence (HR, 0.945; 95% CI, 0.571- 1.563; p = 0.825). LIMITATIONS: The main weakness of this study was the voluntary nature of registration in the Spanish Rectal Cancer Project. CONCLUSIONS: Although bowel perforation and involvement of the circumferential resection margin were more common after abdominoperineal excision than after anterior resection, this study did not identify abdominoperineal excision as a determinant of local recurrence in the context of 3 years of median follow-up. © The ASCRS 2014.


News Article | November 22, 2016
Site: www.eurekalert.org

High concordance rates were observed between diagnoses obtained using a simplified minimally invasive autopsy method and those determined from complete autopsies in a series of deceased adult patients in Mozambique, according to research published in PLOS Medicine by Jaume Ordi and colleagues from ISGlobal, Universitat de Barcelona, Barcelona, Spain. In a linked research article, Khátia Munguambe and colleagues from the Centro de Investigação em Saúde da Manhiça, Universidade Eduardo Mondlane, Maputo, Mozambique, observed that the hypothetical acceptability of the minimally invasive autopsy and willingness to know the cause of death were high across five settings in Gabon, Kenya, Mali, Mozambique, and Pakistan. While complete autopsies are considered the gold standard for the determination of cause of death, they are poorly accepted and difficult to perform in low- and middle- income countries. The simplified minimally invasive autopsy, which consists of histological and microbiological analyses of blood samples, cerebrospinal fluid samples, and tissue samples from solid organs using biopsy needles, could be an alternative method to the complete autopsy. In the first study, the researchers compared the cause of death identified in 112 deceased adult patients using a minimally invasive method with the cause of death identified from a complete autopsy. They observed 75.9% concordance rates between the diagnosis obtained with the minimally invasive autopsy and the gold standard diagnosis, with a particularly high agreement for infectious diseases. In the second study, a mixed-methods approach was used to conduct 504 interviews with different informants, including those who had recently lost a family member, in five different countries. They found that 75% of the participants would be willing to know the cause death of a relative and that the overall hypothetical acceptability of minimally invasive autopsy on a relative was 73%. Overall, these two studies provide support for the feasibility and validity of the minimally invasive autopsy method to be used in low-and middle-income settings to allow reliable estimates of cause of death. In a linked Perspective, Peter Byass of Umeå University, Umeå, Sweden reflects on the potential challenges for minimally invasive autopsies to become routinely used for determining cause of death in low- and middle-income countries. He says "MIA shows signs of being an important addition to the world's available range of cause-of-death assignment methods." Funding: The CaDMIA research project (Validation of the minimally invasive autopsy tool for cause of death investigation in developing countries) is funded by the Bill & Melinda Gates Foundation (Global Health grant number OPP1067522) and by the Spanish Instituto de Salud Carlos III (FIS, PI12/00757). QB has a fellowship from the program Miguel Servet of the ISCIII (Plan Nacional de I+D+I 2008-2011, grant number: CP11/00269). ML is a 1D researcher from CNPq. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: CM is a member of the Editorial Board of PLOS Medicine. Citation: Castillo P, Martínez MJ, Ussene E, Jordao D, Lovane L, Ismail MR, et al. (2016) Validity of a Minimally Invasive Autopsy for Cause of Death Determination in Adults in Mozambique: An Observational Study. PLoS Med 13(11): e1002171. doi:10.1371/journal.pmed.1002171 Author Affiliations: ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain Department of Microbiology, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain Department of Pathology, Maputo Central Hospital, Maputo, Mozambique Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique Department of Medicine, Maputo Central Hospital, Maputo, Mozambique Fundação de Medicina Tropical Doutor Heitor Viera Dourado, Manaus, Amazonas, Brazil Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain Department of Pathology, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona, Spain IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://journals. Funding: This study was conducted as part of the project "Validation of the Minimally Invasive Autopsy (MIA) tool for cause of death investigation in developing countries", funded by the Bill and Melinda Gates Foundation (OPP1067522) and the Fondo de Investigaciones Sanitarias (FIS) program (ISCIII, PI12/00757). QB has a fellowship from the program Miguel Servet of the ISCIII (Plan Nacional de I+D+I 2008-2011, grant number: CP11/00269). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: I have read the journal's policy and the authors of this manuscript have the following competing interests: ZAB and CM are members of the Editorial Board of PLOS Medicine. Citation: Maixenchs M, Anselmo R, Zielinski-Gutiérrez E, Odhiambo FO, Akello C, Ondire M, et al. (2016) Willingness to Know the Cause of Death and Hypothetical Acceptability of the Minimally Invasive Autopsy in Six Diverse African and Asian Settings: A Mixed Methods Socio-Behavioural Study. PLoS Med 13(11): e1002172. doi:10.1371/journal.pmed.1002172 Author Affiliations: Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain Centers for Disease Control and Prevention (CDC-Kenya), Nairobi, Kenya Kenya Medical Research Institute, Centre for Global Health Research, Kisumu, Kenya Centre of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada Centre pour le Développement des Vaccins (CVD-Mali), Bamako, Mali Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany Department of Pathology, Maputo Central Hospital, Maputo, Mozambique Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://journals. Funding: No specific funding was received for this work. Competing Interests: PB is a member of the Editorial Board of PLOS Medicine. Author Affiliations: WHO Collaborating Centre for Verbal Autopsy, Epidemiology & Global Health, Dept. of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden MRC-Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER: http://journals.


