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Roongpisuthipong A.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Chalermchockcharoenkit A.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Sirimai K.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Wanitpongpan P.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | And 4 more authors.
Asian Biomedicine | Year: 2010

Background: Sertaconazole is a new imidazole fungicide introduced for vulvo-vaginal candidiasis. It has an azole group with benzothiophene that inhibits biosynthesis of ergosterol and brings about a massive leak of cytoplasm with consequent fungal cell death. Objective: Assess the safety and efficacy of Sertaconazole in the treatment of fungal vulvo-vaginitis for comparison with Fluconazole and Clotrimazole. Subjects and methods: One-hundred eighty-eight outpatients with fungal vulvo-vaginitis were recruited at Siriraj Hospital, Thailand between August 31, 2004 and January 30, 2006. The patients were given Sertaconazole, Fluconazole, or Clotrimazole, and received vaginal swab and culture for fungus at seventh and 28th days after treatment. Results: Out of 188 cases, 177 cases were followed-up completely. Sertaconazole group included 66 cases where 35 cure, 20 fail, and 7 recurrent cases. Fluconazole group included 60 cases and had 37 cure, six fail, and 20 recurrence cases. Clotrimazole group included 55 cases and had 32 cure, nine fail and 11 recurrent cases. There were risk factors of fungal vulvo-vaginitis, including frequent micturition and small toilet shower flushing. Conclusion: Sertaconazole had similar effectiveness and less side-effect as compared with Fluconazole and Clotrimazole. It appeared to work well with lowest recurrence. Source


Roongpisuthipong A.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Chalermchockcharoenkit A.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Thamkhantho M.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Thanaboonyawat I.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit | Neungton C.,Gynecologic Infectious Diseases and Female Sexually Transmitted Disease Unit
Journal of the Medical Association of Thailand | Year: 2010

Objective: To describe the treatment pattern of condyloma acuminata in female. Material and Method: The 5-year medical records of 449 women treated for genital condyloma acuminata at the Gynecologic Infectious Diseases and Female Sexually Transmitted Disease (GID-FSTD) unit were reviewed. Data included the distribution of age, client by category, anatomical site and size, serologically coexisting sexually transmitted infection (STI), and treatment modalities. Results: About half, 50.1%, of treatment was the application of topical trichloroacetic acid; followed by podophylline in the proportion of 35.5%. While the electric cauterization and imiquimod applications were uncommon therapy. Two-fifth of the subjects, 40.7%, was completely cured, and the remaining cases required additional management. Conclusion: The present setting, the wide range of treatment available is reflection of the fact that there is no ideal management. Source

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