Gyeongbuk Institute for Bio industry andong City

Andong, South Korea

Gyeongbuk Institute for Bio industry andong City

Andong, South Korea
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Sun Y.N.,Chungnam National University | Li W.,Yeungnam University | Song S.B.,Gyeongbuk Institute for Bio industry andong City | Yan X.T.,Korea University | And 2 more authors.
Pharmacognosy Magazine | Year: 2016

Background: Polygonum multiflorum is well-known as «Heshouwu» in traditional Chinese herbal medicine. In Northeast Asia, it is often used as a tonic to prevent premature aging of the kidney and liver, tendons, and bones and strengthening of the lower back and knees. Objective: To research the anti-inflammatory activities of components from P. multiflorum. Materials and Methods: The compounds were isolated by a combination of silica gel and YMC R-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-nuclear magnetic resonance, and mass spectrometry). The anti-inflammatory activities of the isolated compounds 1-15 were evaluated by luciferase reporter gene assays. Results: Fifteen compounds (1-15) were isolated from the roots of P. multiflorum. Compounds 1-5 and 14-15 significantly inhibited tumor necrosis factor-α-induced nuclear factor kappa B-luciferase activity, with IC 50 values of 24.16-37.56 μM. Compounds 1-5 also greatly enhanced peroxisome proliferator-activated receptors transcriptional activity with EC 50 values of 18.26-31.45 μM. Conclusion: The anthraquinone derivatives were the active components from the roots of P. multiflorum as an inhibitor on inflammation-related factors in human hepatoma cells. Therefore, we suggest that the roots of P. multiflorum can be used to treat natural inflammatory diseases. © 2016 Pharmacognosy Magazine | Published by Wolters Kluwer - Medknow.

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