Gynecological Endocrinology

São Paulo, Brazil

Gynecological Endocrinology

São Paulo, Brazil
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De Melo Pompei L.,Gynecological Endocrinology | Giribela A.G.,University of Sao Paulo | Giribela C.G.,University of Sao Paulo
Women's Health | Year: 2011

Considerable advances have been made in the field of combined oral contraceptives since their introduction 50 years ago. This ongoing evolution has been focused on reducing the estrogen dose and synthesizing new progestogens. A recently launched combination of ethinylestradiol 20 μg and drospirenone 3 mg demonstrates the advantages of a lower estrogen dose with the antimineralocorticoid activity of drospirenone that is responsible for the drug's significant antiandrogenic and antimineralocorticoid effects, reflected clinically in lower rates of adverse events including less fluid retention. In addition to the drugs contraceptive efficacy, its effects on the skin and other classic noncontraceptive benefits, the ethinylestradiol 20 μg and drospirenone 3 mg combination has demonstrated highly satisfactory results in women with premenstrual dysphoric syndrome. © 2011 Future Medicine Ltd.

Lipinskaa J.,Gynecological Endocrinology | Lipinskaa J.,Provincial Specialist Hospitalin Olsztyn | Stefanowicz M.,Gynecological Endocrinology | Stefanowicz M.,Provincial Specialist Hospitalin Olsztyn | And 3 more authors.
Polish Annals of Medicine | Year: 2013

Introduction: Vulvar cancerisararetypeofcancer. InPolandin2010therewere491casesof vulvar cancer. Prognosticfactorsthatmayinfluence thecourseofthediseaseandresults of treatmentcanbedividedintofactorsassociatedwithtumor,individualfactorsofthe patient (age,socioeconomicstatus,co-morbidities,bodyweight,motivationtocomply) and environmental factors. Aim: The purposeofthisresearchwastoevaluatetheimpactofindividualandenviron- mental factorsontheprognosisofwomenwithvulvarcancer,regardlessoftheclinical stage. Material andmethods: The studygroupconsistedof48patientswithinvasivesquamouscell carcinoma ofthevulvatreatedsurgicallyintheDepartmentofGynecologicalOncologyin Olsztyn in1995-2008. Analysisincludedage,placeofliving,occupationalstatus, marital status, obstetrichistory,co-morbidities,bodyweight,andhealingofpost- operativewound. Univariate analysisoftheeffectofthesefactorsonsurvivalandrecurrencerateswas performed. Results anddiscussion: Univariate analysisshowedarelationshipbetweenimpairedpost- operative woundhealingandrecurrencerate(p>.05). Woundhealingcomplicatedby abscess formationoccurredmostfrequentlyinpatientswithT2stagetumoranddidnot correlate withlymphnodeinvolvement.Noeffectofage,bodyweight,ageatmenarche and ageatmenopause,andnumberofbirthsonthepresenceorabsenceofrecurrencewas observed (p>.05). Conclusions: In patientswithpost- operativewoundhealingcomplicationsduetoinfection statisticallysignificantworsesurvivalrateshavebeenobserved. Vulvarcancerwasrepeat- edlydiagnosed22yearsaftermenopause, initsadvancedstages(accordingtoFIGO1988).No correlationbetweensurvivalrateanddemographicfactors,environmentalfactors,gyneco- logicalandobstetrichistoryandco-morbiditieswasdemonstrated.Differencebetween overallsurvivalanddisease-specific survival,thatis, excludingdeathsfromcausesunrelated to cancer,was10%. © 2013 Warmin'sko-Mazurska IzbaLekarskawOlsztynie.

Lello S.,Gynecological Endocrinology | Cavani A.,Laboratory of Experimental Immunology
International Journal of Endocrinology | Year: 2014

Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic regimen (EE20/LNG100). This review summarizes clinical pharmacology, cycle control, and effects on lipid and glucose metabolism, coagulation, body weight/body composition, acne, and sexuality of EE20/LNG100. Overall, EE20/LNG100 combination is safe and well tolerated, and in several studies the incidence of adverse events in the treated group was comparable to that of the placebo group. Cycle control was effective and body weight/body composition did not vary among treated and untreated groups in most studies. The EE20/LNG100 combination shows mild or no effect on lipid and glucose metabolism. Lastly, EE20/LNG100 is associated with a low risk of venous thromboembolism (VTE). In conclusion, in the process of decision making for the individualization of EPs choice, EE20/LNG100 should be considered for its favorable clinical profile. © 2014 Stefano Lello and Andrea Cavani.

