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Codina Cazador A.,Hospital Josep Trueta | Ortiz Hurtado H.,Public University of Navarra | Faccalvieri D.,Bellvitge | Biondo S.Sebastiano,Bellvitge | And 13 more authors.
Cirugia Espanola | Year: 2015

Objective: This multicentre observational study aimed to compare outcomes of anterior resection (AR) and abdominal perineal resection (APR) in patients treated for rectal cancer. Methods: Between March 2006 and March 2009 a cohort of 1,598 patients diagnosed with low and mid rectal cancer were operated on in the first 38 hospitals included in the Spanish Rectal Cancer Project. In 1,343 patients the procedure was considered curative. Clinical and outcome results were analysed in relation to the type of surgery performed. All patients were included in the analysis of clinical results. The analysis of outcomes was performed only on patients treated by a curative procedure. Results: Of the 1,598 patients, 1,139 (71.3%) underwent an AR and 459 (28.7%) an APR. In 1,343 patients the procedure was performed with curative intent; from these 973 (72.4%) had an AR and 370 (27.6%) an APR. There were no differences between AR and APR in mortality (29 vs. 18 patients; P=.141). After a median follow up of 60.0 [49.0-60.0] months there were no differences in local recurrence (HR 1.68 [0.87-3.23]; P=.12), metastases (HR 1.31 [0.98-1.76]; P=.064). However, overall survival was worse after APR (HR 1.37 [1.00-1.86]; P=.048). Conclusion: This study did not identify abdominoperineal excision as a determinant of local recurrence or metastases. However, patients treated by this operation have a decreased overall survival. © 2014 AEC. Source


Olaizola A.M.,Miguel Servet | Ameen F.,Assiut University | Ameen F.,King Faisal University | Manrique E.,Miguel Servet
Livestock Science | Year: 2015

In the Mediterranean regions, sheep farming systems are mostly located in less favoured areas and play a multifunctional role. Nevertheless, those systems have experienced a strong decline in the last decades, which has led to the abandonment of pasturelands and other socio-economic changes in some areas. Traditionally, sheep farming systems are associated to cereal crops and remain common in Mediterranean areas. The objectives of this study were (i) to evaluate the possible adaptation strategies for sheep-crop mixed systems in the Sierra and Cañones de Guara Natural Park (SCGNP) to changes in the agricultural policy measures and the labour market, and (ii) to approximate the value of grazing as an environmental function provided by these systems. Four types of mixed sheep-crop systems (MSCS) in SCGNP were established in a previous typology (Bernués et al., 2004. Cahiers Options Méditerranéennes 62, 195-198). In 2007-2008, a survey was carried out 46 farms (95% of sheep farms that used the Natural Park). From that information, four farms were selected, one for each type of MSCS to be modeled. Mixed linear programming models were developed. Five socio-economic scenarios were simulated depending on CAP conditions, availability of labour (farmer pluriactivity), and prioritization of grazing. Under the scenario of total decoupling of the CAP subsidies, the best Gross Margin was obtained by the mixed farm with large flock and oriented to cereal cultivation (MSCS3) and the mixed farm with a large flock (MSCS2), but labour productivity was highest in the most cereal-oriented mixed systems. Off-farm work was economically profitable in the majority of the MSCS, which may lead to a decrease in the livestock farming activity and changes in land use with a reduction in the area leased for grazing, and in the area used for the cultivation of lucerne and sainfoin. Under current conditions (total decoupling of subsidies, high cereal prices), the total production of barley was sold, i.e., not fed to livestock. In contrast, in the scenarios of no subsidies, maximization of the use of pastures, or reduction of barley price, the farmhouse barley consumption for feeding livestock increased. The most livestock oriented farm (MSCS2) was the type of mixed farming system that should receive the least economic compensation for grazing as an environmental function provided by this farm and the most cereal-oriented systems required the most compensation. Nevertheless, the MSCS studied were highly diverse in the distribution of land use and trade-offs exist among the environmental functions performed by them. © 2015 Elsevier B.V. Source


Ortiz H.,Public University of Navarra | Wibe A.,Norwegian University of Science and Technology | Ciga M.A.,Complejo Hospitalario de Navarra | Kreisler E.,University of Barcelona | And 31 more authors.
Diseases of the Colon and Rectum | Year: 2014

