Hubei Research Institute of Chemistry

Wuhan, China

Hubei Research Institute of Chemistry

Wuhan, China
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Liao G.,Wuhan University | Jiang K.,Wuhan University | Jiang S.,Hubei Research Institute of Chemistry | Xia H.,Wuhan University
Journal of Macromolecular Science, Part A: Pure and Applied Chemistry | Year: 2010

A series of multi-block copolymers, poly(L-lactide)-b-poly (-caprolactone) (PLLA-b-PCL) were synthesized. The first step of the synthesis consisted of the transesterification between the PLLA and 1,4-Butanediol, followed by the copolymerization of PLLA-diols and PCL, using isophorone diisocyanate (IPDI) as a coupling agent. The synthesized polymers were characterized by Fourier transform infrared (FTIR) spectra, differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). PLLA/PCL block copolymers were electrospun into ultrafine fibers. The morphology of the electrospun fibrous scaffolds were investigated by Scanning Electron Microscopy (SEM). Results showed that the morphology and diameter of the fibers were affected by the electrospinning solution concentrationan and different weight ratio of PLLA/PCL. These electrospun PLLA-b-PCL fibrous membranes exhibited good flexibility and deformability. In comparison with the electrospun PLLA membrane, the electrospun fibrous membranes of PLLA-b-PCL demonstrated an enhanced elongation with still high tensile strength and Young's modulus to be beneficial for tissue engineering scaffolds. Copyright © Taylor & Francis Group, LLC.


Wu Y.,Wuhan University | Zeng M.,Wuhan University | Zeng M.,University of Sichuan | Xu Q.,Hubei Research Institute of Chemistry | And 4 more authors.
Tribology International | Year: 2012

The present study is to examine the effects of glass-to-rubber transition of resin matrix on the friction and wear characteristics of friction materials, in relation to different types of thermosetting resins. Dynamic mechanical thermal analysis and friction test results revealed that glass-to-rubber transition of thermosetting resins influenced significantly the friction and wear behavior of the composite materials. There was a significant increasing tendency in friction coefficient and wear rate values for all composites when braking temperatures increased to 200 or 250 °C, accompanying the resin matrix converted from glassy state to rubbery state. © 2012 Elsevier Ltd. All rights reserved.


He X.,Wuhan University | Zhong M.,Hubei Research Institute of Chemistry | Zhang T.,Wuhan University | Yang J.,Hubei University for Nationalities | And 5 more authors.
European Journal of Medicinal Chemistry | Year: 2012

In the present study on the development of new anticonvulsants, 16 new1-(8-(benzyloxy)quinolin-2-yl-6-substituted-4,6-diazaspiro[2,4]heptane-5, 7-diones were synthesized and tested for anticonvulsant activity using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) screens, which are the most widely employed seizure models for early identification of candidate anticonvulsants. Their neurotoxicity was determined applying the rotorod test. Two compounds 8e and 8j showed promising anticonvulsant activities in both models employed for anticonvulsant evaluation. The most active compound 8e showed the MES-induced seizures with ED 50 value of 8.6 mg/kg and TD 50 value of 365.3 mg/kg after intraperitoneally injection to mice, which provided compound 8e with a protective index (TD 50/ED 50) of 26.8 in the MES test. © 2011 Elsevier Ltd. All rights reserved.


Jiang S.,Wuhan University | Jiang S.,Hubei Research Institute of Chemistry | Liao G.,Wuhan University
Polymer - Plastics Technology and Engineering | Year: 2012

A series of multiblock copolymer, Poly(L-lactide)-b-Poly(ethylene glycol) (PLLA-b-PEG) were synthesized and characterized by Fourier transform infrared spectra, differential scanning calorimetry and wide angle X-ray diffraction. PLLA-b-PEG fibrous scaffolds were prepared by electrospinning. The morphology of the fibers was affected by the solution concentration and different weight ratio of PLLA/PEG. In comparison with the electrospun PLLA membrane, the electrospun fibrous membranes of PLLA-b-PEG demonstrated an enhanced water absorption percentage and reductive water contact angle. The electrospun PLLA-b-PEG with weight ratio 90/10 and 75/25 fibrous membranes exhibited good flexibility and deformability to be beneficial for tissue engineering scaffolds. © 2012 Copyright Taylor and Francis Group, LLC.


Zeng M.,Wuhan University | Zeng M.,University of Sichuan | Wang J.,Wuhan University | Li R.,Wuhan University | And 5 more authors.
Polymer (United Kingdom) | Year: 2013

Two series of benzoxazine (BOZ) based composites were prepared with graphene oxide (GO) and graphite via in situ intercalative polymerization. Based on isothermal and non-isothermal mode Differential Scanning Calorimetry results, BOZ with the addition of GO could not only decrease the cure temperature, but also increase the cure rate of BOZ. On the contrary, BOZ with the addition of graphite would delay the polymerization of BOZ monomer. It was hypothesized that carboxyl groups of GO acted as weak organic acid which accelerated the ring opening procedure. Interestingly, BOZ/GO composite with 1 wt% GO occupied the least time to form polymer networks, attributing to the catalytic effect and good dispersion of GO. Moreover, BOZ with 1 wt% content of GO had relatively higher glass transition temperature and char yield than those of the corresponding BOZ/graphite sample, which was due to relatively stronger intermolecular interactions between GO and BOZ. © 2013 Elsevier Ltd. All rights reserved.