PubMed | Gynecological Endocrinology
Type: Journal Article | Journal: Women's health (London, England) | Year: 2010

Considerable advances have been made in the field of combined oral contraceptives since their introduction 50 years ago. This ongoing evolution has been focused on reducing the estrogen dose and synthesizing new progestogens. A recently launched combination of ethinylestradiol 20 g and drospirenone 3 mg demonstrates the advantages of a lower estrogen dose with the antimineralocorticoid activity of drospirenone that is responsible for the drugs significant antiandrogenic and antimineralocorticoid effects, reflected clinically in lower rates of adverse events including less fluid retention. In addition to the drugs contraceptive efficacy, its effects on the skin and other classic noncontraceptive benefits, the ethinylestradiol 20 g and drospirenone 3 mg combination has demonstrated highly satisfactory results in women with premenstrual dysphoric syndrome.

News Article | December 9, 2016

LAS VEGAS, NV / ACCESSWIRE / December 9, 2016 / Today at the 24th Annual A4M - World Congress on Anti-Aging Medicine, BioProtein Technology announced the immediate availability of DeSire, an all-natural female libido enhancer. "This will be our show stopper," said Amy Emme, Director of Business Development at BioProtein Technology. The medical community has long anticipated the all-natural libido enhancer as a way to boost their patients' existing hormone therapies. DeSire was designed to be more than a libido enhancer, it utilizes a complex of all-natural ingredients known for their abilities to help balance hormones, increase energy, reduce anxiety and stimulate desire. BioProtein Technology wants DeSire to help women feel good at any age. "We listened to what women want, and keeping them happy is our inspiration," states Chuck Powers, owner of BioProtein Technology. With ingredients backed by clinical research, women now have an all-natural alternative to enhance their libido and support hormone balance. Velvet Antler Extract - Can support multiple hormones like estradiol and estrone and may ease gynecological dysfunctions and reduce the amount of hormone replacement needed by prescription. Collagens and proteins stimulate the endocrine system to reduce anxiety and restore balance to mind and body. Tribulus - Improves sexual desire and satisfaction, increases energy, stimulates androgen receptors for positive responses to circulating hormones, enhances mood and offers urinary tract protection by cleansing the bladder, liver, kidneys and urethra. KSM 66 Ashwaganda® - The highest amount of Withanolides at 5% for maximum efficacy. Protects the body from the effects of stress by decreasing cortisol levels in the body and reducing anxiety which improves sexual function in females. Epimedium PE - Can increase estradiol levels and decrease bone loss for post- menopausal women, contains phytochemicals that can also increase blood flow and improve sexual function. Maca - Phytochemicals reduce the symptoms of menopause- hot flashes, sleep disruptions, night sweats and depression. May balance sex hormones and mood, can increase bone density and also boosts energy. Muira Puama - Libido-boosting in women with low sex drives, can also increase orgasm intensity, supports stress management, fights fatigue and supports cognitive function in as little as two weeks. The ingredients used to preserve DeSire are all natural as well: Organic Grape Alcohol - a chemical-free way to preserve bioactives that actually enhances the absorption of the ingredients and extends shelf life. Stevia - a non-carbohydrate, low-calorie sweetener that helps reduce blood glucose levels and has a long shelf life. DeSire can be an all-natural way to assist women experiencing low libido, menopausal symptoms, declining