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De Melo Pompei L.,Gynecological Endocrinology | Giribela A.G.,University of Sao Paulo | Giribela C.G.,University of Sao Paulo
Women's Health | Year: 2011

Considerable advances have been made in the field of combined oral contraceptives since their introduction 50 years ago. This ongoing evolution has been focused on reducing the estrogen dose and synthesizing new progestogens. A recently launched combination of ethinylestradiol 20 μg and drospirenone 3 mg demonstrates the advantages of a lower estrogen dose with the antimineralocorticoid activity of drospirenone that is responsible for the drug's significant antiandrogenic and antimineralocorticoid effects, reflected clinically in lower rates of adverse events including less fluid retention. In addition to the drugs contraceptive efficacy, its effects on the skin and other classic noncontraceptive benefits, the ethinylestradiol 20 μg and drospirenone 3 mg combination has demonstrated highly satisfactory results in women with premenstrual dysphoric syndrome. © 2011 Future Medicine Ltd.

Lipinskaa J.,Gynecological Endocrinology | Lipinskaa J.,Provincial Specialist Hospitalin Olsztyn | Stefanowicz M.,Gynecological Endocrinology | Stefanowicz M.,Provincial Specialist Hospitalin Olsztyn | And 3 more authors.
Polish Annals of Medicine | Year: 2013

Introduction: Vulvar cancerisararetypeofcancer. InPolandin2010therewere491casesof vulvar cancer. Prognosticfactorsthatmayinfluence thecourseofthediseaseandresults of treatmentcanbedividedintofactorsassociatedwithtumor,individualfactorsofthe patient (age,socioeconomicstatus,co-morbidities,bodyweight,motivationtocomply) and environmental factors. Aim: The purposeofthisresearchwastoevaluatetheimpactofindividualandenviron- mental factorsontheprognosisofwomenwithvulvarcancer,regardlessoftheclinical stage. Material andmethods: The studygroupconsistedof48patientswithinvasivesquamouscell carcinoma ofthevulvatreatedsurgicallyintheDepartmentofGynecologicalOncologyin Olsztyn in1995-2008. Analysisincludedage,placeofliving,occupationalstatus, marital status, obstetrichistory,co-morbidities,bodyweight,andhealingofpost- operativewound. Univariate analysisoftheeffectofthesefactorsonsurvivalandrecurrencerateswas performed. Results anddiscussion: Univariate analysisshowedarelationshipbetweenimpairedpost- operative woundhealingandrecurrencerate(p>.05). Woundhealingcomplicatedby abscess formationoccurredmostfrequentlyinpatientswithT2stagetumoranddidnot correlate withlymphnodeinvolvement.Noeffectofage,bodyweight,ageatmenarche and ageatmenopause,andnumberofbirthsonthepresenceorabsenceofrecurrencewas observed (p>.05). Conclusions: In patientswithpost- operativewoundhealingcomplicationsduetoinfection statisticallysignificantworsesurvivalrateshavebeenobserved. Vulvarcancerwasrepeat- edlydiagnosed22yearsaftermenopause, initsadvancedstages(accordingtoFIGO1988).No correlationbetweensurvivalrateanddemographicfactors,environmentalfactors,gyneco- logicalandobstetrichistoryandco-morbiditieswasdemonstrated.Differencebetween overallsurvivalanddisease-specific survival,thatis, excludingdeathsfromcausesunrelated to cancer,was10%. © 2013 Warmin'sko-Mazurska IzbaLekarskawOlsztynie.

Lello S.,Gynecological Endocrinology | Cavani A.,Laboratory of Experimental Immunology
International Journal of Endocrinology | Year: 2014

Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic regimen (EE20/LNG100). This review summarizes clinical pharmacology, cycle control, and effects on lipid and glucose metabolism, coagulation, body weight/body composition, acne, and sexuality of EE20/LNG100. Overall, EE20/LNG100 combination is safe and well tolerated, and in several studies the incidence of adverse events in the treated group was comparable to that of the placebo group. Cycle control was effective and body weight/body composition did not vary among treated and untreated groups in most studies. The EE20/LNG100 combination shows mild or no effect on lipid and glucose metabolism. Lastly, EE20/LNG100 is associated with a low risk of venous thromboembolism (VTE). In conclusion, in the process of decision making for the individualization of EPs choice, EE20/LNG100 should be considered for its favorable clinical profile. © 2014 Stefano Lello and Andrea Cavani.

PubMed | Gynecological Endocrinology
Type: Journal Article | Journal: Women's health (London, England) | Year: 2010

Considerable advances have been made in the field of combined oral contraceptives since their introduction 50 years ago. This ongoing evolution has been focused on reducing the estrogen dose and synthesizing new progestogens. A recently launched combination of ethinylestradiol 20 g and drospirenone 3 mg demonstrates the advantages of a lower estrogen dose with the antimineralocorticoid activity of drospirenone that is responsible for the drugs significant antiandrogenic and antimineralocorticoid effects, reflected clinically in lower rates of adverse events including less fluid retention. In addition to the drugs contraceptive efficacy, its effects on the skin and other classic noncontraceptive benefits, the ethinylestradiol 20 g and drospirenone 3 mg combination has demonstrated highly satisfactory results in women with premenstrual dysphoric syndrome.

