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PubMed | Chonnam National University, Catholic University of Korea, Seoul National University, Keimyung University and 3 more.
Type: Journal Article | Journal: Clinical breast cancer | Year: 2015

We designed the present study to investigate differences in prognostic factors and failure patterns between patients with invasive micropapillary carcinoma or carcinoma with micropapillary component (IMPC) and randomly matched patients with invasive ductal carcinoma (IDC) of the breast at multiple institutions of the Korean Radiation Oncology Group (KROG).This retrospective multicenter study was performed using subjects treated from January 1999 to November 2011. Female patients who had undergone curative resection for breast cancer without neoadjuvant chemotherapy were considered for this study. Exact matches were made for age ( 3 years), pathologic tumor and node stage, treatment method (surgery with or without radiotherapy), and period when surgery was performed (within 1 year) at the same institution.A total of 534 patients were analyzed. The median follow-up period was 59 months in both groups. In the comparison of clinicopathologic characteristics, rates of lymphovascular invasion (LVI) and nuclear grade III were both significantly higher in IMPC than in IDC (P < .001, P = .01, respectively). During the follow-up period, recurrences developed in 40 patients with IMPC (15.0%) and 21 with IDC (7.9%). Locoregional recurrence (LRR) developed in 22 patients with IMPC (8.2%) and 10 with IDC (3.7%). The rate of distant metastasis did not differ between the 2 groups (P = .52). LRR-free survival (P = .03) and recurrence-free survival (P = .007) were significantly different between the 2 groups, but overall survival was not (P = .67).IMPC is associated with a higher rate of LVI, high nuclear grade, and a propensity for LRR compared to IDC. Modification of the locoregional treatment modality might be needed in this pathologic subtype of breast cancer.


Kang M.H.,Gyeongsang National University | Go S.-I.,Gyeongsang National University | Song H.-N.,Gyeongsang National University | Lee A.,Gyeongsang National University | And 8 more authors.
British Journal of Cancer | Year: 2014

Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment.Methods:We retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital.Results:In total, 187 patients were evaluated. Compared with low NLR (<4), high NLR (≥4) at diagnosis was associated with poor performance status, advanced stage, and lower response rate. Median overall survival (OS) and progression-free survival (PFS) were worse in the high-NLR group (high vs low, 11.17 vs 9.20 months, P=0.019 and 6.90 vs 5.49 months, P=0.005, respectively). In contrast, PLR at diagnosis was not associated with OS or PFS (P=0.467 and P=0.205, respectively). In multivariate analysis, stage, lactate dehydrogenase, and NLR at diagnosis were independent prognostic factors for OS and PFS.Conclusions:NLR is easily measurable and reflects the SCLC prognosis. A future prospective study is warranted to confirm our results. © 2014 Cancer Research UK. All rights reserved.


Go S.-I.,Gyeongsang National University | Lee A.,Gyeongsang National University | Lee U.S.,Gyeongsang National University | Choi H.J.,Gyeongsang National University | And 7 more authors.
Lung Cancer | Year: 2014

Background: The neutrophil-lymphocyte ratio (NLR) has been identified as a potentially useful marker for predicting clinical outcome in patients with cardiovascular disease, diabetes, and various malignancies. The aim of this study was to determine whether NLR at the time of venous thromboembolism (VTE) diagnosis is a prognostic factor for the response to anticoagulation and survival in lung cancer patients treated with anticoagulation for VTE. Patients and methods: We retrospectively analyzed the clinical characteristics, laboratory parameters, and NLR in 114 lung cancer patients newly diagnosed with VTE, among 991 patients pathologically confirmed for lung cancer between July 2008 and August 2013. Results: High NLR was significantly associated with high hematocrit (p= 0.028), high C-reactive protein (p= 0.002), and low albumin (p= 0.001). Compared with the low NLR group, stage IV non-small cell lung cancer (NSCLC) at the time of VTE diagnosis (55.6 vs. 74.6%, p= 0.055), central nervous system metastasis (5.8 vs. 25.8%, p= 0.004), and cancer progression (14.3 vs. 38.8%, p= 0.008) at the time of VTE diagnosis were also significant in the high NLR group. Moreover, the poor response to anticoagulation was statistically correlated with patients with NSCLC (p= 0.037), high NLR (p= 0.004), and low albumin (p= 0.029). Conclusions: The results demonstrate that the NLR at the time of VTE diagnosis could be a useful biomarker for predicting the response and prognosis following anticoagulation in patients with lung cancer and VTE. © 2014 Elsevier Ireland Ltd.