hormone levels, and anxiety, stress, and fatigue. DeSire works with hormone therapies to enhance and support their effects. BioProtein Technology's commitment to deliver quality supplements continues with this breakthrough formula. DeSire is only available through BioProtein Technology. For more information, please visit us at: BioProtein Technology Welcome Video from BioLab Naturals on Vimeo. Founded in 2001, BioProtein Technology is a leader in all-natural therapies and nutraceuticals. The company offers a range of products designed to offer you natural alternatives that provide substantial results to help you be your healthiest. BioProtein Technology and DeSire are either registered trademarks or trademarks of BioProtein Technology in the United States and/or other countries. The names of actual companies and products mentioned herein may be the trademarks of their respective owners. For more information, press only: For more information on DeSire: Velvet Antler Extract: (Su et al., 2001) *(see info below) Tribulus: (Mazaro-Costa et al., 2010) *(see info below) KSM 66 Ashwaganda: (Kaplan et al.,1974) *(see info below) Epimedium PE: (Chen et al., 1996) *(see info below) Maca: (Meissener et al., 2006) *(see info below) Muira Puama: (Waynberg et al., 2000) *see info below ** Velvet Antler Extract references: Su, F.Y., Li, H.P., Wang, Y.M., Huang, Y.X., Xiao, S.M., Xiao, Y.Q., (2001) Protein component extraction and its bioactivity determination on Silka deer antler base. Animal Science and Veterinary Medicine 18, 18-20. ** Tribulus references: Mazaro-Costa R1, Andersen ML, Hachul H, Tufik S. Medicinal plants as alternative treatments for female sexual dysfunction: utopian vision or possible treatment in climacteric women? J Sex Med. 2010 Nov;7(11):3695-714. doi: 10.1111/j.1743-6109.2010.01987.x. Akhtari E, Raisi F, Keshavarz M, Hosseini H, Sohrabvand F, Bioos S, Kamalinejad M, Ghobadi A. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo – controlled study. Daru. 2014 Apr 28;22(1):40. Hammoda HM, Ghazy NM, Harraz FM, Radwan MM, Elsohly MA, Abdallah II. Chemical constituents from Tribulus terrestris and screening of their antioxidant activity. Phytochemistry. 2013 Aug;92:153-9. doi: 10.1016/j.phytochem.2013.04.005. Qureshi A1, Naughton DP, Petroczi A. A systematic review on the herbal extract tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl. 2014 Mar;11(1):64-79. doi: 10.3109/19390211.2014.887602. Wang Z1, Zhang D, Hui S, Zhang Y, Hu S. Effect of tribulus terrestris saponins on behavior and neuroendocrine in chronic mild stress depression rats. J Tradit Chin Med. 2013 Apr;33(2):228-32. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. Journal of Ethnopharmacology. 2003 April;85(2-3):257-60. ** KSM 66 Ashwaganda® references: H. S. Kaplan, "The new sex therapy. Active treatment of sexual dysfunctions (book)," The Journal of Sex Research, vol. 11, 1974. View at Google Scholar J. R. Berman, L. A. Berman, T. J. Werbin, and I. Goldstein, "Female sexual dysfunction: anatomy, physiology, evaluation and treatment options," Current Opinion in Urology, vol. 9, no. 6, pp. 563–568, 1999. View at Publisher • View at Google Scholar • View at Scopus M. A. Perelman, "Clinical application of CNS-Acting agents in FSD," Journal of Sexual Medicine, vol. 4, no. 4, pp. 280–290, 2007. View at Publisher • View at Google Scholar • View at Scopus K. Chandrasekhar, J. Kapoor, and S. Anishetty, "A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandharoot in reducing stress and anxiety in adults," Indian Journal of Psychological Medicine, vol. 34, no. 3, pp. 255–262, 2012. View at Publisher • View at Google Scholar • View at Scopus R. Archana and A. Namasivayam, "Antistressor effect of Withania somnifera," Journal of Ethnopharmacology, vol. 64, no. 1, pp. 91–93, 1998. View at Publisher • View at Google Scholar • View at Scopus K. Öberg and K. S. Fugl-Meyer, "On Swedish women's distressing sexual dysfunctions: some concomitant conditions and life satisfaction," Journal of Sexual Medicine, vol. 2, no. 2, pp. 169–180, 2005. View at Publisher • View at Google Scholar • View at Scopus N. Singh, R. (Mrs.) Nath, A. (Miss) Lata, S. P. Singh, R. P. Kohli, and K. P. Bhargava, "Withania somnifera(Ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an Adaptogen)," Pharmaceutical Biology, vol. 20, no. 1, pp. 29–35, 1982. View at Publisher • View at Google Scholar • View at Scopus A. A. Mahdi, K. K. Shukla, M. K. Ahmad et al., "Withania somnifera improves semen quality in stress-related male fertility," Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 576962, 9 pages, 2011. View at Publisher • View at Google Scholar • View at Scopus V. R. Ambiye, D. Langade, S. Dongre, P. Aptikar, M. Kulkarni, and A. Dongre, "Clinical evaluation of the spermatogenic activity of the root extract of Ashwagandha (Withania somnifera) in oligospermic males: a pilot study," Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 571420, 6 pages, 2013. View at Publisher • View at Google Scholar • View at Scopus D. A. Kalmbach, S. A. Kingsberg, and J. A. Ciesla, "How changes in depression and anxiety symptoms correspond to variations in female sexual response in a nonclinical sample of young women: a daily diary study," Journal of Sexual Medicine, vol. 11, no. 12, pp. 2915–2927, 2014. View at Publisher • View at Google Scholar • View at Scopus B. A. Prairie, S. R. Wisniewski, J. Luther et al., "Symptoms of depressed mood, disturbed sleep, and sexual problems in midlife women: cross-sectional data from the study of women's health across the nation," Journal of Women's Health, vol. 24, no. 2, pp. 119–126, 2015. View at Publisher • View at Google Scholar • View at Scopus D. J. Cosgrove, Z. Gordon, J. E. Bernie et al., "Sexual dysfunction in combat veterans with post-traumatic stress disorder," Urology, vol. 60, no. 5, pp. 881–884, 2002. View at Publisher • View at Google Scholar •View at Scopus B. Auddy, J. Hazra, A. Mitra, B. Abedon, S. Ghosal, and S. L. City, "A standardized Withania somniferaextract significantly reduces stress-related parameters in chronically stressed humans," Journal of the American Nutraceutical Association, vol. 11, pp. 51–57, 2008. View at Google Scholar K. Cooley, O. Szczurko, D. Perri et al., "Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974," PLoS ONE, vol. 4, no. 8, Article ID e6628, 2009. View at Publisher • View at Google Scholar • View at Scopus L. M. Demers, "Androgen deficiency in women; role of accurate testosterone measurements," Maturitas, vol. 67, no. 1, pp. 39–45, 2010. View at Publisher • View at Google Scholar • View at Scopus R. Rosen, C. Brown, J. Heiman et al., "The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function," Journal of Sex and Marital Therapy, vol. 26, no. 2, pp. 191–208, 2000. View at Publisher • View at Google Scholar • View at Scopus L. R. Derogatis, R. Rosen, S. Leiblum, A. Burnett, and J. Heiman, "The Female Sexual Distress Scale (FSDS): initial validation of a standardized scale for assessment of sexually related personal distress in women," Journal of Sex & Marital Therapy, vol. 28, no. 4, pp. 317–330, 2002. View at Publisher • View at Google Scholar • View at Scopus C. H. Mercer, "Sexual behaviour," Medicine, vol. 42, no. 6, pp. 291–293, 2014. View at Publisher • View at Google Scholar M. H. Mirjalili, E. Moyano, M. Bonfill, R. M. Cusido, and J. Palazón, "Steroidal lactones from Withania somnifera, an ancient plant for novel medicine," Molecules, vol. 14, no. 7, pp. 2373–2393, 2009. View at Publisher • View at Google Scholar • View at Scopus K.-J. Oh, M.-J. Chae, H.-S. Lee, H.