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Choi C.W.,Korea Institute of Science and Technology | Song S.B.,Gyeongbuk Institute for Bio industry GIB andong City | Oh J.S.,Korea Institute of Science and Technology | Oh J.S.,Dankook University | Kim Y.H.,Chungnam National University
African Journal of Traditional, Complementary and Alternative Medicines | Year: 2015

Background: Plants still remain a prime source of drugs for the treatment of cancer and can provide leads for the development of novel anticancer agents. Our screening of indigenous medicinal plants from Tanzania has led to the identification of the number of anticancer activity. Material and methods: The current study investigates the cytotoxic activity of methanol extracts of one hundred and thirty seven Tanzania plants used locally for the traditional medicine herb using the MTS assay on the HepG2 cell lines. Result 16% of the tested plant extracts showed moderate to strong inhibitory activity with IC50 values ranging from 17.1 ± 1.1 μg/ml to 79.2 ± 0.7 μg/ml ; meanwhile, ten extracts (7.3%) could demonstrate cytotoxic activity with IC50 values less than 27.6 ± 2.0 μg/ml; twelve extracts (8.8%) could demonstrate cytotoxic activity with IC50 values ranging from 30.4 ± 1.6 μg/ml to 79.2 ± 0.7μg/ml. Conclusion : Especially, a methanol extract from the bark extract of Erythrophleum zimmermannii (Fabaceae) was found to be the most cytotoxicity against HepG2 cell lines (IC50 = 17.1 ± 1.1 μg/ml). © 2015, African Ethnomedicines Network. All rights reseved. Source


Sun Y.N.,Chungnam National University | Li W.,Yeungnam University | Song S.B.,Gyeongbuk Institute for Bio industry GIB andong City | Yan X.T.,Chungnam National University | And 2 more authors.
Natural Product Sciences | Year: 2014

Acanthopanax divaricatus var. albeofructus (ADA) is commonly ingested as a traditional medicine or as a component of a health drink in Korea. In this phytochemical study, nine phenolics (1 - 9) and three lignans (10 - 12) were isolated from the MeOH extract of the stems of ADA. Chemical structures were elucidated by comparing spectroscopic data with reported values. Nuclear factor kappa B (NF-κB) inhibitory activity of the isolated compounds was evaluated using an NF-κB luciferase assay in HepG2 cells. Among them, compounds 1, 3 - 8, and 11 showed significant inhibitory effects on TNFα-induced NF-κB transcriptional activity in a dosedependent manner, with IC50 values ranging from 13.25 to 37.36 μM. Further studies on potential antiinflammatory effects and the benefits of phenolic and lignan components from ADA are warranted. © 2014, Korean Society of Pharmacognosy. All Rights Reserved. Source


Thao N.P.,Vietnam Academy of Science and Technology | Luyen B.T.T.,Vietnam Academy of Science and Technology | Sun Y.N.,Chungnam National University | Song S.B.,Chungnam National University | And 7 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2014

Chromatographic purification of the methanolic extract from the soft coral Sarcophyton pauciplicatum led to the isolation of three polyhydroxylated steroids 1-3, including a new compound, sarcopanol A (1). Their structures were elucidated by spectroscopic analysis and by comparison of the spectroscopic data with those of similar compounds previously reported in literature. The anti-inflammatory effects of isolated compounds were evaluated using nuclear factor kappa B (NF-κB) luciferase and reverse transcription polymerase chain reaction (RT-PCR). The effect of isolated compounds on cell growth was evaluated by MTS assays. Compounds 1 and 2 significantly inhibited TNFα/INFγ-induced NF-κB transcriptional activity in human keratinocyte (HaCaT) cells in a dose-dependent manner, with EC50 values of 8.27 ± 3.28 and 26.07 ± 5.59 μM, respectively. Furthermore, the transcriptional inhibition of these compounds was confirmed by a decrease in cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and intercellular adhesion molecule-1 (ICAM-1) gene expression levels in HaCaT cells. © 2014 Elsevier Ltd. All rights reserved. Source


Li W.,Yeungnam University | Zhou W.,Chungnam National University | Song S.B.,Gyeongbuk Institute for Bio industry GIB andong City | Shim S.H.,Yeungnam University | Kim Y.H.,Chungnam National University
Journal of Natural Products | Year: 2014

Six new (erinarols A-F, 1-6) and five known (7-11) ergostane-type sterol fatty acid esters were isolated from the methanol extract of the dried fruiting bodies of Hericium erinaceum. Their chemical structures were elucidated using chemical and physical methods as well as through comparison of NMR and mass spectral data with those reported previously. This is the first comprehensive investigation on ergostane-type sterol fatty acid esters from H. erinaceum. The isolated compounds were evaluated for their PPAR transactivational effects using a luciferase reporter system. Compounds 1 and 2 significantly activated the transcriptional activity of PPARs in a dose-dependent manner, with EC50 values of 8.2 and 6.4 μM, respectively. Moreover, compounds 1 and 2 also activated PPARα and PPARγ transcriptional activity, with stimulation from 1.3- to 3.9-fold at 20 μM concentrations. © 2014 The American Chemical Society and American Society of Pharmacognosy. Source


Sun Y.N.,Chungnam National University | Li W.,Yeungnam University | Song S.B.,Gyeongbuk Institute for Bio industry GIB andong City | Yan X.T.,Northwest University, China | And 4 more authors.
Natural Product Research | Year: 2015

One novel phenolic compound, (4S,5R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3H)-one (1), as well as 12 known compounds (2–13) was obtained from the aqueous extract of Acacia catechu and their chemical structures were determined by spectroscopic analysis. Compounds 8 and 9 exhibited significant soluble epoxide hydrolase (sEH) inhibitory activities with IC50 values of 26.6 ± 0.5 and 24.4 ± 5.6 μM, respectively. Compounds 7–10 showed significant inhibitory effects on TNFα-induced nuclear factor kappa B (NF-κB) transcriptional activity in a dose-dependent manner, with IC50 values ranging from 11.15 to 19.45 μM. © 2015 Taylor & Francis Source

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