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Cluj-Napoca, Romania

Bolboaca S.D.,Victor Babes University of Medicine and Pharmacy Timisoara | Baizat M.I.,Gynecology Clinic | Drugan T.C.,Victor Babes University of Medicine and Pharmacy Timisoara
Saudi Medical Journal | Year: 2015

Objectives: To assess the neonatal outcomes in newborns with intrauterine growth restriction (IUGR) in a Romanian population in a 3 level maternity unit.Methods: A matched case-control design, with one control for each patient was used. The case group comprised neonates with birth weight and birth length below the 10th percentile for the gestational age. Individual matching by gender and age of gestation was used to identify the control group. Both cases and controls were selected from the infants admitted to and discharged from the Neonatal Ward, at the First Gynecology Clinic, of the County Emergency Hospital Cluj-Napoca, Cluj-Napoca, Romania, between January 2012 and June 2014.Results: One hundred and forty-two subjects were included in each group. The cesarean delivery was significantly more frequent in the IUGR group (66.9%) compared with controls (46.5%; p=0.0006). The Apgar score at one minute was ≥7 for most infants in both groups (77.9% IUGR group versus 77.5% control group), with no significant differences between the groups. A significantly higher percentage of infants in the IUGR group had hypoglycemia or intraventricular hemorrhage compared with the controls (p<0.05). Hypoglycemia proved a significant factor for IUGR (odds ratio = 4.763, 95% confidence interval: 1.711-13.255).Conclusion: Hypoglycemia and intraventricular hemorrhage characterized the IUGR newborns. © 2015, Saudi Med J. All right reserved. Source


Kritas S.K.,Aristotle University of Thessaloniki | Saggini A.,University of Rome Tor Vergata | Cerulli G.,Nicolas Foundation | Caraffa A.,University of Perugia | And 7 more authors.
International Journal of Immunopathology and Pharmacology | Year: 2014

Microglia derive from mononuclear myeloid progenitors and are a major glial complement of the central nervous system. When microglia are activated they secrete inflammatory cytokines and toxic mediators which amplify the inflammatory response. In addition, the microglia inflammatory products are implicated in the neuronal destruction usually observed in various neurodegenerative diseases. Microglia cells express corticotropin releasing hormone (CRH) receptors, and activation of microglia by CRH releases bioactive molecules which have a biological effect in the brain and regulate several neurological diseases. CRH plays a pivotal role in stress responses and is a key mediator of the hypothalamic-pituitary-adrenocortical system. CRH is expressed in human mast cells, leading to autocrine effects and participates in inflammatory response together with neuropeptides, and stimulates mast cells. IL-33-activated mast cells release vascular endothelial growth factor in response to CRH and act synergistically to increase vascular permeability. CRH also up-regulates IL-18 expression by increasing intracellular reactive oxygen in microglia cells. Here we report the relationship between CRH, microglia and mental disorders. Copyright © by BIOLIFE, s a.s. Source


Moffat R.,University of Basel | Bergsma N.,University of Basel | Sartorius G.,University of Basel | Raggi A.,University of Basel | And 2 more authors.
American Journal of Obstetrics and Gynecology | Year: 2014

Objective An increasing proportion of infertile women are subjected to hysteroscopy. The effect of hysteroscopy on the pregnancy rate in assisted reproduction has been demonstrated to be favorable, but cervical dilation in the course of hysteroscopy may have an adverse effect on pregnancy outcome. We sought to investigate the effect of hysteroscopy on the risk of early miscarriage, preterm delivery, low birthweight, and other complications of pregnancy. Study Design This was a longitudinal retrospective cohort study at a university hospital. Data of 654 first-time singleton pregnancies between January 1997 and March 2011 in women with primary infertility were retrieved from a prospective data collection. Four cohorts were constructed based on exposure to hysteroscopy and pregnancy outcome (early miscarriage vs live birth). The primary endpoint was the duration of pregnancy at 37 weeks. Pregnancy outcomes of 167 infertile patients exposed to cervical dilation and hysteroscopy were compared with those of 327 infertile women unexposed to hysteroscopy. Results The incidence of miscarriage, preterm birth, placenta previa, and premature rupture of membranes after maternal exposure to hysteroscopy was similar to that in women not exposed. Conclusion Prior hysteroscopy in infertile women does not affect subsequent pregnancy outcome. © 2014 Mosby, Inc. All rights reserved. Source


Koletzko B.,Ludwig Maximilians University of Munich | Bauer C.P.,Fachklinik Gaissach | Bung P.,Gynecology Clinic | Cremer M.,Nutrition Consultant | And 11 more authors.
Annals of Nutrition and Metabolism | Year: 2014

Diet and physical activity before and during pregnancy affect short- and long-term health of mother and child. The energy needs at the end of pregnancy increase only by about 10% compared to nonpregnant women. An excessive energy intake is undesirable since maternal overweight and excessive weight gain can increase the risks for a high birth weight and later child overweight and diabetes. Maternal weight at the beginning of pregnancy is especially important for pregnancy outcome and child health. Women should strive to achieve normal weight already before pregnancy. Regular physical activity can contribute to a healthy weight and to the health of pregnant women. The need for certain nutrients increases more than energy requirements. Before and during pregnancy, foods with a high content of essential nutrients should be preferentially selected. Supplements should include folic acid and iodine, iron (in case of suboptimal iron stores), the ω-3 fatty acid docosahexaenoic acid (in case of infrequent consumption of ocean fish) and vitamin D (in case of decreased sun exposure and decreased endogenous vitamin D synthesis). Pregnant women should not smoke and not stay in rooms where others smoke or have smoked before (passive smoking). Alcohol consumption should be avoided, since alcohol can harm unborn children. © 2014 S. Karger AG, Basel. Source


Kostova P.,Gynecology Clinic | Zlatkov V.,Sofia University
Journal of B.U.ON. | Year: 2010

Purpose: The present study aimed at analyzing the results of cervical screening carried out in Bulgaria, its effect on basic epidemiological indices, age-related incidence of cervical cancer and their dynamics. It also highlighted the way in which the suspension of organized screening has influenced the epidemiological data for cervical cancer. Methods: Analyses were carried out, based on data from the National Cancer Register, the Central Institute of Statistics and the Oncological Dispensaries. Simple mathematical methods were used to analyze the attendance rate, the rate of inadequate smears and share of biopsies in women with abnormal cytology. Cohort analysis was utilized in determining age-specific incidence. Results: Incidence and mortality were stable during the first 15 years of screening activities, followed by a constant increase which became most obvious after the final interruption of organized screening. The ratio between invasive cancer and carcinoma in situ ranged from 2:1 in 1982 to over 5:1 in 2002 and was due to the faster increasing rates of invasive cancer. Age groups' and birth-cohort analysis for 3 timepoints (1975, 1990, and 2005) with different screening characteristics showed highest incidence in middle-aged women and a higher risk of cervical cancer for every subsequent generation. Conclusion: Bulgaria gives yet another, though "paradoxical", example in support of the importance of organized cervical screening. This conclusion has been reinforced by a distinct deterioration of epidemiological characteristics of cervical cancer in our country as a result of absence of an organized screening. This serious situation lends valid reasons to recommend that the relevant health authorities take a political decision to launch a programme in compliance with the European standards. © 2010 Zerbinis Medical Publications. Source

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