-D. Hong, and K. Park, "Effects of Korean red ginseng on sexual arousal in menopausal women: placebo-controlled, double-blind crossover clinical study," Journal of Sexual Medicine, vol. 7, no. 4, pp. 1469–1477, 2010. View at Publisher • View at Google Scholar • View at Scopus E. Aslan, N. K. Beji, I. Gungor, A. Kadioglu, and B. K. Dikencik, "Re: Prevalence and risk factors for low sexual function in women: a study of 1,009 women in an outpatient clinic of a university hospital in istanbul-a response," Journal of Sexual Medicine, vol. 6, no. 5, pp. 1491–1492, 2009. View at Publisher •View at Google Scholar • View at Scopus R. E. Nappi, F. Albani, P. Vaccaro et al., "Use of the Italian translation of the Female Sexual Function Index (FSFI) in routine gynecological practice," Gynecological Endocrinology, vol. 24, no. 4, pp. 214–219, 2008. View at Publisher • View at Google Scholar • View at Scopus C. M. Meston, A. H. Rellini, and M. J. Telch, "Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women," Archives of Sexual Behavior, vol. 37, no. 4, pp. 530–547, 2008. View at Publisher • View at Google Scholar • View at Scopus R. Basson and L. A. Brotto, "Sexual psychophysiology and effects of sildenafil citrate in oestrogenised women with acquired genital arousal disorder and impaired orgasm: a randomised controlled trial," BJOG, vol. 110, no. 11, pp. 1014–1024, 2003. View at Publisher • View at Google Scholar • View at Scopus ** Epimedium PE references: Chen, C., Sha, M., Yang, S., and Zhang, Z. [Quantitative study of magnoflorine in Epimedium koreanum Nakai.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(11):681-2, 704. View abstract. Chen, H. L., Wang, J. K., Zhang, L. L., and Wu, Z. Y. [Contents of general flavonoides in Epimedium acuminatum Franch. and its differently-processed products]. Zhongguo Zhong.Yao Za Zhi. 2000;25(4):239-241. View abstract. Chen, K. M., Ge, B. F., Ma, H. P., and Zheng, R. L. The serum of rats administered flavonoid extract from Epimedium sagittatum but not the extract itself enhances the development of rat calvarial osteoblast-like cells in vitro. Pharmazie 2004;59(1):61-64. View abstract. Chen, M. D., Kuang, A. K., and Chen, J. L. [Influence of yang-restoring herb medicines upon metabolism of thyroid hormone in normal rats and a drug administration schedule]. Zhong.Xi.Yi.Jie.He.Za Zhi. 1989;9(2):93-5, 70. View abstract. Chen, X., Zhou, M., and Wang, J. [Effect of epimedium sagittatum on soluble IL-2 receptor and IL-6 levels in patients undergoing hemodialysis]. Zhonghua Nei Ke.Za Zhi. 1995;34(2):102-104. View abstract. Cheng, Q. L., Chen, X. M., and Shi, S. Z. [Effects of Epimedium sagittatum on immunopathology and extracellular matrices in rats with chronic renal insufficiency]. Zhonghua Nei Ke.Za Zhi. 1994;33(2):83-86. View abstract. Chiba, K., Yamazaki, M., Umegaki, E., Li, M. R., Xu, Z. W., Terada, S., Taka, M., Naoi, N., and Mohri, T. Neuritogenesis of herbal (+)- and (-)-syringaresinols separated by chiral HPLC in PC12h and Neuro2a cells. Biol.Pharm Bull 2002;25(6):791-793. View abstract. Dong, X. P., Xiao, C. H., Zhang, R., and Li, W. [Chemical studies of Epimedium acuminatum Franch]. Zhongguo Zhong.Yao Za Zhi. 1994;19(10):614-5, 639. View abstract. Gao, B., Yu, J., and Xiao, P. [Chemical constituents from the aerial part of Epimedium brevicornum Maxim.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(5):290-2, 319. View abstract. Guo, B. and Xiao, P. [Determination of flavonoids in different parts of five epimedium plants]. Zhongguo Zhong.Yao Za Zhi. 1996;21(9):523-5, 574. View abstract. Guo, B., Yu, J., and Xiao, P. [Chemical constituents from the whole plant of Epimedium fargesii Franch.]