News Article | December 9, 2016
Site: marketersmedia.com

LAS VEGAS, NV / ACCESSWIRE / December 9, 2016 / Today at the 24th Annual A4M - World Congress on Anti-Aging Medicine, BioProtein Technology announced the immediate availability of DeSire, an all-natural female libido enhancer. "This will be our show stopper," said Amy Emme, Director of Business Development at BioProtein Technology. The medical community has long anticipated the all-natural libido enhancer as a way to boost their patients' existing hormone therapies. DeSire was designed to be more than a libido enhancer, it utilizes a complex of all-natural ingredients known for their abilities to help balance hormones, increase energy, reduce anxiety and stimulate desire. BioProtein Technology wants DeSire to help women feel good at any age. "We listened to what women want, and keeping them happy is our inspiration," states Chuck Powers, owner of BioProtein Technology. With ingredients backed by clinical research, women now have an all-natural alternative to enhance their libido and support hormone balance. Velvet Antler Extract - Can support multiple hormones like estradiol and estrone and may ease gynecological dysfunctions and reduce the amount of hormone replacement needed by prescription. Collagens and proteins stimulate the endocrine system to reduce anxiety and restore balance to mind and body. Tribulus - Improves sexual desire and satisfaction, increases energy, stimulates androgen receptors for positive responses to circulating hormones, enhances mood and offers urinary tract protection by cleansing the bladder, liver, kidneys and urethra. KSM 66 Ashwaganda® - The highest amount of Withanolides at 5% for maximum efficacy. Protects the body from the effects of stress by decreasing cortisol levels in the body and reducing anxiety which improves sexual function in females. Epimedium PE - Can increase estradiol levels and decrease bone loss for post- menopausal women, contains phytochemicals that can also increase blood flow and improve sexual function. Maca - Phytochemicals reduce the symptoms of menopause- hot flashes, sleep disruptions, night sweats and depression. May balance sex hormones and mood, can increase bone density and also boosts energy. Muira Puama - Libido-boosting in women with low sex drives, can also increase orgasm intensity, supports stress management, fights fatigue and supports cognitive function in as little as two weeks. The ingredients used to preserve DeSire are all natural as well: Organic Grape Alcohol - a chemical-free way to preserve bioactives that actually enhances the absorption of the ingredients and extends shelf life. Stevia - a non-carbohydrate, low-calorie sweetener that helps reduce blood glucose levels and has a long shelf life. DeSire can be an all-natural way to assist women experiencing low libido, menopausal symptoms, declining hormone levels, and anxiety, stress, and fatigue. DeSire works with hormone therapies to enhance and support their effects. BioProtein Technology's commitment to deliver quality supplements continues with this breakthrough formula. DeSire is only available through BioProtein Technology. For more information, please visit us at: http://shop.bioproteintech.com/. BioProtein Technology Welcome Video from BioLab Naturals on Vimeo. Founded in 2001, BioProtein Technology is a leader in all-natural therapies and nutraceuticals. The company offers a range of products designed to offer you natural alternatives that provide substantial results to help you be your healthiest. BioProtein Technology and DeSire are either registered trademarks or trademarks of BioProtein Technology in the United States and/or other countries. The names of actual companies and products mentioned herein may be the trademarks of their respective owners. For more information, press only: For more information on DeSire: Velvet Antler Extract: (Su et al., 2001) *(see info below) Tribulus: (Mazaro-Costa et al., 2010) *(see info below) KSM 66 Ashwaganda: (Kaplan et al.,1974) *(see info below) Epimedium PE: (Chen et al., 1996) *(see info below) Maca: (Meissener et al., 2006) *(see info below) Muira Puama: (Waynberg et al., 2000) *see info below ** Velvet Antler Extract references: Su, F.Y., Li, H.P., Wang, Y.M., Huang, Y.X., Xiao, S.M., Xiao, Y.Q., (2001) Protein component extraction and its bioactivity determination on Silka deer antler base. Animal Science and Veterinary Medicine 18, 18-20. ** Tribulus references: Mazaro-Costa R1, Andersen ML, Hachul H, Tufik S. Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women? J Sex Med. 2010 Nov;7(11):3695-714. doi: 10.1111/j.1743-6109.2010.01987.x. Akhtari E, Raisi F, Keshavarz M, Hosseini H, Sohrabvand F, Bioos S, Kamalinejad M, Ghobadi A. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo – controlled study. Daru. 2014 Apr 28;22(1):40. Hammoda HM, Ghazy NM, Harraz FM, Radwan MM, Elsohly MA, Abdallah II. Chemical constituents from Tribulus terrestris and screening of their antioxidant activity. Phytochemistry. 2013 Aug;92:153-9. doi: 10.1016/j.phytochem.2013.04.005. Qureshi A1, Naughton DP, Petroczi A. A systematic review on the herbal extract tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl. 2014 Mar;11(1):64-79. doi: 10.3109/19390211.2014.887602. Wang Z1, Zhang D, Hui S, Zhang Y, Hu S. Effect of tribulus terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats. J Tradit Chin Med. 2013 Apr;33(2):228-32. 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