Borobia M.,Miguel Servet | Ortin A.,Miguel Servet | Ferrer L.M.,Miguel Servet | Ramos J.J.,Miguel Servet | And 2 more authors.
Canadian Journal of Veterinary Research | Year: 2014

Ovine pulmonary adenocarcinoma (OPA) is a transmissible lung cancer caused by Jaggsiekte sheep retrovirus (JSRV). It is difficult to identify animals infected with JSRV but are clinically healthy. The virus does not induce a specific antibody response and, although proviral DNA sequences of JSRV can be found in mononuclear blood cells, the detection is inconsistent. The aim of this study was to investigate the presence of JSRV in the bone marrow of infected sheep and develop a more consistent screening method. Immunohistochemical examination of bone marrow samples from 8 asymptomatic JSRV-infected sheep revealed the presence of positively labelled cells. However, JSRV could not be detected by a highly sensitive polymerase chain reaction (PCR) in bone marrow aspirates periodically collected from these animals. Results suggest that JSRV-infected cells may be present in the bone marrow of symptomless animals, but the number is below the detectable level for PCR. Therefore, this technique does not seem to be helpful for preclinical diagnosis of OPA.


Olaizola A.M.,Miguel Servet | Ameen F.,Assiut University | Ameen F.,King Faisal University | Manrique E.,Miguel Servet
Livestock Science | Year: 2015

In the Mediterranean regions, sheep farming systems are mostly located in less favoured areas and play a multifunctional role. Nevertheless, those systems have experienced a strong decline in the last decades, which has led to the abandonment of pasturelands and other socio-economic changes in some areas. Traditionally, sheep farming systems are associated to cereal crops and remain common in Mediterranean areas. The objectives of this study were (i) to evaluate the possible adaptation strategies for sheep-crop mixed systems in the Sierra and Cañones de Guara Natural Park (SCGNP) to changes in the agricultural policy measures and the labour market, and (ii) to approximate the value of grazing as an environmental function provided by these systems. Four types of mixed sheep-crop systems (MSCS) in SCGNP were established in a previous typology (Bernués et al., 2004. Cahiers Options Méditerranéennes 62, 195-198). In 2007-2008, a survey was carried out 46 farms (95% of sheep farms that used the Natural Park). From that information, four farms were selected, one for each type of MSCS to be modeled. Mixed linear programming models were developed. Five socio-economic scenarios were simulated depending on CAP conditions, availability of labour (farmer pluriactivity), and prioritization of grazing. Under the scenario of total decoupling of the CAP subsidies, the best Gross Margin was obtained by the mixed farm with large flock and oriented to cereal cultivation (MSCS3) and the mixed farm with a large flock (MSCS2), but labour productivity was highest in the most cereal-oriented mixed systems. Off-farm work was economically profitable in the majority of the MSCS, which may lead to a decrease in the livestock farming activity and changes in land use with a reduction in the area leased for grazing, and in the area used for the cultivation of lucerne and sainfoin. Under current conditions (total decoupling of subsidies, high cereal prices), the total production of barley was sold, i.e., not fed to livestock. In contrast, in the scenarios of no subsidies, maximization of the use of pastures, or reduction of barley price, the farmhouse barley consumption for feeding livestock increased. The most livestock oriented farm (MSCS2) was the type of mixed farming system that should receive the least economic compensation for grazing as an environmental function provided by this farm and the most cereal-oriented systems required the most compensation. Nevertheless, the MSCS studied were highly diverse in the distribution of land use and trade-offs exist among the environmental functions performed by them. © 2015 Elsevier B.V.

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