. Zhongguo Zhong.Yao Za Zhi. 1996;21(6):353-5, 383. View abstract. Hu, B. H., Zhou, L. D., and Liu, Y. L. [Acuminatin from the aerial part of Epimedium acuminatum]. Yao Xue.Xue.Bao. 1992;27(5):397-400. View abstract. Iinuma, M., Tanaka, T., Sakakibara, N., Mizuno, M., Matsuda, H., Shiomoto, H., and Kubo, M. [Phagocytic activity of leaves of Epimedium species on mouse reticuloendotherial system]. Yakugaku Zasshi 1990;110(3):179-185. View abstract. Jia, X., Wu, J., and Mao, Q. [Chemical constituents of the root of Epimedium acumiantum Franch]. Zhongguo Zhong.Yao Za Zhi. 1998;23(3):162-4, 192. View abstract. Kuroda, M., Mimaki, Y., Sashida, Y., Umegaki, E., Yamazaki, M., Chiba, K., Mohri, T., Kitahara, M., Yasuda, A., Naoi, N., Xu, Z. W., and Li, M. R. Flavonol glycosides from Epimedium sagittatum and their neurite outgrowth activity on PC12h cells. Planta Med 2000;66(6):575-577. View abstract. Lee, M. K., Choi, Y. J., Sung, S. H., Shin, D. I., Kim, J. W., and Kim, Y. C. Antihepatotoxic activity of icariin, a major constituent of Epimedium koreanum. Planta Med 1995;61(6):523-526. View abstract. Li, J., Lee, L., Gong, Y., Shen, P., Wong, S. P., Wise, S. D., and Yong, E. L. Bioassays for estrogenic activity: development and validation of estrogen receptor (ERalpha/ERbeta) and breast cancer proliferation bioassays to measure serum estrogenic activity in clinical studies. Assay.Drug Dev.Technol. 2009;7(1):80-89. View abstract. Li, S. Y., Ping, G., Geng, L., Seow, W. K., and Thong, Y. H. Immunopharmacology and toxicology of the plant flavonoid baohuoside-1 in mice. Int J Immunopharmacol. 1994;16(3):227-231. View abstract. Li, W. K., Pan, J. Q., Lu, M. J., Xiao, P. G., and Zhang, R. Y. Anhydroicaritin 3-O-rhamnosyl(1-->2)rhamnoside from epimedium koreanum and a reappraisal of other rhamnosyl(1-->2, 1-->3 and 1-->4)rhamnoside structures. Phytochemistry 1996;42(1):213-216. View abstract. Li, W., Guo, B., Xiao, P., Pan, J., Lu, M., and Zhang, R. [Chemical constituents of Epimedium wanshanense S. Z. He et Guo]. Zhongguo Zhong.Yao Za Zhi. 1996;21(10):614-6, 640. View abstract. Liao, H. J., Chen, X. M., and Li, W. G. [Effect of Epimedium sagittatum on quality of life and cellular immunity in patients of hemodialysis maintenance]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(4):202-204. View abstract. Liu, T. Z., Chen, C. Y., Yiin, S. J., Chen, C. H., Cheng, J. T., Shih, M. K., Wang, Y. S., and Chern, C. L. Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol. 2006;44(2):227-235. View abstract. Ma, A., Qi, S., Xu, D., Zhang, X., Daloze, P., and Chen, H. Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo. Transplantation 9-27-2004;78(6):831-838. View abstract. Oh, M. H., Houghton, P. J., Whang, W. K., and Cho, J. H. Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine 2004;11(6):544-548. View abstract. Sun, Y., Fung, K. P., Leung, P. C., Shi, D., and Shaw, P. C. Characterization of medicinal Epimedium species by 5S rRNA gene spacer sequencing. Planta Med 2004;70(3):287-288. View abstract. Tan, X. and Weng, W. [Efficacy of epimedium compound pills in the treatment of the aged patients with kidney deficiency syndrome of ischemic cardio-cerebral vascular diseases]. Hunan.Yi.Ke.Da.Xue.Xue.Bao. 1998;23(5):450-452. View abstract. Wang, T., Zhang, J. C., Chen, Y., Huang, F., Yang, M. S., and Xiao, P. G. [Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum]. Zhongguo Zhong.Yao Za Zhi. 2007;32(8):715-718. View abstract. Wang, Y. K. and Huang, Z. Q. Protective effects of icariin on human umbilical vein endothelial cell injury induced by H2O2 in vitro. Pharmacol.Res 2005;52(2):174-182. View abstract. Wang, Z. Q. and Lou, Y. J. Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. Eur.J Pharmacol. 