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Kim H.J.,Chubu University | Jung C.L.,A-Life Medical | Park I.S.,Kyungpook National University | Suh H.-J.,Gyeongbuk Natural Color Institute | And 2 more authors.
Food Science and Biotechnology | Year: 2013

Curled dock (Rumex crispus L.) is known to have several health benefits including antioxidant, antifungal, and anti-inflammatory effects. The potential to induce phase 2 detoxifying enzymes of butanol extract of curled dock (BECD) seeds was investigated. BECD increased the activity of NAD(P)H:quinone oxidoreductase and expression of phase 2 detoxifying enzymes such as heme oxygenase 1, Γ-glutamylcysteine synthetase, NAD(P)H:quinone oxidoreductase, and glutathione reductase, in both hepa1c1c7 and its mutant BPRc1 cells. The translocation of transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and binding to antioxidant response element (ARE) in the promoter region of phase 2 detoxifying/antioxidant enzymes were promoted by BECD in HepG2-C8 cells. Furthermore, BECD enhanced phosphorylation of Akt in hepatoma cell lines while Nrf2 activation induced by BECD was suppressed by an inhibitor of Akt. This result suggests that BECD induces phase 2 detoxifying enzymes through the Akt/Nrf2/ARE signaling pathway. BECD merits further study to be developed as detoxification agent. © 2013 The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht.


Kim H.J.,Kyungpook National University | Seo J.-Y.,Kyungpook National University | Suh H.-J.,Gyeongbuk Natural Color Institute | Lim S.S.,Hallym University | Kim J.-S.,Kyungpook National University
Nutrition Research and Practice | Year: 2012

Glycyrrhiza uralensis (or licorice) is a widely used Oriental herbal medicine from which the phenylflavonoids dehydroglyasperin C (DGC), dehydroglyasperin D (DGD), and isoangustone A (IsoA) are derived. The purpose of the present study was to evaluate the antioxidant properties of DGC, DGD, and IsoA. The three compounds showed strong ferric reducing activities and effectively scavenged DPPH, ABTS+, and singlet oxygen radicals. Among the three compounds tested, DGC showed the highest free radical scavenging capacity in human hepatoma HepG2 cells as assessed by oxidant-sensitive fluorescent dyes dichlorofluorescein diacetate and dihydroethidium bromide. In addition, all three compounds effectively suppressed lipid peroxidation in rat tissues as well as H2O2-induced ROS production in hepatoma cells. This study demonstrates that among the three phenylflavonoids isolated from licorice, DGC possesses the most potent antioxidant activity, suggesting it has protective effects against chronic diseases caused by reactive oxygen species as well as potential as an antioxidant food additive. © 2012 The Korean Nutrition Society and the Korean Society of Community Nutrition.


Hwang C.-R.,Namhae Garlic Research Institute | Kang M.J.,Namhae Garlic Research Institute | Shim H.J.,Namhae Garlic Research Institute | Suh H.J.,Gyeongbuk Natural Color Institute | And 2 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2015

The objective of this study was to investigate the antioxidant and antiobesity activities of various color resources extracted from natural plants such as, clove, persimmon, gall nut, amur cork, gardenia, safflower, and annatto. Total phenolic content was the highest in gall nut extract (2,441.45 mg/kg) followed by clove extract (1,346.48 mg/kg). DPPH, and ABTS radical scavenging activities and ferric reducing antioxidant power (FRAP) were also higher in gall nut extract. α-Glucosidase inhibitory activity (IC50) was highest in persimmon extract (22.83 μg/mL) followed by gall nut extract. α-Amylase and lipase inhibitory activities were also higher in persimmon extract (49.45% and 61.01%, respectively). Lipid accumulation in 3T3-L1 cells was lower in persimmon, clove, and annatto extracts (81.54%, 83.36%, and 85.70% at 20 μg/mL, respectively). Triglyceride content in 3T3-L1 cells was lowest in clove extract (66.11%) followed by persimmon extract (88.88%). The results of this study suggest that gall nut extract has the highest antioxidant activity, whereas persimmon and clove extract show the antiobesity activities by inhibition of digestive enzymes and fat accumulation in 3T3-L1 cells. These extracts are useful materials for the development of antioxidant and antiobesity functional foods. © 2015, Korean Society of Food Science and Nutrition. All rights reserved.

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