PubMed | Northwest University, China, Chungnam National University, Yeungnam University and c Gyeongbuk Institute for Bio industry GIB andong City
Type: Journal Article | Journal: Natural product research | Year: 2016
One novel phenolic compound, (4S,5R)-4-(3,4-dihydroxyphenyl)-5-(3-oxobutyl)dihydrofuran-2(3H)-one (1), as well as 12 known compounds (2-13) was obtained from the aqueous extract of Acacia catechu and their chemical structures were determined by spectroscopic analysis. Compounds 8 and 9 exhibited significant soluble epoxide hydrolase (sEH) inhibitory activities with IC50 values of 26.60.5 and 24.45.6M, respectively. Compounds 7-10 showed significant inhibitory effects on TNF-induced nuclear factor kappa B (NF-B) transcriptional activity in a dose-dependent manner, with IC50 values ranging from 11.15 to 19.45M.