11-19-2004;504(3):147-153. View abstract. Wei, S. Y., Zhang, P. X., Yang, D. M., Zhang, H. B., and Jiang, B. G. [Traditional Chinese medicine and formulas of improving peripheral nerve regeneration]. Zhongguo Zhong.Yao Za Zhi. 2008;33(17):2069-2072. View abstract. Wu H, Lu Y Du S Chen W Wang Y. [Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes]. [Article in Chinese]. Zhongguo Zhong Yao Za Zhi. 2011;36(19):2648-2652. Wu, B. Y., Zou, J. H., and Meng, S. C. [Effect of wolfberry fruit and epimedium on DNA synthesis of the aging-youth 2BS fusion cells]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(12):926-928. View abstract. Wu, H., Lien, E. J., and Lien, L. L. Chemical and pharmacological investigations of Epimedium species: a survey. Prog.Drug Res 2003;60:1-57. View abstract. Yamamoto, H., Ieda, K., Tsuchiya, S., Yan, K., Tanaka, T., Iinuma, M., and Mizuno, M. Flavonol glycoside production in callus cultures of Epimedium diphyllum. Phytochemistry 1992;31(3):837-840. View abstract. Yan, F. F., Liu, Y., Liu, Y. F., and Zhao, Y. X. Herba Epimedii water extract elevates estrogen level and improves lipid metabolism in postmenopausal women. Phytother.Res. 2008;22(9):1224-1228. View abstract. Yap, S. P., Shen, P., Butler, M. S., Gong, Y., Loy, C. J., and Yong, E. L. New estrogenic prenylflavone from Epimedium brevicornum inhibits the growth of breast cancer cells. Planta Med 2005;71(2):114-119. View abstract. Yin, X. X., Chen, Z. Q., Dang, G. T., Ma, Q. J., and Liu, Z. J. [Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts]. Zhongguo Zhong.Yao Za Zhi. 2005;30(4):289-291. View abstract. Yong, E. L., Wong, S. P., Shen, P., Gong, Y. H., Li, J., and Hong, Y. Standardization and evaluation of botanical mixtures: lessons from a traditional Chinese herb, Epimedium, with oestrogenic properties. Novartis.Found.Symp. 2007;282:173-188. View abstract. Zhao YL, Song HR Fei JX Liang Y Zhang BH Liu QP Wang J Hu P. The effects of Chinese yam-epimedium mixture on respiratory function and quality of life in patients with chronic obstructive pulmonary disease. J Tradit Chin Med. 2012;32(2):203-207. Zhao, L., Lan, L. G., Min, X. L., Lu, A. H., Zhu, L. Q., He, X. H., and He, L. J. [Integrated treatment of traditional Chinese medicine and western medicine for early- and intermediate-stage diabetic nephropathy]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2007;27(7):1052-1055. View abstract. Zhao, Y., Cui, Z., and Zhang, L. [Effects of icariin on the differentiation of HL-60 cells]. Zhonghua Zhong.Liu Za Zhi. 1997;19(1):53-55. View abstract. Zheng, M. S. An experimental study of the anti-HSV-II action of 500 herbal drugs. J Tradit.Chin Med 1989;9(2):113-116. View abstract. Anon. In vitro screening of traditional medicines for anti-HIV activity: memorandum from a WHO meeting. Bull World Health Organ 1989;67:613-8. View abstract. De Naeyer A, Pocock V, Milligan S, De Keukeleire D. Estrogenic activity of a polyphenolic extract of the leaves of Epimedium brevicornum. Fitoterapia 2005;76:35-40. View abstract. Liang, R. N., Liu, J., and Lu, J. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2008;28(4):314-317. View abstract. Lin CC, Ng LT, Hsu FF, et al. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia cell growth. Clin Exp Pharmacol Physiol 2004;31:65-9. View abstract. Ning H, Xin ZC, Lin G, et al. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology 2006;68:1350-4. View abstract. Parisi GC, Zilli M, Miani MP, et al. High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial comparison between wheat bran diet and partially hydrolyzed guar gum (PHGG). Dig Dis Sci 2002;47:1697-704.. View abstract. Phillips M, Sullivan B, Snyder B, et al. Effect of Enzyte on QT and QTc intervals. Arch Intern Med 2010;170:1402-4. View abstract. Shen P, Guo BL, Gong Y, et al. Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry 2007;68:1448-58. View abstract. Yap SP, Shen P, Li J, et al. Molecular and pharmacodynamic properties of estrogenic extracts from the traditional Chinese medicinal herb, Epimedium. J Ethnopharmacol 2007;113:218-24. View abstract. Yin XX, Chen ZQ, Liu ZJ, et al. Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2. Chin Med J (Engl) 2007;120:204-10. View abstract. Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. View abstract. Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res 2007;22:1072-9. View abstract. Zhang X, Li Y, Yang X, et al. Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation. Life Sci 2005;78:180-6. View abstract. Chen, C. C., Huang, Y. L., Sun, C. M., and Shen, C. C. New prenylflavones from the leaves of Epimedium saggitatum. J Nat.Prod. 1996;59(4):412-414. View abstract. ** Maca references: Meissner HO1, Reich-Bilinska H, Mscisz A, Kedzia B. Therapeutic Effects of Pre-Gelatinized Maca (Lepidium Peruvianum Chacon) used as a Non-Hormonal Alternative to HRT in Perimenopausal Women – Clinical Pilot Study. Int J Biomed Sci. 2006 Jun;2(2):143-59. Meissner HO1, Kapczynski W, Mscisz A, Lutomski J. Use of gelatinized maca (lepidium peruvianum) in early postmenopausal women. Int J Biomed Sci. 2005 Jun;1(1):33-45. Dording CM1, Fisher L, Papakostas G, Farabaugh A, Sonawalla S, Fava M, Mischoulon D. A double-blind, randomized, pilot dose-finding study of maca root (L. meyenii) for the management of SSRI-induced sexual dysfunction. CNS Neurosci Ther. 2008 Fall;14(3):182-91. doi: 10.1111/j.1755-5949.2008.00052.x. Brooks NA, Wilcox G, Walker KZ, Ashton JF, Cox MB, Stojanovska L. Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause. 2008 November-December; 15(6):1157-62. doi: 10.1097/gme.0b013e3181732953. Pino-Figueroa A1, Nguyen D, Maher TJ. Neuroprotective effects of Lepidium meyenii (Maca). Ann N Y Acad Sci. 2010 Jun;1199:77-85. doi: 10.1111/j.1749-6632.2009.05174.x. Parker G, Gibson NA, Brotchie H, Heruc G, Reese AM, Hadzi-Pavlovic D. Omega-3 fatty acids and mood disorders. The American Journal of Psychiatry. 2006 June;163(6):969-78. Rubio J, Caldas M, Davilla S, Gasco M, Gonzales GF. Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice. BMC Complementary and Alternative Medicine. 2006 Jun 23;6:23. Uchiyama F1, Jikyo T2, Takeda R2, Ogata M2. Lepidium meyenii (Maca) enhances the serum levels of luteinising hormone in female rats. J Ethnopharmacol. 2014 Feb 3;151(2):897-902. doi: 10.1016/j.jep.2013.11.058. Meissner HO1, Mscisz A, Reich-Bilinska H, Mrozikiewicz P, Bobkiewicz-Kozlowska T, Kedzia B, Lowicka A, Barchia I. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (III) Clinical responses of early-postmenopausal women to Maca in double blind, randomized, Placebo-controlled, crossover configuration, outpatient study. Int J Biomed Sci. 2006 Dec;2(4):375-94. Stone M, Ibarra A, Roller M, Zangara A, Stevenson E. A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen.Journal of Ethnopharmacology. 2009 December 10;126(3):574-6. doi: 10.1016/j.jep.2009.09.012. ** Muira Puama references: Waynberg J1, Brewer S. Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther. 2000 Sep-Oct;17(5):255-62. Mendes FR1, Carlini EA. Brazilian plants as possible adaptogens: an ethnopharmacological survey of books edited in Brazil. J Ethnopharmacol. 2007 Feb 12;109(3):493-500. Figueiró M1, Ilha J, Linck VM, Herrmann AP, Nardin P, Menezes CB, Achaval M, Goncalves CA, Porciuncula LO, Nunes DS, Elisabetsky E. The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model. Phytomedicine. 2011 Feb 15;18(4):327-33. doi: 10.1016/j.phymed.2010.07.013. Piato AL1, Detanico BC, Linck VM, Herrmann AP, Nunes DS, Elisabetsky E. Anti-stress effects of the "tonic"Ptychopetalum olacoides (Marapuama) in mice.Phytomedicine. 2010 Mar;17(3-4):248-53. doi: 10.1016/j.phymed.2009.07.001. Ruitenberg A, Ott A, van Swieten JC, Hofman A, Breteler MM. Incidence of dementia: does gender make a difference? Neurobiology of Aging. 2001 July-August;22(4):575-80.

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