Huang Y.,Wuhan University | Zeng M.,Wuhan University | Zeng M.,University of Sichuan | Ren J.,Wuhan University | And 4 more authors.
Colloids and Surfaces A: Physicochemical and Engineering Aspects | Year: 2012

A series of novel graphene oxide (GO)/poly(acrylic acid- co-acrylamide) super-absorbent hydrogel nanocomposites were prepared by in situ radical solution polymerization. The effects of GO content on the chemical structure, morphology and miscibility of the hydrogels were studied. The swelling behaviors, swelling kinetics and pH-responsive behaviors of the hydrogels were also evaluated. Owing to the hydrogen bonds and possible covalent bonds between GO and polymer chains, relatively lower content (<0.30. wt%) of GO could be dispersed well in the polymer matrix and enhanced the intermolecular interactions between the components effectively. On the contrary, an excessive amount of GO might form large agglomerates and weakened the interfacial interactions, resulting in the micro-phase separation between the components. Furthermore, the swelling capacities and swelling rates of hydrogels went up with increasing GO loadings to 0.30. wt% and then decreased with further increasing GO loadings. It is worth noting that the hydrogel only containing 0.10. wt% GO exhibited significant improvement of swelling capacity in neutral medium, and could also retain relatively higher swelling capacities to a certain degree at acidic and basic solutions. Therefore, the as-prepared GO-based super-absorbent hydrogels might have potential applications in many areas, such as biomedical engineering, construction engineering and hygienic products. © 2012 Elsevier B.V.


Wu Y.,Wuhan University | Zeng M.,Wuhan University | Zeng M.,University of Sichuan | Jin H.,Wuhan University | And 5 more authors.
Tribology Letters | Year: 2012

The present work is a generic study to examine the effects of the glass-to-rubber transition of resin matrix on the friction and wear characteristics of zirconium oxide (ZrO 2) reinforced polybenzoxazine nanocomposites, in relation to the content of ZrO 2. The thermal and tribological properties of the nanocomposites were measured by dynamic mechanical thermal analysis (DMA) and friction test, respectively. DMA results revealed that the storage modulus and T g values of the nanocomposites increased with increasing ZrO 2 content to 4 wt%, due to the exceptional mechanical strength of ZrO 2 particles and the interfacial adhesion between ZrO 2 and matrix to restrict the segmental motion of polymer. The friction coefficient (COF) values as a function of applied load (50-750 N) for the nanocomposites under testing temperatures (50, 100, 200, 250, and 300 °C) were measured. Comparable to the pure resin, the nanocomposites possessed relatively higher COF values with the increase of applied pressure under varying temperatures, which resulted from the reinforcement of ZrO 2. It is noted that the nanocomposites containing 4 wt% ZrO 2 occupied relatively higher modulus and glass transition temperature, resulting in better capability to stabilize the friction coefficient and wear rate under the applied conditions. In addition, the friction mechanism of the nanocomposites were proposed based on the experimental and reference results. © Springer Science+Business Media, LLC 2012.


Liao G.,Wuhan University | Jiang S.,Hubei Research Institute of Chemistry | Xu X.,Hubei Research Institute of Chemistry | Ke Y.,Wuhan University
Materials Letters | Year: 2012

Aligned poly(l-lactide) (PLLA)/poly(ε-caprolactone) (PCL)/hydroxyapatite (HA) composite fibrous membranes were fabricated by electrospinning. Their morphology, porosity, water contact angle and in vitro degradation behaviors were investigated. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) indicated that the electrospun fibers are highly aligned and the HA are oriented along the fiber axis. The PLLA/PCL/HA composite fibers become thinner when HA are incorporated. The energy dispersion spectroscopy (EDS) demonstrated the existence of HA in the PLLA/PCL fibers. In addition, the larger porosity and higher hydrophilic properties induced by HA in the electrospun fibers have improved the biodegradation of the PLLA/PCL/HA fibrous membranes. © 2012 Elsevier B.V. All rights reserved.


Yu F.,Huazhong University of Science and Technology | Li L.,HuBei Research Institute of Chemistry | Chen F.,Huazhong University of Science and Technology | Liu W.,Huazhong University of Science and Technology
Analytical Letters | Year: 2010

A novel chemiluminescence method was proposed for the determination of prulifloxacin. The method was based on the chemiluminescence reaction of the KMnO4-Na2S2O3-PUFX system sensitized by Tb3+. Under the optimum conditions, the chemiluminescence intensity was proportional to the concentration of the PUFX within the range of 5.0 × 10-8 ~ 1.0 × 10-5 molL-1, and the detection limit was 8.0 × 10-9 molL-1. The proposed method was applied to the analysis of PUFX in tables, serum, and urine samples with satisfactory results. The possible mechanism of this sensitized CL reaction was also discussed. © Taylor & Francis Group, LLC.


Wang S.-G.,Hubei Research Institute of Chemistry | Yu J.,Hubei Research Institute of Chemistry | Wang C.,Hubei Research Institute of Chemistry
Gongneng Cailiao yu Qijian Xuebao/Journal of Functional Materials and Devices | Year: 2011

Large size carboxyl crosslinked polystyrene microspheres were prepared by activation swelling polymerization with polystyrene microspheres as seeds obtained by dispersion polymerization, 1, 2-dichloroethane as the swelling agent, dioctyl adipate(DOA) as the assistant swelling agent, divinyl benzene (DVB) as the crosslinking agent and methyl methacrylate (MAA) as the water-soluble functional monomer. Effect of the swelling agent type and size of active seeds on carboxyl crosslinked polystyrene microspheres' largest average particle size and size distribution was researched and carboxyl crosslinked polystyrene microspheres were analysed by IR spectrum and thermogravimetic analysis(TGA). Carboxyl crosslinked polystyrene microspheres and the largest size of 25.0um were obtained, and the thermolysis temperatures was 273. 8°C.

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