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Kim H.S.,Hallym University | Lee G.-W.,Gyeongsang National University | Lee G.-W.,Gyeongsang Institute of Health Science | Lee G.-W.,Gyeongnam Regional Cancer Center | And 12 more authors.
Lung Cancer | Year: 2010

Background: Although platinum-based doublet chemotherapy is considered as standard of care for patients with advanced non-small cell lung cancer (NSCLC), most of them are eventually supposed to experience disease progression. Pemetrexed, docetaxel, erlotinib, and gefitinib have been shown to be active as monotherapy for pretreated patients. In this study, the efficacy of pemetrexed and carboplatin as a salvage therapy for patients with advanced NSCLC is evaluated. Patients and methods: From March 2007 to February 2009, 32 patients who were diagnosed with inoperable NSCLC and treated with one or more prior cisplatin-based chemotherapies were enrolled. Treatment consisted of pemetrexed 500mg/m2 over a 10-min intravenous infusion and carboplatin at an AUC 5mg/mL/min over a 30-min intravenous infusion on Day 1 of a 21-day cycle. All patients were supplemented with folic acid and vitamin B12 to reduce the hematological toxicity of pemetrexed. Results: There were one (3.1%) complete response and five partial (15.6%) responses. The overall response rate was 18.8% and the median response duration was 4.4 months. Among the responders, four patients had adenocarcinoma and two had squamous cell carcinoma. Nine patients had stable disease, and the disease control rate was 46.9%. With a median follow up duration of 9.4 months, the median time to progression was 2.3 months and the median OS was 9.4 months. Seven patients (21.9%) experienced grade 3 and 4 hematologic toxicities; one anemia (3.1%), six neutropenia (18.8%), and six thrombocytopenia (18.8%). Two patients experienced grade 4 febrile neutropenia with infection. Four patients (12.5%) experienced grade 3 non-hematologic toxicities; four asthenia (12.5%), two anorexia (6.3%), and one stomatitis (3.1%). Grade 1-2 peripheral neuropathy developed in 13 patients (40.6%). Conclusion: The combination of pemetrexed and carboplatin showed favorable toxicity profiles and activity in the pretreated patients with advanced NSCLC. It is suggested that this regimen can be a good chemotherapeutic option as a salvage therapy for patients with NSCLC. © 2010 Elsevier Ireland Ltd.


Kim H.M.,Gyeongsang National University | Kim C.Y.,Gyeongsang National University | Kim C.Y.,Gyeongsang Institute of Health Science
Korean Journal of Dermatology | Year: 2012

Background: The incidence of infantile dermatoses shows a tendency to increase, despite medical development and environmental improvement. Infantile dermatoses must be regarded discretely, due to special characteristics of the neonatal and infantile skin. Objective: The purpose of this study is to evaluate the incidence of dermatologie diseases in the infant patients. Methods: One hundred fifty nine out-patients, younger than 1 year who had visited the department of dermatology from January 2001 to December 2011, were analyzed, retrospectively. Results: The 0-1 year age group accounted for 0.58% of all new patients (261/44,718). The ratio of male to female was 1 to 0.69. Patients visited the hospital most frequently in the winter (34.5%). The most common disease was atopic dermatitis (30.3%), followed by hemangioma (9.2%), and irritant contact dermatitis (7.7%). The most common disease group was eczema (44.8%), followed by an infectious skin disease (19.2%), and dermal and subcutaneous tumors (10.7%). Conclusion: This study provides useful data on the incidence and characteristics of dermatologic diseases in infant patients.


Jeong D.S.,Gyeongsang National University | Kim C.Y.,Gyeongsang National University | Kim C.Y.,Gyeongsang Institute of Health Science
Korean Journal of Dermatology | Year: 2015

Background: The internet is a growing source of information for patients, with increasing numbers of people searching for health information on the web. Patients with acne attempt to search for medical information from the internet. Objective: The purpose of this study is to investigate the current information of acne on the internet. Methods: We chose the largest portal sites to investigate the current information of acne and search for 'acne'. Results: 5.3% of the information provided by question-and-answer platform were written by dermatologist. 0.7% of the information provided by personal blog were written by dermatologist. 1.4% of the information provided by internet message board were written by dermatologist. Overall, only 2.4% of the information were written by dermatologist for provide the medical information. Conclusion: The internet provides a great deal of information in many types of resources. However, the quality of information has been more of a concern. Dermatologists should continue to counteract inaccurate information by providing quality information on the internet. Dermatologists should be more aware of the health-related online information and should guide patients to take the accurate information.


Go S.-I.,Gyeongsang National University | Lee A.,Gyeongsang National University | Lee U.S.,Gyeongsang National University | Choi H.J.,Gyeongsang National University | And 7 more authors.
Lung Cancer | Year: 2014

Background: The neutrophil-lymphocyte ratio (NLR) has been identified as a potentially useful marker for predicting clinical outcome in patients with cardiovascular disease, diabetes, and various malignancies. The aim of this study was to determine whether NLR at the time of venous thromboembolism (VTE) diagnosis is a prognostic factor for the response to anticoagulation and survival in lung cancer patients treated with anticoagulation for VTE. Patients and methods: We retrospectively analyzed the clinical characteristics, laboratory parameters, and NLR in 114 lung cancer patients newly diagnosed with VTE, among 991 patients pathologically confirmed for lung cancer between July 2008 and August 2013. Results: High NLR was significantly associated with high hematocrit (p= 0.028), high C-reactive protein (p= 0.002), and low albumin (p= 0.001). Compared with the low NLR group, stage IV non-small cell lung cancer (NSCLC) at the time of VTE diagnosis (55.6 vs. 74.6%, p= 0.055), central nervous system metastasis (5.8 vs. 25.8%, p= 0.004), and cancer progression (14.3 vs. 38.8%, p= 0.008) at the time of VTE diagnosis were also significant in the high NLR group. Moreover, the poor response to anticoagulation was statistically correlated with patients with NSCLC (p= 0.037), high NLR (p= 0.004), and low albumin (p= 0.029). Conclusions: The results demonstrate that the NLR at the time of VTE diagnosis could be a useful biomarker for predicting the response and prognosis following anticoagulation in patients with lung cancer and VTE. © 2014 Elsevier Ireland Ltd.


Kim H.M.,Gyeongsang National University | Lee S.H.,Gyeongsang National University | Kim C.Y.,Gyeongsang National University | Kim C.Y.,Gyeongsang Institute of Health Science
Korean Journal of Dermatology | Year: 2010

Erlotinib (Tarceva ®) is a new anti-cancer agent that acts by inhibiting epidermal growth factor receptor (EGFR) signal transduction. It is currently used in the treatment of advanced stage non-small cell lung cancer and pancreatic cancer. A patient consulted our clinic and she had erythematous patches and vesicles on the submandibular area. She had taken erlotinib for the treatment of recurred lung cancer for 2 weeks. We report here on a case of radiation recall dermatitis that was induced by erlotinib in a 69-year-old woman who was previously irradiated on her submandibular area.

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