Moon Y.S.,Gyeongsang Institute of Health Science | Kim C.Y.,Gyeongsang National University
Korean Journal of Dermatology | Year: 2016

Background: The incidence rates of cutaneous malignant tumors in the Korean population are increasing. However, few clinical studies have been conducted on cutaneous malignant tumors in Gyeongnam Province. Objective: The purpose of this study was to evaluate the prevalence of cutaneous malignant tumors in Western Gyeongnam Province and to compare the results with previous reports of cutaneous malignant tumors. Methods: We retrospectively reviewed 46,277 outpatients who visited the Department of Dermatology from January 2005 to December 2015. Among them, 1,120 patients who underwent biopsy for skin tumors had tumors classified as cutaneous malignant tumors. We compared the histopathological diagnoses and analyzed the distribution of dermatologie diseases and clinical features, including age and sex. Results: The mean age of the patients was 70.0 years. The ratio of male to female patients was 1 : 1.85. Cutaneous malignant and premalignant tumors were found in 2.4% of all new patients. The most common disease was basal cell carcinoma (39.6%), followed by squamous cell carcinoma (31.5%), malignant lymphoma (6.3%), metastatic carcinoma (5.8%), keratoacanthoma (4.2%), malignant melanoma (4.1%), and extramammary Paget's disease (2.8%). The most common premalignant tumor was actinic keratosis (73.2%), followed by Bowen's disease (26.8%). The most common site of cutaneous malignant tumors and premalignant tumors was the face (75.3% and 80.8%, respectively). Conclusion: This study provides useful data on the incidence and characteristics of cutaneous malignant tumors. The frequency of malignant tumors was higher than that found in previous studies.


Kim H.M.,Gyeongsang National University | Lee S.H.,Gyeongsang National University | Kim C.Y.,Gyeongsang National University | Kim C.Y.,Gyeongsang Institute of Health Science
Korean Journal of Dermatology | Year: 2010

Erlotinib (Tarceva ®) is a new anti-cancer agent that acts by inhibiting epidermal growth factor receptor (EGFR) signal transduction. It is currently used in the treatment of advanced stage non-small cell lung cancer and pancreatic cancer. A patient consulted our clinic and she had erythematous patches and vesicles on the submandibular area. She had taken erlotinib for the treatment of recurred lung cancer for 2 weeks. We report here on a case of radiation recall dermatitis that was induced by erlotinib in a 69-year-old woman who was previously irradiated on her submandibular area.


Jeong D.S.,Gyeongsang National University | Kim C.Y.,Gyeongsang National University | Kim C.Y.,Gyeongsang Institute of Health Science
Korean Journal of Dermatology | Year: 2015

Background: The internet is a growing source of information for patients, with increasing numbers of people searching for health information on the web. Patients with acne attempt to search for medical information from the internet. Objective: The purpose of this study is to investigate the current information of acne on the internet. Methods: We chose the largest portal sites to investigate the current information of acne and search for 'acne'. Results: 5.3% of the information provided by question-and-answer platform were written by dermatologist. 0.7% of the information provided by personal blog were written by dermatologist. 1.4% of the information provided by internet message board were written by dermatologist. Overall, only 2.4% of the information were written by dermatologist for provide the medical information. Conclusion: The internet provides a great deal of information in many types of resources. However, the quality of information has been more of a concern. Dermatologists should continue to counteract inaccurate information by providing quality information on the internet. Dermatologists should be more aware of the health-related online information and should guide patients to take the accurate information.


Son S.,Korea University | Kang D.-H.,Korea University | Kang D.-H.,Gyeongsang National University | Choi D.S.,Gyeongsang Institute of Health Science | And 3 more authors.
Journal of Korean Neurosurgical Society | Year: 2011

We present a case report of a 45-year-old woman with spontaneous pneumocephalus accompanied by pneumorrhachis of the thoracic spine, which is a very rare condition generally associated with trauma and thoracic or spinal surgery. The patient had undergone an operation about 10 years earlier to treat a giant cell tumor of the thoracic spine. During the operation, a metallic device was installed, which destroyed the bronchus and caused the formation of a broncho-paraspinal fistula. This is the suspected cause of her pneumocephalus and pneumorrhachis. To our knowledge, this is a very rare case of pneumocephalus accompanied by pneumorrhachis induced by metallic device, and when considering the length of time after surgery these complications presented are also exceptional. © 2011 The Korean Neurosurgical Society.