BACKGROUND: A surgical teaching and auditing program has been implemented to improve the results of treatment for patients with rectal cancer. OBJECTIVE: The aim of this study was to assess the treatment and outcome in patients resected for rectal cancer, focusing on differences relating to the type of resection. DESIGN: This was an observational study. SETTINGS: The study took place throughout the network of hospitals that compose the National Health Service in Spain. PATIENTS: This study included a consecutive cohort of 3355 patients from the Spanish Rectal Cancer Project. The data of patients who were operated on electively, with curative intent, by anterior resection (n = 2333 [69.5%]), abdominoperineal excision (n = 774 [23.1%]), and Hartmann procedure (n = 248 [7.4%]) between March 2006 and May 2010 were analyzed. MAIN OUTCOME MEASURES: Clinical, pathologic, and outcome results were analyzed in relation to the type of surgery performed. RESULTS: After a median follow-up time of 37 months (interquartile range, 30-48 months), bowel perforations were found to be more common in the Hartmann procedure (12.6%) and abdominoperineal groups (10.1%) than in the anterior resection group (2.3%; p < 0.001). Involvement of the circumferential resection margin was also more common in the Hartmann (16.6%) and abdominoperineal groups (14.3%) than in the anterior resection group (6.6%; p < 0.001). Multivariate analysis showed a negative influence on local recurrence, metastasis, survival for advanced stage, intraoperative perforation, invaded circumferential margin, and Hartmann procedure. However, abdominoperineal excision did not significantly influence local recurrence (HR, 0.945; 95% CI, 0.571- 1.563; p = 0.825). LIMITATIONS: The main weakness of this study was the voluntary nature of registration in the Spanish Rectal Cancer Project. CONCLUSIONS: Although bowel perforation and involvement of the circumferential resection margin were more common after abdominoperineal excision than after anterior resection, this study did not identify abdominoperineal excision as a determinant of local recurrence in the context of 3 years of median follow-up. © The ASCRS 2014. Source


Effect of melatonin implants and flock mates on mating performance of rams To evaluate the effect of melatonin implants on mounting capacity of the rams in spring, both in group and individually, 6 males received three implants on February (M), while another 6 males remained as control (C). In late March, 60 ewes were synchronized in estrus and divided into 3 groups (n = 20), introducing 4 males in each group (2M+2C). During six hours a sexual test was performed, recording the number of services and mounts, and the interval between services. Four days later, 60 ewes were divided into 12 groups (n = 5), introducing one male in each group to run single tests. Treated males showed a greater sexual activity than control ones (C: 24.5 ± 3.0; M: 25.9 ± 2.3 mounts+services; P < 0.05) anda shorter interval between services (C: 36.6 ± 6.6; M: 27.6 ± 2.1 min; P < 0.05). In group rams were able to mount and serve a greater number of times than individually (Group: 27.8 ± 3.1; Individual: 22.6 ± 1.8; P < 0.05). In conclusion, treatment of rams with melatonin implants in spring resulted in an increased number and frequency of mounting activity. Moreover, a higher sexual activity was observed when rams were in group. © 2015, Asociacion Interprofesional para el Desarrollo Agrario. All rights reserved. Source


Borobia M.,Miguel Servet | Ortin A.,Miguel Servet | Ferrer L.M.,Miguel Servet | Ramos J.J.,Miguel Servet | And 2 more authors.
Canadian Journal of Veterinary Research | Year: 2014

Ovine pulmonary adenocarcinoma (OPA) is a transmissible lung cancer caused by Jaggsiekte sheep retrovirus (JSRV). It is difficult to identify animals infected with JSRV but are clinically healthy. The virus does not induce a specific antibody response and, although proviral DNA sequences of JSRV can be found in mononuclear blood cells, the detection is inconsistent. The aim of this study was to investigate the presence of JSRV in the bone marrow of infected sheep and develop a more consistent screening method. Immunohistochemical examination of bone marrow samples from 8 asymptomatic JSRV-infected sheep revealed the presence of positively labelled cells. However, JSRV could not be detected by a highly sensitive polymerase chain reaction (PCR) in bone marrow aspirates periodically collected from these animals. Results suggest that JSRV-infected cells may be present in the bone marrow of symptomless animals, but the number is below the detectable level for PCR. Therefore, this technique does not seem to be helpful for preclinical diagnosis of OPA. Source

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