Kim H.M.,Gyeongsang National University | Kim C.Y.,Gyeongsang National University | Kim C.Y.,Gyeongsang Institute of Health Science
Korean Journal of Dermatology | Year: 2012

Background: The incidence of infantile dermatoses shows a tendency to increase, despite medical development and environmental improvement. Infantile dermatoses must be regarded discretely, due to special characteristics of the neonatal and infantile skin. Objective: The purpose of this study is to evaluate the incidence of dermatologie diseases in the infant patients. Methods: One hundred fifty nine out-patients, younger than 1 year who had visited the department of dermatology from January 2001 to December 2011, were analyzed, retrospectively. Results: The 0-1 year age group accounted for 0.58% of all new patients (261/44,718). The ratio of male to female was 1 to 0.69. Patients visited the hospital most frequently in the winter (34.5%). The most common disease was atopic dermatitis (30.3%), followed by hemangioma (9.2%), and irritant contact dermatitis (7.7%). The most common disease group was eczema (44.8%), followed by an infectious skin disease (19.2%), and dermal and subcutaneous tumors (10.7%). Conclusion: This study provides useful data on the incidence and characteristics of dermatologic diseases in infant patients.


PubMed | Gyeongsang National University and Gyeongsang Institute of Health Science
Type: | Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society | Year: 2016

Rotavirus nonstructural protein 4 (NSP4) has been suggested as a pathogen of rotavirus-associated seizures. We investigated pre-existing serum antibodies against NSP4 and VP6 (the most highly immunogenic rotavirus protein) in patients with rotavirus gastroenteritis and its correlation with the occurrence of seizures.With an enzyme-linked immunosorbent assay, IgG and IgA titers against NSP4 (genotype [A] and [B]) and VP6 were measured in acute-phase sera of 202 children aged 0.5-6.0 years with rotavirus gastroenteritis. The clinical characteristics and antibody levels were compared between patients with (seizure group) and without seizures (non-seizure group).The non-seizure and seizure groups comprised 173 and 29 patients, respectively. Age, sex, hospital stay, presence of fever, white blood cell counts, C-reactive protein, vaccine status, IgG/IgA titers for VP6, and IgA titers for both NSP4s did not differ between the groups. The seizure group showed a lower level of IgG against NSP4 [A] (184.5 vs. 163.0U/mL; P=0.03) and NSP4 [B] (269.0 vs. 196.0U/mL; P=0.02). Delayed sampling time from the onset of gastroenteritis symptoms (3 vs. 2 days; P=0.02) and lower serum sodium level (133.4 vs. 136.3mEq/L; P<0.01) were observed in the seizure group. Even after adjusting these factors, anti-NSP4 [A] IgG (OR 2.56 per 100U/mL increment; 95% CI, 1.20-5.26, P=0.01) and anti-NSP4 [B] IgG (OR 1.51 per 100U/mL-increment; 95% CI, 1.04-2.22, P=0.03) were independently associated with protection against seizures.Serum anti-NSP4 IgG might protect rotavirus-associated seizures.


Oh S.Y.,Dong - A University | Jeong C.Y.,Korea University | Hong S.C.,Korea University | Kim T.H.,Korea University | And 10 more authors.
Investigational New Drugs | Year: 2011

Aim We conducted this phase II study in an effort to evaluate the efficacy and safety of a gemcitabine single chemotherapy as a second-line treatment for biliary tract cancer (BTC) patients who evidenced disease progression after the administration of 5-fluorouracil (5-FU)-based palliative chemotherapy. Patients and Method Patients treated previously with 5-FU-based palliative treatment as a BTC were enrolled in this study. Treatment consisted of gemcitabine at a dosage of 1,250 mg/m 2 administered intravenously over a 30-minute period on days 1 and 8 of each 21-day cycle until progression. Results Between Feb. 2006 and July 2009, a total of 32 patients were assigned to treatment groups. 16 patients (50%) had cancers of intrahepatic cholangiocarcinoma, 12 patients (37.5%) had gall bladder cancer, and 4 patients (12.5%) had extra-hepatic cholangiocarcinoma. In the 29 patients whose tumor responses were evaluated, two achieved a partial response, with an overall response rate of 6.9% (95% confidence interval [CI]:0.0-16.7%). Six patients (20.7%) evidenced stable disease and 21 patients (72.4%) evidenced progression during the course of treatment. The median follow-up duration was 23.2 months (range:3.0-53.1 months). The median time to progression (TTP) was 1.6 months (95% CI:1.3-1.9 months), and the median overall survival (OS) time was 4.1 months (95% CI:2.7-5.5 months). Poor performance status (ECOG 2) in patients was predictive of shorter TTP. Lower albumin levels (<3.5 g/dL) in patients were predictive of shorter TTP and OS. Conclusions Despite first salvage chemotherapy in the phase II study for patients with 5-FU refractory BTC, the results in terms of RR, TTP, and OS were lower than expected. However, selected patients with good performance status and sufficient albumin levels may have derived some survival benefits from salvage chemotherapy. © Springer Science+Business Media, LLC 2010.

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